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Stephanie Groman, PhD

Assistant Professor Adjunct of Psychiatry

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Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in ratsAsch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology 2022, 48: 489-497. PMID: 36100654, PMCID: PMC9852230, DOI: 10.1038/s41386-022-01441-y.
Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female ratsVilliamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology 2022, 239: 2885-2901. PMID: 35705734, PMCID: PMC10332493, DOI: 10.1007/s00213-022-06174-w.
Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman S, Carson RE. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3679-3691. PMID: 35633376, PMCID: PMC9826644, DOI: 10.1007/s00259-022-05825-6.
MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIVYoung JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Research Neuroimaging 2022, 321: 111445. PMID: 35101828, DOI: 10.1016/j.pscychresns.2022.111445.
Reinforcement learning detuned in addiction: integrative and translational approachesGroman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.
Paranoia and belief updating during the COVID-19 crisisSuthaharan P, Reed EJ, Leptourgos P, Kenney JG, Uddenberg S, Mathys CD, Litman L, Robinson J, Moss AJ, Taylor JR, Groman SM, Corlett PR. Paranoia and belief updating during the COVID-19 crisis. Nature Human Behaviour 2021, 5: 1190-1202. PMID: 34316049, PMCID: PMC8458246, DOI: 10.1038/s41562-021-01176-8.
Unlocking the Reinforcement-Learning Circuits of the Orbitofrontal CortexGroman SM, Lee D, Taylor JR. Unlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex. Behavioral Neuroscience 2021, 135: 120-128. PMID: 34060870, PMCID: PMC8201418, DOI: 10.1037/bne0000414.
The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in miceGianessi CA, Groman SM, Taylor JR. The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. European Journal Of Neuroscience 2021, 55: 922-938. PMID: 33506530, PMCID: PMC10370500, DOI: 10.1111/ejn.15129.
Paranoia and belief updating during a crisis.Suthaharan P, Reed E, Leptourgos P, Kenney J, Uddenberg S, Mathys C, Litman L, Robinson J, Moss A, Taylor J, Groman S, Corlett P. Paranoia and belief updating during a crisis. Research Square 2021 PMID: 33469574, PMCID: PMC7814833, DOI: 10.21203/rs.3.rs-145987/v1.
Astrocytic Activation to Restore Goal-Directed BehaviorsGroman SM. Astrocytic Activation to Restore Goal-Directed Behaviors. Biological Psychiatry 2020, 88: 744-745. PMID: 33092692, DOI: 10.1016/j.biopsych.2020.07.024.
Introducing the PLOS ONE Collection on the neuroscience of reward and decision makingGroman SM, Ikemoto S, Rushworth M, Taylor JR, Whelan R. Introducing the PLOS ONE Collection on the neuroscience of reward and decision making. PLOS ONE 2020, 15: e0240505. PMID: 33031482, PMCID: PMC7544023, DOI: 10.1371/journal.pone.0240505.
Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in RatsGroman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats. Biological Psychiatry 2020, 88: 777-787. PMID: 32826065, PMCID: PMC8935943, DOI: 10.1016/j.biopsych.2020.06.020.
Reinforcement Learning during Adolescence in RatsAfshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.
Paranoia as a deficit in non-social belief updatingReed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.
Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food ConsumptionBond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. Journal Of Neuroscience 2020, 40: 4727-4738. PMID: 32354856, PMCID: PMC7294796, DOI: 10.1523/jneurosci.3054-18.2020.
The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman AnimalsGroman SM. The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals. 2020, 47: 23-52. PMID: 32157666, DOI: 10.1007/7854_2020_127.
Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administrationGroman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration. Biological Psychiatry 2020, 88: 767-776. PMID: 32312578, PMCID: PMC8954711, DOI: 10.1016/j.biopsych.2020.02.017.
Orbitofrontal Circuits Control Multiple Reinforcement-Learning ProcessesGroman SM, Keistler C, Keip AJ, Hammarlund E, DiLeone RJ, Pittenger C, Lee D, Taylor JR. Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes. Neuron 2019, 103: 734-746.e3. PMID: 31253468, PMCID: PMC6893860, DOI: 10.1016/j.neuron.2019.05.042.
