Emile Boulpaep, MD
Research & Publications
Biography
News
Research Summary
Polarized kidney tubule cells have proteins in the plasma membrane facing the urine that differ from those facing the blood. We are studying the electrical characteristics of these proteins-ion channels and electrogenic transporters-in the two plasma membranes of renal tubule cells. Patchclamp, and molecular biology techniques are being used.
- We study the physiological role and regulation of single small-conductance chloride channels, CFTR, which are activated by cAMP through phosphorylation by protein kinase A.
- We study the ability of CFTR to function as a molecular gating switch for the renal potassium channel ROMK by regulating the ATP sensing of ROMK.
- Using confocal vital microscopy and ion-sensitive fluorescent dyes, we study a model of proximal tubule cell injury induced by angiotensin II, which is accompanied by elevation of intracellular calcium and plasma membrane blebbing.
Specialized Terms: Electrical properties of membrane proteins in plasma membranes and junctions of renal tubule cells
Extensive Research Description
Polarized kidney tubule cells have proteins in the plasma membrane facing the urine that differ from those facing the blood. We are studying the electrical characteristics of these proteins-ion channels and electrogenic transporters-in the two plasma membranes of renal tubule cells. Patch-clamp, optical and molecular biology techniques are being used.
- We study the physiological role and regulation of single small-conductance chloride channels, which are activated by cAMP through phosphorylation by protein kinase A. Our interest is in the intracellular signal transduction pathways involved in the regulation of these renal channels and their homology with the CFTR protein, known to be deficient in cystic fibrosis.
- We study the physiological role and regulation of a cGMP-sensitive non-selective cation channel in the apical membrane of a kidney cell line and its homology with a cGMP-gated non-selective channel of the vertebrate photoreceptor.
- Using confocal vital microscopy and ion-sensitive fluorescent dyes, we study a model of proximal tubule cell injury induced by angiotensin II, which is accompanied by elevation of intracellular calcium and plasma membrane blebbing.
Coauthors
Research Interests
Kidney; Physiology
Selected Publications
- Human PhysiologyBoulpaep E, Boron W. Human Physiology. 2019 DOI: 10.1016/b978-0-12-801238-3.62186-4.
- Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion*Dong K, Yan Q, Lu M, Wan L, Hu H, Guo J, Boulpaep E, Wang W, Giebisch G, Hebert SC, Wang T. Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion*. Journal Of Biological Chemistry 2016, 291: 5259-5269. PMID: 26728465, PMCID: PMC4777858, DOI: 10.1074/jbc.m115.707877.
- Substrate specificity of Rhbg: ammonium and methyl ammonium transportNakhoul N, Abdulnour-Nakhoul S, Boulpaep E, Rabon E, Schmidt E, Hamm L. Substrate specificity of Rhbg: ammonium and methyl ammonium transport. American Journal Of Physiology - Cell Physiology 2010, 299: c695-c705. PMID: 20592240, PMCID: PMC2944323, DOI: 10.1152/ajpcell.00019.2010.
- Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting ductLu M, Dong K, Egan ME, Giebisch GH, Boulpaep EL, Hebert SC. Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting duct. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 6082-6087. PMID: 20231442, PMCID: PMC2851921, DOI: 10.1073/pnas.0902661107.
- CHAPTER 25 INTEGRATED CONTROL OF THE CARDIOVASCULAR SYSTEMBoulpaep E. CHAPTER 25 INTEGRATED CONTROL OF THE CARDIOVASCULAR SYSTEM. 2009, 593-609. DOI: 10.1016/b978-1-4160-3115-4.50028-7.
- Protein-protein interactions among ion channels regulate ion transport in the kidney.Boulpaep E. Protein-protein interactions among ion channels regulate ion transport in the kidney. Bulletin Et Mémoires De L'Académie Royale De Médecine De Belgique 2009, 164: 133-41; discussion 141-2. PMID: 20120088.
- CHAPTER 5 TRANSPORT OF SOLUTES AND WATERAronson P, Boron W, Boulpaep E. CHAPTER 5 TRANSPORT OF SOLUTES AND WATER. 2009, 106-146. DOI: 10.1016/b978-1-4160-3115-4.50008-1.
- CHAPTER 17 ORGANIZATION OF THE CARDIOVASCULAR SYSTEMBoulpaep E. CHAPTER 17 ORGANIZATION OF THE CARDIOVASCULAR SYSTEM. 2009, 429-447. DOI: 10.1016/b978-1-4160-3115-4.50020-2.
