Brent Vander Wyk, PhD
Biostatistician; Core Co-Leader, Geriatrics Staff
Research & Publications
Biography
News
Coauthors
Selected Publications
- A Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries-Differences by Chronic Disease and Race/Ethnicity.Quiñones A, McAvay G, Vander Wyk B, Han L, Nagel C, Allore H. A Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries-Differences by Chronic Disease and Race/Ethnicity. Journal Of Aging And Health 2023, 8982643231210027. PMID: 37879084, DOI: 10.1177/08982643231210027.
- Corrigendum to ‘Maintenance on extended-release naltrexone is associated with reduced injection opioid use among justice-involved persons with opioid use disorder’ [J. Subst. Abuse Treat. vol. 142 (2022)/108852]Lier A, Seval N, Vander Wyk B, Di Paola A, Springer S. Corrigendum to ‘Maintenance on extended-release naltrexone is associated with reduced injection opioid use among justice-involved persons with opioid use disorder’ [J. Subst. Abuse Treat. vol. 142 (2022)/108852]. Journal Of Substance Use And Addiction Treatment 2023, 150: 209074. PMID: 37271717, DOI: 10.1016/j.josat.2023.209074.
- High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathwaysMendes H, Neelakantan U, Liu Y, Fitzpatrick S, Chen T, Wu W, Pruitt A, Jin D, Jamadagni P, Carlson M, Lacadie C, Enriquez K, Li N, Zhao D, Ijaz S, Sakai C, Szi C, Rooney B, Ghosh M, Nwabudike I, Gorodezky A, Chowdhury S, Zaheer M, McLaughlin S, Fernandez J, Wu J, Eilbott J, Wyk B, Rihel J, Papademetris X, Wang Z, Hoffman E. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports 2023, 42: 112243. PMID: 36933215, PMCID: PMC10277173, DOI: 10.1016/j.celrep.2023.112243.
- Featured CoverKonstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Featured Cover. Aging Cell 2023, 22 PMCID: PMC9924937, DOI: 10.1111/acel.13801.
- Population-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US AdultsGill TM, Wyk B, Leo-Summers L, Murphy TE, Becher RD. Population-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US Adults. JAMA Surgery 2022, 157: e225155. PMID: 36260323, PMCID: PMC9582971, DOI: 10.1001/jamasurg.2022.5155.
- Evaluation of the Impact of HIV Serostatus on the Hepatitis C Virus Care Cascade and Injection Drug Use Among Persons Initiating Medication Treatment for Opioid Use DisorderLier A, Wyk B, Di Paola A, Springer S. Evaluation of the Impact of HIV Serostatus on the Hepatitis C Virus Care Cascade and Injection Drug Use Among Persons Initiating Medication Treatment for Opioid Use Disorder. Open Forum Infectious Diseases 2022, 9: ofac624. PMID: 36467300, PMCID: PMC9709708, DOI: 10.1093/ofid/ofac624.
- Review and evaluation of imputation methods for multivariate longitudinal data with mixed‐type incomplete variablesCao Y, Allore H, Wyk B, Gutman R. Review and evaluation of imputation methods for multivariate longitudinal data with mixed‐type incomplete variables. Statistics In Medicine 2022, 41: 5844-5876. PMID: 36220138, PMCID: PMC9771917, DOI: 10.1002/sim.9592.
- Development and validation of a prediction model for persistent functional impairment among older ICU survivorsFerrante LE, Murphy TE, Leo‐Summers L, O'Leary JR, Wyk B, Pisani MA, Gill TM. Development and validation of a prediction model for persistent functional impairment among older ICU survivors. Journal Of The American Geriatrics Society 2022, 71: 188-197. PMID: 36196998, PMCID: PMC9870848, DOI: 10.1111/jgs.18075.
- The Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by RaceQuiñones AR, McAvay GJ, Peak KD, Wyk B, Allore HG. The Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by Race. American Journal Of Epidemiology 2022, 191: 2014-2025. PMID: 35932162, PMCID: PMC10144669, DOI: 10.1093/aje/kwac143.
- Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model dataMullin S, Wyk BV, Asher JL, Compton SR, Allore HG, Zeiss CJ. Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data. PNAS Nexus 2022, 1: pgac096. PMID: 35799833, PMCID: PMC9254158, DOI: 10.1093/pnasnexus/pgac096.
- Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐JMecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Wyk B, Arnsten AFT, Huang Y, Carson RE, van Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.
- Risk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving ReceivedCao Y, Allore H, Gutman R, Wyk B, Jørgensen TSH. Risk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received. Medical Care 2022, 60: 294-301. PMID: 35149662, PMCID: PMC8916995, DOI: 10.1097/mlr.0000000000001697.
- Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmissionZeiss CJ, Asher JL, Wyk B, Allore HG, Compton SR. Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission. PLOS ONE 2021, 16: e0260038. PMID: 34813610, PMCID: PMC8610237, DOI: 10.1371/journal.pone.0260038.
