Michael Caplan, PhD, MD
Research & Publications
Biography
News
Research Summary
The surface membranes of epithelial cells are divided into domains characterized by dramatically different protein compositions. Membrane proteins whose distributions are restricted to one of these domains must incorporate information that specifies their appropriate destinations. We seek to determine how this information is encoded and how it is interpreted.
Our studies of cellular trafficking focus on proteins involved in ion transport, as well as on the proteins associated with polycystic kidney disease. Polycystic kidney disease is a prevalent and serious genetic disorder that distorts the normal architecture of renal epithelial cells and that is a major cause of kidney failure. The Caplan laboratory is working to understand the mechanisms responsible for this condition and to identify targets for new therapies
Specialized Terms: Ion pumps in polarized epithelia; Sorting and function; Polycystic kidney disease
Extensive Research Description
Work in the Caplan laboratory is focused on understanding how membrane proteins are sorted to the appropriate cell surface domains of polarized epithelial cells. One of the proteins whose trafficking we study is the Na,K-ATPase, or sodium pump, which generates the ion gradients responsible for most fluid and electrolyte transport processes in the kidney. The Na,K-ATPase must be restricted to the basolateral surfaces of renal tubule epithelial cells. Much remains to be learned about the partner proteins and trafficking pathways that determine the sodium pump’s subcellular distribution and modulate its activity. We have adapted a novel labeling methodology to investigate the attributes of temporally defined cohorts of Na,K-ATPase.
We can observe directly the trafficking itinerary pursued by newly synthesized Na,K-ATPase and isolate newly synthesized Na,K-ATPase in association with its collections of partner proteins. We find that the basolateral delivery of newly synthesized Na,K-ATPase occurs via a pathway distinct from that pursued by other basolateral membrane proteins. We have also detected interactions between the Na,K-ATPase a-subunit and a collection of novel partner proteins that may govern the pump’s trafficking properties. Thus, we have developed tools that permit us to evaluate the trafficking pathways and partner proteins that govern the post-synthetic sorting and regulation of the epithelial Na,K-ATPase.
We also study a common genetic disease that dramatically alters the structure and function of polarized epithelial cells. In Autosomal Dominant Polycystic Kidney Disease (ADPKD) the normal architecture of the kidney tubules is replaced by large fluid filled cysts, which can ultimately result in renal failure. ADPKD is caused by mutations in the PKD1 or PKD2 genes, which encode the polycystin-1 and polycystin-2 proteins, respectively. Both of these proteins are targeted to cilia in polarized epithelial cells. We have found that polycystin-1 undergoes such a proteolytic cleavage that releases its C-terminal tail (CTT), which enters the nucleus and initiates signaling processes. The cleavage occurs in vivo in association with alterations in mechanical stimuli that may be communicated by signaling through the cilium. The C-terminal tail fragment of polycystin-1 participates in a complex with ß-catenin and acts to profoundly inhibit canonical ß-catenin-dependent Wnt signaling. The polycystin-1 C-terminal tail fragment also appears to modulate gene expression, and may induce expression of cilia-related proteins in renal epithelial cells.
We find that all of the signal transduction machinery found in the cilia of olfactory epithelial cells is present in renal epithelial cells. Our data suggest that olfactory receptors and proteins involved in olfactory signal transduction may play a role in regulating renal flow or transport in response to chemosensory cues.
Coauthors
Research Interests
Cell Biology; Epithelial Cells; Kidney; Polycystic Kidney Diseases; Physiology; Ion Pumps
Selected Publications
- Calcium signalling and transport in the kidneyStaruschenko A, Alexander R, Caplan M, Ilatovskaya D. Calcium signalling and transport in the kidney. Nature Reviews Nephrology 2024, 1-15. PMID: 38641658, DOI: 10.1038/s41581-024-00835-z.
- Delivering Nucleic Acids to ADPKD Cystic Cells via a Nucleic Acid Binding and Cell-Penetrating AntibodyOnuchic L, Quijano E, Reyna-Neyra M, Rai V, Glazer P, Caplan M. Delivering Nucleic Acids to ADPKD Cystic Cells via a Nucleic Acid Binding and Cell-Penetrating Antibody. Journal Of The American Society Of Nephrology 2023, 34: 204-204. DOI: 10.1681/asn.20233411s1204b.
- Identification of Early Transcriptional Markers of ADPKD Cystic Epithelial CellsRai V, Onuchic L, Reyna-Neyra M, Schena G, Craft J, Caplan M. Identification of Early Transcriptional Markers of ADPKD Cystic Epithelial Cells. Journal Of The American Society Of Nephrology 2023, 34: 557-557. DOI: 10.1681/asn.20233411s1557c.
- Polycystin 1 ciliary localization is controlled by mechanosensitive signaling that involves secretion of ATPGresko N, Caplan M. Polycystin 1 ciliary localization is controlled by mechanosensitive signaling that involves secretion of ATP. Physiology 2023, 38: 5731529. DOI: 10.1152/physiol.2023.38.s1.5731529.
- Metabolic effects of polycystin-1 C-terminal tail (CTT) expression in Pkd1-KO miceOnuchic L, Padovano V, Schena G, Shi X, Dong K, Rajendran V, Rai V, Pandya R, Gresko N, Shen H, Somlo S, Caplan M. Metabolic effects of polycystin-1 C-terminal tail (CTT) expression in Pkd1-KO mice. Physiology 2023, 38: 5731616. DOI: 10.1152/physiol.2023.38.s1.5731616.
- The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashionOnuchic L, Padovano V, Schena G, Rajendran V, Dong K, Shi X, Pandya R, Rai V, Gresko N, Ahmed O, Lam T, Wang W, Shen H, Somlo S, Caplan M. The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion. Nature Communications 2023, 14: 1790. PMID: 36997516, PMCID: PMC10063565, DOI: 10.1038/s41467-023-37449-1.
- Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTORSempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2022, 13: 6681. PMID: 36335122, PMCID: PMC9637099, DOI: 10.1038/s41467-022-34363-w.
- The Polycystin-1 C-Terminal Tail (CTT) Suppresses Cystic Disease: Elucidating the Underlying MechanismsOnuchic L, Padovano V, Schena G, Rajendran V, Shi X, Dong K, Gresko N, Shen H, Somlo S, Caplan M. The Polycystin-1 C-Terminal Tail (CTT) Suppresses Cystic Disease: Elucidating the Underlying Mechanisms. Journal Of The American Society Of Nephrology 2022, 33: 398-399. DOI: 10.1681/asn.20223311s1398d.
- Polycystin 1 Ciliary Localization Is Controlled by Chemo- and Mechanosensitive Signaling Processes That Involve the Machinery of GPCR DesensitizationGresko N, Caplan M. Polycystin 1 Ciliary Localization Is Controlled by Chemo- and Mechanosensitive Signaling Processes That Involve the Machinery of GPCR Desensitization. Journal Of The American Society Of Nephrology 2022, 33: 407-407. DOI: 10.1681/asn.20223311s1407a.
- Polycystin-2 in the Endoplasmic Reticulum: Bending Ideas about the Role of the CiliumCaplan MJ. Polycystin-2 in the Endoplasmic Reticulum: Bending Ideas about the Role of the Cilium. Journal Of The American Society Of Nephrology 2022, 33: 1433-1434. PMID: 35906088, PMCID: PMC9342637, DOI: 10.1681/asn.2022050557.
- Polycystin 1 ciliary localization is regulated by its aGPCR activityGresko N, Caplan M. Polycystin 1 ciliary localization is regulated by its aGPCR activity. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4689.
- Membrane phosphoinositides and renal epithelial cell polarity determination in the Xenopus pronephros in vivoSchena G, Rajendran V, Khokha M, Caplan M. Membrane phosphoinositides and renal epithelial cell polarity determination in the Xenopus pronephros in vivo. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4889.
- AMPK and Polycystic Kidney Disease Drug Development: An Interesting Off-Target TargetCaplan MJ. AMPK and Polycystic Kidney Disease Drug Development: An Interesting Off-Target Target. Frontiers In Medicine 2022, 9: 753418. PMID: 35174190, PMCID: PMC8841847, DOI: 10.3389/fmed.2022.753418.
- β3 adrenergic receptor as potential therapeutic target in ADPKDSchena G, Carmosino M, Chiurlia S, Onuchic L, Mastropasqua M, Maiorano E, Schena FP, Caplan MJ. β3 adrenergic receptor as potential therapeutic target in ADPKD. Physiological Reports 2021, 9: e15058. PMID: 34676684, PMCID: PMC8531837, DOI: 10.14814/phy2.15058.
- Membrane Phosphoinositides and Renal Epithelial Cell Polarity Determination in the Xenopus Pronephros In VivoSchena G, Rajendran V, Khokha M, Caplan M. Membrane Phosphoinositides and Renal Epithelial Cell Polarity Determination in the Xenopus Pronephros In Vivo. Journal Of The American Society Of Nephrology 2021, 32: 229-230. DOI: 10.1681/asn.20213210s1229e.
- Polycystin 1 Ciliary Localization Is Regulated by Its aGPCR ActivityGresko N, Caplan M. Polycystin 1 Ciliary Localization Is Regulated by Its aGPCR Activity. Journal Of The American Society Of Nephrology 2021, 32: 397-397. DOI: 10.1681/asn.20213210s1397b.
- The C-Terminal Tail of Polycystin 1 Rescues Cystic Phenotype in a Mitochondrial Enzyme-Dependent FashionOnuchic L, Padovano V, Schena G, Rajendran V, Gresko N, Dong K, Shi X, Shen H, Somlo S, Caplan M. The C-Terminal Tail of Polycystin 1 Rescues Cystic Phenotype in a Mitochondrial Enzyme-Dependent Fashion. Journal Of The American Society Of Nephrology 2021, 32: 11-11. DOI: 10.1681/asn.20213210s111b.
- Defective NAD+ Homeostasis in ADPKD and the Effects of PC1CTT on Redox Modulation and Disease ProgressionOnuchic L, Padovano V, Gresko N, Schena G, Rajendran V, Caplan M. Defective NAD+ Homeostasis in ADPKD and the Effects of PC1CTT on Redox Modulation and Disease Progression. Journal Of The American Society Of Nephrology 2020, 31: 483-483. DOI: 10.1681/asn.20203110s1483b.
- Chloride channels regulate differentiation and barrier functions of the mammalian airwayHe M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY. Chloride channels regulate differentiation and barrier functions of the mammalian airway. ELife 2020, 9: e53085. PMID: 32286221, PMCID: PMC7182432, DOI: 10.7554/elife.53085.