- CHAPTER 20 THE MICROCIRCULATIONBoulpaep E. CHAPTER 20 THE MICROCIRCULATION. 2009, 482-503. DOI: 10.1016/b978-1-4160-3115-4.50023-8.
- CHAPTER 19 ARTERIES AND VEINSBoulpaep E. CHAPTER 19 ARTERIES AND VEINS. 2009, 467-481. DOI: 10.1016/b978-1-4160-3115-4.50022-6.
- CHAPTER 1 FOUNDATIONS OF PHYSIOLOGYBoulpaep E, Boron W. CHAPTER 1 FOUNDATIONS OF PHYSIOLOGY. 2009, 3-6. DOI: 10.1016/b978-1-4160-3115-4.50004-4.
- CHAPTER 23 REGULATION OF ARTERIAL PRESSURE AND CARDIAC OUTPUTBoulpaep E. CHAPTER 23 REGULATION OF ARTERIAL PRESSURE AND CARDIAC OUTPUT. 2009, 554-576. DOI: 10.1016/b978-1-4160-3115-4.50026-3.
- CHAPTER 22 THE HEART AS A PUMPBoulpaep E. CHAPTER 22 THE HEART AS A PUMP. 2009, 529-553. DOI: 10.1016/b978-1-4160-3115-4.50025-1.
- CHAPTER 18 BLOODBoulpaep E. CHAPTER 18 BLOOD. 2009, 448-466. DOI: 10.1016/b978-1-4160-3115-4.50021-4.
- CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidneyLu M, Leng Q, Egan ME, Caplan MJ, Boulpaep EL, Giebisch GH, Hebert SC. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. Journal Of Clinical Investigation 2006, 116: 797-807. PMID: 16470247, PMCID: PMC1361349, DOI: 10.1172/jci26961.
- Corrigendum to “Calcium-dependent, swelling-activated K+ conductance in human neuroblastoma cells” [Biochem. Biophys. Res. Commun. 308 (2003) 759–763]Basavappa S, Mangel A, Boulpaep E. Corrigendum to “Calcium-dependent, swelling-activated K+ conductance in human neuroblastoma cells” [Biochem. Biophys. Res. Commun. 308 (2003) 759–763]. Biochemical And Biophysical Research Communications 2006, 340: 1016-1017. DOI: 10.1016/j.bbrc.2005.12.073.
- RetractionFlavell RA, Kaczmarek LK, Abdallah B, Boulpaep EL, Desai R, Basavappa S, Matza D, Peng YQ, Mehal WZ. Retraction. Science 2005, 310: 1903-1903. PMID: 16373558, DOI: 10.1126/science.310.5756.1903b.
- Requirement of Voltage-Gated Calcium Channel ß4 Subunit for T Lymphocyte FunctionsBadou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Requirement of Voltage-Gated Calcium Channel ß4 Subunit for T Lymphocyte Functions. Science 2005, 307: 117-121. PMID: 15637280, DOI: 10.1126/science.1100582.
- Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertensionKahle KT, MacGregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP. Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 14877-14882. PMID: 15465913, PMCID: PMC522037, DOI: 10.1073/pnas.0406172101.
- Characteristics of renal Rhbg as an NH4+ transporterNakhoul N, DeJong H, Abdulnour-Nakhoul S, Boulpaep E, Hering-Smith K, Hamm L. Characteristics of renal Rhbg as an NH4+ transporter. American Journal Of Physiology. Renal Physiology 2004, 288: f170-f181. PMID: 15353405, DOI: 10.1152/ajprenal.00419.2003.
- Calcium-dependent, swelling-activated K+ conductance in human neuroblastoma cellsBasavappa S, Mangel A, Boulpaep E. Calcium-dependent, swelling-activated K+ conductance in human neuroblastoma cells. Biochemical And Biophysical Research Communications 2003, 308: 759-763. PMID: 12927783, DOI: 10.1016/s0006-291x(03)01481-5.
- Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colonJoiner WJ, Basavappa S, Vidyasagar S, Nehrke K, Krishnan S, Binder HJ, Boulpaep EL, Rajendran VM. Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon. AJP Gastrointestinal And Liver Physiology 2003, 285: g185-g196. PMID: 12606302, DOI: 10.1152/ajpgi.00337.2002.
- Free-flow potential profile along rat kidney proximal tubule. 1974.. Free-flow potential profile along rat kidney proximal tubule. 1974. J Am Soc Nephrol 2001, 12: 2197-2206. PMID: 11562421, DOI: 10.1681/ASN.V12102197.