- The Incidence and Cumulative Risk of Major Surgery in Older Persons in the United StatesBecher RD, Vander Wyk B, Leo-Summers L, Desai MM, Gill TM. The Incidence and Cumulative Risk of Major Surgery in Older Persons in the United States. Annals Of Surgery 2021, 277: 87-92. PMID: 34261884, PMCID: PMC8758792, DOI: 10.1097/sla.0000000000005077.
- Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling studyChen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study. Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.
- Functional Magnetic Resonance ImagingOosting D, Vander Wyk B. Functional Magnetic Resonance Imaging. 2021, 2133-2139. DOI: 10.1007/978-3-319-91280-6_102101.
- Design and implementation of a prospective cohort study of persons living with and without HIV infection who are initiating medication treatment for opioid use disorderBiondi BE, Mohanty S, Wyk BV, Montgomery RR, Shaw AC, Springer SA. Design and implementation of a prospective cohort study of persons living with and without HIV infection who are initiating medication treatment for opioid use disorder. Contemporary Clinical Trials Communications 2021, 21: 100704. PMID: 33490708, PMCID: PMC7807244, DOI: 10.1016/j.conctc.2021.100704.
- Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and MortalityMcAvay GJ, Wyk B, Allore H. Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality. The Journals Of Gerontology Series A 2020, 76: 1668-1677. PMID: 33320184, PMCID: PMC8361334, DOI: 10.1093/gerona/glaa314.
- Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signaturesZhao Y, Amodio M, Wyk B, Gerritsen B, Kumar MM, van Dijk D, Moon K, Wang X, Malawista A, Richards MM, Cahill ME, Desai A, Sivadasan J, Venkataswamy MM, Ravi V, Fikrig E, Kumar P, Kleinstein SH, Krishnaswamy S, Montgomery RR. Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures. PLOS Neglected Tropical Diseases 2020, 14: e0008112. PMID: 32150565, PMCID: PMC7082063, DOI: 10.1371/journal.pntd.0008112.
- Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged MiceMach J, Gemikonakli G, Logan C, Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice. The Journals Of Gerontology Series A 2020, 76: 1010-1018. PMID: 32147704, PMCID: PMC8140051, DOI: 10.1093/gerona/glaa060.
- Menagerie: A text-mining tool to support animal-human translation in neurodegeneration researchZeiss CJ, Shin D, Wyk B, Beck AP, Zatz N, Sneiderman CA, Kilicoglu H. Menagerie: A text-mining tool to support animal-human translation in neurodegeneration research. PLOS ONE 2019, 14: e0226176. PMID: 31846471, PMCID: PMC6917268, DOI: 10.1371/journal.pone.0226176.
- Chronic Conditions, Medically Supportive Care Partners, And Functional Disability Among Cognitively Impaired AdultsVan Ness PH, Vroomen J, Leo-Summers L, Wyk B, Allore HG. Chronic Conditions, Medically Supportive Care Partners, And Functional Disability Among Cognitively Impaired Adults. Innovation In Aging 2019, 3: igz018. PMID: 31286072, PMCID: PMC6604743, DOI: 10.1093/geroni/igz018.
- Predictors of Functional Decline Among Older Intensive Care Unit (ICU) SurvivorsFerrante L, Murphy T, Vander Wyk B, Leo-Summers L, Pisani M, Gill T. Predictors of Functional Decline Among Older Intensive Care Unit (ICU) Survivors. 2019, a5674-a5674. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5674.
- Sociodemographic Factors and Characteristics of Caregivers as Determinants of Skilled Nursing Facility Admissions When Modeled Jointly With Functional LimitationsJørgensen TSH, Allore H, MacNeil Vroomen JL, Wyk BV, Agogo GO. Sociodemographic Factors and Characteristics of Caregivers as Determinants of Skilled Nursing Facility Admissions When Modeled Jointly With Functional Limitations. Journal Of The American Medical Directors Association 2019, 20: 1599-1604.e4. PMID: 30902676, PMCID: PMC7444598, DOI: 10.1016/j.jamda.2019.01.154.
- Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-RewardSukhodolsky DG, Wyk B, Eilbott JA, McCauley SA, Ibrahim K, Crowley MJ, Pelphrey KA. Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 38-48. PMID: 26784537, PMCID: PMC4779273, DOI: 10.1089/cap.2015.0164.
- Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite genderBolling DZ, Pelphrey KA, Wyk B. Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender. Social Neuroscience 2015, 11: 475-486. PMID: 26592311, PMCID: PMC4976300, DOI: 10.1080/17470919.2015.1117019.
- Functional Magnetic Resonance ImagingOosting D, Vander Wyk B. Functional Magnetic Resonance Imaging. 2015, 1-7. DOI: 10.1007/978-1-4614-6435-8_102101-1.
- Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disordersBolling DZ, Pelphrey KA, Wyk B. Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders. Developmental Cognitive Neuroscience 2015, 13: 75-83. PMID: 26011751, PMCID: PMC4470300, DOI: 10.1016/j.dcn.2015.04.007.