- A cut above (and below): Protein cleavage in the regulation of polycystin trafficking and signalingPadovano V, Mistry K, Merrick D, Gresko N, Caplan MJ. A cut above (and below): Protein cleavage in the regulation of polycystin trafficking and signaling. Cellular Signalling 2020, 72: 109634. PMID: 32283256, PMCID: PMC7269866, DOI: 10.1016/j.cellsig.2020.109634.
- Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membraneWu J, Rowart P, Jouret F, Gassaway BM, Rajendran V, Rinehart J, Caplan MJ. Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membrane. American Journal Of Physiology - Cell Physiology 2020, 318: c486-c501. PMID: 31913699, PMCID: PMC7099514, DOI: 10.1152/ajpcell.00422.2019.
- Holding open the door reveals a new view of polycystin channel functionCaplan MJ. Holding open the door reveals a new view of polycystin channel function. EMBO Reports 2019, 20: e49156. PMID: 31556469, PMCID: PMC6832007, DOI: 10.15252/embr.201949156.
- Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)Schena G, Caplan MJ. Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask). Cells 2019, 8: 357. PMID: 30995798, PMCID: PMC6523418, DOI: 10.3390/cells8040357.
- Polycystin 1 is an atypical adhesion GPCR that responds to non‐canonical WNT signals and inhibits GSK3βGresko N, Merrick D, Mistry K, Caplan M. Polycystin 1 is an atypical adhesion GPCR that responds to non‐canonical WNT signals and inhibits GSK3β. The FASEB Journal 2019, 33: 863.10-863.10. DOI: 10.1096/fasebj.2019.33.1_supplement.863.10.
- Novel protein trafficking and signaling pathways in kidney physiology and pathophysiologyCaplan M, Padovano V, Gresko N, Olesen C, Schena G, Mistry K, Bateson R. Novel protein trafficking and signaling pathways in kidney physiology and pathophysiology. The FASEB Journal 2019, 33: 20.2-20.2. DOI: 10.1096/fasebj.2019.33.1_supplement.20.2.
- The Polycystin Complex Reveals Its ComplexityPadovano V, Caplan MJ. The Polycystin Complex Reveals Its Complexity. Biochemistry 2018, 57: 6917-6918. PMID: 30540438, DOI: 10.1021/acs.biochem.8b01205.
- Newly synthesized polycystin‐1 takes different trafficking pathways to the apical and ciliary membranesGilder AL, Chapin HC, Padovano V, Hueschen CL, Rajendran V, Caplan MJ. Newly synthesized polycystin‐1 takes different trafficking pathways to the apical and ciliary membranes. Traffic 2018, 19: 933-945. PMID: 30125442, PMCID: PMC6237641, DOI: 10.1111/tra.12612.
- Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZMerrick D, Mistry K, Wu J, Gresko N, Baggs JE, Hogenesch JB, Sun Z, Caplan MJ. Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ. Human Molecular Genetics 2018, 28: 16-30. PMID: 30215740, PMCID: PMC6298236, DOI: 10.1093/hmg/ddy322.
- Metabolism and mitochondria in polycystic kidney disease research and therapyPadovano V, Podrini C, Boletta A, Caplan MJ. Metabolism and mitochondria in polycystic kidney disease research and therapy. Nature Reviews Nephrology 2018, 14: 678-687. PMID: 30120380, DOI: 10.1038/s41581-018-0051-1.
- Implications of AMPK in the Formation of Epithelial Tight JunctionsRowart P, Wu J, Caplan MJ, Jouret F. Implications of AMPK in the Formation of Epithelial Tight Junctions. International Journal Of Molecular Sciences 2018, 19: 2040. PMID: 30011834, PMCID: PMC6073107, DOI: 10.3390/ijms19072040.
- Advances & challenges in developing gene therapies for rare kidney diseasesPadovano V, Caplan M. Advances & challenges in developing gene therapies for rare kidney diseases. Cell And Gene Therapy Insights 2018, 4: 951-964. DOI: 10.18609/cgti.2018.094.
- The secretory pathway at 50: a golden anniversary for some momentous grains of silverMatlin KS, Caplan MJ. The secretory pathway at 50: a golden anniversary for some momentous grains of silver. Molecular Biology Of The Cell 2017, 28: 229-232. PMID: 28082520, PMCID: PMC5231891, DOI: 10.1091/mbc.e16-07-0508.
- The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial functionPadovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ. The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Molecular Biology Of The Cell 2016, 28: 261-269. PMID: 27881662, PMCID: PMC5231895, DOI: 10.1091/mbc.e16-08-0597.
- Newly synthesized and recycling pools of the apical protein gp135 do not occupy the same compartmentsStoops EH, Hull M, Caplan MJ. Newly synthesized and recycling pools of the apical protein gp135 do not occupy the same compartments. Traffic 2016, 17: 1272-1285. PMID: 27649479, PMCID: PMC5123909, DOI: 10.1111/tra.12449.
- Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergySrivastava KD, Siefert A, Fahmy TM, Caplan MJ, Li XM, Sampson HA. Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. Journal Of Allergy And Clinical Immunology 2016, 138: 536-543.e4. PMID: 27130858, DOI: 10.1016/j.jaci.2016.01.047.
- Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacySiefert AL, Caplan MJ, Fahmy TM. Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacy. Biomaterials 2016, 97: 85-96. PMID: 27162077, PMCID: PMC5999034, DOI: 10.1016/j.biomaterials.2016.03.039.
- The tail of polycystin-1 pays the kidney a complementCaplan MJ. The tail of polycystin-1 pays the kidney a complement. American Journal Of Physiology. Renal Physiology 2016, 310: f1180-f1181. PMID: 27009337, DOI: 10.1152/ajprenal.00141.2016.
- The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135Stoops E, Hull M, Olesen C, Mistry K, Harder J, Rivera-Molina F, Toomre D, Caplan M. The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135. The Journal Of General Physiology 2015, 146: 1466oia69. DOI: 10.1085/jgp.1466oia69.
- The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135Stoops EH, Hull M, Olesen C, Mistry K, Harder JL, Rivera-Molina F, Toomre D, Caplan MJ. The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135. Journal Of Cell Biology 2015, 211: 287-294. PMID: 26504168, PMCID: PMC4621837, DOI: 10.1083/jcb.201502045.
- Dual pulse-chase microscopy reveals early divergence in the biosynthetic trafficking of the Na,K-ATPase and E-cadherinFarr GA, Hull M, Stoops EH, Bateson R, Caplan MJ. Dual pulse-chase microscopy reveals early divergence in the biosynthetic trafficking of the Na,K-ATPase and E-cadherin. Molecular Biology Of The Cell 2015, 26: 4401-4411. PMID: 26424804, PMCID: PMC4666135, DOI: 10.1091/mbc.e14-09-1385.
- Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in miceHatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan MJ, Ueno Y, Tsukita S, Asano S. Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice. Hepatology 2015, 61: 1660-1671. PMID: 25311759, PMCID: PMC6083834, DOI: 10.1002/hep.27565.
- Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein StabilityPedrozo Z, Criollo A, Battiprolu PK, Morales CR, Contreras-Ferrat A, Fernández C, Jiang N, Luo X, Caplan MJ, Somlo S, Rothermel BA, Gillette TG, Lavandero S, Hill JA. Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability. Circulation 2015, 131: 2131-2142. PMID: 25888683, PMCID: PMC4470854, DOI: 10.1161/circulationaha.114.013537.
- Akt Substrate of 160 kD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal IschemiaAlves DS, Thulin G, Loffing J, Kashgarian M, Caplan MJ. Akt Substrate of 160 kD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia. Journal Of The American Society Of Nephrology 2015, 26: 2765-2776. PMID: 25788531, PMCID: PMC4625659, DOI: 10.1681/asn.2013101040.
- Investigation of Peanut Oral Immunotherapy Using CpG/Peanut-Nanoparticles in a Murine Model of Peanut AllergySrivastava K, Siefert A, Fahmy T, Caplan M, Li X, Sampson H. Investigation of Peanut Oral Immunotherapy Using CpG/Peanut-Nanoparticles in a Murine Model of Peanut Allergy. Journal Of Allergy And Clinical Immunology 2015, 135: ab235. DOI: 10.1016/j.jaci.2014.12.1701.
- Chemical and Physical Sensors in the Regulation of Renal FunctionPluznick JL, Caplan MJ. Chemical and Physical Sensors in the Regulation of Renal Function. Clinical Journal Of The American Society Of Nephrology 2014, 10: 1626-1635. PMID: 25280495, PMCID: PMC4559500, DOI: 10.2215/cjn.00730114.
- SNAP-Tag to Monitor Trafficking of Membrane Proteins in Polarized Epithelial CellsStoops EH, Farr GA, Hull M, Caplan MJ. SNAP-Tag to Monitor Trafficking of Membrane Proteins in Polarized Epithelial Cells. Methods In Molecular Biology 2014, 1174: 171-182. PMID: 24947381, DOI: 10.1007/978-1-4939-0944-5_11.
- Trafficking to the Apical and Basolateral Membranes in Polarized Epithelial CellsStoops EH, Caplan MJ. Trafficking to the Apical and Basolateral Membranes in Polarized Epithelial Cells. Journal Of The American Society Of Nephrology 2014, 25: 1375-1386. PMID: 24652803, PMCID: PMC4073435, DOI: 10.1681/asn.2013080883.
- Polycystin-1 cleavage and the regulation of transcriptional pathwaysMerrick D, Bertuccio CA, Chapin HC, Lal M, Chauvet V, Caplan MJ. Polycystin-1 cleavage and the regulation of transcriptional pathways. Pediatric Nephrology 2013, 29: 505-511. PMID: 23824180, PMCID: PMC3844055, DOI: 10.1007/s00467-013-2548-y.
- Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivityBryniarski K, Ptak W, Jayakumar A, Püllmann K, Caplan MJ, Chairoungdua A, Lu J, Adams BD, Sikora E, Nazimek K, Marquez S, Kleinstein SH, Sangwung P, Iwakiri Y, Delgato E, Redegeld F, Blokhuis BR, Wojcikowski J, Daniel AW, Kormelink T, Askenase PW. Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. Journal Of Allergy And Clinical Immunology 2013, 132: 170-181.e9. PMID: 23727037, PMCID: PMC4176620, DOI: 10.1016/j.jaci.2013.04.048.