- An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channelChoi I, Aalkjaer C, Boulpaep E, Boron W. An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Nature 2000, 405: 571-575. PMID: 10850716, DOI: 10.1038/35014615.
- Regulation of volume‐activated chloride channels by P‐glycoprotein: phosphorylation has the final say!Idriss H, Hannun Y, Boulpaep E, Basavappa S. Regulation of volume‐activated chloride channels by P‐glycoprotein: phosphorylation has the final say! The Journal Of Physiology 2000, 524: 629-636. PMID: 10790147, PMCID: PMC2269906, DOI: 10.1111/j.1469-7793.2000.00629.x.
- Immunolocalization of the electrogenic Na+- HCO 3 − cotransporter in mammalian and amphibian kidneySchmitt B, Biemesderfer D, Romero M, Boulpaep E, Boron W. Immunolocalization of the electrogenic Na+- HCO 3 − cotransporter in mammalian and amphibian kidney. American Journal Of Physiology 1999, 276: f27-f38. PMID: 9887077, DOI: 10.1152/ajprenal.1999.276.1.f27.
- Transcellular Chloride Pathways in Ambystoma Proximal TubuleAbdulnour-Nakhoul S, Boulpaep E. Transcellular Chloride Pathways in Ambystoma Proximal Tubule. The Journal Of Membrane Biology 1998, 166: 15-35. PMID: 9784583, DOI: 10.1007/s002329900444.
- Properties of an Inwardly Rectifying ATP-sensitive K+ Channel in the Basolateral Membrane of Renal Proximal TubuleMauerer U, Boulpaep E, Segal A. Properties of an Inwardly Rectifying ATP-sensitive K+ Channel in the Basolateral Membrane of Renal Proximal Tubule. The Journal Of General Physiology 1998, 111: 139-160. PMID: 9417141, PMCID: PMC1887768, DOI: 10.1085/jgp.111.1.139.
- Regulation of an Inwardly Rectifying ATP-sensitive K+ Channel in the Basolateral Membrane of Renal Proximal TubuleMauerer U, Boulpaep E, Segal A. Regulation of an Inwardly Rectifying ATP-sensitive K+ Channel in the Basolateral Membrane of Renal Proximal Tubule. The Journal Of General Physiology 1998, 111: 161-180. PMID: 9417142, PMCID: PMC1887764, DOI: 10.1085/jgp.111.1.161.
- The electrogenic Na/HCO3 cotransporter.Boron W, Fong P, Hediger M, Boulpaep E, Romero M. The electrogenic Na/HCO3 cotransporter. Wiener Klinische Wochenschrift 1997, 109: 445-56. PMID: 9261985.
- Tubule electrophysiology: from single channels back to the renal epithelium.Boulpaep E. Tubule electrophysiology: from single channels back to the renal epithelium. Wiener Klinische Wochenschrift 1997, 109: 489-92. PMID: 9261991.
- Expression cloning and characterization of a renal electrogenic Na+ /HCO3− cotransporterRomero M, Hediger M, Boulpaep E, Boron W. Expression cloning and characterization of a renal electrogenic Na+ /HCO3− cotransporter. Nature 1997, 387: 409-413. PMID: 9163427, DOI: 10.1038/387409a0.
- The Renal Electrogenic Na+:HCO3− CotransporterBoron W, Hediger M, Boulpaep E, Romero M. The Renal Electrogenic Na+:HCO3− Cotransporter. Journal Of Experimental Biology 1997, 200: 263-268. PMID: 9050234, DOI: 10.1242/jeb.200.2.263.
- A novel preparation of dissociated renal proximal tubule cells that maintain epithelial polarity in suspensionSegal A, Boulpaep E, Maunsbach A. A novel preparation of dissociated renal proximal tubule cells that maintain epithelial polarity in suspension. American Journal Of Physiology 1996, 270: c1843-c1863. PMID: 8764170, DOI: 10.1152/ajpcell.1996.270.6.c1843.
- Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney.Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV. Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney. Journal Of Clinical Investigation 1996, 97: 2525-2533. PMID: 8647945, PMCID: PMC507338, DOI: 10.1172/jci118700.
- Primary structure and functional expression of a cGMP-gated potassium channel.Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, Desir GV. Primary structure and functional expression of a cGMP-gated potassium channel. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11711-11715. PMID: 8524834, PMCID: PMC40472, DOI: 10.1073/pnas.92.25.11711.
