Karim Ibrahim
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Research Summary
Karim Ibrahim is an Assistant Professor at the Yale Child Study Center. His translational neuroscience research focuses on brain networks associated with emotion regulation impairments in childhood-onset psychiatric disorders. Dr. Karim Ibrahim’s research is interdisciplinary and integrates multimodal imaging methods including functional and structural MRI, machine learning, and network neuroscience/connectomics approaches to identify biomarkers relevant to child psychopathology. His recent interests lie in using and developing tools predictive modeling/machine learning approaches that leverage large-scale neuroimaging datasets, including data from the Adolescent Brain Cognitive Development (ABCD) study, for identifying robust brain-based biomarkers. Among other things in this area, his research also investigates dynamics of the human functional connectome and large-scale networks, how brain connectivity is altered in mental health disorders (such as a disruptive behavior disorders, anxiety disorders, and autism spectrum disorder) and the neural response to treatment in youths. As a licensed clinical child psychologist, he also has extensive experience in developmental psychopathology, including assessments and cognitive-behavioral interventions for autism spectrum disorder, mood, anxiety, and disruptive behavior. Karim completed a postdoctoral fellowship at the Yale Child Study Center T32 research program in Translational Developmental Neuroscience and through an award from the Yale Center for Clinical Investigation multidisciplinary research training program.
Extensive Research Description
Multimodal Imaging Biomarkers of Cognitive Control Networks in Children with Disruptive Behavior (K23 MH128451). This study investigates the neural mechanisms of emotion regulation difficulties in youth with disruptive behavior. Disruptive behaviors include aggression, noncompliance, irritability, anger outburst, and/or easily frustrated. The study utilizes fMRI to identify brain networks involved in emotion regulation and that are implicated in childhood disruptive behaviors. Funded by the National Institute of Mental Health, this 5-year study will enroll 135 participants between the ages of 9 to 12 years with varying levels of disruptive behaviors. A subgroup of participants will also be enrolled with a diagnosis of autism spectrum disorder (ASD) with and without co-occurring behavioral difficulties. Study participants complete parent- and self-report measures of emotion and social functioning, diagnostic assessments of child psychopathology including autism, and fMRI. This study leverages fMRI to understand patterns of functional connectivity across brain networks involved in emotion regulation in youths with disruptive behavior.
Coauthors
Research Interests
Social Perception; Attention Deficit and Disruptive Behavior Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Functional Neuroimaging; Cognitive Neuroscience; Autism Spectrum Disorder; Machine Learning; Emotional Regulation
Public Health Interests
Biomarkers
Selected Publications
- Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysisIbrahim K, Iturmendi-Sabater I, Vasishth M, Barron D, Guardavaccaro M, Funaro M, Holmes A, McCarthy G, Eickhoff S, Sukhodolsky D. Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis. Schizophrenia Research 2024, 264: 298-313. PMID: 38215566, PMCID: PMC10922721, DOI: 10.1016/j.schres.2023.12.003.
- Aggression Is Associated With Social Adaptive Functioning in Children With ASD and AnxietyKalvin C, Jordan R, Rowley S, Weis A, Ibrahim K, Sukhodolsky D. Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety. Focus On Autism And Other Developmental Disabilities 2023, 38: 168-176. PMID: 38469453, PMCID: PMC10927274, DOI: 10.1177/10883576231165265.
- Disruption in Large-Scale Brain Networks is Linked to Maladaptive Childhood AggressionIbrahim K, McCarthy G, Scheinost D, Sukhodolsky D. Disruption in Large-Scale Brain Networks is Linked to Maladaptive Childhood Aggression. Biological Psychiatry 2022, 91: s87. DOI: 10.1016/j.biopsych.2022.02.233.
- Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairmentIbrahim K, Kalvin C, Morand-Beaulieu S, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment. Cerebral Cortex 2022, 32: 4371-4385. PMID: 35059702, PMCID: PMC9574236, DOI: 10.1093/cercor/bhab489.
- Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorderMorand-Beaulieu S, Smith SD, Ibrahim K, Wu J, Leckman JF, Crowley MJ, Sukhodolsky DG. Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder. Cortex 2021, 147: 157-168. PMID: 35042055, PMCID: PMC8816877, DOI: 10.1016/j.cortex.2021.12.006.
- Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behaviorSukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.
- Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modelingIbrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DG. Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. Molecular Psychiatry 2021, 27: 985-999. PMID: 34690348, PMCID: PMC9035467, DOI: 10.1038/s41380-021-01317-5.
- Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorderIbrahim K, Soorya LV, Halpern DB, Gorenstein M, Siper PM, Wang AT. Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder. Autism Research 2021, 14: 2495-2511. PMID: 34486810, DOI: 10.1002/aur.2603.
- Neural Mechanisms of Emotional DysregulationIbrahim K, McCarthy G, Sukhodolsky D. Neural Mechanisms of Emotional Dysregulation. 2021, 3115-3117. DOI: 10.1007/978-3-319-91280-6_102453.
- Anger Rumination in Children with Autism Spectrum DisorderIbrahim K, Jordan R, Rowley S, Sukhodolsky D. Anger Rumination in Children with Autism Spectrum Disorder. 2021, 205-209. DOI: 10.1007/978-3-319-91280-6_102452.
- RDoC and AutismIbrahim K, Sukhodolsky D. RDoC and Autism. 2021, 3840-3841. DOI: 10.1007/978-3-319-91280-6_102261.
- Conducting CBT for Anxiety in Children with Autism Spectrum Disorder During COVID-19 PandemicKalvin CB, Jordan RP, Rowley SN, Weis A, Wood KS, Wood JJ, Ibrahim K, Sukhodolsky DG. Conducting CBT for Anxiety in Children with Autism Spectrum Disorder During COVID-19 Pandemic. Journal Of Autism And Developmental Disorders 2021, 51: 4239-4247. PMID: 33385281, PMCID: PMC7775616, DOI: 10.1007/s10803-020-04845-1.
- Parent Emotion Socialization in Children with Autism Spectrum Disorder and Co-Occurring AnxietyJordan R, Kalvin CB, Ibrahim K, Sukhodolsky DG. Parent Emotion Socialization in Children with Autism Spectrum Disorder and Co-Occurring Anxiety. Research On Child And Adolescent Psychopathology 2020, 49: 125-137. PMID: 33442839, PMCID: PMC7809195, DOI: 10.1007/s10802-020-00731-7.
- Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behaviorIbrahim K, Kalvin C, Li F, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior. Developmental Cognitive Neuroscience 2020, 47: 100884. PMID: 33254067, PMCID: PMC7704291, DOI: 10.1016/j.dcn.2020.100884.
- Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity IndexKalvin CB, Gladstone TR, Jordan R, Rowley S, Marsh CL, Ibrahim K, Sukhodolsky DG. Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index. Journal Of Autism And Developmental Disorders 2020, 51: 1496-1507. PMID: 32734421, PMCID: PMC7855357, DOI: 10.1007/s10803-020-04627-9.
- 4516 Sex Differences in the Cortical Structure in Children with Irritability and Disruptive BehaviorIbrahim K, Li F, He G, Pelphrey K, McCarthy G, Sukhodolsky D. 4516 Sex Differences in the Cortical Structure in Children with Irritability and Disruptive Behavior. Journal Of Clinical And Translational Science 2020, 4: 144-145. PMCID: PMC8823378, DOI: 10.1017/cts.2020.426.
- Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive BehaviorGrazioplene R, Tseng WL, Cimino K, Kalvin C, Ibrahim K, Pelphrey KA, Sukhodolsky DG. Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 5: 490-498. PMID: 32144044, PMCID: PMC7214205, DOI: 10.1016/j.bpsc.2019.12.018.
- Neural Mechanisms of Emotional DysregulationIbrahim K, McCarthy G, Sukhodolsky D. Neural Mechanisms of Emotional Dysregulation. 2019, 1-4. DOI: 10.1007/978-1-4614-6435-8_102453-1.
- Anger Rumination in Children with Autism Spectrum DisorderIbrahim K, Jordan R, Rowley S, Sukhodolsky D. Anger Rumination in Children with Autism Spectrum Disorder. 2019, 1-5. DOI: 10.1007/978-1-4614-6435-8_102452-1.
- Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorderKalvin CB, Marsh CL, Ibrahim K, Gladstone TR, Woodward D, Grantz H, Ventola P, Sukhodolsky DG. Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder. Autism Research 2019, 13: 93-103. PMID: 31643143, PMCID: PMC7062240, DOI: 10.1002/aur.2220.
- 6.14 SEX DIFFERENCES IN THE ASSOCIATION BETWEEN DISRUPTIVE BEHAVIOR DISORDERS AND BRAIN STRUCTURE IN CHILDREN AND ADOLESCENTSIbrahim K, Kalvin C, Li F, He G, McCarthy G, Sukhodolsky D. 6.14 SEX DIFFERENCES IN THE ASSOCIATION BETWEEN DISRUPTIVE BEHAVIOR DISORDERS AND BRAIN STRUCTURE IN CHILDREN AND ADOLESCENTS. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: s275. DOI: 10.1016/j.jaac.2019.08.406.
- 1.24 ASSESSING IRRITABILITY IN CHILDREN WITH ASD USING THE AFFECTIVE REACTIVITY INDEXKalvin C, Ibrahim K, Marsh C, Sukhodolsky D. 1.24 ASSESSING IRRITABILITY IN CHILDREN WITH ASD USING THE AFFECTIVE REACTIVITY INDEX. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: s154. DOI: 10.1016/j.jaac.2019.08.046.
- Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum DisorderIbrahim K, Kalvin C, Marsh CL, Anzano A, Gorynova L, Cimino K, Sukhodolsky DG. Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3656-3668. PMID: 31144231, PMCID: PMC7035789, DOI: 10.1007/s10803-019-04085-y.
- Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive BehaviorIbrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 1031-1041. PMID: 30979647, PMCID: PMC7173634, DOI: 10.1016/j.bpsc.2019.01.009.
- 5.27 Discrepancies Between Parent Ratings and Child Self-Report of Anxiety and Irritability in Children With ASDMarsh C, Ibrahim K, Gladstone T, Sukhodolsky D. 5.27 Discrepancies Between Parent Ratings and Child Self-Report of Anxiety and Irritability in Children With ASD. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: s235. DOI: 10.1016/j.jaac.2018.09.320.
- RDoC and AutismIbrahim K, Sukhodolsky D. RDoC and Autism. 2018, 1-2. DOI: 10.1007/978-1-4614-6435-8_102261-1.
- Meta-analysis of organizational skills interventions for children and adolescents with Attention-Deficit/Hyperactivity DisorderBikic A, Reichow B, McCauley SA, Ibrahim K, Sukhodolsky DG. Meta-analysis of organizational skills interventions for children and adolescents with Attention-Deficit/Hyperactivity Disorder. Clinical Psychology Review 2016, 52: 108-123. PMID: 28088557, DOI: 10.1016/j.cpr.2016.12.004.
- Cognitive-Behavioral Therapy for a 9-Year-Old Girl With Disruptive Mood Dysregulation DisorderTudor ME, Ibrahim K, Bertschinger E, Piasecka J, Sukhodolsky DG. Cognitive-Behavioral Therapy for a 9-Year-Old Girl With Disruptive Mood Dysregulation Disorder. Clinical Case Studies 2016, 15: 459-475. PMID: 29081722, PMCID: PMC5658126, DOI: 10.1177/1534650116669431.
- Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-RewardSukhodolsky DG, Wyk B, Eilbott JA, McCauley SA, Ibrahim K, Crowley MJ, Pelphrey KA. Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 38-48. PMID: 26784537, PMCID: PMC4779273, DOI: 10.1089/cap.2015.0164.
- Behavioral Interventions for Anger, Irritability, and Aggression in Children and AdolescentsSukhodolsky DG, Smith SD, McCauley SA, Ibrahim K, Piasecka JB. Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 58-64. PMID: 26745682, PMCID: PMC4808268, DOI: 10.1089/cap.2015.0120.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Mental Health & Behavioral Research | Brain Imaging Study of Emotion Regulation in Children |
| Child Development & Autism; Children's Health; Mental Health & Behavioral Research | CBT for Anxiety in Children With Autism |