- An inversin convergence. Focus on “Inversin modulates the cortical actin network during mitosis”Caplan MJ. An inversin convergence. Focus on “Inversin modulates the cortical actin network during mitosis”. American Journal Of Physiology - Cell Physiology 2013, 305: c22-c23. PMID: 23677797, DOI: 10.1152/ajpcell.00126.2013.
- Epithelial morphogenesis of MDCK cells in three-dimensional collagen culture is modulated by interleukin-8Wells EK, Yarborough O, Lifton RP, Cantley LG, Caplan MJ. Epithelial morphogenesis of MDCK cells in three-dimensional collagen culture is modulated by interleukin-8. American Journal Of Physiology - Cell Physiology 2013, 304: c966-c975. PMID: 23485708, PMCID: PMC3651639, DOI: 10.1152/ajpcell.00261.2012.
- Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulationPluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 4410-4415. PMID: 23401498, PMCID: PMC3600440, DOI: 10.1073/pnas.1215927110.
- Chapter 1 Epithelial Cell Structure and PolarityMatlin K, Caplan M. Chapter 1 Epithelial Cell Structure and Polarity. 2013, 3-43. DOI: 10.1016/b978-0-12-381462-3.00001-x.
- Chapter 80 Autosomal Dominant Polycystic Kidney DiseaseSomlo S, Torres V, Caplan M. Chapter 80 Autosomal Dominant Polycystic Kidney Disease. 2013, 2645-2688. DOI: 10.1016/b978-0-12-381462-3.00080-x.
- Polycystin-1C terminus cleavage and its relation with polycystin-2, two proteins involved in polycystic kidney disease.Bertuccio CA, Caplan MJ. Polycystin-1C terminus cleavage and its relation with polycystin-2, two proteins involved in polycystic kidney disease. Medicina 2013, 73: 155-62. PMID: 23570767.
- Activation of the Ca2+-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membraneJouret F, Wu J, Hull M, Rajendran V, Mayr B, Schöfl C, Geibel J, Caplan MJ. Activation of the Ca2+-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membrane. Journal Of Cell Science 2013, 126: 5132-5142. PMID: 24013548, PMCID: PMC3828589, DOI: 10.1242/jcs.127555.
- VIP17/MAL expression modulates epithelial cyst formation and ciliogenesisTakiar V, Mistry K, Carmosino M, Schaeren-Wiemers N, Caplan MJ. VIP17/MAL expression modulates epithelial cyst formation and ciliogenesis. American Journal Of Physiology - Cell Physiology 2012, 303: c862-c871. PMID: 22895261, PMCID: PMC3469709, DOI: 10.1152/ajpcell.00338.2011.
- A New Therapeutic Strategy for Autosomal Dominant Polycystic Kidney Disease: Activation of AMP Kinase by MetforminCaplan M. A New Therapeutic Strategy for Autosomal Dominant Polycystic Kidney Disease: Activation of AMP Kinase by Metformin. 2012 DOI: 10.21236/ada592091.
- Novel sensory signaling systems in the kidneyPluznick JL, Caplan MJ. Novel sensory signaling systems in the kidney. Current Opinion In Nephrology & Hypertension 2012, 21: 404-409. PMID: 22569342, DOI: 10.1097/mnh.0b013e328354a6bd.
- AS160: a new Na,K‐ATPase partner that regulates the trafficking of the sodium pump in response to energy depletion and renal ischemiaAlves D, Thulin G, Loffing J, Kashgarian M, Caplan M. AS160: a new Na,K‐ATPase partner that regulates the trafficking of the sodium pump in response to energy depletion and renal ischemia. The FASEB Journal 2012, 26: lb808-lb808. DOI: 10.1096/fasebj.26.1_supplement.lb808.
- Role of Calcineurin in Polycystin Protein Trafficking to the Primary Cilium in LLCPK CellsGilder A, Chapin H, Caplan M. Role of Calcineurin in Polycystin Protein Trafficking to the Primary Cilium in LLCPK Cells. The FASEB Journal 2012, 26: 868.3-868.3. DOI: 10.1096/fasebj.26.1_supplement.868.3.
- Polycystin‐1 stimulates skeletogenesis via TAZ‐mediated activation of RunX2Merrick D, Wu J, Baggs J, Hogenesch J, Caplan M. Polycystin‐1 stimulates skeletogenesis via TAZ‐mediated activation of RunX2. The FASEB Journal 2012, 26: lb811-lb811. DOI: 10.1096/fasebj.26.1_supplement.lb811.
- Inactivation of glycogen‐synthase kinase 3 beta in Madin‐Darby Canine Kidney cells increases epithelial resistanceJouret F, Rajendran V, Caplan M. Inactivation of glycogen‐synthase kinase 3 beta in Madin‐Darby Canine Kidney cells increases epithelial resistance. The FASEB Journal 2012, 26: 1152.13-1152.13. DOI: 10.1096/fasebj.26.1_supplement.1152.13.
- Biosynthetic sorting of the sodium pump: Visualization of the segregation of newly synthesized epithelial Na,K‐ATPase from apically directed proteinsStoops E, Farr G, Caplan M. Biosynthetic sorting of the sodium pump: Visualization of the segregation of newly synthesized epithelial Na,K‐ATPase from apically directed proteins. The FASEB Journal 2012, 26: 885.6-885.6. DOI: 10.1096/fasebj.26.1_supplement.885.6.
- Protein Phosphatase 2A Interacts with the Na+,K+-ATPase and Modulates Its Trafficking by Inhibition of Its Association with ArrestinKimura T, Han W, Pagel P, Nairn AC, Caplan MJ. Protein Phosphatase 2A Interacts with the Na+,K+-ATPase and Modulates Its Trafficking by Inhibition of Its Association with Arrestin. PLOS ONE 2011, 6: e29269. PMID: 22242112, PMCID: PMC3248462, DOI: 10.1371/journal.pone.0029269.
- The γ-Secretase Cleavage Product of Polycystin-1 Regulates TCF and CHOP-Mediated Transcriptional Activation through a p300-Dependent MechanismMerrick D, Chapin H, Baggs JE, Yu Z, Somlo S, Sun Z, Hogenesch JB, Caplan MJ. The γ-Secretase Cleavage Product of Polycystin-1 Regulates TCF and CHOP-Mediated Transcriptional Activation through a p300-Dependent Mechanism. Developmental Cell 2011, 22: 197-210. PMID: 22178500, PMCID: PMC3264829, DOI: 10.1016/j.devcel.2011.10.028.
- Interactions between β-Catenin and the HSlo Potassium Channel Regulates HSlo Surface ExpressionBian S, Bai JP, Chapin H, Le Moellic C, Dong H, Caplan M, Sigworth FJ, Navaratnam DS. Interactions between β-Catenin and the HSlo Potassium Channel Regulates HSlo Surface Expression. PLOS ONE 2011, 6: e28264. PMID: 22194818, PMCID: PMC3237428, DOI: 10.1371/journal.pone.0028264.
- Look who's talking. . . .Caplan M. Look who's talking. . . . Physiology (Bethesda, Md.) 2011, 26: 306. PMID: 22013187, DOI: 10.1152/physiol.00031.2011.
- Macrophages Promote Cyst Growth in Polycystic Kidney DiseaseKarihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG. Macrophages Promote Cyst Growth in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2011, 22: 1809-1814. PMID: 21921140, PMCID: PMC3187181, DOI: 10.1681/asn.2011010084.
- Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemiaSeo-Mayer PW, Thulin G, Zhang L, Alves DS, Ardito T, Kashgarian M, Caplan MJ. Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia. American Journal Of Physiology. Renal Physiology 2011, 301: f1346-f1357. PMID: 21849490, PMCID: PMC3233870, DOI: 10.1152/ajprenal.00420.2010.
- Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseasesChoi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, Caplan MJ, Pontoglio M, Somlo S, Igarashi P. Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 10679-10684. PMID: 21670265, PMCID: PMC3127890, DOI: 10.1073/pnas.1016214108.
- Renal Cystic Disease Proteins Play Critical Roles in the Organization of the Olfactory EpitheliumPluznick JL, Rodriguez-Gil DJ, Hull M, Mistry K, Gattone V, Johnson CA, Weatherbee S, Greer CA, Caplan MJ. Renal Cystic Disease Proteins Play Critical Roles in the Organization of the Olfactory Epithelium. PLOS ONE 2011, 6: e19694. PMID: 21614130, PMCID: PMC3094399, DOI: 10.1371/journal.pone.0019694.
- AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane* ♦Zhang L, Jouret F, Rinehart J, Sfakianos J, Mellman I, Lifton RP, Young LH, Caplan MJ. AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane* ♦. Journal Of Biological Chemistry 2011, 286: 16879-16890. PMID: 21383016, PMCID: PMC3089531, DOI: 10.1074/jbc.m110.186932.
- Regulated Intramembrane Proteolysis: Signaling Pathways and Biological FunctionsLal M, Caplan M. Regulated Intramembrane Proteolysis: Signaling Pathways and Biological Functions. Physiology 2011, 26: 34-44. PMID: 21357901, DOI: 10.1152/physiol.00028.2010.
- Activating AMP-activated protein kinase (AMPK) slows renal cystogenesisTakiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2462-2467. PMID: 21262823, PMCID: PMC3038735, DOI: 10.1073/pnas.1011498108.
- Polycystic kidney disease: Pathogenesis and potential therapiesTakiar V, Caplan MJ. Polycystic kidney disease: Pathogenesis and potential therapies. Biochimica Et Biophysica Acta 2010, 1812: 1337-1343. PMID: 21146605, PMCID: PMC3139769, DOI: 10.1016/j.bbadis.2010.11.014.
- The cell biology of polycystic kidney diseaseChapin HC, Caplan MJ. The cell biology of polycystic kidney disease. Journal Of Cell Biology 2010, 191: 701-710. PMID: 21079243, PMCID: PMC2983067, DOI: 10.1083/jcb.201006173.
- Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic SiteChapin HC, Rajendran V, Caplan MJ. Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic Site. Molecular Biology Of The Cell 2010, 21: 4338-4348. PMID: 20980620, PMCID: PMC3002387, DOI: 10.1091/mbc.e10-05-0407.