- A Calcium-activated and nucleotide-sensitive nonselective cation channel in M-1 mouse cortical collecting duct cellsKorbmacher C, Volk T, Segal A, Boulpaep E, Frömter E. A Calcium-activated and nucleotide-sensitive nonselective cation channel in M-1 mouse cortical collecting duct cells. The Journal Of Membrane Biology 1995, 146: 29-45. PMID: 7563035, DOI: 10.1007/bf00232678.
- Whole-cell currents in single and confluent M-1 mouse cortical collecting duct cells.Korbmacher C, Segal A, Fejes-Tóth G, Giebisch G, Boulpaep E. Whole-cell currents in single and confluent M-1 mouse cortical collecting duct cells. The Journal Of General Physiology 1993, 102: 761-793. PMID: 8270912, PMCID: PMC2229168, DOI: 10.1085/jgp.102.4.761.
- Endothelin increases [Ca2+]i in M-1 mouse cortical collecting duct cells by a dual mechanismKorbmacher C, Boulpaep E, Giebisch G, Geibel J. Endothelin increases [Ca2+]i in M-1 mouse cortical collecting duct cells by a dual mechanism. American Journal Of Physiology 1993, 265: c349-c357. PMID: 8368264, DOI: 10.1152/ajpcell.1993.265.2.c349.
- Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel.Ahmad I, Korbmacher C, Segal A, Cheung P, Boulpaep E, Barnstable C. Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 10262-10266. PMID: 1279673, PMCID: PMC50318, DOI: 10.1073/pnas.89.21.10262.
- Differentiated Transport Properties of Primary Cultured Distal NephronWhite S, Boulpaep E, Giebisch G. Differentiated Transport Properties of Primary Cultured Distal Nephron. Cellular Physiology And Biochemistry 1992, 2: 323-335. DOI: 10.1159/000154655.
- Single Sodium Channels in the Apical Membrane of Proximal Tubule Cells in CultureBoulpaep E, Drake-Baumann R. Single Sodium Channels in the Apical Membrane of Proximal Tubule Cells in Culture. 1991, 1669-1676. DOI: 10.1007/978-3-662-35158-1_175.
- Immunoelectron microscope localization of Na,K-TPase in transport pathways in proximal tubule epitheliumMaunsbach A, Boulpaep E. Immunoelectron microscope localization of Na,K-TPase in transport pathways in proximal tubule epithelium. Micron 1991, 22: 55-56. DOI: 10.1016/0739-6260(91)90088-h.
- Bicarbonate transport mechanisms in the Ambystoma kidney proximal tubule: transepithelial potential measurements.Bock J, Boulpaep E. Bicarbonate transport mechanisms in the Ambystoma kidney proximal tubule: transepithelial potential measurements. The Yale Journal Of Biology And Medicine 1990, 63: 529-47. PMID: 2092412, PMCID: PMC2589409.
- The electrogenic Na/HCO3 cotransporterBoron W, Boulpaep E. The electrogenic Na/HCO3 cotransporter. Kidney International 1989, 36: 392-402. PMID: 2687566, DOI: 10.1038/ki.1989.208.
- IntroductionGiebisch G, Boulpaep E. Introduction. Kidney International 1989, 36: 333. DOI: 10.1038/ki.1989.200.
- MECHANISMS OF WATER TRANSPORT BY EPITHELIAL CELLSTripathi S, Boulpaep E. MECHANISMS OF WATER TRANSPORT BY EPITHELIAL CELLS. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 1989, 74: 385-417. PMID: 2678220, DOI: 10.1113/expphysiol.1989.sp003288.
- Cell membrane water permeabilities and streaming currents in Ambystoma proximal tubuleTripathi S, Boulpaep E. Cell membrane water permeabilities and streaming currents in Ambystoma proximal tubule. American Journal Of Physiology 1988, 255: f188-f203. PMID: 3394810, DOI: 10.1152/ajprenal.1988.255.1.f188.
- Glucocorticoids have a different action than aldosterone on target tissueHalevy J, Boulpaep E, Budinger M, Binder H, Hayslett J. Glucocorticoids have a different action than aldosterone on target tissue. American Journal Of Physiology 1988, 254: f153-f158. PMID: 3337244, DOI: 10.1152/ajprenal.1988.254.1.f153.
- Ultrastructural changes in isolated perfused proximal tubules during osmotic water flowMaunsbach A, Tripathi S, Boulpaep E. Ultrastructural changes in isolated perfused proximal tubules during osmotic water flow. American Journal Of Physiology 1987, 253: f1091-f1104. PMID: 3425719, DOI: 10.1152/ajprenal.1987.253.6.f1091.
