D. S. Fahmeed Hyder, PhD
Research & Publications
Biography
News
Research Summary
Speciailzed Terms: Brain energy metabolism; Neurovascular and neurometabolic coupling; BOLD technology; BIRDS technology; Calibrated fMRI technology; SAR technology; Cancer imaging and therapy technology; Molecular probes and nanocarriers
Extensive Research Description
Specific areas of interest in functional imaging include (i) understanding the role of the extraordinarily high energy demands of ongoing and intrinsic activity within neural populations as potential for quantitative disease biomarker, (ii) advancing the spatiotemporal resolution of functional imaging to understand the relation of cellular metabolism in health and disease (e.g., healthy aging, Alzheimer’s disease, depression, epilepsy, schizophrenia), and (iii) developing advanced calibrated fMRI methods for using oxidative energy as an absolute index of neural activity, both with task and rest paradigms, across cortical and subcortical regions.
For molecular imaging we use a method called BIRDS, which we developed and quite unconventionally detects the paramagnetically-shifted and non-exchangeable protons from lanthanide (or transition) metal ion probes for high spatiotemporal resolution biosensing. Highly precise molecular imaging of temperature and pH is achievable with BIRDS. Current areas of relevance are (i) design of new molecular probes for BIRDS, (ii) early cancer detection and metastasis using absolute pH imaging, (iii) application of new probes for BIRDS as molecular targets for diseases (e.g., diabetes), and (iv) detection of tumor response to treatments (e.g., radiation, chemotherapy, heat).
Calibrated fMRI for basal metabolism – simulation studies to assess sensitivities required for fMRI and perfusion data to extract basal metabolism from calibrated fMRI data
Quantitative metabolic PET – analysis of whole brain PET data of glucose and oxidative metabolism in the human brain in relation to blood flow
Liposomal BIRDS – development and/or characterization of newly developed probes encapsulated inside liposomes for BIRDS
Dendrimeric BIRDS – development and/or characterization of newly developed macromolecular-based probes for BIRDS
Coauthors
Research Interests
Biomedical Engineering; Magnetic Resonance Imaging; Neoplasms by Histologic Type; Neurosciences; Radiology; Molecular Probes
Research Images
Selected Publications
- A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic strokeLyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, Kim S, Cabeen R, Koenig J, Akhter K, Arbab A, Avery B, Beatty H, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman A, Hyder F, Imai T, Johnson C, Khan M, Kamat P, Karuppagounder S, Kumskova M, Mihailovic J, Mandeville J, Morais A, Patel R, Sanganahalli B, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez S, Aronowski J, Ayata C, Chauhan A, Leira E, Hess D, Koehler R, McCullough L, Sansing L. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Science Translational Medicine 2023, 15: eadg8656. PMID: 37729432, DOI: 10.1126/scitranslmed.adg8656.
- Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulbJames S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.
- Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2DiNuzzo M, Dienel G, Behar K, Petroff O, Benveniste H, Hyder F, Giove F, Michaeli S, Mangia S, Herculano‐Houzel S, Rothman D. Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2. Journal Of Neurochemistry 2023 PMID: 37150946, PMCID: PMC10628336, DOI: 10.1111/jnc.15839.
- 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the CortexDriesen N, Herman P, Rowland M, Thompson G, Qiu M, He G, Criscuolo E, Fineberg S, Barron D, Helgeson L, Lacadie C, Chow R, Gueorguieva R, Straun T, Krystal J, Hyder F. 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex. Biological Psychiatry 2023, 93: s268-s269. DOI: 10.1016/j.biopsych.2023.02.670.
- Computational Image-Based Stroke Assessment for Evaluation of Cerebroprotectants with Longitudinal and Multi-Site Preclinical MRICabeen R, Mandeville J, Hyder F, Sanganahalli B, Thedens D, Arbab A, Huang S, Bibic A, Tarakci E, Mihailovic J, Morais A, Lamb J, Nagarkatti K, Toga A, Lyden P, Ayata C. Computational Image-Based Stroke Assessment for Evaluation of Cerebroprotectants with Longitudinal and Multi-Site Preclinical MRI. 2023, 00: 1-5. DOI: 10.1109/isbi53787.2023.10230408.
- Author Correction: A consensus protocol for functional connectivity analysis in the rat brainGrandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière D, Blockx I, Bortel A, Broadwater M, Cardoso B, Célestine M, Chavez-Negrete J, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes F, Fowler C, Fuentes-Ibañez A, Garin C, Gelderman E, Golden C, Guo C, Henckens M, Hennessy L, Herman P, Hofwijks N, Horien C, Ionescu T, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee S, Lillywhite A, Liu Y, Liu Y, López -Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan M, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens D, Nava-Gomez L, Nonaka H, Ortiz J, Paasonen J, Peeters L, Pereira M, Perez P, Pompilus M, Prior M, Rakhmatullin R, Reimann H, Reinwald J, Del Rio R, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten T, Ryoke R, Sack M, Salvan P, Sanganahalli B, Schroeter A, Seewoo B, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith J, Smith C, Sobczak F, Stenroos P, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García M, Tudela R, van den Berg M, van der Marel K, van Hout A, Vertullo R, Vidal B, Vrooman R, Wang V, Wank I, Watson D, Yin T, Zhang Y, Zurbruegg S, Achard S, Alcauter S, Auer D, Barbier E, Baudewig J, Beckmann C, Beckmann N, Becq G, Blezer E, Bolbos R, Boretius S, Bouvard S, Budinger E, Buxbaum J, Cash D, Chapman V, Chuang K, Ciobanu L, Coolen B, Dalley J, Dhenain M, Dijkhuizen R, Esteban O, Faber C, Febo M, Feindel K, Forloni G, Fouquet J, Garza-Villarreal E, Gass N, Glennon J, Gozzi A, Gröhn O, Harkin A, Heerschap A, Helluy X, Herfert K, Heuser A, Homberg J, Houwing D, Hyder F, Ielacqua G, Jelescu I, Johansen-Berg H, Kaneko G, Kawashima R, Keilholz S, Keliris G, Kelly C, Kerskens C, Khokhar J, Kind P, Langlois J, Lerch J, López-Hidalgo M, Manahan-Vaughan D, Marchand F, Mars R, Marsella G, Micotti E, Muñoz-Moreno E, Near J, Niendorf T, Otte W, Pais-Roldán P, Pan W, Prado-Alcalá R, Quirarte G, Rodger J, Rosenow T, Sampaio-Baptista C, Sartorius A, Sawiak S, Scheenen T, Shemesh N, Shih Y, Shmuel A, Soria G, Stoop R, Thompson G, Till S, Todd N, Van Der Linden A, van der Toorn A, van Tilborg G, Vanhove C, Veltien A, Verhoye M, Wachsmuth L, Weber-Fahr W, Wenk P, Yu X, Zerbi V, Zhang N, Zhang B, Zimmer L, Devenyi G, Chakravarty M, Hess A. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience 2023, 26: 1127-1128. PMID: 37072562, DOI: 10.1038/s41593-023-01328-1.