Investigating the computational underpinnings of addictionGroman SM. Investigating the computational underpinnings of addiction. Neuropsychopharmacology 2019, 44: 2149-2150. PMID: 31076651, PMCID: PMC6897857, DOI: 10.1038/s41386-019-0412-x.
Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatmentGianessi CA, Groman SM, Thompson SL, Jiang M, van der Stelt M, Taylor JR. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction Biology 2019, 25: e12768. PMID: 31056846, PMCID: PMC7790504, DOI: 10.1111/adb.12768.
Bi‐directional modulation of food habit expression by the endocannabinoid systemGianessi CA, Groman SM, Taylor JR. Bi‐directional modulation of food habit expression by the endocannabinoid system. European Journal Of Neuroscience 2019, 49: 1610-1622. PMID: 30589475, PMCID: PMC7790508, DOI: 10.1111/ejn.14330.
Model-Free and Model-Based Influences in Addiction-Related BehaviorsGroman SM, Massi B, Mathias SR, Lee D, Taylor JR. Model-Free and Model-Based Influences in Addiction-Related Behaviors. Biological Psychiatry 2019, 85: 936-945. PMID: 30737015, PMCID: PMC6534429, DOI: 10.1016/j.biopsych.2018.12.017.
Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage TaskGroman SM, Massi B, Mathias SR, Curry DW, Lee D, Taylor JR. Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task. Journal Of Neuroscience 2018, 39: 295-306. PMID: 30413646, PMCID: PMC6325257, DOI: 10.1523/jneurosci.2219-18.2018.
Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in RatsGroman SM, Rich KM, Smith NJ, Lee D, Taylor JR. Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats. Neuropsychopharmacology 2017, 43: 770-780. PMID: 28741627, PMCID: PMC5809784, DOI: 10.1038/npp.2017.159.
Model-Based Control in Dimensional PsychiatryVoon V, Reiter A, Sebold M, Groman S. Model-Based Control in Dimensional Psychiatry. Biological Psychiatry 2017, 82: 391-400. PMID: 28599832, DOI: 10.1016/j.biopsych.2017.04.006.
Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female MiceRapanelli M, Frick LR, Xu M, Groman SM, Jindachomthong K, Tamamaki N, Tanahira C, Taylor JR, Pittenger C. Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biological Psychiatry 2017, 82: 194-203. PMID: 28347488, PMCID: PMC5374721, DOI: 10.1016/j.biopsych.2017.01.020.
Explaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience.Feeney EJ, Groman SM, Taylor JR, Corlett PR. Explaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience. Schizophrenia Bulletin 2017, 43: 263-272. PMID: 28177090, PMCID: PMC5605246, DOI: 10.1093/schbul/sbw194.
Dopamine D3 Receptor Availability Is Associated with Inflexible Decision MakingGroman SM, Smith NJ, Petrullli JR, Massi B, Chen L, Ropchan J, Huang Y, Lee D, Morris ED, Taylor JR. Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making. Journal Of Neuroscience 2016, 36: 6732-6741. PMID: 27335404, PMCID: PMC4916249, DOI: 10.1523/jneurosci.3253-15.2016.
Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical ModelKaneko G, Sanganahalli BG, Groman SM, Wang H, Coman D, Rao J, Herman P, Jiang L, Rich K, de Graaf RA, Taylor JR, Hyder F. Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biological Psychiatry 2016, 81: 503-513. PMID: 27450031, PMCID: PMC5130616, DOI: 10.1016/j.biopsych.2016.05.019.
Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeysElsworth JD, Jentsch JD, Groman SM, Roth RH, Redmond ED, Leranth C. Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys. The Journal Of Comparative Neurology 2015, 523: 1248-1257. PMID: 25557059, PMCID: PMC4390445, DOI: 10.1002/cne.23735.
Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal CortexElsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE, Kim JD, Diano S, Roth RH. Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex. The International Journal Of Neuropsychopharmacology 2014, 18: pyu048. PMID: 25522392, PMCID: PMC4438537, DOI: 10.1093/ijnp/pyu048.
In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink RateGroman SM, James AS, Seu E, Tran S, Clark TA, Harpster SN, Crawford M, Burtner JL, Feiler K, Roth RH, Elsworth JD, London ED, Jentsch JD. In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate. Journal Of Neuroscience 2014, 34: 14443-14454. PMID: 25339755, PMCID: PMC4205561, DOI: 10.1523/jneurosci.3037-14.2014.