- pH-Dependent electrical properties and buffer permeability of theNecturus renal proximal tubule cellSteels P, Boulpaep E. pH-Dependent electrical properties and buffer permeability of theNecturus renal proximal tubule cell. The Journal Of Membrane Biology 1987, 100: 165-182. PMID: 3430572, DOI: 10.1007/bf02209148.
- Aldosterone increases the maximal turnover rate of the sodium pumpHalevy J, Boulpaep E, Binder H, Hayslett J. Aldosterone increases the maximal turnover rate of the sodium pump. Pflügers Archiv - European Journal Of Physiology 1987, 410: 476-480. PMID: 3432052, DOI: 10.1007/bf00586528.
- Isolated perfused Ambystoma proximal tubule: hydrodynamics modulates ultrastructureTripathi S, Boulpaep E, Maunsbach A. Isolated perfused Ambystoma proximal tubule: hydrodynamics modulates ultrastructure. American Journal Of Physiology 1987, 252: f1129-f1147. PMID: 3591955, DOI: 10.1152/ajprenal.1987.252.6.f1129.
- Electrochemical analysis of renal Na+-glucose cotransport in salamander proximal tubulesMorgunov N, Boulpaep E. Electrochemical analysis of renal Na+-glucose cotransport in salamander proximal tubules. American Journal Of Physiology 1987, 252: f154-f169. PMID: 3812699, DOI: 10.1152/ajprenal.1987.252.1.f154.
- Regulation of single potassium ion channels from apical membrane of rabbit collecting tubuleHunter M, Lopes A, Boulpaep E, Giebisch G. Regulation of single potassium ion channels from apical membrane of rabbit collecting tubule. American Journal Of Physiology 1986, 251: f725-f733. PMID: 2429562, DOI: 10.1152/ajprenal.1986.251.4.f725.
- Submicron tip breakage and silanization control improve ion-selective microelectrodesTripathi S, Morgunov N, Boulpaep E. Submicron tip breakage and silanization control improve ion-selective microelectrodes. American Journal Of Physiology 1985, 249: c514-c521. PMID: 4061634, DOI: 10.1152/ajpcell.1985.249.5.c514.
- Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubuleHirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.
- Single channel recordings of calcium-activated potassium channels in the apical membrane of rabbit cortical collecting tubules.Hunter M, Lopes A, Boulpaep E, Giebisch G. Single channel recordings of calcium-activated potassium channels in the apical membrane of rabbit cortical collecting tubules. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 4237-4239. PMID: 6330754, PMCID: PMC345404, DOI: 10.1073/pnas.81.13.4237.
- Quantitative ultrastructure and functional correlates in proximal tubule of Ambystoma and NecturusMaunsbach A, Boulpaep E. Quantitative ultrastructure and functional correlates in proximal tubule of Ambystoma and Necturus. American Journal Of Physiology 1984, 246: f710-f724. PMID: 6720973, DOI: 10.1152/ajprenal.1984.246.5.f710.
- Rheogenic transport in the renal proximal tubule.Sackin H, Boulpaep E. Rheogenic transport in the renal proximal tubule. The Journal Of General Physiology 1983, 82: 819-851. PMID: 6319539, PMCID: PMC2228722, DOI: 10.1085/jgp.82.6.819.
- Paracellular shunt ultrastructure and changes in fluid transport in Necturus proximal tubuleMaunsbach A, Boulpaep E. Paracellular shunt ultrastructure and changes in fluid transport in Necturus proximal tubule. Kidney International 1983, 24: 610-619. PMID: 6663983, DOI: 10.1038/ki.1983.201.
- Chloride transport across the basolateral cell membrane of theNecturus proximal tubule: Dependence on bicarbonate and sodiumGuggino W, London R, Boulpaep E, Giebisch G. Chloride transport across the basolateral cell membrane of theNecturus proximal tubule: Dependence on bicarbonate and sodium. The Journal Of Membrane Biology 1983, 71: 227-240. PMID: 6302263, DOI: 10.1007/bf01875464.
- Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport.Boron W, Boulpaep E. Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport. The Journal Of General Physiology 1983, 81: 53-94. PMID: 6833997, PMCID: PMC2215562, DOI: 10.1085/jgp.81.1.53.
- Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange.Boron W, Boulpaep E. Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange. The Journal Of General Physiology 1983, 81: 29-52. PMID: 6833996, PMCID: PMC2215563, DOI: 10.1085/jgp.81.1.29.
