Catharine Duman, PhD
Associate Research Scientist in Psychiatry
Research & Publications
Biography
News
Coauthors
Selected Publications
- Distinct downstream targets of the medial prefrontal cortex underlie discrete antidepressant responses to ketamineShinohara R, Hare B, Liu R, Li J, Li X, Duman C, DiLeone R, Duman R. Distinct downstream targets of the medial prefrontal cortex underlie discrete antidepressant responses to ketamine. Proceedings For Annual Meeting Of The Japanese Pharmacological Society 2022, 95: 1-o-011. DOI: 10.1254/jpssuppl.95.0_1-o-011.
- Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulationFukumoto K, Fogaça M, Liu RJ, Duman CH, Li XY, Chaki S, Duman RS. Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation. Neuropsychopharmacology 2020, 45: 1725-1734. PMID: 32396921, PMCID: PMC7419563, DOI: 10.1038/s41386-020-0705-0.
- GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actionsGerhard DM, Pothula S, Liu RJ, Wu M, Li XY, Girgenti MJ, Taylor SR, Duman CH, Delpire E, Picciotto M, Wohleb ES, Duman RS. GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions. Journal Of Clinical Investigation 2020, 130: 1336-1349. PMID: 31743111, PMCID: PMC7269589, DOI: 10.1172/jci130808.
- Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodentsGhosal S, Duman CH, Liu RJ, Wu M, Terwilliger R, Girgenti MJ, Wohleb E, Fogaca MV, Teichman EM, Hare B, Duman RS. Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents. Neurobiology Of Disease 2019, 134: 104669. PMID: 31707118, DOI: 10.1016/j.nbd.2019.104669.
- N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effectsFogaça MV, Fukumoto K, Franklin T, Liu RJ, Duman CH, Vitolo OV, Duman RS. N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects. Neuropsychopharmacology 2019, 44: 2230-2238. PMID: 31454827, PMCID: PMC6898593, DOI: 10.1038/s41386-019-0501-x.
- Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activationKato T, Pothula S, Liu RJ, Duman CH, Terwilliger R, Vlasuk GP, Saiah E, Hahm S, Duman RS. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. Journal Of Clinical Investigation 2019, 129: 2542-2554. PMID: 30990795, PMCID: PMC6546461, DOI: 10.1172/jci126859.
- Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamineFukumoto K, Fogaça M, Liu RJ, Duman C, Kato T, Li XY, Duman RS. Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 116: 297-302. PMID: 30559184, PMCID: PMC6320534, DOI: 10.1073/pnas.1814709116.
- Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like BehaviorWohleb ES, Terwilliger R, Duman CH, Duman RS. Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior. Biological Psychiatry 2017, 83: 38-49. PMID: 28697890, PMCID: PMC6506225, DOI: 10.1016/j.biopsych.2017.05.026.
- GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from KetamineLiu RJ, Duman C, Kato T, Hare B, Lopresto D, Bang E, Burgdorf J, Moskal J, Taylor J, Aghajanian G, Duman RS. GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine. Neuropsychopharmacology 2016, 42: 1231-1242. PMID: 27634355, PMCID: PMC5437877, DOI: 10.1038/npp.2016.202.
- Spine synapse remodeling in the pathophysiology and treatment of depressionDuman CH, Duman RS. Spine synapse remodeling in the pathophysiology and treatment of depression. Neuroscience Letters 2015, 601: 20-29. PMID: 25582786, PMCID: PMC4497940, DOI: 10.1016/j.neulet.2015.01.022.
- REDD1 is essential for stress-induced synaptic loss and depressive behaviorOta KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine 2014, 20: 531-535. PMID: 24728411, PMCID: PMC4016190, DOI: 10.1038/nm.3513.
- Evaluating Effects of EPO in Rodent Behavioral Assays Related to DepressionDuman C, Newton S. Evaluating Effects of EPO in Rodent Behavioral Assays Related to Depression. 2013, 982: 127-140. PMID: 23456866, DOI: 10.1007/978-1-62703-308-4_8.
- Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female ratsHermes G, Li N, Duman C, Duman R. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiology & Behavior 2010, 104: 354-359. PMID: 21185848, PMCID: PMC3387788, DOI: 10.1016/j.physbeh.2010.12.019.
