Douglas Rothman, PhD
Professor of Radiology and Biomedical Imaging and of Biomedical Engineering; Director Yale MR Research Center
Research & Publications
Biography
News
Coauthors
Selected Publications
- A 3D atlas of functional human brain energetic connectome based on neuropil distributionYu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.
- Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle modelRothman D, Behar K, Dienel G. Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model. Journal Of Neurochemistry 2022 PMID: 36089566, DOI: 10.1111/jnc.15619.
- 232-OR: Alterations in Decision-Making Neurocircuits during Hypoglycemia in Patients with T1DMDEAJON-JACKSON J, RANGEL E, LACADIE C, GREENE A, BELFORT-DEAGUIAR R, CONSTABLE T, ROTHMAN D, HWANG J. 232-OR: Alterations in Decision-Making Neurocircuits during Hypoglycemia in Patients with T1DM. Diabetes 2022, 71 DOI: 10.2337/db22-232-or.
- P193. Right Lateral Amygdala Nucleus Volume in Adolescents and Young Adults With Bipolar Disorder Assessed With High Field Magnetic Resonance ImagingYe J, Fan S, Coman D, Kolosowska N, Goldman D, Spencer L, Qiu M, Dhaher R, Sankar A, Colic L, Mason G, Rothman D, Fudge J, Berretta S, Blumberg H. P193. Right Lateral Amygdala Nucleus Volume in Adolescents and Young Adults With Bipolar Disorder Assessed With High Field Magnetic Resonance Imaging. Biological Psychiatry 2022, 91: s165. DOI: 10.1016/j.biopsych.2022.02.427.
- BIMG-21. DEUTERIUM METABOLIC IMAGING (DMI), A NEW, MRI-BASED TECHNIQUE FOR MAPPING BRAIN TUMOR METABOLISM IN VIVOCorbin Z, Fulbright R, Rothman D, de Graaf R, De Feyter H. BIMG-21. DEUTERIUM METABOLIC IMAGING (DMI), A NEW, MRI-BASED TECHNIQUE FOR MAPPING BRAIN TUMOR METABOLISM IN VIVO. Neuro-Oncology Advances 2021, 3: i5-i5. PMCID: PMC7994324, DOI: 10.1093/noajnl/vdab024.020.
- Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter CyclesRothman D, De Feyter H, Mason G, de Graaf R, Hyder F, Behar K. Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles. 2021, 688-700. DOI: 10.1016/b978-0-12-819460-7.00341-8.
- 369-OR: [1,2-13C2]-L-Glutamine Mass Isotopomers Map Hepatic Mitochondrial Metabolism without Tracer InterferenceSIEBEL S, CARDONE R, ABULIZI A, RAAISA R, WILLIAMS R, SEHGAL R, BUTRICO G, CLINE G, ROTHMAN D, MASON G, KIBBEY R. 369-OR: [1,2-13C2]-L-Glutamine Mass Isotopomers Map Hepatic Mitochondrial Metabolism without Tracer Interference. Diabetes 2020, 69 DOI: 10.2337/db20-369-or.
- 1762-P: Poor Sleep Quality Is Associated with Lower Absolute Cerebral Glucose LevelsSTANLEY T, GUNAWAN F, REDEKER N, JIANG L, COPPOLI A, ROTHMAN D, MASON G, HWANG J. 1762-P: Poor Sleep Quality Is Associated with Lower Absolute Cerebral Glucose Levels. Diabetes 2020, 69 DOI: 10.2337/db20-1762-p.
- 1772-P: Reversibility of Altered Brain Glucose Kinetics in T2DMRANGEL E, GUNAWAN F, JIANG L, SAVOYE M, DAI F, ROTHMAN D, MASON G, HWANG J. 1772-P: Reversibility of Altered Brain Glucose Kinetics in T2DM. Diabetes 2020, 69 DOI: 10.2337/db20-1772-p.
- NIMG-15. DEUTERIUM METABOLIC IMAGING (DMI) MEASURES THE WARBURG EFFECT IN BRAIN TUMORSCorbin Z, Prado I, Fulbright R, Rothman D, de Graaf R, De Feyter H. NIMG-15. DEUTERIUM METABOLIC IMAGING (DMI) MEASURES THE WARBURG EFFECT IN BRAIN TUMORS. Neuro-Oncology 2019, 21: vi164-vi164. PMCID: PMC6847058, DOI: 10.1093/neuonc/noz175.687.
- 228-OR: Cerebral Glucose Transport and Metabolism in ObesityGUNAWAN F, JIANG L, LEVENTHAL J, PACH J, RANGEL E, BELFORT-DEAGUIAR R, COPPOLI A, ROTHMAN D, SHERWIN R, MASON G, HWANG J. 228-OR: Cerebral Glucose Transport and Metabolism in Obesity. Diabetes 2019, 68 DOI: 10.2337/db19-228-or.
- Elevated Nonesterified Fatty Acids (NEFA) Are Associated with Blunted Hyperglycemia-Induced Increments in Brain Glucose LevelsLAM W, JIANG L, BUTRICO G, CLINE G, RANGEL E, HAMZA M, PARIKH L, BELFORT-DEAGUIAR R, ROTHMAN D, MASON G, SHERWIN R, HWANG J. Elevated Nonesterified Fatty Acids (NEFA) Are Associated with Blunted Hyperglycemia-Induced Increments in Brain Glucose Levels. Diabetes 2018, 67 DOI: 10.2337/db18-2427-pub.