- Altered brain connectivity in sagittal craniosynostosis.Beckett JS, Brooks ED, Lacadie C, Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA. Altered brain connectivity in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2014, 13: 690-8. PMID: 24745341, DOI: 10.3171/2014.3.peds13516.
- Oxytocin enhances brain function in children with autismGordon I, Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.
- Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responsesGordon I, Eilbott JA, Feldman R, Pelphrey KA, Wyk B. Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses. Social Neuroscience 2013, 8: 544-554. PMID: 24044427, DOI: 10.1080/17470919.2013.832374.
- Equivalent neural responses in children and adolescents with and without autism during judgments of affectWyk B, Hoffman F, Pelphrey KA. Equivalent neural responses in children and adolescents with and without autism during judgments of affect. Developmental Cognitive Neuroscience 2013, 8: 121-130. PMID: 24016745, PMCID: PMC3931746, DOI: 10.1016/j.dcn.2013.08.001.
- Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findingsZebardast N, Crowley MJ, Bloch MH, Mayes LC, Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.
- Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case StudiesVoos AC, Pelphrey KA, Tirrell J, Bolling DZ, Wyk B, Kaiser MD, McPartland JC, Volkmar FR, Ventola P. Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies. Journal Of Autism And Developmental Disorders 2012, 43: 1-10. PMID: 23104615, PMCID: PMC4999079, DOI: 10.1007/s10803-012-1683-9.
- Action representation in the superior temporal sulcus in children and adults: An fMRI studyWyk B, Voos A, Pelphrey KA. Action representation in the superior temporal sulcus in children and adults: An fMRI study. Developmental Cognitive Neuroscience 2012, 2: 409-416. PMID: 22727762, PMCID: PMC3431200, DOI: 10.1016/j.dcn.2012.04.004.
- Differential brain responses to social exclusion by one's own versus opposite-gender peersBolling DZ, Pelphrey KA, Wyk B. Differential brain responses to social exclusion by one's own versus opposite-gender peers. Social Neuroscience 2011, 7: 331-346. PMID: 21981758, PMCID: PMC4520218, DOI: 10.1080/17470919.2011.623181.
- Enhanced neural responses to rule violation in children with autism: A comparison to social exclusionBolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Kaiser MD, Wyk BC, Wu J, Mayes LC, Pelphrey KA. Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion. Developmental Cognitive Neuroscience 2011, 1: 280-294. PMID: 21743819, PMCID: PMC3129780, DOI: 10.1016/j.dcn.2011.02.002.
- Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorderPelphrey KA, Shultz S, Hudac CM, Wyk B. Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder. Journal Of Child Psychology And Psychiatry 2011, 52: 631-644. PMID: 21244421, PMCID: PMC3096715, DOI: 10.1111/j.1469-7610.2010.02349.x.
- Neural signatures of autismKaiser MD, Hudac CM, Shultz S, Lee SM, Cheung C, Berken AM, Deen B, Pitskel NB, Sugrue DR, Voos AC, Saulnier CA, Ventola P, Wolf JM, Klin A, Wyk B, Pelphrey KA. Neural signatures of autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 21223-21228. PMID: 21078973, PMCID: PMC3000300, DOI: 10.1073/pnas.1010412107.
- Cortical integration of audio–visual speech and non-speech stimuliWyk B, Ramsay GJ, Hudac CM, Jones W, Lin D, Klin A, Lee SM, Pelphrey KA. Cortical integration of audio–visual speech and non-speech stimuli. Brain And Cognition 2010, 74: 97-106. PMID: 20709442, PMCID: PMC3869029, DOI: 10.1016/j.bandc.2010.07.002.
- Brain mechanisms for representing what another person seesHeyda RD, Green SR, Wyk B, Morris JP, Pelphrey KA. Brain mechanisms for representing what another person sees. NeuroImage 2010, 50: 693-700. PMID: 20056152, PMCID: PMC2824003, DOI: 10.1016/j.neuroimage.2009.12.101.
- Individual Differences in Personality Predict How People Look at FacesPerlman SB, Morris JP, Wyk B, Green SR, Doyle JL, Pelphrey KA. Individual Differences in Personality Predict How People Look at Faces. PLOS ONE 2009, 4: e5952. PMID: 19543398, PMCID: PMC2695783, DOI: 10.1371/journal.pone.0005952.
Clinical Trials
Conditions | Study Title |
---|---|
Diseases of the Cardiovascular System; Mental Health & Behavioral Research | An Intervention to Reduce Readmission Rates in Young Women with Acute Myocardial Infarction (AMI) |
Child Development & Autism; Children's Health; Mental Health & Behavioral Research | Anger Control Training for Youth With Tourette Syndrome |
Immune System; Men's Health; Women's Health | Effects of circadian regulation and sleep on immune responses |
Child Development & Autism; Children's Health; Mental Health & Behavioral Research | CBT for Anxiety in Children With Autism |