Rolando Garcia Milian, MLS, AHIP
Biomedical Sciences Research Support Librarian and Lecturer in Epidemiology; Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Research & Publications
Biography
News
Locations
Research Summary
We provide support for functional annotation, analysis, and integration of multi-omics data as well as hypothesis narrowing using a number of public data repositories and knowledge bases
Coauthors
Research Interests
Information Science; Genomics; Proteomics; Metabolomics; Diseases; Chemicals and Drugs
Public Health Interests
Genetics, Genomics, Epigenetics; Toxicology
Research Image
Collaboration network of Bioinformatics Support Program
Network representation of the research articles resulting from collaborations between Medical Library Bioinformatics Support Program and groups/departments at the YSM
Selected Publications
- Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironmentChiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins K, Robbins K, Qu R, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze L, Henze L, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Bi Y, Goedegebuure S, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Politi K, Kluger Y, Kluger Y, Palucka K, Palucka K, Fields R, Fields R, Flavell R, Flavell R. Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment. Journal For ImmunoTherapy Of Cancer 2023, 11: e006921. PMID: 37487666, PMCID: PMC10373695, DOI: 10.1136/jitc-2023-006921.
- Partnering with health sciences libraries to address challenges in bioimaging data management and sharing.Silkotch C, Garcia-Milian R, Hersey D. Partnering with health sciences libraries to address challenges in bioimaging data management and sharing. Histochem Cell Biol 2023 PMID: 37247072, DOI: 10.1007/s00418-023-02198-1.
- Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesiclesGanesh S, Lam T, Garcia-Milian R, D'Souza D, Nairn A, Elgert K, Eitan E, Ranganathan M. Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles. The World Journal Of Biological Psychiatry 2023, 24: 603-613. PMID: 36994633, PMCID: PMC10471733, DOI: 10.1080/15622975.2023.2197039.
- Association of lesion location with post-stroke depression in China: a systematic review and meta-analysis.Luo X, Fang W, Ji J, Zhang Y, Garcia-Milian R, Wang Z, Tan Y, Wang S, Wang X, Guo X, Luo X. Association of lesion location with post-stroke depression in China: a systematic review and meta-analysis. EC Psychology And Psychiatry 2023, 12: 34-45. PMID: 36913221, PMCID: PMC9997510.
- The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaquesKabir I, Zhang X, Dave J, Chakraborty R, Qu R, Chandran R, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin K, Fernández-Hernando C, Greif D. The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques. Nature Aging 2023, 3: 64-81. PMID: 36743663, PMCID: PMC9894379, DOI: 10.1038/s43587-022-00342-5.
- Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cellsWang Y, Chen Y, Garcia-Milian R, Golla JP, Charkoftaki G, Lam TT, Thompson DC, Vasiliou V. Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells. Chemico-Biological Interactions 2022, 368: 110175. PMID: 36162455, PMCID: PMC9891852, DOI: 10.1016/j.cbi.2022.110175.
- Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in ratsAsch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology 2022, 48: 489-497. PMID: 36100654, PMCID: PMC9852230, DOI: 10.1038/s41386-022-01441-y.
- HIV viral transcription and immune perturbations in the CNS of people with HIV despite ARTFarhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART. JCI Insight 2022, 7: e160267. PMID: 35801589, PMCID: PMC9310520, DOI: 10.1172/jci.insight.160267.
- Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in miceCharkoftaki G, Tan WY, Berrios-Carcamo P, Orlicky DJ, Golla JP, Garcia-Milian R, Aalizadeh R, Thomaidis NS, Thompson DC, Vasiliou V. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice. Chemico-Biological Interactions 2022, 360: 109931. PMID: 35429548, PMCID: PMC9364420, DOI: 10.1016/j.cbi.2022.109931.
- Peer Teaching as Bioinformatics Training Strategy: Incentives, Challenges, and BenefitsRahman NT, Meyer C, Thakral D, Cai WL, Chen AT, Obaid R, Garcia-Milian R. Peer Teaching as Bioinformatics Training Strategy: Incentives, Challenges, and Benefits. Medical Reference Services Quarterly 2022, 41: 13-25. PMID: 35225737, DOI: 10.1080/02763869.2022.2020568.
- Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesisChandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature Communications 2021, 12: 7179. PMID: 34893592, PMCID: PMC8664937, DOI: 10.1038/s41467-021-27499-8.
- Cellular and Molecular Diversity in SclerodermaHinchcliff M, Garcia-Milian R, Di Donato S, Dill K, Bundschuh E, Galdo FD. Cellular and Molecular Diversity in Scleroderma. Seminars In Immunology 2021, 58: 101648. PMID: 35940960, DOI: 10.1016/j.smim.2022.101648.
- Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 functionThompson B, Chen Y, Davidson EA, Garcia-Milian R, Golla JP, Apostolopoulos N, Orlicky DJ, Schey K, Thompson DC, Vasiliou V. Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function. The Ocular Surface 2021, 22: 190-203. PMID: 34425299, PMCID: PMC8560581, DOI: 10.1016/j.jtos.2021.08.010.
- Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genesTiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT. Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. Reproductive BioMedicine Online 2021, 43: 614-626. PMID: 34417138, DOI: 10.1016/j.rbmo.2021.06.015.
- In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum DisorderFurnary T, Garcia-Milian R, Liew Z, Whirledge S, Vasiliou V. In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder. Toxics 2021, 9: 97. PMID: 33925648, PMCID: PMC8146009, DOI: 10.3390/toxics9050097.
- Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach.Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJW, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach. Toxicological Sciences 2021, 183: 338-351. PMID: 33693819, PMCID: PMC8921626, DOI: 10.1093/toxsci/kfab030.
- Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cellsBurman A, Garcia-Milian R, Wood M, DeWitt NA, Vasiliou V, Guller S, Abrahams VM, Whirledge S. Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells. Placenta 2020, 104: 146-160. PMID: 33348283, DOI: 10.1016/j.placenta.2020.12.002.
- Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrheaAhsan MK, Figueroa-Hall L, Baratta V, Garcia-Milian R, Lam TT, Hoque K, Salas PJ, Ameen NA. Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea. AJP Gastrointestinal And Liver Physiology 2020, 319: g121-g132. PMID: 32567324, PMCID: PMC7500270, DOI: 10.1152/ajpgi.00076.2020.
- Gene X environment: the cellular environment governs the transcriptional response to environmental chemicalsBurman A, Garcia-Milian R, Whirledge S. Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals. Human Genomics 2020, 14: 19. PMID: 32448403, PMCID: PMC7247264, DOI: 10.1186/s40246-020-00269-1.
- IFNγ potentiates TNFα/TNFR1 signaling to induce FAT10 expression in macrophages.Kandel-Kfir M, Garcia-Milan R, Gueta I, Lubitz I, Ben-Zvi I, Shaish A, Shir L, Harats D, Mahajan M, Canaan A, Kamari Y. IFNγ potentiates TNFα/TNFR1 signaling to induce FAT10 expression in macrophages. Molecular Immunology 2020, 117: 101-109. PMID: 31759325, DOI: 10.1016/j.molimm.2019.11.004.
- Librarians as methodological peer reviewers for systematic reviews: results of an online surveyGrossetta Nardini HK, Batten J, Funaro MC, Garcia-Milian R, Nyhan K, Spak JM, Wang L, Glover JG. Librarians as methodological peer reviewers for systematic reviews: results of an online survey. Research Integrity And Peer Review 2019, 4: 23. PMID: 31798974, PMCID: PMC6882225, DOI: 10.1186/s41073-019-0083-5.
- Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon CancerSun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer. Translational Oncology 2019, 13: 42-56. PMID: 31760268, PMCID: PMC6883319, DOI: 10.1016/j.tranon.2019.09.004.
- Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune responseSahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, GarcÃa-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, Suárez Y. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. Journal Of Clinical Investigation 2019, 129: 5518-5536. PMID: 31710308, PMCID: PMC6877327, DOI: 10.1172/jci127125.
- Transcriptome-wide piRNA profiling in human brains for aging genetic factors.Mao Q, Fan L, Wang X, Lin X, Cao Y, Zheng C, Zhang Y, Zhang H, Garcia-Milian R, Kang L, Shi J, Yu T, Wang K, Zuo L, Li CR, Guo X, Luo X. Transcriptome-wide piRNA profiling in human brains for aging genetic factors. 2019, 4 PMID: 32149191, PMCID: PMC7059831.
- Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosisChen Y, Manna SK, Golla S, Krausz KW, Cai Y, Garcia-Milian R, Chakraborty T, Chakraborty J, Chatterjee R, Thompson DC, Gonzalez FJ, Vasiliou V. Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis. Free Radical Biology And Medicine 2019, 143: 127-139. PMID: 31351176, PMCID: PMC6848780, DOI: 10.1016/j.freeradbiomed.2019.07.025.
- Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactionsAlofe O, Kisanga E, Inayat-Hussain SH, Fukumura M, Garcia-Milian R, Perera L, Vasiliou V, Whirledge S. Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions. Environment International 2019, 131: 104969. PMID: 31310931, PMCID: PMC6728168, DOI: 10.1016/j.envint.2019.104969.