- Increased Glycemic Variability Is Associated with Augmented Brain Glucose Transport amongst Poorly Controlled T1DM IndividualsHWANG J, JIANG L, LAM W, RANGEL E, ROTHMAN D, MASON G, SHERWIN R. Increased Glycemic Variability Is Associated with Augmented Brain Glucose Transport amongst Poorly Controlled T1DM Individuals. Diabetes 2018, 67 DOI: 10.2337/db18-204-or.
- 662 Ketamine and Rapastinel Effects on Glutamate CyclingSanacora G, Chowdhury G, Rothman D, Behar K. 662 Ketamine and Rapastinel Effects on Glutamate Cycling. Biological Psychiatry 2017, 81: s268. DOI: 10.1016/j.biopsych.2017.02.1071.
- Spectral Editingde Graaf R, Rothman D. Spectral Editing. 2016, 1147-1156. DOI: 10.1002/9780470034590.emrstm1456.
- ATPS-14KETOGENIC DIET-INDUCED INCREASE IN MCT1 FACILITATES KETONE BODY OXIDATION IN RAT GLIOMASDe Feyter H, Behar K, Ip K, Hyder F, Drewes L, de Graaf R, Rothman D. ATPS-14KETOGENIC DIET-INDUCED INCREASE IN MCT1 FACILITATES KETONE BODY OXIDATION IN RAT GLIOMAS. Neuro-Oncology 2015, 17: v21-v21. PMCID: PMC4638437, DOI: 10.1093/neuonc/nov204.14.
- Superconductor Analog-to-Digital Converter for High-Resolution Magnetic Resonance ImagingRadparvar M, Talalaevskii A, Webber R, Kadin A, Track E, de Graaf R, Nixon T, Rothman D. Superconductor Analog-to-Digital Converter for High-Resolution Magnetic Resonance Imaging. IEEE Transactions On Applied Superconductivity 2015, 25: 1-5. DOI: 10.1109/tasc.2014.2361132.
- Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative EnergyHyder F, Fulbright R, Shulman R, Rothman D. Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 368-368. PMCID: PMC3915214, DOI: 10.1038/jcbfm.2013.205.
- Chapter 4.2 Carbon (13C) MRSRothman D, De Feyter H. Chapter 4.2 Carbon (13C) MRS. 2014, 312-330. DOI: 10.1016/b978-0-12-401688-0.00023-9.
- Chapter 1.1 Basis of Magnetic ResonanceJuchem C, Rothman D. Chapter 1.1 Basis of Magnetic Resonance. 2014, 3-14. DOI: 10.1016/b978-0-12-401688-0.00001-x.
- Metabolomic Profiling of Children’s Brains Undergoing General Anesthesia With Sevoflurane and PropofolJacob Z, Li H, Makaryus R, Zhang S, Reinsel R, Lee H, Feng T, Rothman D, Benveniste H. Metabolomic Profiling of Children’s Brains Undergoing General Anesthesia With Sevoflurane and Propofol. Survey Of Anesthesiology 2013, 57: 139. DOI: 10.1097/01.sa.0000428779.04189.52.
- CMR02 Mapping by Calibrated fMRIHyder F, Shu C, Herman P, Sanganahalli B, Coman D, Rothman D. CMR02 Mapping by Calibrated fMRI. 2013, 20130539: 85-109. DOI: 10.1201/b14814-5.
- Les coils d’angiographie en résonnance magnétique implantés chirurgicalement améliorent la résolution et permettent la visualisation dynamique du flux sanguinFitzgerald T, Muto A, Fancher T, Brown P, Martin K, Muhs B, Rothman D, Constable R, Sampath S, Dardik A. Les coils d’angiographie en résonnance magnétique implantés chirurgicalement améliorent la résolution et permettent la visualisation dynamique du flux sanguin. Annales De Chirurgie Vasculaire 2010, 24: 266-277. DOI: 10.1016/j.acvfr.2010.09.010.
- Baseline brain energy supports the state of consciousnessShulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11096-11101. PMID: 19549837, PMCID: PMC2708743, DOI: 10.1073/pnas.0903941106.
- Hypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral AssessmentChahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F, Schwartz ML. Hypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral Assessment. Cerebral Cortex 2009, 19: 2891-2901. PMID: 19380380, PMCID: PMC2774398, DOI: 10.1093/cercor/bhp068.
- Chapter 21 Assessment of In Vivo Mitochondrial Metabolism by Magnetic Resonance SpectroscopyBefroy DE, Petersen K, Rothman DL, Shulman GI. Chapter 21 Assessment of In Vivo Mitochondrial Metabolism by Magnetic Resonance Spectroscopy. 2009, 457: 373-393. PMID: 19426879, PMCID: PMC3077057, DOI: 10.1016/s0076-6879(09)05021-6.
- Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamicsFitzgerald T, Muto A, Fancher T, Brown P, Martin K, Muhs B, Rothman D, Constable R, Sampath S, Dardik A. Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamics. Journal Of The American College Of Surgeons 2008, 207: s113. DOI: 10.1016/j.jamcollsurg.2008.06.292.