- A consensus protocol for functional connectivity analysis in the rat brainGrandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière D, Blockx I, Bortel A, Broadwater M, Cardoso B, Célestine M, Chavez-Negrete J, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes F, Fowler C, Fuentes-Ibañez A, Garin C, Gelderman E, Golden C, Guo C, Henckens M, Hennessy L, Herman P, Hofwijks N, Horien C, Ionescu T, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee S, Lillywhite A, Liu Y, Liu Y, López -Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan M, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens D, Nava-Gomez L, Nonaka H, Ortiz J, Paasonen J, Peeters L, Pereira M, Perez P, Pompilus M, Prior M, Rakhmatullin R, Reimann H, Reinwald J, Del Rio R, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten T, Ryoke R, Sack M, Salvan P, Sanganahalli B, Schroeter A, Seewoo B, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith J, Smith C, Sobczak F, Stenroos P, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García M, Tudela R, van den Berg M, van der Marel K, van Hout A, Vertullo R, Vidal B, Vrooman R, Wang V, Wank I, Watson D, Yin T, Zhang Y, Zurbruegg S, Achard S, Alcauter S, Auer D, Barbier E, Baudewig J, Beckmann C, Beckmann N, Becq G, Blezer E, Bolbos R, Boretius S, Bouvard S, Budinger E, Buxbaum J, Cash D, Chapman V, Chuang K, Ciobanu L, Coolen B, Dalley J, Dhenain M, Dijkhuizen R, Esteban O, Faber C, Febo M, Feindel K, Forloni G, Fouquet J, Garza-Villarreal E, Gass N, Glennon J, Gozzi A, Gröhn O, Harkin A, Heerschap A, Helluy X, Herfert K, Heuser A, Homberg J, Houwing D, Hyder F, Ielacqua G, Jelescu I, Johansen-Berg H, Kaneko G, Kawashima R, Keilholz S, Keliris G, Kelly C, Kerskens C, Khokhar J, Kind P, Langlois J, Lerch J, López-Hidalgo M, Manahan-Vaughan D, Marchand F, Mars R, Marsella G, Micotti E, Muñoz-Moreno E, Near J, Niendorf T, Otte W, Pais-Roldán P, Pan W, Prado-Alcalá R, Quirarte G, Rodger J, Rosenow T, Sampaio-Baptista C, Sartorius A, Sawiak S, Scheenen T, Shemesh N, Shih Y, Shmuel A, Soria G, Stoop R, Thompson G, Till S, Todd N, Van Der Linden A, van der Toorn A, van Tilborg G, Vanhove C, Veltien A, Verhoye M, Wachsmuth L, Weber-Fahr W, Wenk P, Yu X, Zerbi V, Zhang N, Zhang B, Zimmer L, Devenyi G, Chakravarty M, Hess A. A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience 2023, 26: 673-681. PMID: 36973511, PMCID: PMC10493189, DOI: 10.1038/s41593-023-01286-8.
- Abstract WMP110: Vascular Endothelial Growth Factor C Confers Neuroprotection And Ameliorates Ischemic Stroke OutcomesSimoes Braga Boisserand L, Lee S, Bouchart J, Medeiros Geraldo L, Sanganahalli B, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. Abstract WMP110: Vascular Endothelial Growth Factor C Confers Neuroprotection And Ameliorates Ischemic Stroke Outcomes. Stroke 2023, 54: awmp110-awmp110. DOI: 10.1161/str.54.suppl_1.wmp110.
- Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functionsde Arce K, Ribic A, Chowdhury D, Watters K, Thompson G, Sanganahalli B, Lippard E, Rohlmann A, Strittmatter S, Missler M, Hyder F, Biederer T. Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions. Nature Communications 2023, 14: 459. PMID: 36709330, PMCID: PMC9884278, DOI: 10.1038/s41467-023-36042-w.
- Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizuresMcCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.
- Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adultsReitlo L, Mihailovic J, Stensvold D, Wisløff U, Hyder F, Håberg A. Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults. GeroScience 2023, 45: 1667-1685. PMID: 36626020, PMCID: PMC10400748, DOI: 10.1007/s11357-022-00719-9.
- Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) TrialMorais A, Locascio J, Sansing L, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig J, Bosetti F, Lyden P, Ayata C, Bosetti F, Koenig J, Lyden P, Lamb J, Nagarkatti K, Hess D, Kamat P, Khan M, Dhandapani K, Arbab A, Siddiqui S, Smith C, Nisar M, Leira E, Chauhan A, Dhanesha N, Patel R, Kumskova M, Thedens D, Wang K, Ayata C, Morais A, Imai T, Qin T, Jin X, Erdogan T, Yu L, Mandeville J, Kimberly W, Whittier J, Lo E, Arai K, Van Leyen K, Sansing L, Hyder F, Mihailovic J, Sanganahalli B, Diaz-Perez S, Velazquez S, Beatty H, Johnson C, Herman A, Boisserand L, Immakavar E, Koehler R, Dawson T, Dawson V, Shi Y, Avery B, Lannon S, Bibic A, Akhter K, Karuppagounder S, Aronowski J, McCullough L, Obertas L, Goh A, Huang S, Chauhan A. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke 2023, 54: 620-631. PMID: 36601951, PMCID: PMC9870939, DOI: 10.1161/strokeaha.122.040638.
- Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiographyMishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.
- White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiologyJindachomthong K, Yang C, Huang Y, Coman D, Rapanelli M, Hyder F, Dougherty J, Frick L, Pittenger C. White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology. Frontiers In Molecular Neuroscience 2022, 15: 1037481. PMID: 36504678, PMCID: PMC9731796, DOI: 10.3389/fnmol.2022.1037481.
- MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the LiverSantana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, DOI: 10.1016/j.jvir.2022.11.013.
- Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell typeO’Connor D, Mandino F, Shen X, Horien C, Ge X, Herman P, Hyder F, Crair M, Papademetris X, Lake E, Constable. Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type. NeuroImage 2022, 264: 119735. PMID: 36347441, PMCID: PMC9808917, DOI: 10.1016/j.neuroimage.2022.119735.
- Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord InjurySanganahalli B, Pavuluri S, Chitturi J, Herman P, Elkabes S, Heary R, Hyder F, Kannurpatti S. Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord Injury. Neurotrauma Reports 2022, 3: 421-432. PMID: 36337081, PMCID: PMC9622206, DOI: 10.1089/neur.2022.0040.
- A 3D atlas of functional human brain energetic connectome based on neuropil distributionYu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.
- Comparative Study of Specific Loss Power and Transverse Relaxivity of Spinel Ferrite Nanoensembles Coated With Chitosan and Polyethylene GlycolHoque S, Islam M, Hoq A, Haque M, Maritim S, Coman D, Hyder F. Comparative Study of Specific Loss Power and Transverse Relaxivity of Spinel Ferrite Nanoensembles Coated With Chitosan and Polyethylene Glycol. Frontiers In Nanotechnology 2021, 3: 644080. DOI: 10.3389/fnano.2021.644080.
- Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter CyclesRothman D, De Feyter H, Mason G, de Graaf R, Hyder F, Behar K. Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles. 2021, 688-700. DOI: 10.1016/b978-0-12-819460-7.00341-8.
- Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRIKaczmarz S, Göttler J, Petr J, Hansen M, Mouridsen K, Zimmer C, Hyder F, Preibisch C. Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 380-396. PMID: 32237952, PMCID: PMC7812517, DOI: 10.1177/0271678x20912364.
- PreImplantation Factor promotes Oligodentrocyte differentiation by modulating NCOR2 and long non-coding RNA H19 of the Oligodendrocyte Progenitor CellsSpinelli M, Boucard C, Ornaghi S, Schoeberlein A, Keller I, Coman D, Hyder F, Zhang L, Haesler V, Bordey A, Barnea E, Paidas M, Surbek D, Mueller M. PreImplantation Factor promotes Oligodentrocyte differentiation by modulating NCOR2 and long non-coding RNA H19 of the Oligodendrocyte Progenitor Cells. Zeitschrift Für Geburtshilfe Und Neonatologie 2019, 223: e18-e18. DOI: 10.1055/s-0039-3401110.
- Mechanisms of Heterogeneous Targeted Therapy Response in Brain MetastasisAdua S, Zhao M, Parent M, Hyder F, Nguyen D. Mechanisms of Heterogeneous Targeted Therapy Response in Brain Metastasis. Journal Of Thoracic Oncology 2017, 12: s1547. DOI: 10.1016/j.jtho.2017.06.065.
- Metabolic demands of neural-hemodynamic associated and disassociated areas in brainSanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F. Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. Cerebrovascular And Brain Metabolism Reviews 2016, 36: 1695-1707. PMID: 27562867, PMCID: PMC5076793, DOI: 10.1177/0271678x16664531.
- Towards longitudinal mapping of extracellular pH in gliomasHuang Y, Coman D, Herman P, Rao JU, Maritim S, Hyder F. Towards longitudinal mapping of extracellular pH in gliomas. NMR In Biomedicine 2016, 29: 1364-1372. PMID: 27472471, PMCID: PMC5035200, DOI: 10.1002/nbm.3578.
- Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRIShu CY, Sanganahalli BG, Coman D, Herman P, Hyder F. Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI. 2016, 225: 99-122. PMID: 27130413, DOI: 10.1016/bs.pbr.2016.02.003.
- Imaging the intratumoral–peritumoral extracellular pH gradient of gliomasComan D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.
- Quantitative β mapping for calibrated fMRIShu CY, Sanganahalli BG, Coman D, Herman P, Rothman DL, Hyder F. Quantitative β mapping for calibrated fMRI. NeuroImage 2015, 126: 219-228. PMID: 26619788, PMCID: PMC4733593, DOI: 10.1016/j.neuroimage.2015.11.042.
- ATPS-14KETOGENIC DIET-INDUCED INCREASE IN MCT1 FACILITATES KETONE BODY OXIDATION IN RAT GLIOMASDe Feyter H, Behar K, Ip K, Hyder F, Drewes L, de Graaf R, Rothman D. ATPS-14KETOGENIC DIET-INDUCED INCREASE IN MCT1 FACILITATES KETONE BODY OXIDATION IN RAT GLIOMAS. Neuro-Oncology 2015, 17: v21-v21. PMCID: PMC4638437, DOI: 10.1093/neuonc/nov204.14.
- Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)Huang Y, Coman D, Hyder F, Ali MM. Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS). Bioconjugate Chemistry 2015, 26: 2315-2323. PMID: 26497087, PMCID: PMC4784965, DOI: 10.1021/acs.bioconjchem.5b00568.
- Decreased Subcortical Cholinergic Arousal in Focal SeizuresMotelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased Subcortical Cholinergic Arousal in Focal Seizures. Neuron 2015, 85: 561-572. PMID: 25654258, PMCID: PMC4319118, DOI: 10.1016/j.neuron.2014.12.058.
- Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS)Maritim S, Huang Y, Coman D, Hyder F. Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). JBIC Journal Of Biological Inorganic Chemistry 2014, 19: 1385-1398. PMID: 25304046, PMCID: PMC4348029, DOI: 10.1007/s00775-014-1200-z.
- Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of BehaviorShulman RG, Hyder F, Rothman DL. Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1721-1735. PMID: 25160670, PMCID: PMC4269754, DOI: 10.1038/jcbfm.2014.145.
- Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal ActivityLin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1440-1443. PMID: 24984898, PMCID: PMC4158670, DOI: 10.1038/jcbfm.2014.114.
- Physiological Basis of BOLD fMRI DecreasesKim R, Hyder F, Blumenfeld H. Physiological Basis of BOLD fMRI Decreases. 2014, 88: 221-236. DOI: 10.1007/978-1-4939-0724-3_11.
- Water-Soluble Anisotropic Iron Oxide Nanoparticles: Dextran-Coated Crystalline Nanoplates and NanoflowersPalchoudhury S, Hyder F, Vanderlick T, Geerts N. Water-Soluble Anisotropic Iron Oxide Nanoparticles: Dextran-Coated Crystalline Nanoplates and Nanoflowers. Particulate Science And Technology 2014, 32: 224-233. DOI: 10.1080/02726351.2013.850460.
- Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative EnergyHyder F, Fulbright R, Shulman R, Rothman D. Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 368-368. PMCID: PMC3915214, DOI: 10.1038/jcbfm.2013.205.
- Intranasal epidermal growth factor treatment rescues neonatal brain injuryScafidi J, Hammond TR, Scafidi S, Ritter J, Jablonska B, Roncal M, Szigeti-Buck K, Coman D, Huang Y, McCarter RJ, Hyder F, Horvath TL, Gallo V. Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature 2013, 506: 230-234. PMID: 24390343, PMCID: PMC4106485, DOI: 10.1038/nature12880.
- Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRIHerman P, Sanganahalli BG, Blumenfeld H, Rothman DL, Hyder F. Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15115-15120. PMID: 23980158, PMCID: PMC3773779, DOI: 10.1073/pnas.1307154110.
- Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence modelvan Luijtelaar G, Mishra AM, Edelbroek P, Coman D, Frankenmolen N, Schaapsmeerders P, Covolato G, Danielson N, Niermann H, Janeczko K, Kiemeneij A, Burinov J, Bashyal C, Coquillette M, Lüttjohann A, Hyder F, Blumenfeld H, van Rijn CM. Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. Neurobiology Of Disease 2013, 60: 126-138. PMID: 23978468, PMCID: PMC3952020, DOI: 10.1016/j.nbd.2013.08.013.
- In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolutionComan D, de Graaf R, Rothman DL, Hyder F. In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR In Biomedicine 2013, 26: 1589-1595. PMID: 23881869, PMCID: PMC3800475, DOI: 10.1002/nbm.2995.
- Increased resting functional connectivity in spike‐wave epilepsy in WAG/Rij ratsMishra AM, Bai X, Motelow JE, DeSalvo MN, Danielson N, Sanganahalli BG, Hyder F, Blumenfeld H. Increased resting functional connectivity in spike‐wave epilepsy in WAG/Rij rats. Epilepsia 2013, 54: 1214-1222. PMID: 23815571, PMCID: PMC3703864, DOI: 10.1111/epi.12227.
- Functional MRI and neural responses in a rat model of Alzheimer's diseaseSanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage 2013, 79: 404-411. PMID: 23648961, PMCID: PMC3700380, DOI: 10.1016/j.neuroimage.2013.04.099.
- CMR02 Mapping by Calibrated fMRIHyder F, Shu C, Herman P, Sanganahalli B, Coman D, Rothman D. CMR02 Mapping by Calibrated fMRI. 2013, 20130539: 85-109. DOI: 10.1201/b14814-5.
- Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRISanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI. PLOS ONE 2013, 8: e63317. PMID: 23650561, PMCID: PMC3641133, DOI: 10.1371/journal.pone.0063317.
- Mitochondrial Calcium Uptake Capacity Modulates Neocortical ExcitabilitySanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 1115-1126. PMID: 23591650, PMCID: PMC3705442, DOI: 10.1038/jcbfm.2013.61.
- Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemiaHerzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.
- Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levelsHyder F, Rothman DL, Bennett MR. Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3549-3554. PMID: 23319606, PMCID: PMC3587194, DOI: 10.1073/pnas.1214912110.
- Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative EnergyHyder F, Fulbright RK, Shulman RG, Rothman DL. Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 339-347. PMID: 23299240, PMCID: PMC3587823, DOI: 10.1038/jcbfm.2012.207.
- Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular ZoneLacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone. Journal Of Neuroscience 2012, 32: 16435-16448. PMID: 23152626, PMCID: PMC3520061, DOI: 10.1523/jneurosci.1457-12.2012.
- Quantitative fMRI and oxidative neuroenergeticsHyder F, Rothman DL. Quantitative fMRI and oxidative neuroenergetics. NeuroImage 2012, 62: 985-994. PMID: 22542993, PMCID: PMC3389300, DOI: 10.1016/j.neuroimage.2012.04.027.
- Abstract 4296: Ultrasmall gadolinium-loaded polymer nanoparticles for imaging in glioblastomaHimes B, Zhou J, Patel T, Coman D, Hyder F, Saltzman M. Abstract 4296: Ultrasmall gadolinium-loaded polymer nanoparticles for imaging in glioblastoma. Cancer Research 2012, 72: 4296-4296. DOI: 10.1158/1538-7445.am2012-4296.
- S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular ZoneLacar B, Herman P, Hartman NW, Hyder F, Bordey A. S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone. PLOS ONE 2012, 7: e31960. PMID: 22359646, PMCID: PMC3281100, DOI: 10.1371/journal.pone.0031960.
- Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual SystemBailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F. Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System. Cerebral Cortex 2012, 23: 210-222. PMID: 22298731, PMCID: PMC3513959, DOI: 10.1093/cercor/bhs008.