- AS160 Associates with the Na+,K+-ATPase and Mediates the Adenosine Monophosphate-stimulated Protein Kinase-dependent Regulation of Sodium Pump Surface ExpressionAlves DS, Farr GA, Seo-Mayer P, Caplan MJ. AS160 Associates with the Na+,K+-ATPase and Mediates the Adenosine Monophosphate-stimulated Protein Kinase-dependent Regulation of Sodium Pump Surface Expression. Molecular Biology Of The Cell 2010, 21: 4400-4408. PMID: 20943949, PMCID: PMC3002392, DOI: 10.1091/mbc.e10-06-0507.
- MAL/VIP17, a New Player in the Regulation of NKCC2 in the KidneyCarmosino M, Rizzo F, Procino G, Basco D, Valenti G, Forbush B, Schaeren-Wiemers N, Caplan MJ, Svelto M. MAL/VIP17, a New Player in the Regulation of NKCC2 in the Kidney. Molecular Biology Of The Cell 2010, 21: 3985-3997. PMID: 20861303, PMCID: PMC2982131, DOI: 10.1091/mbc.e10-05-0456.
- Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signalingChairoungdua A, Smith DL, Pochard P, Hull M, Caplan MJ. Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling. Journal Of Cell Biology 2010, 190: 1079-1091. PMID: 20837771, PMCID: PMC3101591, DOI: 10.1083/jcb.201002049.
- TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile EncephalitisDemento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile Encephalitis. The Journal Of Immunology 2010, 185: 2989-2997. PMID: 20660705, PMCID: PMC3753007, DOI: 10.4049/jimmunol.1000768.
- Association with β-COP Regulates the Trafficking of the Newly Synthesized Na,K-ATPase*Morton MJ, Farr GA, Hull M, Capendeguy O, Horisberger JD, Caplan MJ. Association with β-COP Regulates the Trafficking of the Newly Synthesized Na,K-ATPase*. Journal Of Biological Chemistry 2010, 285: 33737-33746. PMID: 20801885, PMCID: PMC2962472, DOI: 10.1074/jbc.m110.141119.
- Lymphocytes Accelerate Epithelial Tight Junction Assembly: Role of AMP-Activated Protein Kinase (AMPK)Tang XX, Chen H, Yu S, Zhang L, Caplan MJ, Chan HC. Lymphocytes Accelerate Epithelial Tight Junction Assembly: Role of AMP-Activated Protein Kinase (AMPK). PLOS ONE 2010, 5: e12343. PMID: 20808811, PMCID: PMC2925955, DOI: 10.1371/journal.pone.0012343.
- Visualizing Protein Trafficking: Membrane Proteins Follow Multiple Trafficking Pathways to the Basolateral Cell Surface in Polarized Epithelial CellsFarr G, Alves D, Stoops E, Hull M, Caplan M. Visualizing Protein Trafficking: Membrane Proteins Follow Multiple Trafficking Pathways to the Basolateral Cell Surface in Polarized Epithelial Cells. Microscopy And Microanalysis 2010, 16: 958-959. DOI: 10.1017/s1431927610053560.
- Telling kidneys to cease and decystTakiar V, Caplan MJ. Telling kidneys to cease and decyst. Nature Medicine 2010, 16: 751-752. PMID: 20613749, DOI: 10.1038/nm0710-751.
- Targeting Toll-like receptors on dendritic cells modifies the TH2 response to peanut allergens in vitroPochard P, Vickery B, Berin MC, Grishin A, Sampson HA, Caplan M, Bottomly K. Targeting Toll-like receptors on dendritic cells modifies the TH2 response to peanut allergens in vitro. Journal Of Allergy And Clinical Immunology 2010, 126: 92-97.e5. PMID: 20538332, PMCID: PMC2902661, DOI: 10.1016/j.jaci.2010.04.003.
- Renal Cystic Proteins in the Olfactory Epithelium (OE)Pluznick J, Rodriguez‐Gil D, Hull M, Mistry K, Gattone V, Johnson C, Weatherbee S, Greer C, Caplan M. Renal Cystic Proteins in the Olfactory Epithelium (OE). The FASEB Journal 2010, 24: 1002.17-1002.17. DOI: 10.1096/fasebj.24.1_supplement.1002.17.
- Exosome‐release of beta‐catenin: A novel mechanism to antagonize Wnt signalingChairoungdua A, Smith D, Pochard P, Hull M, Caplan M. Exosome‐release of beta‐catenin: A novel mechanism to antagonize Wnt signaling. The FASEB Journal 2010, 24: 715.3-715.3. DOI: 10.1096/fasebj.24.1_supplement.715.3.
- Systems biology and the biology of systems.Caplan M. Systems biology and the biology of systems. Physiology (Bethesda, Md.) 2010, 25: 58. PMID: 20430950, DOI: 10.1152/physiol.00010.2010.
- Polarized traffic towards the cell surface: how to find the routeCarmosino M, Valenti G, Caplan M, Svelto M. Polarized traffic towards the cell surface: how to find the route. Biology Of The Cell 2010, 102: 75-91. PMID: 19909237, DOI: 10.1042/bc20090134.
- Chapter 11 Detecting the Surface Localization and Cytoplasmic Cleavage of Membrane-Bound ProteinsChapin HC, Rajendran V, Capasso A, Caplan MJ. Chapter 11 Detecting the Surface Localization and Cytoplasmic Cleavage of Membrane-Bound Proteins. Methods In Cell Biology 2009, 94: 223-239. PMID: 20362093, PMCID: PMC3063071, DOI: 10.1016/s0091-679x(08)94011-5.
- Partial Correction of Cystic Fibrosis Defects with PLGA Nanoparticles Encapsulating CurcuminCartiera MS, Ferreira EC, Caputo C, Egan ME, Caplan MJ, Saltzman WM. Partial Correction of Cystic Fibrosis Defects with PLGA Nanoparticles Encapsulating Curcumin. Molecular Pharmaceutics 2009, 7: 86-93. PMID: 19886674, PMCID: PMC2815009, DOI: 10.1021/mp900138a.
- Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiencyCu Y, LeMoëllic C, Caplan MJ, Saltzman WM. Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency. Nanomedicine Nanotechnology Biology And Medicine 2009, 6: 334-343. PMID: 19800989, PMCID: PMC2847641, DOI: 10.1016/j.nano.2009.09.001.
- POSH Stimulates the Ubiquitination and the Clathrin-independent Endocytosis of ROMK1 Channels*Lin DH, Yue P, Pan CY, Sun P, Zhang X, Han Z, Roos M, Caplan M, Giebisch G, Wang WH. POSH Stimulates the Ubiquitination and the Clathrin-independent Endocytosis of ROMK1 Channels*. Journal Of Biological Chemistry 2009, 284: 29614-29624. PMID: 19710010, PMCID: PMC2785594, DOI: 10.1074/jbc.m109.041582.
- Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cellsFarr GA, Hull M, Mellman I, Caplan MJ. Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. Journal Of Cell Biology 2009, 186: 269-282. PMID: 19620635, PMCID: PMC2717640, DOI: 10.1083/jcb.200901021.
- Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression*Bertuccio CA, Chapin HC, Cai Y, Mistry K, Chauvet V, Somlo S, Caplan MJ. Polycystin-1 C-terminal Cleavage Is Modulated by Polycystin-2 Expression*. Journal Of Biological Chemistry 2009, 284: 21011-21026. PMID: 19491093, PMCID: PMC2742866, DOI: 10.1074/jbc.m109.017756.
- Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacyDemento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 2009, 27: 3013-3021. PMID: 19428913, PMCID: PMC2695996, DOI: 10.1016/j.vaccine.2009.03.034.
- Localization of proteins associated with renal cystic diseases to the olfactory epitheliumPluznick J, Rodriguez‐Gil D, Mistry K, Hull M, Johnson C, Greer C, Caplan M. Localization of proteins associated with renal cystic diseases to the olfactory epithelium. The FASEB Journal 2009, 23: 796.11-796.11. DOI: 10.1096/fasebj.23.1_supplement.796.11.
- Inflammasome-activating biodegradable nanoparticulates as vaccine delivery systems (135.80)Fahmy T, DEMENTO S, Eisenbarth S, Caplan M, Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell R. Inflammasome-activating biodegradable nanoparticulates as vaccine delivery systems (135.80). The Journal Of Immunology 2009, 182: 135.80-135.80. DOI: 10.4049/jimmunol.182.supp.135.80.
- Interesting times.Caplan M. Interesting times. Physiology (Bethesda, Md.) 2009, 24: 74. PMID: 19364909, DOI: 10.1152/physiol.00004.2009.
- The uptake and intracellular fate of PLGA nanoparticles in epithelial cellsCartiera MS, Johnson KM, Rajendran V, Caplan MJ, Saltzman WM. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 2009, 30: 2790-2798. PMID: 19232712, PMCID: PMC3195413, DOI: 10.1016/j.biomaterials.2009.01.057.
- Functional expression of the olfactory signaling system in the kidneyPluznick JL, Zou DJ, Zhang X, Yan Q, Rodriguez-Gil DJ, Eisner C, Wells E, Greer CA, Wang T, Firestein S, Schnermann J, Caplan MJ. Functional expression of the olfactory signaling system in the kidney. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 2059-2064. PMID: 19174512, PMCID: PMC2644163, DOI: 10.1073/pnas.0812859106.
- Peanut Induced Dendritic Cell (DC) Maturation and Cytokine Production Is Modulated by the Microbial Components of EMP-123, Leading to Changes in Adaptive Immunity In VitroVickery B, Pochard P, Caplan M, Sampson H, Berin M, Bottomly K. Peanut Induced Dendritic Cell (DC) Maturation and Cytokine Production Is Modulated by the Microbial Components of EMP-123, Leading to Changes in Adaptive Immunity In Vitro. Journal Of Allergy And Clinical Immunology 2009, 123: s211. DOI: 10.1016/j.jaci.2008.12.806.
- Dystroglycan and AMP Kinase: Polarity's Protectors when the Power Goes OutZhang L, Seo-Mayer P, Caplan MJ. Dystroglycan and AMP Kinase: Polarity's Protectors when the Power Goes Out. Developmental Cell 2009, 16: 1-2. PMID: 19154710, PMCID: PMC2997531, DOI: 10.1016/j.devcel.2008.12.004.
- The Cytoplasmic Tail Dileucine Motif LL572 Determines the Glycosylation Pattern of Membrane-type 1 Matrix Metalloproteinase*Ludwig T, Theissen SM, Morton MJ, Caplan MJ. The Cytoplasmic Tail Dileucine Motif LL572 Determines the Glycosylation Pattern of Membrane-type 1 Matrix Metalloproteinase*. Journal Of Biological Chemistry 2008, 283: 35410-35418. PMID: 18955496, PMCID: PMC2602891, DOI: 10.1074/jbc.m801816200.