- Coding of Peripheral Olfactory Information in the Olfactory Bulb of Small AnimalsXu F, Shafer J, Liu N, Rothman D, Hyder F, Shepherd G. Coding of Peripheral Olfactory Information in the Olfactory Bulb of Small Animals. 2008, 279-283. DOI: 10.1007/978-1-4020-8387-7_49.
- In Vivo Assessment of Intracellular Oxygenation during Fatiguing Isometric Contractions of the Ankle DorsiflexorsWigmore D, Befroy D, Lanza I, Rothman D, Kent-Braun J. In Vivo Assessment of Intracellular Oxygenation during Fatiguing Isometric Contractions of the Ankle Dorsiflexors. Medicine & Science In Sports & Exercise 2006, 38: s520. DOI: 10.1249/00005768-200605001-03046.
- The intra and inter-subject reproducibility of rodent olfactory bulb activity maps measured with fMRISchafer J, Kida I, Xu F, Rothman D, Hyder F. The intra and inter-subject reproducibility of rodent olfactory bulb activity maps measured with fMRI. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s336-s336. DOI: 10.1038/sj.jcbfm.9591524.0336.
- High resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij ratsBlumenfeld H, Nersesyan H, Khubchandani M, Schridde U, Berman R, Rothman D, Hyder F. High resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij rats. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s409-s409. DOI: 10.1038/sj.jcbfm.9591524.0409.
- Energetic costs associated with glutamatergic and gabaergic neurotransmissionde Graaf R, Patel A, Mason G, Rothman D, Shulman R, Behar K. Energetic costs associated with glutamatergic and gabaergic neurotransmission. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s706-s706. DOI: 10.1038/sj.jcbfm.9591524.0707.
- Cerebral pyruvate carboxylase flux is unaltered during bicuculline‐seizuresPatel A, Chowdhury G, de Graaf R, Rothman D, Shulman R, Behar K. Cerebral pyruvate carboxylase flux is unaltered during bicuculline‐seizures. Journal Of Neuroscience Research 2005, 80: 738-738. DOI: 10.1002/jnr.20554.
- MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 DiabetesShulman G, Rothman D. MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes. 2004, 45-57. DOI: 10.1002/0470011505.ch4.
- 13C NMR Studies of Heart Glycogen MetabolismLaughlin M, Rothman D, Shulman R. 13C NMR Studies of Heart Glycogen Metabolism. 2004, 87-102. DOI: 10.1002/0470011505.ch7.
- Phosphorylation of Allosteric Enzymes Can Serve Homeostasis rather than Control Flux: The Example of Glycogen SynthaseSchafer J, Fell D, Rothman D, Shulman R. Phosphorylation of Allosteric Enzymes Can Serve Homeostasis rather than Control Flux: The Example of Glycogen Synthase. 2004, 59-71. DOI: 10.1002/0470011505.ch5.
- Lactate, Glycogen and FatigueShulman R, Rothman D. Lactate, Glycogen and Fatigue. 2004, 125-135. DOI: 10.1002/0470011505.ch9.
- Summarized Reflections on MetabolismShulman R, Rothman D, Schafer J. Summarized Reflections on Metabolism. 2004, 175-184. DOI: 10.1002/0470011505.ch13.
- NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter PathwaysBehar K, Rothman D. NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter Pathways. 2004, 99-110. DOI: 10.1002/0470020520.ch6.
- IntroductionRothman D, Shulman R. Introduction. 2004, 1-9. DOI: 10.1002/0470020520.ch1.
- Corrigendum to “A comparison of 13C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-13C]glucose” [Brain Research Protocols, 10 (2003) 181–190]☆Mason G, Petersen K, de Graaf R, Kanamatsu T, Otsuki T, Rothman D. Corrigendum to “A comparison of 13C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-13C]glucose” [Brain Research Protocols, 10 (2003) 181–190]☆. Brain Research 2003, 11: 143. DOI: 10.1016/s1385-299x(03)00021-7.
- Windows on the working brain: magnetic resonance spectroscopyPrichard J, Alger J, Arnold D, Petroff O, Rothman D. Windows on the working brain: magnetic resonance spectroscopy. 2002, 146-159. DOI: 10.1017/cbo9781316134993.012.
- Quantitative fMRI of rat brain by multi-modal MRI and MRS measurementsHyder F, Kida I, Smith A, Blumenfeld H, Shulman R, Rothman D. Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements. International Congress Series 2002, 1235: 57-71. DOI: 10.1016/s0531-5131(02)00173-5.
- Magnetic Resonance Spectroscopic Studies of Neurotransmitters and Energy Metabolism in EpilepsyPetroff O, Pan J, Rothman D. Magnetic Resonance Spectroscopic Studies of Neurotransmitters and Energy Metabolism in Epilepsy. Epilepsia 2002, 43: 40-50. DOI: 10.1046/j.1528-1157.2002.043s1040.x.
- Spectroscopic Assessment of Alterations in Macromolecule and Small-Molecule Metabolites in Human Brain After StrokeGraham G, Hwang J, Rothman D, Prichard J. Spectroscopic Assessment of Alterations in Macromolecule and Small-Molecule Metabolites in Human Brain After Stroke. Stroke 2001, 32: 2797-2802. PMID: 11739976, DOI: 10.1161/hs1201.099414.
- Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibitionPatel A, Rothman D, Cline G, Behar K. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Research 2001, 919: 207-220. PMID: 11701133, DOI: 10.1016/s0006-8993(01)03015-3.
