The glucocorticoid receptor is found in nearly every cell type. It is the receptor for the body's endogenous steroid (cortisol) as well as for the many synthetic steroids (prednisone, dexamethasone) that are used therapeutically for a variety of conditions. Studies have clearly shown that this receptor has tissue-specific functions and that loss of the receptor in specific tissuess produces profound and unexpected phenotypes. I am interested in determining the role of this receptor in the endothelium, and more recently, in podocytes, the specialized cells which maintain the filtration barrier in the kdiney.
Specialized Terms: Glucocorticoid-induced hypertension; Vascular endothelial glucocorticoid receptor; Steroids and sepsis; Atherosclerosis; Podocyte glucocorticoid receptor and nephrotic syndrome
Fibrosis; Glucocorticoids; Hypertension; Inflammation; Nephrology; Nephrotic Syndrome; Pediatrics; Steroids; Sepsis; Atherosclerosis; Wnt Signaling Pathway