- Epithelial junctions and polarity: complexes and kinasesCaplan MJ, Seo-Mayer P, Zhang L. Epithelial junctions and polarity: complexes and kinases. Current Opinion In Nephrology & Hypertension 2008, 17: 506-512. PMID: 18695392, PMCID: PMC3057677, DOI: 10.1097/mnh.0b013e32830baaae.
- Exon Loss Accounts for Differential Sorting of Na-K-Cl Cotransporters in Polarized Epithelial CellsCarmosino M, Giménez I, Caplan M, Forbush B. Exon Loss Accounts for Differential Sorting of Na-K-Cl Cotransporters in Polarized Epithelial Cells. Molecular Biology Of The Cell 2008, 19: 4341-4351. PMID: 18667527, PMCID: PMC2555935, DOI: 10.1091/mbc.e08-05-0478.
- Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signalingLal M, Song X, Pluznick JL, Di Giovanni V, Merrick DM, Rosenblum ND, Chauvet V, Gottardi CJ, Pei Y, Caplan MJ. Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling. Human Molecular Genetics 2008, 17: 3105-3117. PMID: 18632682, PMCID: PMC2722884, DOI: 10.1093/hmg/ddn208.
- Design opportunities for actively targeted nanoparticle vaccinesFahmy TM, Demento SL, Caplan MJ, Mellman I, Saltzman WM. Design opportunities for actively targeted nanoparticle vaccines. Nanomedicine 2008, 3: 343-355. PMID: 18510429, PMCID: PMC5545123, DOI: 10.2217/17435889.3.3.343.
- What you don't know can't hurt you. . . .Caplan M. What you don't know can't hurt you. . . . Physiology (Bethesda, Md.) 2008, 23: 60. PMID: 18400688, DOI: 10.1152/physiol.00005.2008.
- Apical membrane expression of NKCC2 is directed by a domain within its cytoplasmic C‐terminusCarmosino M, Gimenez I, Caplan M, Forbush B. Apical membrane expression of NKCC2 is directed by a domain within its cytoplasmic C‐terminus. The FASEB Journal 2008, 22: 935.4-935.4. DOI: 10.1096/fasebj.22.1_supplement.935.4.
- The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration ratePluznick J, Zou D, Zhang X, Yan Q, Rodriguez‐Gil D, Eisner C, Wells E, Greer C, Schnermann J, Wang T, Firestein S, Caplan M. The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate. The FASEB Journal 2008, 22: 761.12-761.12. DOI: 10.1096/fasebj.22.1_supplement.761.12.
- Regulation of Polycystin‐1 C terminal cleavage by Polycystin‐2Bertuccio C, Cai Y, Somlo S, Caplan M. Regulation of Polycystin‐1 C terminal cleavage by Polycystin‐2. The FASEB Journal 2008, 22: 942.9-942.9. DOI: 10.1096/fasebj.22.1_supplement.942.9.
- POSH decreases ROMK1 channel activity through stimulating clatharin‐independent and dynamin‐dependent endocytosis.Lin D, Yue P, Sun P, Jin Y, Roos M, Caplan M, Wang W. POSH decreases ROMK1 channel activity through stimulating clatharin‐independent and dynamin‐dependent endocytosis. The FASEB Journal 2008, 22: 1180.1-1180.1. DOI: 10.1096/fasebj.22.1_supplement.1180.1.
- Expression of Tetraspan Protein CD63 Activates Protein-tyrosine Kinase (PTK) and Enhances the PTK-induced Inhibition of ROMK Channels*Lin D, Kamsteeg EJ, Zhang Y, Jin Y, Sterling H, Yue P, Roos M, Duffield A, Spencer J, Caplan M, Wang WH. Expression of Tetraspan Protein CD63 Activates Protein-tyrosine Kinase (PTK) and Enhances the PTK-induced Inhibition of ROMK Channels*. Journal Of Biological Chemistry 2008, 283: 7674-7681. PMID: 18211905, DOI: 10.1074/jbc.m705574200.
- CHAPTER 1 Epithelial Cell Structure and PolarityMatlin K, Caplan M. CHAPTER 1 Epithelial Cell Structure and Polarity. 2008, 1-34. DOI: 10.1016/b978-012088488-9.50004-8.
- CHAPTER 81 Autosomal Dominant Polycystic Kidney Disease and Inherited Cystic DiseasesSomlo S, Torres V, Caplan M. CHAPTER 81 Autosomal Dominant Polycystic Kidney Disease and Inherited Cystic Diseases. 2008, 2283-2313. DOI: 10.1016/b978-012088488-9.50084-x.
- Chapter 4 Protein Trafficking in Polarized CellsDuffield A, Caplan MJ, Muth TR. Chapter 4 Protein Trafficking in Polarized Cells. International Review Of Cytology 2008, 270: 145-179. PMID: 19081536, DOI: 10.1016/s1937-6448(08)01404-4.
- MAL decreases the internalization of the aquaporin-2 water channelKamsteeg EJ, Duffield AS, Konings IB, Spencer J, Pagel P, Deen PM, Caplan MJ. MAL decreases the internalization of the aquaporin-2 water channel. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 16696-16701. PMID: 17940053, PMCID: PMC2034241, DOI: 10.1073/pnas.0708023104.
- Teach your children well. . . .Caplan M. Teach your children well. . . . Physiology (Bethesda, Md.) 2007, 22: 298. PMID: 17928542, DOI: 10.1152/physiol.00029.2007.
- Arrestins and Spinophilin Competitively Regulate Na+,K+-ATPase Trafficking through Association with a Large Cytoplasmic Loop of the Na+,K+-ATPaseKimura T, Allen PB, Nairn AC, Caplan MJ. Arrestins and Spinophilin Competitively Regulate Na+,K+-ATPase Trafficking through Association with a Large Cytoplasmic Loop of the Na+,K+-ATPase. Molecular Biology Of The Cell 2007, 18: 4508-4518. PMID: 17804821, PMCID: PMC2043564, DOI: 10.1091/mbc.e06-08-0711.
- Transport protein sorting in polarized epithelial cells.Zhang L, Caplan MJ. Transport protein sorting in polarized epithelial cells. Acta Physiol Sinica 2007, 59: 505-11. PMID: 17700970.
- Tetraspan proteins: regulators of renal structure and functionCaplan MJ, Kamsteeg EJ, Duffield A. Tetraspan proteins: regulators of renal structure and function. Current Opinion In Nephrology & Hypertension 2007, 16: 353-358. PMID: 17565278, DOI: 10.1097/mnh.0b013e328177b1fa.
- The Future of the PumpCaplan MJ. The Future of the Pump. Journal Of Clinical Gastroenterology 2007, 41: s217-s222. PMID: 17575526, DOI: 10.1097/mcg.0b013e31803233da.
- Functional Expression of Key Components of the Olfactory Receptor Signaling Pathway in the Distal NephronPluznick J, Zhang X, Zou D, Yan Q, Wells E, Wang T, Firestein S, Caplan M. Functional Expression of Key Components of the Olfactory Receptor Signaling Pathway in the Distal Nephron. The FASEB Journal 2007, 21: a500-a500. DOI: 10.1096/fasebj.21.5.a500.
- Expression of tetraspanin protein CD63 enhances the PTK‐induced inhibition of ROMK channelsLin D, Kamsteeg R, Sterling H, Jin Y, Zhang Y, Roos M, Spencer J, Caplan M, Wang W. Expression of tetraspanin protein CD63 enhances the PTK‐induced inhibition of ROMK channels. The FASEB Journal 2007, 21: a1331-a1332. DOI: 10.1096/fasebj.21.6.a1331-d.
- AMP-activated protein kinase regulates the assembly of epithelial tight junctionsZhang L, Li J, Young LH, Caplan MJ. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 17272-17277. PMID: 17088526, PMCID: PMC1859922, DOI: 10.1073/pnas.0608531103.
- An Extracellular Loop of the Human Non-Gastric H,K-ATPase a-subunit is Involved in Apical Plasma Membrane PolarizationLerner M, Lemke D, Bertram H, Schillers H, Oberleithner H, Caplan MJ, Reinhardt J. An Extracellular Loop of the Human Non-Gastric H,K-ATPase a-subunit is Involved in Apical Plasma Membrane Polarization. Cellular Physiology And Biochemistry 2006, 18: 75-84. PMID: 16914892, DOI: 10.1159/000095169.
- A failure to communicate . . .Caplan M. A failure to communicate . . . Physiology (Bethesda, Md.) 2006, 21: 156. PMID: 16714473, DOI: 10.1152/physiol.00016.2006.
- CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidneyLu M, Leng Q, Egan ME, Caplan MJ, Boulpaep EL, Giebisch GH, Hebert SC. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. Journal Of Clinical Investigation 2006, 116: 797-807. PMID: 16470247, PMCID: PMC1361349, DOI: 10.1172/jci26961.
- Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells*Grimm DH, Karihaloo A, Cai Y, Somlo S, Cantley LG, Caplan MJ. Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells*. Journal Of Biological Chemistry 2005, 281: 137-144. PMID: 16278216, DOI: 10.1074/jbc.m507845200.
- The C-Terminal Tail of the Polycystin-1 Protein Interacts with the Na,K-ATPase α-SubunitZatti A, Chauvet V, Rajendran V, Kimura T, Pagel P, Caplan MJ. The C-Terminal Tail of the Polycystin-1 Protein Interacts with the Na,K-ATPase α-Subunit. Molecular Biology Of The Cell 2005, 16: 5087-5093. PMID: 16107561, PMCID: PMC1266409, DOI: 10.1091/mbc.e05-03-0200.
- Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminusChauvet V, Tian X, Husson H, Grimm D, Wang T, Hieseberger T, Igarashi P, Bennett A, Ibraghimov-Beskrovnaya O, Somlo S, Caplan M. Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. Journal Of Clinical Investigation 2005, 115: 788-788. DOI: 10.1172/jci21753c1.
- Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminusChauvet V, Tian X, Husson H, Grimm DH, Wang T, Hieseberger T, Igarashi P, Bennett AM, Ibraghimov-Beskrovnaya O, Somlo S, Caplan MJ. Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. Journal Of Clinical Investigation 2004, 114: 1433-1443. PMID: 15545994, PMCID: PMC525739, DOI: 10.1172/jci21753.