- Cellular and paracellular resistances of theNecturus proximal tubuleGuggino W, Windhager E, Boulpaep E, Giebisch G. Cellular and paracellular resistances of theNecturus proximal tubule. The Journal Of Membrane Biology 1982, 67: 143-154. PMID: 7097759, DOI: 10.1007/bf01868657.
- Electrical properties of chloride transport across theNecturus proximal tubuleGuggino W, Boulpaep E, Giebisch G. Electrical properties of chloride transport across theNecturus proximal tubule. The Journal Of Membrane Biology 1982, 65: 185-196. PMID: 7062339, DOI: 10.1007/bf01869962.
- Ionic conductive properties and electrophysiology of the rabbit cortical collecting tubuleO'Neil R, Boulpaep E. Ionic conductive properties and electrophysiology of the rabbit cortical collecting tubule. American Journal Of Physiology 1982, 243: f81-f95. PMID: 7091368, DOI: 10.1152/ajprenal.1982.243.1.f81.
- Isolated perfused salamander proximal tubule. II. Monovalent ion replacement and rheogenic transportSackin H, Boulpaep E. Isolated perfused salamander proximal tubule. II. Monovalent ion replacement and rheogenic transport. American Journal Of Physiology 1981, 241: f540-f555. PMID: 7304748, DOI: 10.1152/ajprenal.1981.241.5.f540.
- Isolated perfused salamander proximal tubule: methods, electrophysiology, and transportSackin H, Boulpaep E. Isolated perfused salamander proximal tubule: methods, electrophysiology, and transport. American Journal Of Physiology 1981, 241: f39-f52. PMID: 7246773, DOI: 10.1152/ajprenal.1981.241.1.f39.
- The rheogenic nature of sodium transport in leaky epithelia studied by equivalent circuit analysis.Sackin H, Boulpaep E. The rheogenic nature of sodium transport in leaky epithelia studied by equivalent circuit analysis. Progress In Clinical And Biological Research 1981, 73: 57-66. PMID: 6275400.
- Hydrogen and bicarbonate transport by salamander proximal tubule cells.Boron W, Boulpaep E. Hydrogen and bicarbonate transport by salamander proximal tubule cells. Kroc Foundation Series 1981, 15: 253-67. PMID: 6951947.
- Hydrostatic pressure changes related to paracellular shunt ultrastructure in proximal tubuleMaunsbach A, Boulpaep E. Hydrostatic pressure changes related to paracellular shunt ultrastructure in proximal tubule. Kidney International 1980, 17: 732-748. PMID: 7191026, DOI: 10.1038/ki.1980.86.
- Organic substrate effects on and heterogeneity of Necturus proximal tubule functionForster J, Steels P, Boulpaep E. Organic substrate effects on and heterogeneity of Necturus proximal tubule function. Kidney International 1980, 17: 479-490. PMID: 6771454, DOI: 10.1038/ki.1980.56.
- PrefaceBoulpaep E. Preface. 1980, 13: xix-xx. DOI: 10.1016/s0070-2161(08)60267-1.
- Chapter 12 Electrical Analysis of Intraepithelial BarriersBoulpaep E, Sackin H. Chapter 12 Electrical Analysis of Intraepithelial Barriers. 1980, 13: 169-197. DOI: 10.1016/s0070-2161(08)60280-4.
- Effect of amiloride on the apical cell membrane cation channels of a sodium-absorbing, potassium-secreting renal epitheliumO'Neil R, Boulpaep E. Effect of amiloride on the apical cell membrane cation channels of a sodium-absorbing, potassium-secreting renal epithelium. The Journal Of Membrane Biology 1979, 50: 365-387. PMID: 513119, DOI: 10.1007/bf01868898.
- Equivalent electrical circuit analysis and rheogenic pumps in epithelia.Boulpaep E, Sackin H. Equivalent electrical circuit analysis and rheogenic pumps in epithelia. The FASEB Journal 1979, 38: 2030-6. PMID: 437145.
- Modulation of cell membrane area in renal collecting tubules by corticosteroid hormones.Wade J, O'Neil R, Pryor J, Boulpaep E. Modulation of cell membrane area in renal collecting tubules by corticosteroid hormones. Journal Of Cell Biology 1979, 81: 439-445. PMID: 468913, PMCID: PMC2110313, DOI: 10.1083/jcb.81.2.439.
- 14. Solute-Coupled Water Transport in the KidneyBoulpaep E. 14. Solute-Coupled Water Transport in the Kidney. 1978, 294-315. DOI: 10.4159/harvard.9780674367227.c18.