- Regulated necrosis and failed repair in cisplatin-induced chronic kidney diseaseLandau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Kidney International 2019, 95: 797-814. PMID: 30904067, PMCID: PMC6543531, DOI: 10.1016/j.kint.2018.11.042.
- Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cellsCharkoftaki G, Thompson DC, Golla JP, Garcia-Milian R, Lam TT, Engel J, Vasiliou V. Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. Chemico-Biological Interactions 2019, 304: 88-96. PMID: 30851239, PMCID: PMC7988342, DOI: 10.1016/j.cbi.2019.02.030.
- Hepatic metabolic adaptation in a murine model of glutathione deficiencyChen Y, Golla S, Garcia-Milian R, Thompson DC, Gonzalez FJ, Vasiliou V. Hepatic metabolic adaptation in a murine model of glutathione deficiency. Chemico-Biological Interactions 2019, 303: 1-6. PMID: 30794799, PMCID: PMC6743730, DOI: 10.1016/j.cbi.2019.02.015.
- Estrogen receptor-alpha isoforms are the main estrogen receptors expressed in non-small cell lung carcinoma.Pelekanou V, Anastasiou E, Bakogeorgou E, Notas G, Kampa M, Garcia-Milian R, Lavredaki K, Moustou E, Chinari G, Arapantoni P, O'Grady A, Georgoulias V, Tsapis A, Stathopoulos EN, Castanas E. Estrogen receptor-alpha isoforms are the main estrogen receptors expressed in non-small cell lung carcinoma. Steroids 2019, 142: 65-76. PMID: 29454903, DOI: 10.1016/j.steroids.2018.01.008.
- Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic ClampMis MA, Yang Y, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG. Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp. Journal Of Neuroscience 2018, 39: 382-392. PMID: 30459225, PMCID: PMC6335750, DOI: 10.1523/jneurosci.2433-18.2018.
- Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubberPerkins AN, Inayat-Hussain SH, Deziel NC, Johnson CH, Ferguson SS, Garcia-Milian R, Thompson DC, Vasiliou V. Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubber. Environmental Research 2018, 169: 163-172. PMID: 30458352, PMCID: PMC6396308, DOI: 10.1016/j.envres.2018.10.018.
- Prioritization of reproductive toxicants in unconventional oil and gas operations using a multi-country regulatory data-driven hazard assessmentInayat-Hussain SH, Fukumura M, Aziz A, Jin CM, Jin LW, Garcia-Milian R, Vasiliou V, Deziel NC. Prioritization of reproductive toxicants in unconventional oil and gas operations using a multi-country regulatory data-driven hazard assessment. Environment International 2018, 117: 348-358. PMID: 29793188, DOI: 10.1016/j.envint.2018.05.010.
- Data challenges of biomedical researchers in the age of omics.Garcia-Milian R, Hersey D, Vukmirovic M, Duprilot F. Data challenges of biomedical researchers in the age of omics. PeerJ 2018, 6: e5553. PMID: 30221093, PMCID: PMC6138043, DOI: 10.7717/peerj.5553.
- Genome-wide significant, replicated and functional risk variants for Alzheimer’s diseaseGuo X, Qiu W, Garcia-Milian R, Lin X, Zhang Y, Cao Y, Tan Y, Wang Z, Shi J, Wang J, Liu D, Song L, Xu Y, Wang X, Liu N, Sun T, Zheng J, Luo J, Zhang H, Xu J, Kang L, Ma C, Wang K, Luo X. Genome-wide significant, replicated and functional risk variants for Alzheimer’s disease. Journal Of Neural Transmission 2017, 124: 1455-1471. PMID: 28770390, PMCID: PMC5654670, DOI: 10.1007/s00702-017-1773-0.
- Interinstitutional collaboration for end-user bioinformatics training: Cytoscape as a case study.Brandenburg MD, Garcia-Milian R. Interinstitutional collaboration for end-user bioinformatics training: Cytoscape as a case study. Journal Of The Medical Library Association : JMLA 2017, 105: 179-184. PMID: 28377683, PMCID: PMC5370611, DOI: 10.5195/jmla.2017.224.
- Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine DependenceZuo L, Garcia-Milian R, Guo X, Zhong C, Tan Y, Wang Z, Wang J, Wang X, Kang L, Lu L, Chen X, Li CR, Luo X. Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Genes 2016, 7: 95. PMID: 27827986, PMCID: PMC5126781, DOI: 10.3390/genes7110095.