- Gastric parietal cell acid secretion in mice can be regulated independently of H+/K+ ATPase endocytosisNguyen NV, Gleeson PA, Courtois-Coutry N, Caplan MJ, van Driel IR. Gastric parietal cell acid secretion in mice can be regulated independently of H+/K+ ATPase endocytosis. Gastroenterology 2004, 127: 145-154. PMID: 15236181, DOI: 10.1053/j.gastro.2004.04.016.
- Sorting of H,K‐ATPase β‐Subunit in MDCK and LLC‐PK1 Cells is Independent of μ1B Adaptin ExpressionDuffield A, Fölsch H, Mellman I, Caplan MJ. Sorting of H,K‐ATPase β‐Subunit in MDCK and LLC‐PK1 Cells is Independent of μ1B Adaptin Expression. Traffic 2004, 5: 449-461. PMID: 15117319, DOI: 10.1111/j.1398-9219.2004.00192.x.
- Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis DefectsEgan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glöckner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ. Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects. Science 2004, 304: 600-602. PMID: 15105504, DOI: 10.1126/science.1093941.
- The COOH-terminal tail of the GAT-2 GABA transporter contains a novel motif that plays a role in basolateral targetingBrown A, Muth T, Caplan M. The COOH-terminal tail of the GAT-2 GABA transporter contains a novel motif that plays a role in basolateral targeting. American Journal Of Physiology - Cell Physiology 2003, 286: c1071-c1077. PMID: 15075206, DOI: 10.1152/ajpcell.00291.2003.
- The tetraspanin CD63 enhances the internalization of the H,K-ATPase β-subunitDuffield A, Kamsteeg EJ, Brown AN, Pagel P, Caplan MJ. The tetraspanin CD63 enhances the internalization of the H,K-ATPase β-subunit. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 15560-15565. PMID: 14660791, PMCID: PMC307607, DOI: 10.1073/pnas.2536699100.
- TRANSPORT PROTEIN TRAFFICKING IN POLARIZED CELLSMuth TR, Caplan MJ. TRANSPORT PROTEIN TRAFFICKING IN POLARIZED CELLS. Annual Review Of Cell And Developmental Biology 2003, 19: 333-366. PMID: 14570573, DOI: 10.1146/annurev.cellbio.19.110701.161425.
- Polycystin-1 Distribution Is Modulated by Polycystin-2 Expression in Mammalian Cells*Grimm DH, Cai Y, Chauvet V, Rajendran V, Zeltner R, Geng L, Avner ED, Sweeney W, Somlo S, Caplan MJ. Polycystin-1 Distribution Is Modulated by Polycystin-2 Expression in Mammalian Cells*. Journal Of Biological Chemistry 2003, 278: 36786-36793. PMID: 12840011, DOI: 10.1074/jbc.m306536200.
- How megalin finds its way: identification of a novel apical sorting motif. Focus on “Identification of an apical sorting determinant in the cytoplasmic tail of megalin”Caplan MJ. How megalin finds its way: identification of a novel apical sorting motif. Focus on “Identification of an apical sorting determinant in the cytoplasmic tail of megalin”. American Journal Of Physiology - Cell Physiology 2003, 284: c1101-c1104. PMID: 12676652, DOI: 10.1152/ajpcell.00004.2003.
- Ion Pump‐Interacting Proteins: Promising New PartnersPAGEL P, ZATTI A, KIMURA T, DUFFIELD A, CHAUVET V, RAJENDRAN V, CAPLAN MJ. Ion Pump‐Interacting Proteins: Promising New Partners. Annals Of The New York Academy Of Sciences 2003, 986: 360-368. PMID: 12763851, DOI: 10.1111/j.1749-6632.2003.tb07215.x.
- Extracellular Domains, Transmembrane Segments, and Intracellular Domains Interact To Determine the Cation Selectivity of Na,K- and Gastric H,K-ATPase †Mense M, Rajendran V, Blostein R, Caplan MJ. Extracellular Domains, Transmembrane Segments, and Intracellular Domains Interact To Determine the Cation Selectivity of Na,K- and Gastric H,K-ATPase †. Biochemistry 2002, 41: 9803-9812. PMID: 12146946, DOI: 10.1021/bi025819z.
- Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cellsEgan ME, Glöckner-Pagel J, Ambrose C, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, Caplan MJ. Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells. Nature Medicine 2002, 8: 485-492. PMID: 11984593, DOI: 10.1038/nm0502-485.
- THE AQUAPORIN-2 WATER CHANNEL IN AUTOSOMAL DOMINANT PRIMARY NOCTURNAL ENURESISDEEN PM, DAHL N, CAPLAN MJ. THE AQUAPORIN-2 WATER CHANNEL IN AUTOSOMAL DOMINANT PRIMARY NOCTURNAL ENURESIS. Journal Of Urology 2002, 167: 1447-1450. PMID: 11832768, DOI: 10.1016/s0022-5347(05)65341-4.
- Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membraneDeen PM, Van Balkom BW, Savelkoul PJ, Kamsteeg EJ, Van Raak M, Jennings ML, Muth TR, Rajendran V, Caplan MJ. Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membrane. American Journal Of Physiology. Renal Physiology 2002, 282: f330-f340. PMID: 11788448, DOI: 10.1152/ajprenal.0168.2001.
- The NH2-terminus of Norepinephrine Transporter Contains a Basolateral Localization Signal for Epithelial CellsGu H, Wu X, Giros B, Caron M, Caplan M, Rudnick G. The NH2-terminus of Norepinephrine Transporter Contains a Basolateral Localization Signal for Epithelial Cells. Molecular Biology Of The Cell 2001, 12: 3797-3807. PMID: 11739781, PMCID: PMC60756, DOI: 10.1091/mbc.12.12.3797.
- Ion pump sorting in polarized renal epithelial cellsCaplan M. Ion pump sorting in polarized renal epithelial cells. Kidney International 2001, 60: 427-430. PMID: 11473621, DOI: 10.1046/j.1523-1755.2001.060002427.x.
- Ion Pumps in Polarized Cells: Sorting and Regulation of the Na+,K+- and H+,K+-ATPases*Dunbar L, Caplan M. Ion Pumps in Polarized Cells: Sorting and Regulation of the Na+,K+- and H+,K+-ATPases*. Journal Of Biological Chemistry 2001, 276: 29617-29620. PMID: 11404365, DOI: 10.1074/jbc.r100023200.
- The C-terminal Tail of the Metabotropic Glutamate Receptor Subtype 7 Is Necessary but Not Sufficient for Cell Surface Delivery and Polarized Targeting in Neurons and Epithelia*McCarthy J, Lim S, Elkind N, Trimmer J, Duvoisin R, Rodriguez-Boulan E, Caplan M. The C-terminal Tail of the Metabotropic Glutamate Receptor Subtype 7 Is Necessary but Not Sufficient for Cell Surface Delivery and Polarized Targeting in Neurons and Epithelia*. Journal Of Biological Chemistry 2000, 276: 9133-9140. PMID: 11106656, DOI: 10.1074/jbc.m008290200.
- Differential localization of human nongastric H+-K+-ATPase ATP1AL1 in polarized renal epithelial cellsReinhardt J, Grishin A, Oberleithner H, Caplan M. Differential localization of human nongastric H+-K+-ATPase ATP1AL1 in polarized renal epithelial cells. American Journal Of Physiology. Renal Physiology 2000, 279: f417-f425. PMID: 10966921, DOI: 10.1152/ajprenal.2000.279.3.f417.
- The cell biology of ion pumps: sorting and regulationDunbar L, Caplan M. The cell biology of ion pumps: sorting and regulation. European Journal Of Cell Biology 2000, 79: 557-563. PMID: 11001492, DOI: 10.1078/0171-9335-00079.
- The Roles of Carbohydrate Chains of the β-Subunit on the Functional Expression of Gastric H+,K+-ATPase*Asano S, Kawada K, Kimura T, Grishin A, Caplan M, Takeguchi N. The Roles of Carbohydrate Chains of the β-Subunit on the Functional Expression of Gastric H+,K+-ATPase*. Journal Of Biological Chemistry 2000, 275: 8324-8330. PMID: 10722662, DOI: 10.1074/jbc.275.12.8324.
- A Transmembrane Segment Determines the Steady-State Localization of an Ion-Transporting Adenosine TriphosphataseDunbar L, Aronson P, Caplan M. A Transmembrane Segment Determines the Steady-State Localization of an Ion-Transporting Adenosine Triphosphatase. Journal Of Cell Biology 2000, 148: 769-778. PMID: 10684257, PMCID: PMC2169368, DOI: 10.1083/jcb.148.4.769.
- Residues of the Fourth Transmembrane Segments of the Na,K-ATPase and the Gastric H,K-ATPase Contribute to Cation Selectivity*Mense M, Dunbar L, Blostein R, Caplan M. Residues of the Fourth Transmembrane Segments of the Na,K-ATPase and the Gastric H,K-ATPase Contribute to Cation Selectivity*. Journal Of Biological Chemistry 2000, 275: 1749-1756. PMID: 10636871, DOI: 10.1074/jbc.275.3.1749.
- Nongastric H+,K+-ATPase: cell biologic and functional properties.Grishin AV, Reinhard J, Dunbar LA, Courtois-Coutry N, Wang T, Giebisch G, Caplan MJ. Nongastric H+,K+-ATPase: cell biologic and functional properties. Seminars In Nephrology 1999, 19: 421-30. PMID: 10511382.
- Cation Selectivity of Gastric H,K-ATPase and Na,K-ATPase Chimeras*Blostein R, Dunbar L, Mense M, Scanzano R, Wilczynska A, Caplan M. Cation Selectivity of Gastric H,K-ATPase and Na,K-ATPase Chimeras*. Journal Of Biological Chemistry 1999, 274: 18374-18381. PMID: 10373442, DOI: 10.1074/jbc.274.26.18374.
- Regulation of myocardial glucose uptake and transport during ischemia and energetic stressYoung L, Russell R, Yin R, Caplan M, Ren J, Bergeron R, Shulman G, Sinusas A. Regulation of myocardial glucose uptake and transport during ischemia and energetic stress. The American Journal Of Cardiology 1999, 83: 25-30. PMID: 10750583, DOI: 10.1016/s0002-9149(99)00253-2.
- Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPaseLi D, Cheng S, Fisone G, Caplan M, Ohtomo Y, Aperia A. Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase. American Journal Of Physiology 1998, 275: f863-f869. PMID: 9843902, DOI: 10.1152/ajprenal.1998.275.6.f863.
