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Ellen J. Hoffman, MD, PhD

Associate Professor in the Child Study Center

Research & Publications
Biography
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Selected Publications

Signaling Pathways and Sex Differential Processes in Autism Spectrum DisorderEnriquez KD, Gupta AR, Hoffman EJ. Signaling Pathways and Sex Differential Processes in Autism Spectrum Disorder Frontiers In Psychiatry 2021, 12: 716673. PMID: 34690830, PMCID: PMC8531220, DOI: 10.3389/fpsyt.2021.716673.
PTEN mutations in autism spectrum disorder and congenital hydrocephalus: developmental pleiotropy and therapeutic targetsDeSpenza T, Carlson M, Panchagnula S, Robert S, Duy PQ, Mermin-Bunnell N, Reeves BC, Kundishora A, Elsamadicy AA, Smith H, Ocken J, Alper SL, Jin SC, Hoffman EJ, Kahle KT. PTEN mutations in autism spectrum disorder and congenital hydrocephalus: developmental pleiotropy and therapeutic targets Trends In Neurosciences 2021, 44: 961-976. PMID: 34625286, PMCID: PMC8692171, DOI: 10.1016/j.tins.2021.08.007.
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypesKroll F, Powell GT, Ghosh M, Gestri G, Antinucci P, Hearn TJ, Tunbak H, Lim S, Dennis HW, Fernandez JM, Whitmore D, Dreosti E, Wilson SW, Hoffman EJ, Rihel J. A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes ELife 2021, 10: e59683. PMID: 33416493, PMCID: PMC7793621, DOI: 10.7554/elife.59683.
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalusJin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus Nature Medicine 2020, 26: 1754-1765. PMID: 33077954, PMCID: PMC7871900, DOI: 10.1038/s41591-020-1090-2.
Chapter 26 Modeling autism spectrum disorders in zebrafishDreosti E, Hoffman E, Rihel J. Chapter 26 Modeling autism spectrum disorders in zebrafish 2020, 451-480. DOI: 10.1016/b978-0-12-817528-6.00026-7.
De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette’s Disorder and AutismCappi C, Oliphant ME, Péter Z, Zai G, Conceição do Rosário M, Sullivan CAW, Gupta AR, Hoffman EJ, Virdee M, Olfson E, Abdallah SB, Willsey AJ, Shavitt RG, Miguel EC, Kennedy JL, Richter MA, Fernandez TV. De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette’s Disorder and Autism Biological Psychiatry 2019, 87: 1035-1044. PMID: 31771860, PMCID: PMC7160031, DOI: 10.1016/j.biopsych.2019.09.029.
RESEARCH SYMPOSIUM: ADVANCES IN THE GENETICS OF NEURODEVELOPMENTAL DISORDERS: TRANSLATING FINDINGS TO THE CLINICHoffman E, Cochran D. RESEARCH SYMPOSIUM: ADVANCES IN THE GENETICS OF NEURODEVELOPMENTAL DISORDERS: TRANSLATING FINDINGS TO THE CLINIC Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: s315. DOI: 10.1016/j.jaac.2019.07.727.
Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and FutureSakai C, Ijaz S, Hoffman EJ. Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and Future Frontiers In Molecular Neuroscience 2018, 11: 294. PMID: 30210288, PMCID: PMC6123572, DOI: 10.3389/fnmol.2018.00294.
18.0 Molecular and Genetic Mechanisms in Autism: From Bench to BedsideHoffman E, State M. 18.0 Molecular and Genetic Mechanisms in Autism: From Bench to Bedside Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 56: s329. DOI: 10.1016/j.jaac.2017.07.679.
13.0 Neurogenetic Syndromes Associated With Autism Spectrum Disorder: Three Syndromes That Include Atypical Social InteractionPalumbo M, McDougle C, Hoffman E. 13.0 Neurogenetic Syndromes Associated With Autism Spectrum Disorder: Three Syndromes That Include Atypical Social Interaction Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 56: s19. DOI: 10.1016/j.jaac.2017.07.075.
Assessing Risk: Gene DiscoveryFernandez TV, Gupta AR, Hoffman EJ. Assessing Risk: Gene Discovery. In Lewis’s Child and Adolescent Psychiatry: A Comprehensive Textbook, 5th Edition, Eds. Martin, A, Bloch, MH, Volkmar FR. Philadelphia: Wolters Kluwers, 2017.
20.0 Molecular and Genetic Mechanisms in Autism Spectrum Disorder: From Bench to BedsideHoffman E, State M. 20.0 Molecular and Genetic Mechanisms in Autism Spectrum Disorder: From Bench to Bedside Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: s288. DOI: 10.1016/j.jaac.2016.07.231.