- Cerebral blood volume changes with functional and CO2 challenges: quantitative BOLD imagingHyder F, Kida I, Kennan R, Rothman D. Cerebral blood volume changes with functional and CO2 challenges: quantitative BOLD imaging. NeuroImage 2001, 13: 983. DOI: 10.1016/s1053-8119(01)92321-3.
- Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissãoMason G, Behar K, Krystal J, Rothman D. Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissão. Brazilian Journal Of Psychiatry 2001, 23: 6-10. DOI: 10.1590/s1516-44462001000500004.
- Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopyChase J, Rothman D, Shulman R. Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy. AJP Endocrinology And Metabolism 2001, 280: e598-e607. PMID: 11254467, DOI: 10.1152/ajpendo.2001.280.4.e598.
- In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusionSibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.
- Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced KetosisPan J, Rothman D, Behar K, Stein D, Hetherington H. Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 1502-1507. PMID: 11043913, DOI: 10.1097/00004647-200010000-00012.
- Meeting Report: Transcranial Magnetic Stimulation and Studies of Human CognitionFitzpatrick S, Rothman D. Meeting Report: Transcranial Magnetic Stimulation and Studies of Human Cognition. Journal Of Cognitive Neuroscience 2000, 12: 704-709. PMID: 10936921, DOI: 10.1162/089892900562327.
- 304. Cortical GABA reduced in unipolar but not bipolar depressionMason G, Sanacora G, Anand A, Epperson C, Goddard A, Rothman D, Charney D, Krystal J. 304. Cortical GABA reduced in unipolar but not bipolar depression. Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00568-0.
- 411. Measurement of the rate of pyruvate carboxylase in human brain by 13C MRSMason G, Petersen K, Shen J, Behar K, Petroff O, Shulman G, Rothman D. 411. Measurement of the rate of pyruvate carboxylase in human brain by 13C MRS. Biological Psychiatry 2000, 47: s126. DOI: 10.1016/s0006-3223(00)00681-8.
- 305. Reduced cortical GABA in depression is not due to decreased gray matterSanacora G, Mason G, Rothman D, Epperson C, Goddard A, Krystal J. 305. Reduced cortical GABA in depression is not due to decreased gray matter. Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00569-2.
- 303. Measurement of human cortical GABA synthesis in vivoMason G, Petersen K, Shen J, Behar K, Petroff O, Shulman G, Rothman D. 303. Measurement of human cortical GABA synthesis in vivo. Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00567-9.
- Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study.Krssak M, Petersen K, Bergeron R, Price T, Laurent D, Rothman D, Roden M, Shulman G. Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 748-54. PMID: 10690886, DOI: 10.1210/jcem.85.2.6354.
- Proton MRS: GABA and glutamate.Petroff O, Mattson R, Rothman D. Proton MRS: GABA and glutamate. Advances In Neurology 2000, 83: 261-71. PMID: 10999208.
- In vivo detection and quantification of scalar coupled 1H NMR resonancesde Graaf R, Rothman D. In vivo detection and quantification of scalar coupled 1H NMR resonances. Concepts In Magnetic Resonance 2000, 13: 32-76. DOI: 10.1002/1099-0534(2001)13:1<32::aid-cmr4>3.0.co;2-j.
- Linear projection method for automatic slice shimmingShen J, Rothman D, Hetherington H, Pan J. Linear projection method for automatic slice shimming. Magnetic Resonance In Medicine 1999, 42: 1082-1088. PMID: 10571929, DOI: 10.1002/(sici)1522-2594(199912)42:6<1082::aid-mrm12>3.0.co;2-g.
- New Approaches to Functional NeuroenergeticsFitzpatrick S, Rothman D. New Approaches to Functional Neuroenergetics. Journal Of Cognitive Neuroscience 1999, 11: 467-471. PMID: 10507889, DOI: 10.1162/089892999563454.
- Applications of Magnetic Resonance Spectroscopy to PsychiatrySanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry. The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
- 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRSSanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS. Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
- In vivo chemical shift imaging of γ‐aminobutyric acid in the human brainShen J, Shungu D, Rothman D. In vivo chemical shift imaging of γ‐aminobutyric acid in the human brain. Magnetic Resonance In Medicine 1999, 41: 35-42. PMID: 10025609, DOI: 10.1002/(sici)1522-2594(199901)41:1<35::aid-mrm7>3.0.co;2-c.
- Energy on demand.Magistretti P, Pellerin L, Rothman D, Shulman R. Energy on demand. Science 1999, 283: 496-7. PMID: 9988650, DOI: 10.1126/science.283.5401.496.
- New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures.Petroff O, Behar K, Rothman D. New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures. Advances In Neurology 1999, 79: 939-45. PMID: 10514877.
- In vivo lactate and β‐hydroxybutyrate editing using a pure‐phase refocusing pulse trainShen J, Novotny E, Rothman D. In vivo lactate and β‐hydroxybutyrate editing using a pure‐phase refocusing pulse train. Magnetic Resonance In Medicine 1998, 40: 783-788. PMID: 9797163, DOI: 10.1002/mrm.1910400520.
- Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal ActivitySibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.
