Leonid Tyan, PhD
Associate Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTORSempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2022, 13: 6681. PMID: 36335122, PMCID: PMC9637099, DOI: 10.1038/s41467-022-34363-w.
- Caveolin-3 prevents swelling-induced membrane damage via regulation of ICl,swell activity.Turner DGP, Tyan L, DeGuire FC, Medvedev RY, Stroebel SJ, Lang D, Glukhov AV. Caveolin-3 prevents swelling-induced membrane damage via regulation of ICl,swell activity. Biophysical Journal 2022, 121: 1643-1659. PMID: 35378081, PMCID: PMC9117929, DOI: 10.1016/j.bpj.2022.04.001.
- Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes.Tyan L, Turner D, Komp KR, Medvedev RY, Lim E, Glukhov AV. Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes. American Journal Of Physiology. Heart And Circulatory Physiology 2021, 320: H787-H797. PMID: 33416459, PMCID: PMC8082791, DOI: 10.1152/ajpheart.00569.2020.
- A compartmentalized mathematical model of mouse atrial myocytes.Asfaw TN, Tyan L, Glukhov AV, Bondarenko VE. A compartmentalized mathematical model of mouse atrial myocytes. American Journal Of Physiology. Heart And Circulatory Physiology 2020, 318: H485-H507. PMID: 31951471, PMCID: PMC7099449, DOI: 10.1152/ajpheart.00460.2019.
- Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.Laforest B, Dai W, Tyan L, Lazarevic S, Shen KM, Gadek M, Broman MT, Weber CR, Moskowitz IP. Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis. The Journal Of Clinical Investigation 2019, 129: 4937-4950. PMID: 31609246, PMCID: PMC6819107, DOI: 10.1172/JCI124231.
- Caveolae-Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis.Egorov YV, Lang D, Tyan L, Turner D, Lim E, Piro ZD, Hernandez JJ, Lodin R, Wang R, Schmuck EG, Raval AN, Ralphe CJ, Kamp TJ, Rosenshtraukh LV, Glukhov AV. Caveolae-Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis. Journal Of The American Heart Association 2019, 8: e012748. PMID: 31597508, PMCID: PMC6818041, DOI: 10.1161/JAHA.119.012748.
- A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. ELife 2019, 8 PMID: 30896405, PMCID: PMC6428569, DOI: 10.7554/eLife.41814.
- Long QT syndrome caveolin-3 mutations differentially modulate Kv 4 and Cav 1.2 channels to contribute to action potential prolongation.Tyan L, Foell JD, Vincent KP, Woon MT, Mesquitta WT, Lang D, Best JM, Ackerman MJ, McCulloch AD, Glukhov AV, Balijepalli RC, Kamp TJ. Long QT syndrome caveolin-3 mutations differentially modulate Kv 4 and Cav 1.2 channels to contribute to action potential prolongation. The Journal Of Physiology 2019, 597: 1531-1551. PMID: 30588629, PMCID: PMC6418751, DOI: 10.1113/JP276014.
- Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. ELife 2017, 6 PMID: 29280435, PMCID: PMC5745077, DOI: 10.7554/eLife.31683.
- Electrophysiology and metabolism of caveolin-3-overexpressing mice.Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Research In Cardiology 2016, 111: 28. PMID: 27023865, PMCID: PMC5336321, DOI: 10.1007/s00395-016-0542-9.
- Coordination of dendritic inhibition through local disinhibitory circuits.Francavilla R, Luo X, Magnin E, Tyan L, Topolnik L. Coordination of dendritic inhibition through local disinhibitory circuits. Frontiers In Synaptic Neuroscience 2015, 7: 5. PMID: 25767448, PMCID: PMC4341546, DOI: 10.3389/fnsyn.2015.00005.
- Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry.Tyan L, Chamberland S, Magnin E, Camiré O, Francavilla R, David LS, Deisseroth K, Topolnik L. Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2014, 34: 4534-47. PMID: 24671999, PMCID: PMC6608127, DOI: 10.1523/JNEUROSCI.3813-13.2014.
- SGK3 regulates Ca(2+) entry and migration of dendritic cells.Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2012, 30: 1423-35. PMID: 23171960, PMCID: PMC6175581, DOI: 10.1159/000343330.
- Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Föller M, Lang F. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney International 2011, 80: 61-7. PMID: 21451460, PMCID: PMC6049080, DOI: 10.1038/ki.2011.67.
- Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1).Eylenstein A, Gehring EM, Heise N, Shumilina E, Schmidt S, Szteyn K, Münzer P, Nurbaeva MK, Eichenmüller M, Tyan L, Regel I, Föller M, Kuhl D, Soboloff J, Penner R, Lang F. Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1). FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2011, 25: 2012-21. PMID: 21385992, PMCID: PMC3999400, DOI: 10.1096/fj.10-178210.
- Inhibition of voltage-gated K+ channels in dendritic cells by rapamycin.Tyan L, Sopjani M, Dërmaku-Sopjani M, Schmid E, Yang W, Xuan NT, Shumilina E, Lang F. Inhibition of voltage-gated K+ channels in dendritic cells by rapamycin. American Journal Of Physiology. Cell Physiology 2010, 299: C1379-85. PMID: 20926775, DOI: 10.1152/ajpcell.00367.2010.
- Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.Shumilina E, Zemtsova IM, Heise N, Schmid E, Eichenmüller M, Tyan L, Rexhepaj R, Lang F. Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2010, 26: 699-706. PMID: 21063107, DOI: 10.1159/000322337.