20.3 ZEBRAFISH MODELS OF AUTISM-RISK GENES AS A PATH TOWARD DRUG DISCOVERYHoffman E. 20.3 ZEBRAFISH MODELS OF AUTISM-RISK GENES AS A PATH TOWARD DRUG DISCOVERY Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: s289. DOI: 10.1016/j.jaac.2016.07.234.
5.32 A ZEBRAFISH MODEL FOR IDENTIFYING COMMON BIOLOGICAL MECHANISMS AND PHARMACOLOGICAL PATHWAYS IN AUTISM SPECTRUM DISORDERSIjaz S, Ghosh M, Wilson S, Rihel J, Giraldez A, State M, Hoffman E. 5.32 A ZEBRAFISH MODEL FOR IDENTIFYING COMMON BIOLOGICAL MECHANISMS AND PHARMACOLOGICAL PATHWAYS IN AUTISM SPECTRUM DISORDERS Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: s194. DOI: 10.1016/j.jaac.2016.09.291.
Zebrafish: A Translational Model System for Studying Neuropsychiatric DisordersIjaz S, Hoffman EJ. Zebrafish: A Translational Model System for Studying Neuropsychiatric Disorders Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 746-748. PMID: 27566113, PMCID: PMC5521170, DOI: 10.1016/j.jaac.2016.06.008.
Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJ, Wilson SW, Rihel J, State MW, Giraldez AJ. Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2 Neuron 2016, 89: 725-733. PMID: 26833134, PMCID: PMC4766582, DOI: 10.1016/j.neuron.2015.12.039.
Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of AutismWillsey AJ, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K, Devlin B, Sestan N, State MW. Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism Cell 2013, 155: 997-1007. PMID: 24267886, PMCID: PMC3995413, DOI: 10.1016/j.cell.2013.10.020.
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA) Nature Methods 2010, 8: 67-69. PMID: 21151135, PMCID: PMC3018472, DOI: 10.1038/nmeth.1542.
Progress in Cytogenetics: Implications for Child PsychopathologyHoffman EJ, State MW. Progress in Cytogenetics: Implications for Child Psychopathology Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 736-751. PMID: 20643309, DOI: 10.1016/j.jaac.2010.03.016.
Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons.Hoffman EJ, Mintz CD, Wang S, McNickle DG, Salton SR, Benson DL. Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons. Neuroscience 2008, 157: 556-65. PMID: 18926887, PMCID: PMC2626542, DOI: 10.1016/j.neuroscience.2008.08.071.
Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: efficient identification of known microduplications and identification of a novel microduplication in ASMT.Cai G, Edelmann L, Goldsmith JE, Cohen N, Nakamine A, Reichert JG, Hoffman EJ, Zurawiecki DM, Silverman JM, Hollander E, Soorya L, Anagnostou E, Betancur C, Buxbaum JD. Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: efficient identification of known microduplications and identification of a novel microduplication in ASMT. BMC Medical Genomics 2008, 1: 50. PMID: 18925931, PMCID: PMC2588447, DOI: 10.1186/1755-8794-1-50.
A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders.Sakurai T, Reichert J, Hoffman EJ, Cai G, Jones HB, Faham M, Buxbaum JD. A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders. Autism Research : Official Journal Of The International Society For Autism Research 2008, 1: 251-7. PMID: 19360675, PMCID: PMC2678895, DOI: 10.1002/aur.30.
Anxiety disorders: a comprehensive review of pharmacotherapies.Hoffman EJ, Mathew SJ. Anxiety disorders: a comprehensive review of pharmacotherapies. The Mount Sinai Journal Of Medicine, New York 2008, 75: 248-62. PMID: 18704983, DOI: 10.1002/msj.20041.
Mathew, SJ, Hoffman, EJ, & Charney, DS. Pharmacotherapy of Anxiety Disorders. In Neurobiology of Mental Illness, 3rd Ed., Eds. Charney, D.S. & Nestler E.J. Oxford, Oxford University Press, 2009: 731-754Mathew, SJ, Hoffman, EJ, & Charney, DS. Pharmacotherapy of Anxiety Disorders. In Neurobiology of Mental Illness, 3rd Ed., Eds. Charney, D.S. & Nestler E.J. Oxford, Oxford University Press, 2009: 731-754

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Ellen J. Hoffman, MD, PhD

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Research & Publications

Biography

News

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Selected Publications