- 15N-NMR Spectroscopy Studies of Ammonia Transport and Glutamine Synthesis in the Hyperammonemic Rat BrainShen J, Sibson N, Cline G, Behar K, Rothman D, Shulman R. 15N-NMR Spectroscopy Studies of Ammonia Transport and Glutamine Synthesis in the Hyperammonemic Rat Brain. Developmental Neuroscience 1998, 20: 434-443. PMID: 9778582, DOI: 10.1159/000017341.
- Interpreting functional imaging studies in terms of neurotransmitter cyclingShulman R, Rothman D. Interpreting functional imaging studies in terms of neurotransmitter cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11993-11998. PMID: 9751778, PMCID: PMC21753, DOI: 10.1073/pnas.95.20.11993.
- Mapping Glutamatergic Activity: Stoichiometric Coupling of Brain Glucose Metabolism and Neurotransmitter Glutamate CyclingSibson N, Mason G, Behar K, Rothman D, Shulman R. Mapping Glutamatergic Activity: Stoichiometric Coupling of Brain Glucose Metabolism and Neurotransmitter Glutamate Cycling. NeuroImage 1998, 7: s287. DOI: 10.1016/s1053-8119(18)31120-0.
- 24. Quantification of cortical GABA levels in neuropsychiatric patientsSanacora G, Goddard A, Gil R, D'Souza D, Abi-Saab W, Petroff O, Mattson R, Mason G, Behar K, Ciarcia J, Berman R, Charney D, Rothman D, Krystal J. 24. Quantification of cortical GABA levels in neuropsychiatric patients. Biological Psychiatry 1998, 43: s8. DOI: 10.1016/s0006-3223(98)90472-3.
- Measuring human brain GABA in vivoPetroff O, Rothman D. Measuring human brain GABA in vivo. Molecular Neurobiology 1998, 16: 97-121. PMID: 9554704, DOI: 10.1007/bf02740605.
- Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activitySibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.
- Homocarnosine and the measurement of neuronal pH in patients with epilepsyRothman D, Behar K, Prichard J, Petroff O. Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magnetic Resonance In Medicine 1997, 38: 924-929. PMID: 9402193, DOI: 10.1002/mrm.1910380611.
- Improvements on an in Vivo automatic shimming method (FASTERMAP)Shen J, Rycyna R, Rothman D. Improvements on an in Vivo automatic shimming method (FASTERMAP). Magnetic Resonance In Medicine 1997, 38: 834-839. PMID: 9358459, DOI: 10.1002/mrm.1910380521.
- Fast Automatic Adjustment of On-Axis Shims for High-Resolution NMRShen J, Rothman D. Fast Automatic Adjustment of On-Axis Shims for High-Resolution NMR. Journal Of Magnetic Resonance 1997, 127: 229-232. PMID: 9281488, DOI: 10.1006/jmre.1997.1205.
- In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cyclingSibson N, Dhankhar A, Mason G, Behar K, Rothman D, Shulman R. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2699-2704. PMID: 9122259, PMCID: PMC20152, DOI: 10.1073/pnas.94.6.2699.
- Adiabatic Slice-Selective Excitation for Surface CoilsShen J, Rothman D. Adiabatic Slice-Selective Excitation for Surface Coils. Journal Of Magnetic Resonance 1997, 124: 72-79. PMID: 9169211, DOI: 10.1006/jmre.1996.7483.
- 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopyBehar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy. Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.
- Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin TherapyPetroff O, Behar K, Mattson R, Rothman D. Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy. Journal Of Neurochemistry 1996, 67: 2399-2404. PMID: 8931472, DOI: 10.1046/j.1471-4159.1996.67062399.x.
- Low brain GABA level is associated with poor seizure controlPetroff O, Rothman D, Behar K, Mattson R. Low brain GABA level is associated with poor seizure control. Annals Of Neurology 1996, 40: 908-911. PMID: 9007096, DOI: 10.1002/ana.410400613.
- Human brain GABA levels rise rapidly after initiation of vigabatrin therapyPetroff O, Rothman D, Behar K, Collins T, Mattson R. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology 1996, 47: 1567-1571.. PMID: 8960747, DOI: 10.1212/wnl.47.6.1567.
- Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis.Shulman R, Rothman D. Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7491-7495. PMID: 8755501, PMCID: PMC38772, DOI: 10.1073/pnas.93.15.7491.
- Dynamic shim updating: A new approach towards optimized whole brain shimmingBlamire A, Rothman D, Nixon T. Dynamic shim updating: A new approach towards optimized whole brain shimming. Magnetic Resonance In Medicine 1996, 36: 159-165. PMID: 8795035, DOI: 10.1002/mrm.1910360125.
- Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dosePetroff O, Rothman D, Behar K, Mattson R. Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Neurology 1996, 46: 1459-1463. PMID: 8628502, DOI: 10.1212/wnl.46.5.1459.
- Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brainHwang J, Graham G, Behar K, Alger J, Prichard J, Rothman D. Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain. Magnetic Resonance In Medicine 1996, 35: 633-639. PMID: 8722812, DOI: 10.1002/mrm.1910350502.
- 1H NMR Studies of Glucose Transport in the Human BrainGruetter R, Novotny† E, Boulware† S, Rothman* D, Shulman R. 1H NMR Studies of Glucose Transport in the Human Brain. Cerebrovascular And Brain Metabolism Reviews 1996, 16: 427-438. PMID: 8621747, DOI: 10.1097/00004647-199605000-00009.