- Mouse Health Span: Why Lifespan is No Longer EnoughSierra F, Buffenstein R, Austad S, Richardson A, Halloran J, Lin A, Zheng W, Burbank R, Hussong S, Podlutskaya N, Hart M, Javors M, Strong R, Richardson A, Lechleiter J, Fox P, Galvan V, Lin A, Coman D, Rothman D, Hyder F, Korde S, Galvan V, Jaffe D, Rentería R, Vasalauskaite A, Akimov N, Rendón S, Fischer K, Austad S, Styskal J, Salmon A, Musi N, Richardson A, Kruse S, Siegel M, Szeto H, Marcinek D, Dube S, Flores L, Salmon A, Ortiz M, Roman M, Musi N, Qi W, Lee S, Hubbard G, Van Remmen H, Bhattacharya A, Liu Y, Kirkland J, Pirtskhalava T, Tchkonia T, Richardson A, Ikeno Y, Salmon A, Styskal J, Richardson A, Hill C, Arum O, Wang F, Boparai R, Fang Y, Spong A, Westbrook R, Masternak M, Bartke A, Sathyaseelan D, Walsh M, Hamilton R, Pulliam D, Shi Y, Van Remmen H, Hill S, Pulliam D, Sathyaseelan D, Liu Y, Van Remmen H, Seldeen K, Pang M, Rodríguez-Gonzalez M, Hernandez M, Yu P, Troen B, Bai X, Wey M, Martinez A, Martinez V, Fernandez E, Strong R, Martinez P, Bai X, Wey M, Martinez V, Strong R, Fernandez E, Evans T, Jaramillo C, Van Remmen H, Rahman M, Rios C, Shi Y, Bhattacharya A, Sabia M, Jernigan A, Mohiuddin R, Van Remmen H, Hamilton R, Walsh M, Shi Y, Bhattacharya A, Chaudhuri A, Van Remmen H, Shultz K, Godfrey D, Ackert-Bicknell C, Curtis J, Nguyen C, Wersto R, Jang Y, Wagers A, Mattison J, Ferrucci L, de Cabo R, Victor D, Sharma R, Vanegas D, Tiwari M, Herman B, Shi Y, Walsh M, Pulliam D, Hamilton R, Liu Y, Zhang Y, Jaramillo C, Van Remmen H, Jiang S, Orihuela C, Rodriguez K, Buffenstein R, Bonnel C, Arteaga-Cortes L, Leland M, Dube P, Kraig E, Roman M, Flores L, Ortiz M, Dube S, Zhang Y, Lee S, Hubbard G, Ikeno Y, Ortiz M, Flores L, Dube S, Roman M, Bhattacharya A, Zhang Y, Salmon A, Qi W, Liu Y, Lee S, Van Remmen H, Richardson A, Hubbard G, Ikeno Y, Lewis K, Buffenstein R, Walsh M, Bhattachrya A, Van Remmen H, Treaster S, Maslin K, Ridgway I, Chaudhuri A, Austad S, Fok W, Bokov A, Gelfond J, Zhang Y, Doderer M, Chen Y, Javors M, Wood B, Zhang Y, Becker K, Richardson A, Perez V, Chaudhuri A, Wei R, Tiwari M, Sharma L, Vanegas D, Bai Y, Herman B, Sataranatarajan K, Feliers D, Mariappan M, Lee H, Lee M, Day R, Yelamanchili H, Choudhury G, Barnes J, Van Remmen H, Richardson A, Kasinath B, Zhang Y, Walsh M, Ikeno Y, Diaz V, Curiel T, Lindsey M, Van Remmen H, Richardson A, Soto V, Bokov A, Gelfond J, Sloane L, Diaz V, Maslin K, Treaster S, Richardson A, Austad S, Fischer K, Pulliam D, Hill S, Qi W, Salmon A, Sathyaseelan D, Van Remmen H, Martin-Montalvo A, Mercken E, Mitchell S, Palacios H, Bernier M, de Cabo R, McDonald P, Maizi B, Arking R, Jung-Won S, Marowsky N, Nichols T, Rahman A, Miah T, Sarao P, Khasawneh R, Unnikrishnan A, Heydari A, Silver R, Arking R, Mishur R, Judkins J, Butler J, Mahanti P, Schroeder F, Rea S, Mitchell S, Ward T, Palacios H, Minor R, de Cabo R, Bokov A, Gelfond J, Sloane L, Fischer K, Maslin K, Rendon S, Soto V, Oddo S, Majumder S, Kasinath B, Natarajan K, Oyajobi B, Gupta A, McCluskey B, Van Remmen H, Walsh M, Lindsey M, Richardson A, Austad S, Maslin K, Treaster S, Sloane L, Soto V, Fischer K, Austad S, Hussong S, Halloran J, Burbank R, Lin A, Soto V, Galvan V, Fischer K, Gelfond J, Bokov A, Soto V, Sloane L, Maslin K, Treaster S, Diaz V, Espinoza S, Richardson A, Austad S, Singh R, Martinez V, Halloran J, Burbank R, Diaz V, Galvan V, Fernandez E, Strong R. Mouse Health Span: Why Lifespan is No Longer Enough. Pathobiology Of Aging & Age-related Diseases 2012, 2: 20276. PMCID: PMC3535693, DOI: 10.3402/pba.v2i0.20276.
- Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij RatMishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.
- Neuroanatomical changes in a mouse model of early life neglectDuque A, Coman D, Carlyle BC, Bordner KA, George ED, Papademetris X, Hyder F, Simen AA. Neuroanatomical changes in a mouse model of early life neglect. Brain Structure And Function 2011, 217: 459-472. PMID: 21984312, PMCID: PMC3664301, DOI: 10.1007/s00429-011-0350-9.
- Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brainHerman P, Sanganahalli BG, Hyder F, Eke A. Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain. NeuroImage 2011, 58: 1060-1069. PMID: 21777682, PMCID: PMC3705180, DOI: 10.1016/j.neuroimage.2011.06.082.
- Evidence for the importance of measuring total brain activity in neuroimagingHyder F, Rothman DL. Evidence for the importance of measuring total brain activity in neuroimaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 5475-5476. PMID: 21441108, PMCID: PMC3078349, DOI: 10.1073/pnas.1102026108.
- A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinateComan D, Kiefer GE, Rothman DL, Sherry AD, Hyder F. A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate. NMR In Biomedicine 2011, 24: 1216-1225. PMID: 22020775, PMCID: PMC3267016, DOI: 10.1002/nbm.1677.
- Neuronal correlate of BOLD signal fluctuations at rest: Err on the side of the baselineHyder F, Rothman DL. Neuronal correlate of BOLD signal fluctuations at rest: Err on the side of the baseline. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10773-10774. PMID: 20534504, PMCID: PMC2890714, DOI: 10.1073/pnas.1005135107.
- Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−Coman D, Trubel HK, Hyder F. Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−. NMR In Biomedicine 2010, 23: 277-285. PMID: 19957287, PMCID: PMC2843767, DOI: 10.1002/nbm.1461.
- Cerebral oxygen demand for short‐lived and steady‐state eventsHerman P, Sanganahalli BG, Blumenfeld H, Hyder F. Cerebral oxygen demand for short‐lived and steady‐state events. Journal Of Neurochemistry 2009, 109: 73-79. PMID: 19393011, PMCID: PMC2714475, DOI: 10.1111/j.1471-4159.2009.05844.x.
- Oxidative Neuroenergetics in Event-Related ParadigmsSanganahalli BG, Herman P, Blumenfeld H, Hyder F. Oxidative Neuroenergetics in Event-Related Paradigms. Journal Of Neuroscience 2009, 29: 1707-1718. PMID: 19211878, PMCID: PMC2760964, DOI: 10.1523/jneurosci.5549-08.2009.
- Brain temperature and pH measured by 1H chemical shift imaging of a thulium agentComan D, Trubel HK, Rycyna RE, Hyder F. Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent. NMR In Biomedicine 2009, 22: 229-239. PMID: 19130468, PMCID: PMC2735415, DOI: 10.1002/nbm.1312.
- Coding of Peripheral Olfactory Information in the Olfactory Bulb of Small AnimalsXu F, Shafer J, Liu N, Rothman D, Hyder F, Shepherd G. Coding of Peripheral Olfactory Information in the Olfactory Bulb of Small Animals. 2008, 279-283. DOI: 10.1007/978-1-4020-8387-7_49.
- CNS lupus in MRL/Faslpr mice (130.15)Choi J, Chahboune H, Hyder F, Craft J. CNS lupus in MRL/Faslpr mice (130.15). The Journal Of Immunology 2007, 178: s230-s230. DOI: 10.4049/jimmunol.178.supp.130.15.
- Untersuchung des Wirkmechanismus bei pharyngealer selektiver HirnkühlungKipfmüller F, Maegele M, Herman P, Doll H, Schurer L, Hyder F, Trübel H. Untersuchung des Wirkmechanismus bei pharyngealer selektiver Hirnkühlung. Zeitschrift Für Geburtshilfe Und Neonatologie 2007, 211 DOI: 10.1055/s-2007-983130.
- Veränderungen des zerebralen Blutflusses während pharyngealer und externer HirnkühlungTrübel H, Maegele M, Lefering R, Doll H, Schurer L, Kipfmüller F, Hyder F, Herman P. Veränderungen des zerebralen Blutflusses während pharyngealer und externer Hirnkühlung. Zeitschrift Für Geburtshilfe Und Neonatologie 2007, 211 DOI: 10.1055/s-2007-983131.
- Sevoflurane 0.25 MAC Affects Association Cortex More Than Primary Cortex - fMRI Study in VolunteersRamani R, Qiu M, Shulman R, Hyder F, Constable R. Sevoflurane 0.25 MAC Affects Association Cortex More Than Primary Cortex - fMRI Study in Volunteers. Journal Of Neurosurgical Anesthesiology 2005, 17: 242-243. DOI: 10.1097/01.ana.0000187752.71537.c3.
- Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance ImagingQiu M, Ramani R, Shulman R, Hyder F, Rajeevan N, Constable R. Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance Imaging. Journal Of Neurosurgical Anesthesiology 2005, 17: 224-225. DOI: 10.1097/01.ana.0000187715.47773.67.
- Influence of volatile induction agents on fMRI and neural activitySanganahalli B, Herman P, Hyder F. Influence of volatile induction agents on fMRI and neural activity. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s395-s395. DOI: 10.1038/sj.jcbfm.9591524.0395.
- Effects of isoflurane induction on inter-animal reproducibilitySanganahalli B, Herman P, Hyder F. Effects of isoflurane induction on inter-animal reproducibility. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s397-s397. DOI: 10.1038/sj.jcbfm.9591524.0397.
- Volatile induction agents affect adaptation in α-chloralose anesthetized ratSanganahalli B, Herman P, Hyder F. Volatile induction agents affect adaptation in α-chloralose anesthetized rat. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s401-s401. DOI: 10.1038/sj.jcbfm.9591524.0401.
- High resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij ratsBlumenfeld H, Nersesyan H, Khubchandani M, Schridde U, Berman R, Rothman D, Hyder F. High resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij rats. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s409-s409. DOI: 10.1038/sj.jcbfm.9591524.0409.
- Neural basis of localized and delocalized fMRI patternsMaandag N, Smith A, Blumenfeld H, Shulman R, Hyder F. Neural basis of localized and delocalized fMRI patterns. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s383-s383. DOI: 10.1038/sj.jcbfm.9591524.0383.
- Fractal properties of neurophysiologic signals in rat somatosensory cortexHerman P, Wahab S, Eke A, Hyder F. Fractal properties of neurophysiologic signals in rat somatosensory cortex. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s186-s186. DOI: 10.1038/sj.jcbfm.9591524.0186.
- Fractal patterns of local and global CBF in rat brain during hypotensionHerman P, Trübel H, Hyder F, Eke A. Fractal patterns of local and global CBF in rat brain during hypotension. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s195-s195. DOI: 10.1038/sj.jcbfm.9591524.0195.
- Fractal correlation structure in fMRI data of rat brainHerman P, Kida I, Sanganahalli B, Hyder F, Eke A. Fractal correlation structure in fMRI data of rat brain. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s379-s379. DOI: 10.1038/sj.jcbfm.9591524.0379.
- Neuroenergetic basis of regional temperature dynamics in brainTrübel H, Sacolick L, Hyder F. Neuroenergetic basis of regional temperature dynamics in brain. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s76-s76. DOI: 10.1038/sj.jcbfm.9591524.0076.
- Effects of volatile agents on neurophysiology in α-chloralose anesthetized ratsSanganahalli B, Herman P, Hyder F. Effects of volatile agents on neurophysiology in α-chloralose anesthetized rats. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s200-s200. DOI: 10.1038/sj.jcbfm.9591524.0200.
- The intra and inter-subject reproducibility of rodent olfactory bulb activity maps measured with fMRISchafer J, Kida I, Xu F, Rothman D, Hyder F. The intra and inter-subject reproducibility of rodent olfactory bulb activity maps measured with fMRI. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s336-s336. DOI: 10.1038/sj.jcbfm.9591524.0336.
- Dynamic relationship between changes in CBF and CBV during somatosensory stimulation: Implications for calibrated fMRIKida I, Hyder F. Dynamic relationship between changes in CBF and CBV during somatosensory stimulation: Implications for calibrated fMRI. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s369-s369. DOI: 10.1038/sj.jcbfm.9591524.0369.
- Dynamic Imaging of Perfusion and Oxygenation by Functional Magnetic Resonance ImagingKida I, Maciejewski P, Hyder F. Dynamic Imaging of Perfusion and Oxygenation by Functional Magnetic Resonance Imaging. Cerebrovascular And Brain Metabolism Reviews 2004, 24: 1369-1381. DOI: 10.1097/00004647-200412000-00006.
- Nichtinvasive Messung der Hirntemperatur mittels 1H-NMR-SpektroskopieTrübel H, Herman P, Kampmann C, Novotny E, Hyder F. Nichtinvasive Messung der Hirntemperatur mittels 1H-NMR-Spektroskopie. Zeitschrift Für Geburtshilfe Und Neonatologie 2004, 208 DOI: 10.1055/s-2004-829409.