- Health and safety during Canal construction In 100 Years of The Panama Canal. Celebrating the CentennialSchaefer N, Stoyan-Rosenzweig N, and Garcia-Milian R. (2014) Health and safety during Canal construction In 100 Years of The Panama Canal. Celebrating the Centennial 1914- 2014, 2014 (p. 134-141) Faircount Media Group, Tampa, FL
- The use of Research Electronic Data Capture (REDCap) software to create a database of librarian-mediated literature searches.Lyon JA, Garcia-Milian R, Norton HF, Tennant MR. The use of Research Electronic Data Capture (REDCap) software to create a database of librarian-mediated literature searches. Medical Reference Services Quarterly 2014, 33: 241-52. PMID: 25023012, PMCID: PMC4339087, DOI: 10.1080/02763869.2014.925379.
- Moving beyond the bookshelves.Lessick S, Rumsey E, Pearson DS, Roksandic S, Dexter N, Gillum S, Garner M, Walton D, Ballinger B, Garcia-Milian R, Norton HF, Samsundar DR, Reynolds J. Moving beyond the bookshelves. Journal Of The Medical Library Association : JMLA 2013, 101: 239-43. PMID: 24163592, PMCID: PMC3794676, DOI: 10.3163/1536-5050.101.4.002.
- Librarians as Part of Cross-Disciplinary, Multi-Institutional Team Projects: Experiences from the VIVO Collaboration.Garcia-Milian R, Norton HF, Auten B, Davis VI, Holmes KL, Johnson M, Tennant MR. Librarians as Part of Cross-Disciplinary, Multi-Institutional Team Projects: Experiences from the VIVO Collaboration. Science & Technology Libraries 2013, 32: 160-175. PMID: 23833333, PMCID: PMC3700548, DOI: 10.1080/0194262X.2013.791183.
- Changing the face of reference: adapting biomedical and health information services for the classroom, clinic, and beyond.Tennant MR, Auten B, Botero CE, Butson LC, Edwards ME, Garcia-Milian R, Lyon JA, Norton HF. Changing the face of reference: adapting biomedical and health information services for the classroom, clinic, and beyond. Medical Reference Services Quarterly 2012, 31: 280-301. PMID: 22853302, DOI: 10.1080/02763869.2012.698172.
- The presence of academic health sciences libraries on Facebook: the relationship between content and library popularity.Garcia-Milian R, Norton HF, Tennant MR. The presence of academic health sciences libraries on Facebook: the relationship between content and library popularity. Medical Reference Services Quarterly 2012, 31: 171-87. PMID: 22559180, DOI: 10.1080/02763869.2012.670588.
- Molecular analysis of resistance to interferon in patients with laryngeal papillomatosis.Garciá-Millián R, Santos A, Perea SE, González-Cabañas R, Valenzuela C, Araña M. Molecular analysis of resistance to interferon in patients with laryngeal papillomatosis. Cytokines, Cellular & Molecular Therapy 1999, 5: 79-85. PMID: 10515680.
- Detection and typing of human papillomavirus DNA in benign and malignant tumours of laryngeal epithelium.GarcÃa-Milián R, Hernández H, Panadé L, RodrÃguez C, González N, Valenzuela C, Araña MD, Perea SE. Detection and typing of human papillomavirus DNA in benign and malignant tumours of laryngeal epithelium. Acta Oto-laryngologica 1998, 118: 754-8. PMID: 9840518, DOI: 10.1080/00016489850183313.
- [Genetic expression of nerve growth factor in the central nervous system. Evaluation of an experimental model for Alzheimer's dementia].González-Hoyuela M, Soto J, GarcÃa-Milian R, Ubieta R, Francis L, Conde-Vázquez R. [Genetic expression of nerve growth factor in the central nervous system. Evaluation of an experimental model for Alzheimer's dementia]. Revista De Neurologia 1998, 26: 204-7. PMID: 9563089.
- Modulation of human papillomavirus type 16 mRNA in cervical invasive carcinoma patients by interferon-alpha therapy.GarcÃa-Milián R, Rios MA, Amigó M, DÃaz D, Guilar O, Silveira M, Araña MJ, Perea SE. Modulation of human papillomavirus type 16 mRNA in cervical invasive carcinoma patients by interferon-alpha therapy. Journal Of Interferon & Cytokine Research : The Official Journal Of The International Society For Interferon And Cytokine Research 1996, 16: 739-43. PMID: 8887059.
- Interferon-alpha elicits downregulation of human papillomavirus 18 mRNA in HeLa cells by selective repression of endogenous viral transcription.Perea SE, López-Ocejo O, GarcÃa-Milian R, Araña MJ. Interferon-alpha elicits downregulation of human papillomavirus 18 mRNA in HeLa cells by selective repression of endogenous viral transcription. Journal Of Interferon & Cytokine Research : The Official Journal Of The International Society For Interferon And Cytokine Research 1995, 15: 495-501. PMID: 7553218, DOI: 10.1089/jir.1995.15.495.