- Chapter One Models of DepressionDuman C. Chapter One Models of Depression. 2010, 82: 1-21. PMID: 20472130, DOI: 10.1016/s0083-6729(10)82001-1.
- Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral EffectsGirgenti MJ, Hunsberger J, Duman CH, Sathyanesan M, Terwilliger R, Newton SS. Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects. Biological Psychiatry 2009, 66: 267-274. PMID: 19185286, DOI: 10.1016/j.biopsych.2008.12.005.
- Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exerciseDuman CH, Schlesinger L, Terwilliger R, Russell DS, Newton SS, Duman RS. Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise. Behavioural Brain Research 2008, 198: 366-371. PMID: 19056428, PMCID: PMC2729431, DOI: 10.1016/j.bbr.2008.11.016.
- Corrigendum to “Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice” [Brain Res. 1199 (2008) 148–158]Duman C, Schlesinger L, Russell D, Duman R. Corrigendum to “Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice” [Brain Res. 1199 (2008) 148–158]. Brain Research 2008, 1218: 313. DOI: 10.1016/j.brainres.2008.04.053.
- Voluntary exercise produces antidepressant and anxiolytic behavioral effects in miceDuman CH, Schlesinger L, Russell DS, Duman RS. Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Research 2008, 1199: 148-158. PMID: 18267317, PMCID: PMC2330082, DOI: 10.1016/j.brainres.2007.12.047.
- Antidepressant actions of the exercise-regulated gene VGFHunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS. Antidepressant actions of the exercise-regulated gene VGF. Nature Medicine 2007, 13: 1476-1482. PMID: 18059283, DOI: 10.1038/nm1669.
- A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant TreatmentDuman CH, Schlesinger L, Kodama M, Russell DS, Duman RS. A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment. Biological Psychiatry 2006, 61: 661-670. PMID: 16945347, DOI: 10.1016/j.biopsych.2006.05.047.
- TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor TargetingSimen BB, Duman CH, Simen AA, Duman RS. TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting. Biological Psychiatry 2006, 59: 775-785. PMID: 16458261, DOI: 10.1016/j.biopsych.2005.10.013.
- Neurobiology and Treatment of Anxiety: Signal Transduction and Neural PlasticityDuman C, Duman R. Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity. 2005, 169: 305-334. PMID: 16594263, DOI: 10.1007/3-540-28082-0_11.
- Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocainePeakman M, Colby C, Perrotti L, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen M, Stock J, Duman R, McNeish J, Barrot M, Self D, Nestler E, Schaeffer E. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Research 2003, 970: 73-86. PMID: 12706249, DOI: 10.1016/s0006-8993(03)02230-3.
- Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brainCaldarone B, Duman C, Picciotto M. Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain. Neuropharmacology 2000, 39: 2779-2784. PMID: 11044747, DOI: 10.1016/s0028-3908(00)00137-4.
- Short-latency interneurons in the dorsal nucleus of the little skate, Raja erinaceaDuman C. Short-latency interneurons in the dorsal nucleus of the little skate, Raja erinacea. Brain Research 1997, 771: 80-88. PMID: 9383011, DOI: 10.1016/s0006-8993(97)00859-7.
- Distinct but Overlapping Populations of Commissural and GABAergic Neurons in the Dorsal Nucleus of the Little Skate, Raja erinaceaDuman C, Bodznick D. Distinct but Overlapping Populations of Commissural and GABAergic Neurons in the Dorsal Nucleus of the Little Skate, Raja erinacea. Brain Behavior And Evolution 1997, 49: 99-109. PMID: 9031733, DOI: 10.1159/000112984.
- A role for GABAergic inhibition in electrosensory processing and common mode rejection in the dorsal nucleus of the little skate, Raja erinaceaDuman C, Bodznick D. A role for GABAergic inhibition in electrosensory processing and common mode rejection in the dorsal nucleus of the little skate, Raja erinacea. Journal Of Comparative Physiology A 1996, 179: 797-807. PMID: 8956498, DOI: 10.1007/bf00207358.