- Rothman, Douglas L.: In Flux Veritas: Contributions to the Development of in vivo 13 C MRSRothman D. Rothman, Douglas L.: In Flux Veritas: Contributions to the Development of in vivo 13 C MRS. 1996 DOI: 10.1002/9780470034590.emrhp1067.
- The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsyPetroff O, Rothman D, Behar K, Lamoureux D, Mattson R. The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy. Annals Of Neurology 1996, 39: 95-99. PMID: 8572673, DOI: 10.1002/ana.410390114.
- In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.Shulman R, Bloch G, Rothman D. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8535-8542. PMID: 7567971, PMCID: PMC41002, DOI: 10.1073/pnas.92.19.8535.
- Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human BrainPetroff O, Rothman D, Behar K, Mattson R. Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain. Epilepsia 1995, 36: 457-464. PMID: 7614922, DOI: 10.1111/j.1528-1157.1995.tb00486.x.
- Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentrationMagnusson I, Rothman D, Gerard D, Katz L, Shulman G. Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration. Diabetes 1995, 44: 185-189. DOI: 10.2337/diabetes.44.2.185.
- In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance SpectroscopyNovotny E, Avison M, Herschkowitz N, Petroff O, Prichard J, Seashore M, Rothman D. In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance Spectroscopy. Pediatric Research 1995, 37: 244-249. PMID: 7731764, DOI: 10.1203/00006450-199502000-00020.
- Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopyMattson R, Petroff O, Rothman D, Behar K. Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy. Acta Neurologica Scandinavica. Supplementum 1995, 92: 27-30. PMID: 7495186, DOI: 10.1111/j.1600-0404.1995.tb00496.x.
- Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMRMason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.
- NMR studies of human brain functionShulman R, Rothman D, Blamire A. NMR studies of human brain function. Trends In Biochemical Sciences 1994, 19: 522-526. PMID: 7846759, DOI: 10.1016/0968-0004(94)90050-7.
- Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance SpectroscopyMattson R, Petroff O, Rothman D, Behar K. Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy. Epilepsia 1994, 35: s29-s32. PMID: 8039467, DOI: 10.1111/j.1528-1157.1994.tb05963.x.
- Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]GlucoseGruetter R, Novotny E, Boulware S, Mason G, Rothman D, Shulman G, Prichard J, Shulman R. Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose. Journal Of Neurochemistry 1994, 63: 1377-1385. PMID: 7931289, DOI: 10.1046/j.1471-4159.1994.63041377.x.
- Analysis of macromolecule resonances in 1H NMR spectra of human brainBehar K, Rothman D, Spencer D, Petroff O. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magnetic Resonance In Medicine 1994, 32: 294-302. PMID: 7984061, DOI: 10.1002/mrm.1910320304.
- Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRSBlamire A, Graham G, Rothman D, Prichard J. Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS. Magnetic Resonance Imaging 1994, 12: 1227-1235. PMID: 7854028, DOI: 10.1016/0730-725x(94)90087-8.
- Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study.Graham G, Blamire A, Rothman D, Brass L, Fayad P, Petroff O, Prichard J. Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study. Stroke 1993, 24: 1891-1896. PMID: 8248973, DOI: 10.1161/01.str.24.12.1891.
- Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation.Chen W, Novotny E, Zhu X, Rothman D, Shulman R. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 9896-9900. PMID: 8234332, PMCID: PMC47679, DOI: 10.1073/pnas.90.21.9896.
- Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.Rothman D, Petroff O, Behar K, Mattson R. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 5662-5666. PMID: 8516315, PMCID: PMC46781, DOI: 10.1073/pnas.90.12.5662.
- Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans.McCarthy G, Blamire A, Rothman D, Gruetter R, Shulman R. Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4952-4956. PMID: 8506340, PMCID: PMC46631, DOI: 10.1073/pnas.90.11.4952.
- Nuclear magnetic resonance imaging and spectroscopy of human brain function.Shulman R, Blamire A, Rothman D, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 3127-3133. PMID: 8475050, PMCID: PMC46253, DOI: 10.1073/pnas.90.8.3127.
- NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged IschemiaHossmann K, Behar K, Rothman D. NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia. 1993, 57: 21-29. PMID: 8421952, DOI: 10.1007/978-3-7091-9266-5_3.
- Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance SpectroscopyPetroff O, Novotny E, Avison M, Rothman D, Alger J, Ogino T, Shulman G, Prichard J. Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 1022-1029. PMID: 1400641, DOI: 10.1038/jcbfm.1992.139.
- Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brainGruetter R, Rothman D, Novotny E, Shulman G, Prichard J, Shulman R. Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brain. Magnetic Resonance In Medicine 1992, 27: 183-188. PMID: 1435204, DOI: 10.1002/mrm.1910270118.
- Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes.Petroff O, Graham G, Blamire A, Al-Rayess M, Rothman D, Fayad P, Brass L, Shulman R, Prichard J. Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology 1992, 42: 1349-54. PMID: 1620345, DOI: 10.1212/wnl.42.7.1349.
- Localized 13C NMR spectroscopy of myo‐inositol in the human brain in vivoGruetter R, Rothman D, Novotny E, Hulman R. Localized 13C NMR spectroscopy of myo‐inositol in the human brain in vivo. Magnetic Resonance In Medicine 1992, 25: 204-210. PMID: 1593953, DOI: 10.1002/mrm.1910250121.