Sex chromosome complement influences operant responding for a palatable food in miceSeu E, Groman SM, Arnold AP, Jentsch JD. Sex chromosome complement influences operant responding for a palatable food in mice. Genes Brain & Behavior 2014, 13: 527-534. PMID: 24861924, PMCID: PMC4079740, DOI: 10.1111/gbb.12143.
Dissecting impulsivity and its relationships to drug addictionsJentsch JD, Ashenhurst JR, Cervantes MC, Groman SM, James AS, Pennington ZT. Dissecting impulsivity and its relationships to drug addictions. Annals Of The New York Academy Of Sciences 2014, 1327: 1-26. PMID: 24654857, PMCID: PMC4360991, DOI: 10.1111/nyas.12388.
Methamphetamine-induced increases in putamen gray matter associate with inhibitory controlGroman SM, Morales AM, Lee B, London ED, Jentsch JD. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 2013, 229: 527-538. PMID: 23748383, PMCID: PMC3770792, DOI: 10.1007/s00213-013-3159-9.
Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primatesGroman SM, Jentsch JD. Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates. Current Opinion In Neurobiology 2013, 23: 625-631. PMID: 23528268, PMCID: PMC3731407, DOI: 10.1016/j.conb.2013.03.001.
Diminished neurokinin‐1 receptor availability in patients with two forms of chronic visceral painJarcho JM, Feier NA, Bert A, Labus JA, Lee M, Stains J, Ebrat B, Groman SM, Tillisch K, Brody AL, London ED, Mandelkern MA, Mayer EA. Diminished neurokinin‐1 receptor availability in patients with two forms of chronic visceral pain. Pain 2013, 154: 987-996. PMID: 23582152, PMCID: PMC4294187, DOI: 10.1016/j.pain.2013.02.026.
Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning PerformanceGroman SM, James AS, Seu E, Crawford MA, Harpster SN, Jentsch JD. Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance. Biological Psychiatry 2013, 73: 756-762. PMID: 23332512, PMCID: PMC3615106, DOI: 10.1016/j.biopsych.2012.12.002.
An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in HumansDean AC, Groman SM, Morales AM, London ED. An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans. Neuropsychopharmacology 2012, 38: 259-274. PMID: 22948978, PMCID: PMC3527116, DOI: 10.1038/npp.2012.179.
Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine ExposureGroman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure. Journal Of Neuroscience 2012, 32: 5843-5852. PMID: 22539846, PMCID: PMC3353813, DOI: 10.1523/jneurosci.0029-12.2012.
Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addictionGroman SM, Jentsch JD. Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction. Depression And Anxiety 2011, 29: 295-306. PMID: 22147558, DOI: 10.1002/da.20897.
Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administrationElsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology 2011, 62: 1442-1452. PMID: 21875607, PMCID: PMC3711239, DOI: 10.1016/j.neuropharm.2011.08.026.
Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination LearningGroman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning. Journal Of Neuroscience 2011, 31: 7291-7299. PMID: 21593313, PMCID: PMC3114883, DOI: 10.1523/jneurosci.0363-11.2011.
Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk TaskJentsch JD, Woods JA, Groman SM, Seu E. Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk Task. Neuropsychopharmacology 2010, 35: 1797-1806. PMID: 20375994, PMCID: PMC3055471, DOI: 10.1038/npp.2010.47.
Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorderGroman SM, James AS, Jentsch JD. Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder. Neuroscience & Biobehavioral Reviews 2008, 33: 690-698. PMID: 18789354, PMCID: PMC2728075, DOI: 10.1016/j.neubiorev.2008.08.008.
Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in MonkeysJames AS, Groman SM, Seu E, Jorgensen M, Fairbanks LA, Jentsch JD. Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys. Journal Of Neuroscience 2007, 27: 14358-14364. PMID: 18160643, PMCID: PMC6673444, DOI: 10.1523/jneurosci.4508-07.2007.
Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in MonkeysLee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys. Neuropsychopharmacology 2007, 32: 2125-2134. PMID: 17299511, DOI: 10.1038/sj.npp.1301337.

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Stephanie Groman, PhD

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