- Factors influencing transepithelial potential difference in mammalian distal tubuleHayslett J, Boulpaep E, Giebisch G. Factors influencing transepithelial potential difference in mammalian distal tubule. American Journal Of Physiology 1978, 234: f182-f191. PMID: 629352, DOI: 10.1152/ajprenal.1978.234.3.f182.
- Changes in the intracellular electrochemical potentials of Na+, K+ and Cl- in single cells of the proximal tubule of the Necturous kidney induced by rapid changes in the extracellular perfusion fluids [proceedings].Khuri RN, Agulian SK, Boulpae EL, Simon W, Giebisch G. Changes in the intracellular electrochemical potentials of Na+, K+ and Cl- in single cells of the proximal tubule of the Necturous kidney induced by rapid changes in the extracellular perfusion fluids [proceedings]. Arzneimittelforschung 1978, 28: 879. PMID: 581982.
- Electrophysiological Measurements on the Renal TubuleBoulpaep E, Giebisch G. Electrophysiological Measurements on the Renal Tubule. 1978, 165-193. DOI: 10.1007/978-1-4615-8894-8_7.
- Segmental heterogeneity and effects of organic solutes on ion transport across the Nectums proximal tubule studied with electrophysiological techniquesSteels P, Boulpaep E. Segmental heterogeneity and effects of organic solutes on ion transport across the Nectums proximal tubule studied with electrophysiological techniques. Archives Of Physiology And Biochemistry 1978, 86: 688-689. PMID: 83844, DOI: 10.3109/13813457809055945.
- Electrical characteristics of the mammalian distal tubule: Comparison of Ling-Gerard and macroelectrodesHayslett J, Boulpaep E, Kashgarian M, Giebisch G. Electrical characteristics of the mammalian distal tubule: Comparison of Ling-Gerard and macroelectrodes. Kidney International 1977, 12: 324-331. PMID: 604621, DOI: 10.1038/ki.1977.119.
- The effect of organic solutes on proximal tubular fluid absorption in Necturus kidney [proceedings].Boulpaep E, Forster J, Steels P. The effect of organic solutes on proximal tubular fluid absorption in Necturus kidney [proceedings]. Archives Of Physiology And Biochemistry 1977, 85: 623-4. PMID: 72543.
- Role of the paracellular pathway in isotonic fluid movement across the renal tubule.Boulpaep E, Sackin H. Role of the paracellular pathway in isotonic fluid movement across the renal tubule. The Yale Journal Of Biology And Medicine 1977, 50: 115-31. PMID: 331692, PMCID: PMC2595392.
- Introductory RemarksBoulpaep E. Introductory Remarks. The Yale Journal Of Biology And Medicine 1977, 50: 97-98. PMCID: PMC2595396.
- THE ROLE OF HYDROSTATIC AND COLLOID-OSMOTIC PRESSURE ON THE PARACELLULAR PATHWAY AND ON SOLUTE AND WATER ABSORPTIONBoulpaep E. THE ROLE OF HYDROSTATIC AND COLLOID-OSMOTIC PRESSURE ON THE PARACELLULAR PATHWAY AND ON SOLUTE AND WATER ABSORPTION. 1977, 355-371. DOI: 10.1016/b978-0-12-392050-8.50033-9.
- Electrical phenomena in the nephronBoulpaep E. Electrical phenomena in the nephron. Kidney International 1976, 9: 88-102. PMID: 940266, DOI: 10.1038/ki.1976.14.
- Recent advances in electrophysiology of the nephron.Boulpaep EL. Recent advances in electrophysiology of the nephron. Annu Rev Physiol 1976, 38: 21-36. PMID: 769655, DOI: 10.1146/annurev.ph.38.030176.000320.
- Models for coupling of salt and water transport; Proximal tubular reabsorption in Necturus kidney.Sackin H, Boulpaep E. Models for coupling of salt and water transport; Proximal tubular reabsorption in Necturus kidney. The Journal Of General Physiology 1975, 66: 671-733. PMID: 1104761, PMCID: PMC2226230, DOI: 10.1085/jgp.66.6.671.
- Nonelectrolyte permeability of the paracellular pathway in Necturus proximal tubule.Berry CA, Boulpaep EL. Nonelectrolyte permeability of the paracellular pathway in Necturus proximal tubule. Am J Physiol 1975, 228: 581-95. PMID: 1119579, DOI: 10.1152/ajplegacy.1975.228.2.581.