- Localized 1H NMR spectra of glutamate in the human brainRothman D, Hanstock C, Petroff O, Novotny E, Prichard J, Shulman R. Localized 1H NMR spectra of glutamate in the human brain. Magnetic Resonance In Medicine 1992, 25: 94-106. PMID: 1350656, DOI: 10.1002/mrm.1910250110.
- NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat BrainMason G, Rothman D, Behar K, Shulman R. NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 434-447. PMID: 1349022, DOI: 10.1038/jcbfm.1992.61.
- NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat BrainMason G, Behar K, Rothman D, Shulman R. NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 448-455. PMID: 1569138, DOI: 10.1038/jcbfm.1992.62.
- Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients.Graham G, Blamire A, Howseman A, Rothman D, Fayad P, Brass L, Petroff O, Shulman R, Prichard J. Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke 1992, 23: 333-340. PMID: 1542892, DOI: 10.1161/01.str.23.3.333.
- 1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man.Avison M, Rothman D, Nixon T, Long W, Siegel N. 1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 6053-6057. PMID: 2068084, PMCID: PMC52020, DOI: 10.1073/pnas.88.14.6053.
- Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, Howseman A, Hanstock C, Shulman R. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 5829-5831. PMID: 2062861, PMCID: PMC51971, DOI: 10.1073/pnas.88.13.5829.
- Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMRPan J, Hamm J, Hetherington H, Rothman D, Shulman R. Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMR. Magnetic Resonance In Medicine 1991, 20: 57-65. PMID: 1943662, DOI: 10.1002/mrm.1910200107.
- 13C-NMR measurements of muscle glycogen during low-intensity exercisePrice T, Rothman D, Avison M, Buonamico P, Shulman R. 13C-NMR measurements of muscle glycogen during low-intensity exercise. Journal Of Applied Physiology 1991, 70: 1836-1844. PMID: 2055862, DOI: 10.1152/jappl.1991.70.4.1836.
- High Resolution NMR Studies of Cerebral Glucose Metabolism in Rats and HumansShulman R, Rothman D, Behar K, Prichard J. High Resolution NMR Studies of Cerebral Glucose Metabolism in Rats and Humans. 1991, 291: 5-8. PMID: 1927690, DOI: 10.1007/978-1-4684-5931-9_2.
- Direct carbon versus proton heteronuclear editing of 2‐13C ethanol in rabbit brain in vivo: A sensitivity comparisonNovotny E, Ogino T, Rothman D, Petroff O, Prichard J, Shulman R. Direct carbon versus proton heteronuclear editing of 2‐13C ethanol in rabbit brain in vivo: A sensitivity comparison. Magnetic Resonance In Medicine 1990, 16: 431-443. PMID: 2077334, DOI: 10.1002/mrm.1910160310.
- 13C NMR relaxation times of hepatic glycogen in vitro and in vivo.Zang L, Laughlin M, Rothman D, Shulman R. 13C NMR relaxation times of hepatic glycogen in vitro and in vivo. Biochemistry 1990, 29: 6815-20. PMID: 2397215, DOI: 10.1021/bi00481a009.
- Proton NMR Observation of Phenylalanine and an Aromatic Metabolite in the Rabbit Brain in VivoAvison M, Herschkowitz N, Novotny E, Petroff O, Rothman D, Colombo J, Bachmann C, Shulman R, Prichard J. Proton NMR Observation of Phenylalanine and an Aromatic Metabolite in the Rabbit Brain in Vivo. Pediatric Research 1990, 27: 566-570. PMID: 2162514, DOI: 10.1203/00006450-199006000-00005.
- Measurement of ethanol in the human brain using NMR spectroscopy.Hanstock C, Rothman D, Shulman R, Novotny E, Petroff O, Prichard J. Measurement of ethanol in the human brain using NMR spectroscopy. Journal Of Studies On Alcohol And Drugs 1990, 51: 104-7. PMID: 2308346, DOI: 10.15288/jsa.1990.51.104.
- 1H NMR visibility of mammalian glycogen in solution.Zang L, Rothman D, Shulman R. 1H NMR visibility of mammalian glycogen in solution. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 1678-1680. PMID: 2308928, PMCID: PMC53545, DOI: 10.1073/pnas.87.5.1678.
- NMR Spectroscopic Investigation of the Recovery of Energy and Acid—Base Homeostasis in the Cat Brain after Prolonged IschemiaBehar K, Rothman D, Hossmann K. NMR Spectroscopic Investigation of the Recovery of Energy and Acid—Base Homeostasis in the Cat Brain after Prolonged Ischemia. Cerebrovascular And Brain Metabolism Reviews 1989, 9: 655-665. PMID: 2777935, DOI: 10.1038/jcbfm.1989.93.
- Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle.Jue T, Rothman D, Tavitian B, Shulman R. Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 1439-1442. PMID: 2922392, PMCID: PMC286711, DOI: 10.1073/pnas.86.5.1439.
- A fully localized 1H homonuclear editing sequence to observe lactate in human skeletal muscle after exerciseHetherington H, Hamm J, Pan J, Rothman D, Shulman R. A fully localized 1H homonuclear editing sequence to observe lactate in human skeletal muscle after exercise. Journal Of Magnetic Resonance (1969) 1989, 82: 86-96. DOI: 10.1016/0022-2364(89)90167-4.
