Ruth Asch
Associate Research Scientist in Psychiatry
Research & Publications
Biography
News
Coauthors
Selected Publications
- Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorderAsch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, DOI: 10.1016/j.jad.2024.06.025.
- 5. Lower SV2A Synaptic Density Following Chronic Stress and Relationships With Cognitive Impairment: An In Vivo [18F]SynVesT-1 and PET Study in Male and Female RatsAsch R, Cai Z, DiLeone R, Carson R, Liston C, Esterlis I. 5. Lower SV2A Synaptic Density Following Chronic Stress and Relationships With Cognitive Impairment: An In Vivo [18F]SynVesT-1 and PET Study in Male and Female Rats. Biological Psychiatry 2024, 95: s75-s76. DOI: 10.1016/j.biopsych.2024.02.183.
- First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific BindingDrake L, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery P, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer A, Gallezot J, Carson R, Cai Z, Huang Y. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266470. PMID: 38360052, PMCID: PMC10924160, DOI: 10.2967/jnumed.123.266470.
- Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive DisordersFan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.
- Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PETAsch R, Naganawa M, Nabulsi N, Huan Y, Esterlis I, Carson R. Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 2120-2129. PMID: 37669455, PMCID: PMC10925870, DOI: 10.1177/0271678x231200423.
- Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress DisordersBaldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders. Chronic Stress 2023, 7: 24705470231154842. PMID: 36843572, PMCID: PMC9943964, DOI: 10.1177/24705470231154842.
- Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female RatsAsch R, Fowles K, Pietrzak R, Taylor J, Esterlis I. Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats. Chronic Stress 2023, 7: 24705470231215001. PMID: 38024327, PMCID: PMC10666551, DOI: 10.1177/24705470231215001.
- The metabotropic glutamate receptor 5 as a biomarker for psychiatric disordersAsch R, Hillmer A, Baldassarri S, Esterlis I. The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders. 2022, 168: 265-310. PMID: 36868631, DOI: 10.1016/bs.irn.2022.10.007.
- Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive DisorderHolmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.
- Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in ratsAsch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology 2022, 48: 489-497. PMID: 36100654, PMCID: PMC9852230, DOI: 10.1038/s41386-022-01441-y.
- Lower synaptic density is associated with psychiatric and cognitive alterations in obesityAsch RH, Holmes SE, Jastreboff AM, Potenza MN, Baldassarri SR, Carson RE, Pietrzak RH, Esterlis I. Lower synaptic density is associated with psychiatric and cognitive alterations in obesity. Neuropsychopharmacology 2021, 47: 543-552. PMID: 34294874, PMCID: PMC8674236, DOI: 10.1038/s41386-021-01111-5.
- Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment styleAsch RH, Esterlis I, Wendt FR, Kachadourian L, Southwick SM, Gelernter J, Polimanti R, Pietrzak RH. Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style. The World Journal Of Biological Psychiatry 2021, 22: 792-799. PMID: 33821766, PMCID: PMC8925016, DOI: 10.1080/15622975.2021.1907721.
- The hidden burden of social anxiety disorder in U.S. military veterans: Results from the National Health and Resilience in Veterans StudyByrne SP, Fogle BM, Asch R, Esterlis I, Harpaz-Rotem I, Tsai J, Pietrzak RH. The hidden burden of social anxiety disorder in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2021, 291: 9-14. PMID: 34022553, DOI: 10.1016/j.jad.2021.04.088.
- Psychological Resilience to the Challenges of Physical Aging in Older U.S. Veterans: Results From the 2019-2020 National Health and Resilience in Veterans StudyAsch RH, Kachadourian L, Southwick SM, Esterlis I, Pietrzak RH. Psychological Resilience to the Challenges of Physical Aging in Older U.S. Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2021, 29: 1280-1285. PMID: 34053836, PMCID: PMC8553809, DOI: 10.1016/j.jagp.2021.04.013.
- Risk and resilience factors associated with traumatic loss-related PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans StudyAsch RH, Esterlis I, Southwick SM, Pietrzak RH. Risk and resilience factors associated with traumatic loss-related PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry Research 2021, 298: 113775. PMID: 33578060, DOI: 10.1016/j.psychres.2021.113775.
- Predicting Post-Concussion Symptom Recovery in Adolescents Using a Novel Artificial IntelligenceFleck D, Ernest N, Asch R, Adler C, Cohen K, Yuan W, Kunkel B, Krikorian R, Wade S, Babcock L. Predicting Post-Concussion Symptom Recovery in Adolescents Using a Novel Artificial Intelligence. Journal Of Neurotrauma 2020, 38: 830-836. PMID: 33115345, PMCID: PMC7987358, DOI: 10.1089/neu.2020.7018.
- Perinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signalingAsch R, Schurdak J, McNamara R. Perinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signaling. Nutritional Neuroscience 2019, 24: 735-746. PMID: 31599208, PMCID: PMC7145725, DOI: 10.1080/1028415x.2019.1674507.
- Chapter 1 Essentiality of Omega-3 Polyunsaturated Fatty Acids for Mammalian Brain Development: A Translational PerspectiveMcNamara R, Asch R. Chapter 1 Essentiality of Omega-3 Polyunsaturated Fatty Acids for Mammalian Brain Development: A Translational Perspective. 2019, 3-20. DOI: 10.1016/b978-0-12-815238-6.00001-8.
- Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI studyMcNamara R, Schurdak J, Asch R, Lindquist D. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. Nutritional Neuroscience 2017, 22: 587-595. PMID: 29286866, PMCID: PMC6251752, DOI: 10.1080/1028415x.2017.1419550.
- Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging StudyMcNamara R, Schurdak J, Asch R, Peters B, Lindquist D. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental Neuroscience 2017, 40: 84-92. PMID: 29216635, DOI: 10.1159/000484554.
- Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS studyMcNamara R, Asch R, Schurdak J, Lindquist D. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study. Psychiatry Research Neuroimaging 2017, 270: 39-45. PMID: 29049903, PMCID: PMC5671887, DOI: 10.1016/j.pscychresns.2017.10.003.
- Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS studyLindquist D, Asch R, Schurdak J, McNamara R. Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study. Journal Of Psychiatric Research 2017, 95: 143-146. PMID: 28846858, PMCID: PMC5653412, DOI: 10.1016/j.jpsychires.2017.08.014.
- Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findingsMcNamara R, Asch R, Lindquist D, Krikorian R. Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings. Prostaglandins Leukotrienes And Essential Fatty Acids 2017, 136: 23-34. PMID: 28529008, PMCID: PMC5680156, DOI: 10.1016/j.plefa.2017.05.001.
- Governing roles for Trib3 pseudokinase during stress erythropoiesis.Dev A, Asch R, Jachimowicz E, Rainville N, Johnson A, Greenfest-Allen E, Wojchowski DM. Governing roles for Trib3 pseudokinase during stress erythropoiesis. Exp Hematol 2017, 49: 48-55.e5. PMID: 28062363, DOI: 10.1016/j.exphem.2016.12.010.