- Additive Effects of Hyperinsulinemia and Ischemia on Myocardial GLUT1 and GLUT4 Translocation In VivoRussell R, Yin R, Caplan M, Hu X, Ren J, Shulman G, Sinusas A, Young L. Additive Effects of Hyperinsulinemia and Ischemia on Myocardial GLUT1 and GLUT4 Translocation In Vivo. Circulation 1998, 98: 2180-2186. PMID: 9815873, DOI: 10.1161/01.cir.98.20.2180.
- A tyrosine-based signal regulates H-K-ATPase-mediated potassium reabsorption in the kidneyWang T, Courtois-Coutry N, Giebisch G, Caplan M. A tyrosine-based signal regulates H-K-ATPase-mediated potassium reabsorption in the kidney. American Journal Of Physiology 1998, 275: f818-f826. PMID: 9815140, DOI: 10.1152/ajprenal.1998.275.5.f818.
- ATP1AL1, a Member of the Non-gastric H,K-ATPase Family, Functions as a Sodium Pump*Grishin A, Caplan M. ATP1AL1, a Member of the Non-gastric H,K-ATPase Family, Functions as a Sodium Pump*. Journal Of Biological Chemistry 1998, 273: 27772-27778. PMID: 9774385, DOI: 10.1074/jbc.273.43.27772.
- Tyrosine-based Membrane Protein Sorting Signals Are Differentially Interpreted by Polarized Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells*Roush D, Gottardi C, Naim H, Roth M, Caplan M. Tyrosine-based Membrane Protein Sorting Signals Are Differentially Interpreted by Polarized Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells*. Journal Of Biological Chemistry 1998, 273: 26862-26869. PMID: 9756932, DOI: 10.1074/jbc.273.41.26862.
- Identification of Sorting Determinants in the C-terminal Cytoplasmic Tails of the γ-Aminobutyric Acid Transporters GAT-2 and GAT-3*Muth T, Ahn J, Caplan M. Identification of Sorting Determinants in the C-terminal Cytoplasmic Tails of the γ-Aminobutyric Acid Transporters GAT-2 and GAT-3*. Journal Of Biological Chemistry 1998, 273: 25616-25627. PMID: 9748227, DOI: 10.1074/jbc.273.40.25616.
- Conformational alterations resulting from mutations in cytoplasmic domains of the alpha subunit of the Na,K-ATPase.Blostein R, Daly SE, Boxenbaum N, Lane LK, Arguello JM, Lingrel JB, Karlish SJ, Caplan MJ, Dunbar L. Conformational alterations resulting from mutations in cytoplasmic domains of the alpha subunit of the Na,K-ATPase. Acta Physiologica Scandinavica. Supplementum 1998, 643: 275-81. PMID: 9789570.
- Gastric H+/K+-ATPase: targeting signals in the regulation of physiologic functionCaplan M. Gastric H+/K+-ATPase: targeting signals in the regulation of physiologic function. Current Opinion In Cell Biology 1998, 10: 468-473. PMID: 9719867, DOI: 10.1016/s0955-0674(98)80060-4.
- Sorting of P-type ATPases in polarized epithelial cells.Dunbar LA, Courtois-Coutry N, Roush DL, Muth TR, Gottardi CJ, Rajendran V, Geibel J, Kashgarian M, Caplan MJ. Sorting of P-type ATPases in polarized epithelial cells. Acta Physiologica Scandinavica. Supplementum 1998, 643: 289-95. PMID: 9789572.
- A basolateral sorting signal is encoded in the α-subunit of Na-K-ATPaseMuth TR, Gottardi CJ, Roush DL, Caplan MJ. A basolateral sorting signal is encoded in the α-subunit of Na-K-ATPase. American Journal Of Physiology 1998, 274: c688-c696. PMID: 9530100, DOI: 10.1152/ajpcell.1998.274.3.c688.
- Signals and Mechanisms of Sorting in Epithelial PolarityGottardi C, Caplan M. Signals and Mechanisms of Sorting in Epithelial Polarity. Advances In Molecular And Cell Biology 1998, 26: 95-131. PMCID: PMC7147917, DOI: 10.1016/s1569-2558(08)60020-x.
- [25] Expression of neurotransmitter transport systems in polarized cellsAhn J, Pietrini G, Muth TR, Caplan MJ. [25] Expression of neurotransmitter transport systems in polarized cells. Methods In Enzymology 1998, 296: 370-388. PMID: 9779461, DOI: 10.1016/s0076-6879(98)96027-x.
- Epithelial Cell Polarity: Challenges and MethodologiesCaplan M, Rodriguez‐Boulan E. Epithelial Cell Polarity: Challenges and Methodologies. 1997, 665-688. DOI: 10.1002/cphy.cp140117.
- Sorting of Ion Pumps in Polarized Epithelial Cells.aDUNBAR L, ROUSH D, COURTOIS‐COUTRY N, MUTH T, GOTTARDI CJ, RAJENDRAN V, GEIBEL J, KASHGARIAN M, CAPLAN M. Sorting of Ion Pumps in Polarized Epithelial Cells.a. Annals Of The New York Academy Of Sciences 1997, 834: 514-523. PMID: 9405853, DOI: 10.1111/j.1749-6632.1997.tb52309.x.
- Sorting and trafficking of ion transport proteins in polarized epithelial cellsMuth T, Dunbar L, Cortois-Coutry N, Roush D, Caplan M. Sorting and trafficking of ion transport proteins in polarized epithelial cells. Current Opinion In Nephrology & Hypertension 1997, 6: 455-459. PMID: 9327204, DOI: 10.1097/00041552-199709000-00008.
- A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid SecretionCourtois-Coutry N, Roush D, Rajendran V, McCarthy J, Geibel J, Kashgarian M, Caplan M. A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion. Cell 1997, 90: 501-510. PMID: 9267030, DOI: 10.1016/s0092-8674(00)80510-3.
- Ion pumps in epithelial cells: sorting, stabilization, and polarityCaplan MJ. Ion pumps in epithelial cells: sorting, stabilization, and polarity. American Journal Of Physiology 1997, 272: g1304-g1313. PMID: 9227464, DOI: 10.1152/ajpgi.1997.272.6.g1304.
- Membrane polarity in epithelial cells: protein sorting and establishment of polarized domainsCaplan MJ. Membrane polarity in epithelial cells: protein sorting and establishment of polarized domains. American Journal Of Physiology 1997, 272: f425-f429. PMID: 9140041, DOI: 10.1152/ajprenal.1997.272.4.f425.
- Sorting of Two Polytopic Proteins, the γ-Aminobutyric Acid and Betaine Transporters, in Polarized Epithelial Cells*Perego C, Bulbarelli A, Longhi R, Caimi M, Villa A, Caplan M, Pietrini G. Sorting of Two Polytopic Proteins, the γ-Aminobutyric Acid and Betaine Transporters, in Polarized Epithelial Cells*. Journal Of Biological Chemistry 1997, 272: 6584-6592. PMID: 9045687, DOI: 10.1074/jbc.272.10.6584.
- Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo.Young L, Renfu Y, Russell R, Hu X, Caplan M, Ren J, Shulman G, Sinusas A. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation 1997, 95: 415-22. PMID: 9008459, DOI: 10.1161/01.cir.95.2.415.
- Cloned Catecholamine Transporters Expressed in Polarized Epithelial Cells: Sorting, Drug Sensitivity, and Ion-Coupling StoichiometryGu H, Caplan MJ, Rudnick G. Cloned Catecholamine Transporters Expressed in Polarized Epithelial Cells: Sorting, Drug Sensitivity, and Ion-Coupling Stoichiometry. Advances In Pharmacology 1997, 42: 175-179. PMID: 9327872, DOI: 10.1016/s1054-3589(08)60721-8.
- SORTING OF GABA TRANSPORTER PROTEINS IN POLARIZED CELLSCAPLAN M. SORTING OF GABA TRANSPORTER PROTEINS IN POLARIZED CELLS. Neurochemistry International 1996, 29: 357-360. PMID: 8939443, DOI: 10.1016/0197-0186(95)00159-x.
- Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells.Brill SR, Ross KE, Davidow CJ, Ye M, Grantham JJ, Caplan MJ. Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 10206-10211. PMID: 8816777, PMCID: PMC38362, DOI: 10.1073/pnas.93.19.10206.
- Functional expression of the cDNA encoded by the human ATP1AL1 geneGrishin AV, Bevensee MO, Modyanov NN, Rajendran V, Boron WF, Caplan MJ. Functional expression of the cDNA encoded by the human ATP1AL1 gene. American Journal Of Physiology 1996, 271: f539-f551. PMID: 8853415, DOI: 10.1152/ajprenal.1996.271.3.f539.
- Real-time detection of the surface delivery of newly synthesized membrane proteins.Andreose JS, Fumagalli G, Sigworth FJ, Caplan MJ. Real-time detection of the surface delivery of newly synthesized membrane proteins. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7661-7666. PMID: 8755532, PMCID: PMC38803, DOI: 10.1073/pnas.93.15.7661.
- Cell-specific Sorting of Biogenic Amine Transporters Expressed in Epithelial Cells*Gu H, Ahn J, Caplan M, Blakely R, Levey A, Rudnick G. Cell-specific Sorting of Biogenic Amine Transporters Expressed in Epithelial Cells*. Journal Of Biological Chemistry 1996, 271: 18100-18106. PMID: 8663573, DOI: 10.1074/jbc.271.30.18100.
- Polarized Expression of GABA Transporters in Madin-Darby Canine Kidney Cells and Cultured Hippocampal Neurons (∗)Ahn J, Mundigl O, Muth T, Rudnick G, Caplan M. Polarized Expression of GABA Transporters in Madin-Darby Canine Kidney Cells and Cultured Hippocampal Neurons (∗). Journal Of Biological Chemistry 1996, 271: 6917-6924. PMID: 8636119, DOI: 10.1074/jbc.271.12.6917.
- Developmental regulation of membrane protein sorting in Drosophila embryosShiel MJ, Caplan MJ. Developmental regulation of membrane protein sorting in Drosophila embryos. American Journal Of Physiology 1995, 269: c207-c216. PMID: 7631747, DOI: 10.1152/ajpcell.1995.269.1.c207.
- The generation of epithelial polarity in mammalian and Drosophila embryosShiel M, Caplan M. The generation of epithelial polarity in mammalian and Drosophila embryos. Seminars In Cell And Developmental Biology 1995, 6: 39-46. DOI: 10.1016/s1044-5781(06)80083-6.