- Pressure Control of Sodium Reabsorption and Intercellular Backflux across Proximal Kidney TubuleGrandchamp A, Boulpaep E. Pressure Control of Sodium Reabsorption and Intercellular Backflux across Proximal Kidney Tubule. Journal Of Clinical Investigation 1974, 54: 69-82. PMID: 4834883, PMCID: PMC301525, DOI: 10.1172/jci107751.
- Effects on intrarenal pressure on sodium reabsorption and the permeability of the route of intercellular shunt of the proximal tubule.Grandchamp A, Boulpaep E. Effects on intrarenal pressure on sodium reabsorption and the permeability of the route of intercellular shunt of the proximal tubule. Minerva Nefrologica 1973, 20: 375. PMID: 4792774.
- Electrophysiological techniques in kidney micropuncture.Boulpaep EL. Electrophysiological techniques in kidney micropuncture. Yale J Biol Med 1972, 45: 397-413. PMID: 4638662.
- Electrophoretic method of ion injection in single kidney cells.Tadokoro M, Boulpaep EL. Electrophoretic method of ion injection in single kidney cells. Yale J Biol Med 1972, 45: 432-5. PMID: 4638665.
- Permeability changes of the proximal tubule of Necturus during saline loading.Boulpaep EL. Permeability changes of the proximal tubule of Necturus during saline loading. Am J Physiol 1972, 222: 517-31. PMID: 5022659, DOI: 10.1152/ajplegacy.1972.222.3.517.
- Effect of intraluminal pressure on proximal tubular sodium reabsorptin. A shrinking drop micropuncture study.Grandchamp A, Boulpaep E. Effect of intraluminal pressure on proximal tubular sodium reabsorptin. A shrinking drop micropuncture study. The Yale Journal Of Biology And Medicine 1972, 45: 275-88. PMID: 4638650, PMCID: PMC2591956.
- Renal Micropuncture Techniques: A Symposium *Giebisch G, Boulpaep E, Wright F. Renal Micropuncture Techniques: A Symposium *. The Yale Journal Of Biology And Medicine 1972, 45: 187-190. PMCID: PMC2591944.
- Renal function studies on the isobaric autoperfused dog kidney.Seely JF, Boulpaep EL. Renal function studies on the isobaric autoperfused dog kidney. Am J Physiol 1971, 221: 1075-83. PMID: 5111248, DOI: 10.1152/ajplegacy.1971.221.4.1075.
- Electrophysiology of proximal and distal tubules in the autoperfused dog kidney.Boulpaep EL, Seely JF. Electrophysiology of proximal and distal tubules in the autoperfused dog kidney. Am J Physiol 1971, 221: 1084-96. PMID: 5111249, DOI: 10.1152/ajplegacy.1971.221.4.1084.
- Electrolyte transport in kidney tubule cellsGiebisch G, Boulpaep E, Whittembury G. Electrolyte transport in kidney tubule cells. Philosophical Transactions Of The Royal Society B Biological Sciences 1971, 262: 175-196. PMID: 4399217, DOI: 10.1098/rstb.1971.0088.
- PERMEABILITY OF HEART MUSCLE TO CHOLINE.BOULPAEP E. PERMEABILITY OF HEART MUSCLE TO CHOLINE. Arch Int Physiol Biochim 1963, 71: 623-5. PMID: 14048773.
- [Transport of sodium-24 in the cardiac muscle].BOULPAEP E. [Transport of sodium-24 in the cardiac muscle]. Arch Int Physiol Biochim 1962, 70: 113-4. PMID: 13871831.
- [Effect of monoidoacetic acid on the duration of the action potential of the ventricular muscle of the frog].BOULPAEP E. [Effect of monoidoacetic acid on the duration of the action potential of the ventricular muscle of the frog]. Arch Int Pharmacodyn Ther 1959, 120: 502-4. PMID: 13803263.
- [Adaptation of the duration of cardiac action potential to changing of the frequency of excitants].CARMELIET E, BOULPAEP E. [Adaptation of the duration of cardiac action potential to changing of the frequency of excitants]. Arch Int Physiol Biochim 1958, 66: 87-8. PMID: 13509802.
- [Effect of 2,4-dinitrophenol on the duration of action potential of the ventricular muscle in frog].CARMELIET E, BOULPAEP E. [Effect of 2,4-dinitrophenol on the duration of action potential of the ventricular muscle in frog]. C R Seances Soc Biol Fil 1957, 151: 2226-8. PMID: 13585759.