- Selektive Hirnkühlung zur Therapie epileptischer AnfälleTrübel H, Herman P, Kampmann C, Novotny E, Hyder F. Selektive Hirnkühlung zur Therapie epileptischer Anfälle. Zeitschrift Für Geburtshilfe Und Neonatologie 2004, 208 DOI: 10.1055/s-2004-829410.
- Brain and Mind: An NMR PerspectiveShulman R, Hyder F. Brain and Mind: An NMR Perspective. 2004, 295-309. DOI: 10.1002/0470020520.ch16.
- Relationship between CMRO2 and Neuronal ActivityHyder F, Blumenfeld H. Relationship between CMRO2 and Neuronal Activity. 2004, 173-194. DOI: 10.1002/0470020520.ch10.
- Deriving Changes in CMRO2 from Calibrated fMRIHyder F. Deriving Changes in CMRO2 from Calibrated fMRI. 2004, 147-171. DOI: 10.1002/0470020520.ch9.
- Brain temperature changes during selective brain coolingTrübel H, Herman P, Kampmann C, Huth R, Maciejewski P, Hyder F, Novotny E. Brain temperature changes during selective brain cooling. Critical Care 2003, 7: p091. PMCID: PMC3301536, DOI: 10.1186/cc1980.
- Neuroenergetic Basis of Functional MRI: Implications for Efficiency of Brain WorkHyder F. Neuroenergetic Basis of Functional MRI: Implications for Efficiency of Brain Work. 2003, 73-74. DOI: 10.1109/nebc.2003.1215998.
- Quantitative fMRI of rat brain by multi-modal MRI and MRS measurementsHyder F, Kida I, Smith A, Blumenfeld H, Shulman R, Rothman D. Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements. International Congress Series 2002, 1235: 57-71. DOI: 10.1016/s0531-5131(02)00173-5.
- Lactate efflux and the neuroenergetic basis of brain functionShulman R, Hyder F, Rothman D. Lactate efflux and the neuroenergetic basis of brain function. NMR In Biomedicine 2001, 14: 389-396. PMID: 11746930, DOI: 10.1002/nbm.741.
- Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRIHyder F, Kida I, Behar K, Kennan R, Maciejewski P, Rothman D. Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR In Biomedicine 2001, 14: 413-431. PMID: 11746934, DOI: 10.1002/nbm.733.
- Cerebral blood volume changes with functional and CO2 challenges: quantitative BOLD imagingHyder F, Kida I, Kennan R, Rothman D. Cerebral blood volume changes with functional and CO2 challenges: quantitative BOLD imaging. NeuroImage 2001, 13: 983. DOI: 10.1016/s1053-8119(01)92321-3.
- Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imagingShulman R, Hyder F, Rothman D. Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6417-6422. PMID: 11344262, PMCID: PMC33483, DOI: 10.1073/pnas.101129298.
- Inhibition of Voltage-Dependent Sodium Channels Suppresses the Functional Magnetic Resonance Imaging Response to Forepaw Somatosensory Activation in the RodentKida I, Hyder F, Behar K. Inhibition of Voltage-Dependent Sodium Channels Suppresses the Functional Magnetic Resonance Imaging Response to Forepaw Somatosensory Activation in the Rodent. Cerebrovascular And Brain Metabolism Reviews 2001, 21: 585-591. PMID: 11333369, DOI: 10.1097/00004647-200105000-00013.
- Topiramate Rapidly Raises Brain GABA in Epilepsy PatientsPetroff O, Hyder F, Rothman D, Mattson R. Topiramate Rapidly Raises Brain GABA in Epilepsy Patients. Epilepsia 2001, 42: 543-548. PMID: 11440351, DOI: 10.1046/j.1528-1157.2001.18800.x.
- Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizuresPetroff O, Hyder F, Rothman D, Mattson R. Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures. Neurology 2001, 56: 709-715. PMID: 11274303, DOI: 10.1212/wnl.56.6.709.
- What you see is what you think – or is it?Pellerin L, Sibson N, Hadjikhani N, Hyder F. What you see is what you think – or is it? Trends In Neurosciences 2001, 24: 71-72. PMID: 11252265, DOI: 10.1016/s0166-2236(00)01715-x.
- Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRIXu F, Kida I, Hyder F, Shulman R. Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 10601-10606. PMID: 10973488, PMCID: PMC27071, DOI: 10.1073/pnas.180321397.
- Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy PatientsPetroff O, Hyder F, Rothman D, Mattson R. Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients. Epilepsia 2000, 41: 675-680. PMID: 10840398, DOI: 10.1111/j.1528-1157.2000.tb00227.x.
- High-Resolution CMRO2 Mapping in Rat Cortex: A Multiparametric Approach to Calibration of BOLD Image Contrast at 7 TeslaKida I, Kennan R, Rothman D, Behar K, Hyder F. High-Resolution CMRO2 Mapping in Rat Cortex: A Multiparametric Approach to Calibration of BOLD Image Contrast at 7 Tesla. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 847-860. PMID: 10826536, DOI: 10.1097/00004647-200005000-00012.
- Quantitative multi-modal functional MRI with blood oxygenation level dependent exponential decays adjusted for flow attenuated inversion recovery (BOLDED AFFAIR)Hyder F, Renken R, Kennan R, Rothman D. Quantitative multi-modal functional MRI with blood oxygenation level dependent exponential decays adjusted for flow attenuated inversion recovery (BOLDED AFFAIR). Magnetic Resonance Imaging 2000, 18: 227-235. PMID: 10745130, DOI: 10.1016/s0730-725x(00)00125-9.
- Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance StudyHyder F, Kennan R, Kida I, Mason G, Behar K, Rothman D. Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 485-498. PMID: 10724113, DOI: 10.1097/00004647-200003000-00007.
- In vivo carbon‐edited detection with proton echo‐planar spectroscopic imaging (ICED PEPSI): [3,4‐13CH2]glutamate/glutamine tomography in rat brainHyder F, Renken R, Rothman D. In vivo carbon‐edited detection with proton echo‐planar spectroscopic imaging (ICED PEPSI): [3,4‐13CH2]glutamate/glutamine tomography in rat brain. Magnetic Resonance In Medicine 1999, 42: 997-1003. PMID: 10571918, DOI: 10.1002/(sici)1522-2594(199912)42:6<997::aid-mrm1>3.0.co;2-1.
- Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRSVerhoeff N, Petroff O, Hyder F, Zoghbi S, Fujita M, Rajeevan N, Rothman D, Seibyl J, Mattson R, Innis R. Effects of Vigabatrin on the GABAergic System as Determined by [123I]Iomazenil SPECT and GABA MRS. Epilepsia 1999, 40: 1433-1438. PMID: 10528940, DOI: 10.1111/j.1528-1157.1999.tb02016.x.
- In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergeticsRothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.
- Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial SeizuresPetroff O, Hyder F, Collins T, Mattson R, Rothman D. Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures. Epilepsia 1999, 40: 958-964. PMID: 10403220, DOI: 10.1111/j.1528-1157.1999.tb00803.x.
- Localized 1H NMR measurements of 2‐pyrrolidinone in human brain in vivoHyder F, Petroff O, Mattson R, Rothman D. Localized 1H NMR measurements of 2‐pyrrolidinone in human brain in vivo. Magnetic Resonance In Medicine 1999, 41: 889-896. PMID: 10332870, DOI: 10.1002/(sici)1522-2594(199905)41:5<889::aid-mrm6>3.0.co;2-r.
- GABA Changes with Vigabatrin in the Developing Human BrainNovotny E, Hyder F, Shevell M, Rothman D. GABA Changes with Vigabatrin in the Developing Human Brain. Epilepsia 1999, 40: 462-466. PMID: 10219272, DOI: 10.1111/j.1528-1157.1999.tb00741.x.
- Stimulated changes in localized cerebral energy consumption under anesthesiaShulman R, Rothman D, Hyder F. Stimulated changes in localized cerebral energy consumption under anesthesia. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 3245-3250. PMID: 10077669, PMCID: PMC15927, DOI: 10.1073/pnas.96.6.3245.
- Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsyPetroff O, Hyder F, Mattson R, Rothman D. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology 1999, 52: 473-478. PMID: 10025774, DOI: 10.1212/wnl.52.3.473.
- Regulation of Cerebral Oxygen DeliveryHyder F, Shulman R, Rothman D. Regulation of Cerebral Oxygen Delivery. 1999, 471: 99-110. PMID: 10659136, DOI: 10.1007/978-1-4615-4717-4_12.
- Toward Absolute Quantitation of Bold Functional MRIKida I, Hyder F, Kennan R, Behar K. Toward Absolute Quantitation of Bold Functional MRI. 1999, 471: 681-689. PMID: 10659202, DOI: 10.1007/978-1-4615-4717-4_78.
- Vigabatrin increases human brain homocarnosine and improves seizure controlPetroff O, Mattson R, Behar K, Hyder F, Rothman D. Vigabatrin increases human brain homocarnosine and improves seizure control. Annals Of Neurology 1998, 44: 948-952. PMID: 9851440, DOI: 10.1002/ana.410440614.
- A model for the regulation of cerebral oxygen deliveryHyder F, Shulman R, Rothman D. A model for the regulation of cerebral oxygen delivery. Journal Of Applied Physiology 1998, 85: 554-564. PMID: 9688733, DOI: 10.1152/jappl.1998.85.2.554.
- Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRIYang X, Renken R, Hyder F, Siddeek M, Greer C, Shepherd G, Shulman R. Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 7715-7720. PMID: 9636216, PMCID: PMC22734, DOI: 10.1073/pnas.95.13.7715.
- Functional MRI bold signal coincides with electrical activity in the rat whisker barrelsYang X, Hyder F, Shulman R. Functional MRI bold signal coincides with electrical activity in the rat whisker barrels. Magnetic Resonance In Medicine 1997, 38: 874-877. PMID: 9402186, DOI: 10.1002/mrm.1910380604.
- Oxidative Glucose Metabolism in Rat Brain During Single Forepaw Stimulation: A Spatially Localized 1H[13C] Nuclear Magnetic Resonance StudyHyder F, Rothman* D, Mason† G, Rangarajan A, Behar‡ K, Shulman R. Oxidative Glucose Metabolism in Rat Brain During Single Forepaw Stimulation: A Spatially Localized 1H[13C] Nuclear Magnetic Resonance Study. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 1040-1047. PMID: 9346428, DOI: 10.1097/00004647-199710000-00005.
- “Willed action”: A functional MRI study of the human prefrontal cortex during a sensorimotor taskHyder F, Phelps E, Wiggins C, Labar K, Blamire A, Shulman R. “Willed action”: A functional MRI study of the human prefrontal cortex during a sensorimotor task. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6989-6994. PMID: 9192679, PMCID: PMC21272, DOI: 10.1073/pnas.94.13.6989.
- FMRI of the prefrontal cortex during overt verbal fluencyPhelps E, Hyder F, Blamire A, Shulman R. FMRI of the prefrontal cortex during overt verbal fluency. Neuroreport 1997, 8: 561-565. PMID: 9080448, DOI: 10.1097/00001756-199701200-00036.
- Image reconstruction of sequentially sampled echo-planar dataHyder F, Rothman D, Blamire A. Image reconstruction of sequentially sampled echo-planar data. Magnetic Resonance Imaging 1995, 13: 97-103. PMID: 7898286, DOI: 10.1016/0730-725x(94)00068-e.
- Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw StimulationHyder F, Behar K, Martin M, Blamire A, Shulman R. Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation. Cerebrovascular And Brain Metabolism Reviews 1994, 14: 649-655. PMID: 8014212, DOI: 10.1038/jcbfm.1994.81.
- Applications of nuclear magnetic cross‐relaxation spectroscopy to tissuesGrad J, Mendelson D, Hyder F, Bryant R. Applications of nuclear magnetic cross‐relaxation spectroscopy to tissues. Magnetic Resonance In Medicine 1991, 17: 452-459. PMID: 2062216, DOI: 10.1002/mrm.1910170216.
- Direct measurements of longitudinal relaxation and magnetization transfer in heterogeneous systemsGrad J, Mendelson D, Hyder F, Bryant R. Direct measurements of longitudinal relaxation and magnetization transfer in heterogeneous systems. Journal Of Magnetic Resonance (1969) 1990, 86: 416-419. DOI: 10.1016/0022-2364(90)90275-e.
Clinical Trials
Conditions | Study Title |
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Mental Health & Behavioral Research | AMPA Receptor Components of the Anti-Depressant Ketamine Response |