- Biotinylation and assessment of membrane polarity: caveats and methodological concernsGottardi CJ, Dunbar LA, Caplan MJ. Biotinylation and assessment of membrane polarity: caveats and methodological concerns. American Journal Of Physiology 1995, 268: f285-f295. PMID: 7864168, DOI: 10.1152/ajprenal.1995.268.2.f285.
- Na+,K+-ATPase in the Choroid Plexus REGULATION BY SEROTONIN/PROTEIN KINASE C PATHWAY (∗)Fryckstedt J, Caplan M, Aperia A, Fisone G, Snyder G, Greengard P. Na+,K+-ATPase in the Choroid Plexus REGULATION BY SEROTONIN/PROTEIN KINASE C PATHWAY (∗). Journal Of Biological Chemistry 1995, 270: 2427-2430. PMID: 7852300, DOI: 10.1074/jbc.270.6.2427.
- Sorting of the Gastric H,K‐ATPase in Endocrine and Epithelial CellsaROUSH D, GOTTARDI C, CAPLAN M. Sorting of the Gastric H,K‐ATPase in Endocrine and Epithelial Cellsa. Annals Of The New York Academy Of Sciences 1994, 733: 212-222. PMID: 7978870, DOI: 10.1111/j.1749-6632.1994.tb17271.x.
- The axonal gamma-aminobutyric acid transporter GAT-1 is sorted to the apical membranes of polarized epithelial cells.Pietrini G, Suh YJ, Edelmann L, Rudnick G, Caplan MJ. The axonal gamma-aminobutyric acid transporter GAT-1 is sorted to the apical membranes of polarized epithelial cells. Journal Of Biological Chemistry 1994, 269: 4668-4674. PMID: 8308038, DOI: 10.1016/s0021-9258(17)41828-x.
- Chapter 8 Synthesis and Sorting of Ion Pumps in Polarized CellsGottardi C, Pietrini G, Shiel M, Caplan M. Chapter 8 Synthesis and Sorting of Ion Pumps in Polarized Cells. Current Topics In Membranes 1994, 41: 143-168. DOI: 10.1016/s0070-2161(08)60458-x.
- Sorting of ion transport proteins in polarized cellsGottardi C, Pietrini G, Roush D, Caplan M. Sorting of ion transport proteins in polarized cells. Journal Of Cell Science. Supplement 1993, 1993: 13-20. PMID: 8144688, DOI: 10.1242/jcs.1993.supplement_17.3.
- Aldosterone-mediated Na/K-ATPase expression is alpha 1 isoform specific in the renal cortical collecting duct.Welling PA, Caplan M, Sutters M, Giebisch G. Aldosterone-mediated Na/K-ATPase expression is alpha 1 isoform specific in the renal cortical collecting duct. Journal Of Biological Chemistry 1993, 268: 23469-23476. PMID: 8226873, DOI: 10.1016/s0021-9258(19)49486-6.
- Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases. Identification of protein domains that participate in Na,K-ATPase and H,K-ATPase subunit assemblyGottardi CJ, Caplan MJ. Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases. Identification of protein domains that participate in Na,K-ATPase and H,K-ATPase subunit assembly. Journal Of Biological Chemistry 1993, 268: 14342-14347. PMID: 8390991, DOI: 10.1016/s0021-9258(19)85246-8.
- Functional properties of an H,K-ATPase/Na,K-ATPase chimeraBlostein R, Zhang R, Gottardi C, Caplan M. Functional properties of an H,K-ATPase/Na,K-ATPase chimera. Journal Of Biological Chemistry 1993, 268: 10654-10658. PMID: 8387526, DOI: 10.1016/s0021-9258(18)82247-5.
- Delivery of Na+,K+-ATPase in Polarized Epithelial CellsGottardi C, Caplan M. Delivery of Na+,K+-ATPase in Polarized Epithelial Cells. Science 1993, 260: 552-554. PMID: 8386395, DOI: 10.1126/science.8386395.
- An ion-transporting ATPase encodes multiple apical localization signals.Gottardi CJ, Caplan MJ. An ion-transporting ATPase encodes multiple apical localization signals. Journal Of Cell Biology 1993, 121: 283-293. PMID: 8385670, PMCID: PMC2200096, DOI: 10.1083/jcb.121.2.283.
- Cell surface biotinylation in the determination of epithelial membrane polarityGottardi C, Caplan M. Cell surface biotinylation in the determination of epithelial membrane polarity. Cytotechnology 1992, 14: 173-180. DOI: 10.1007/bf01409008.
- Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture.Pietrini G, Matteoli M, Banker G, Caplan MJ. Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 8414-8418. PMID: 1326755, PMCID: PMC49930, DOI: 10.1073/pnas.89.18.8414.
- Distinct pathways for basolateral targeting of membrane and secretory proteins in polarized epithelial cells.Boll W, Partin JS, Katz AI, Caplan MJ, Jamieson JD. Distinct pathways for basolateral targeting of membrane and secretory proteins in polarized epithelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 8592-8596. PMID: 1656451, PMCID: PMC52555, DOI: 10.1073/pnas.88.19.8592.
- Chapter 2 Biogenesis and Sorting of Plasma Membrane ProteinsCaplan M. Chapter 2 Biogenesis and Sorting of Plasma Membrane Proteins. Current Topics In Membranes 1991, 39: 37-86. PMCID: PMC7128438, DOI: 10.1016/s0070-2161(08)60800-x.
- Biosynthesis of the Na,K-ATPase in Madin-Darby canine kidney cells. Activation and cell surface delivery.Caplan MJ, Forbush B, Palade GE, Jamieson JD. Biosynthesis of the Na,K-ATPase in Madin-Darby canine kidney cells. Activation and cell surface delivery. Journal Of Biological Chemistry 1990, 265: 3528-3534. PMID: 2154482, DOI: 10.1016/s0021-9258(19)39801-1.
- Polarized distribution of Na+,K+-ATPase in giant cells elicited in vivo and in vitro.Vignery A, Niven-Fairchild T, Ingbar DH, Caplan M. Polarized distribution of Na+,K+-ATPase in giant cells elicited in vivo and in vitro. Journal Of Histochemistry & Cytochemistry 1989, 37: 1265-1271. PMID: 2546991, DOI: 10.1177/37.8.2546991.
- Immunocytochemical localization of plasmalemmal proteins in semi-thin sections of epithelial monolayers.Smith ZD, Caplan MJ, Jamieson JD. Immunocytochemical localization of plasmalemmal proteins in semi-thin sections of epithelial monolayers. Journal Of Histochemistry & Cytochemistry 1988, 36: 311-316. PMID: 2449492, DOI: 10.1177/36.3.2449492.
- Sorting of newly synthesized Na,K-ATPase in polarized epithelial cells.Caplan MJ, Anderson HC, Palade GE, Jamieson JD. Sorting of newly synthesized Na,K-ATPase in polarized epithelial cells. Progress In Clinical And Biological Research 1988, 268B: 51-8. PMID: 2851829.
- Dependence on pH of polarized sorting of secreted proteinsCaplan M, Stow J, Newman A, Madri J, Anderson H, Farquhar M, Palade G, Jamieson J. Dependence on pH of polarized sorting of secreted proteins. Nature 1987, 329: 632-635. PMID: 2821405, DOI: 10.1038/329632a0.
- Monoclonal antibody localization of Na+-K+-ATPase in the exocrine pancreas and parotid of the dogSmith ZD, Caplan MJ, Forbush B, Jamieson JD. Monoclonal antibody localization of Na+-K+-ATPase in the exocrine pancreas and parotid of the dog. American Journal Of Physiology 1987, 253: g99-g109. PMID: 2441610, DOI: 10.1152/ajpgi.1987.253.2.g99.
- Localization of Na+,K+-ATPase alpha-subunit to the sinusoidal and lateral but not canalicular membranes of rat hepatocytes.Sztul ES, Biemesderfer D, Caplan MJ, Kashgarian M, Boyer JL. Localization of Na+,K+-ATPase alpha-subunit to the sinusoidal and lateral but not canalicular membranes of rat hepatocytes. Journal Of Cell Biology 1987, 104: 1239-1248. PMID: 3032985, PMCID: PMC2114466, DOI: 10.1083/jcb.104.5.1239.
- Processing and Sorting of Proteins Synthesized in the Endoplasmic ReticulumCaplan M, Rosenzweig S, Jamieson J. Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum. 1987, 273-281. DOI: 10.1007/978-1-4613-1943-6_16.
- Intracellular sorting and polarized cell surface delivery of (Na+,K+)ATPase, an endogenous component of MDCK cell basolateral plasma membranesCaplan M, Anderson H, Palade G, Jamieson J. Intracellular sorting and polarized cell surface delivery of (Na+,K+)ATPase, an endogenous component of MDCK cell basolateral plasma membranes. Cell 1986, 46: 623-631. PMID: 3015421, DOI: 10.1016/0092-8674(86)90888-3.
- Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclastBaron R, Neff L, Roy C, Boisvert A, Caplan M. Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast. Cell 1986, 46: 311-320. PMID: 2424614, DOI: 10.1016/0092-8674(86)90748-8.
- Newly synthesized Na,K-ATPase alpha-subunit has no cytosolic intermediate in MDCK cells.Caplan MJ, Palade GE, Jamieson JD. Newly synthesized Na,K-ATPase alpha-subunit has no cytosolic intermediate in MDCK cells. Journal Of Biological Chemistry 1986, 261: 2860-2865. PMID: 3005269, DOI: 10.1016/s0021-9258(17)35866-0.
- Processing and Sorting of Proteins Synthesized in the Endoplasmic ReticulumCaplan M, Rosenzweig S, Jamieson J. Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum. 1986, 273-281. DOI: 10.1007/978-1-4613-2097-5_16.
- Monoclonal antibody to Na,K-ATPase: Immunocytochemical localization along nephron segmentsKashgarian M, Biemesderfer D, Caplan M, Forbush B. Monoclonal antibody to Na,K-ATPase: Immunocytochemical localization along nephron segments. Kidney International 1985, 28: 899-913. PMID: 3003443, DOI: 10.1038/ki.1985.216.
- Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA.Schneider JW, Mercer RW, Caplan M, Emanuel JR, Sweadner KJ, Benz EJ, Levenson R. Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 6357-6361. PMID: 2994074, PMCID: PMC391053, DOI: 10.1073/pnas.82.18.6357.