- Volume localization with a single surface coilPan J, Hetherington H, Hamm J, Rothman D, Shulman R. Volume localization with a single surface coil. Journal Of Magnetic Resonance (1969) 1989, 81: 608-616. DOI: 10.1016/0022-2364(89)90101-7.
- Intracellular pH in human skeletal muscle by 1H NMR.Pan J, Hamm J, Rothman D, Shulman R. Intracellular pH in human skeletal muscle by 1H NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 7836-7839. PMID: 3186694, PMCID: PMC282291, DOI: 10.1073/pnas.85.21.7836.
- Volume-selected proton spectroscopy in the human brainHanstock C, Rothman D, Jue T, Shulman R. Volume-selected proton spectroscopy in the human brain. Journal Of Magnetic Resonance (1969) 1988, 77: 583-588. DOI: 10.1016/0022-2364(88)90018-2.
- Spatially localized 1H NMR spectra of metabolites in the human brain.Hanstock C, Rothman D, Prichard J, Jue T, Shulman R. Spatially localized 1H NMR spectra of metabolites in the human brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 1821-1825. PMID: 3162309, PMCID: PMC279871, DOI: 10.1073/pnas.85.6.1821.
- Detection of human muscle glycogen by natural abundance 13C NMR.Avison M, Rothman D, Nadel E, Shulman R. Detection of human muscle glycogen by natural abundance 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 1634-1636. PMID: 3422752, PMCID: PMC279828, DOI: 10.1073/pnas.85.5.1634.
- Surface coil localization of 31P NMR signals from orthotopic human kidney and liver.Jue T, Rothman D, Lohman J, Hughes E, Hanstock C, Shulman R. Surface coil localization of 31P NMR signals from orthotopic human kidney and liver. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 971-974. PMID: 3422493, PMCID: PMC279682, DOI: 10.1073/pnas.85.4.971.
- Combined 1H and 31P NMR Studies of the Rat Brain in Vivo: Effects of Altered Intracellular pH on MetabolismaBEHAR K, ROTHMAN D, FITZPATRICK S, HETHERINGTON H, SHULMAN R. Combined 1H and 31P NMR Studies of the Rat Brain in Vivo: Effects of Altered Intracellular pH on Metabolisma. Annals Of The New York Academy Of Sciences 1987, 508: 81-88. PMID: 3125776, DOI: 10.1111/j.1749-6632.1987.tb32896.x.
- Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies.Petroff O, Prichard J, Behar K, Rothman D, Alger J, Shulman R. Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies. Neurology 1985, 35: 1681-8. PMID: 2933595, DOI: 10.1212/wnl.35.12.1681.
- Phase cycling of composite refocusing pulses to eliminate dispersive refocusing magnetizationHetherington H, Rothman D. Phase cycling of composite refocusing pulses to eliminate dispersive refocusing magnetization. Journal Of Magnetic Resonance (1969) 1985, 65: 348-354. DOI: 10.1016/0022-2364(85)90017-4.
- 1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.Rothman D, Behar K, Hetherington H, Hollander J, Bendall M, Petroff O, Shulman R. 1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 1633-1637. PMID: 2858850, PMCID: PMC397326, DOI: 10.1073/pnas.82.6.1633.
- Application of multipulse NMR to observe 13C‐labeled metabolites in biological systemsBendall M, Hollander J, Arias‐Mendoza F, Rothman D, Behar K, Shulman R. Application of multipulse NMR to observe 13C‐labeled metabolites in biological systems. Magnetic Resonance In Medicine 1985, 2: 56-64. PMID: 3831677, DOI: 10.1002/mrm.1910020107.
- A pulse sequence for simplifying hydrogen NMR spectra of biological tissuesRothman D, Arias-Mendoza F, Shulman G, Shulman R. A pulse sequence for simplifying hydrogen NMR spectra of biological tissues. Journal Of Magnetic Resonance (1969) 1984, 60: 430-436. DOI: 10.1016/0022-2364(84)90054-4.
- Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs.Neurohr K, Gollin G, Neurohr J, Rothman D, Shulman R. Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs. Biochemistry 1984, 23: 5029-35. PMID: 6498174, DOI: 10.1021/bi00316a031.
- Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo.Rothman D, Behar K, Hetherington H, Shulman R. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6330-6334. PMID: 6149543, PMCID: PMC391917, DOI: 10.1073/pnas.81.20.6330.
- Surface coil spin-echo spectra without cycling the refocusing pulse through all four phasesRothman D, Behar K, Hollander J, Shulman R. Surface coil spin-echo spectra without cycling the refocusing pulse through all four phases. Journal Of Magnetic Resonance (1969) 1984, 59: 157-159. DOI: 10.1016/0022-2364(84)90294-4.
- Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).Behar K, Rothman D, Shulman R, Petroff O, Prichard J. Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T). Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 2517-2519. PMID: 6585812, PMCID: PMC345093, DOI: 10.1073/pnas.81.8.2517.
- Natural-abundance 13C NMR measurement of hepatic glycogen in the living rabbitAlger J, Behar K, Rothman D, Shulman R. Natural-abundance 13C NMR measurement of hepatic glycogen in the living rabbit. Journal Of Magnetic Resonance (1969) 1984, 56: 334-337. DOI: 10.1016/0022-2364(84)90112-4.
Clinical Trials
Conditions | Study Title |
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Diabetes Mellitus - Type 1; Diseases of the Endocrine System; Diseases of the Nervous System | Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM |