Julie Goodwin, MD
Associate Professor of Pediatrics (Nephrology); Section Chief, Pediatric Nephrology; Fellowship Program Director
Research & Publications
Biography
News
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Research Summary
The glucocorticoid receptor is found in nearly every cell type. It is the receptor for the body's endogenous steroid (cortisol) as well as for the many synthetic steroids (prednisone, dexamethasone) that are used therapeutically for a variety of conditions. Studies have clearly shown that this receptor has tissue-specific functions and that loss of the receptor in specific tissuess produces profound and unexpected phenotypes. I am interested in determining the role of this receptor in the endothelium, and more recently, in podocytes, the specialized cells which maintain the filtration barrier in the kdiney.
Specialized Terms: Glucocorticoid-induced hypertension; Vascular endothelial glucocorticoid receptor; Steroids and sepsis; Atherosclerosis; Podocyte glucocorticoid receptor and nephrotic syndrome
Extensive Research Description
- Characterization and mechanism of glucocorticoid-induced hypertension in several mouse models with tissue-specific knockout of the glucocorticoid receptor
- Effect of the knockout of the glucocorticoid receptor in the endothelium in a mouse model of LPS-induced sepsis, with and without steroid treatment
- Role of the endothelial glucocorticoid receptor in the development of atherosclerosis and vascular inflammation
- Role of the podocyte glucocorticoid receptor in the development of nephrotic syndrome
- Endothelial GR control of the Wnt signaling pathway
- Efndothelial-podocyte crosstalk in renal fibrosis and cardiorenal disease
Coauthors
Research Interests
Fibrosis; Glucocorticoids; Hypertension; Inflammation; Nephrology; Nephrotic Syndrome; Pediatrics; Steroids; Sepsis; Atherosclerosis; Wnt Signaling Pathway
Selected Publications
- Endothelial Dysfunction in Cardiorenal Conditions: Implications of Endothelial Glucocorticoid Receptor-Wnt SignalingAkhter M, Goodwin J. Endothelial Dysfunction in Cardiorenal Conditions: Implications of Endothelial Glucocorticoid Receptor-Wnt Signaling. International Journal Of Molecular Sciences 2023, 24: 14261. PMID: 37762564, PMCID: PMC10531724, DOI: 10.3390/ijms241814261.
- Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db miceSrivastava S, Goodwin J. Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice. American Journal Of Physiology. Renal Physiology 2023, 325: f519-f526. PMID: 37589053, DOI: 10.1152/ajprenal.00105.2023.
- Endothelial Dysfunction and Vascular Remodeling in HypertensionGoodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2023, 195-215. DOI: 10.1007/978-3-031-06231-5_41.
- Endothelial Dysfunction and Vascular Remodeling in HypertensionGoodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2022, 1-21. DOI: 10.1007/978-3-319-31420-4_41-2.
- Fanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? QuestionsNugent JT, Reardon J, Crana C, Greenberg JH, Warejko JK, Goodwin JE. Fanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? Questions. Pediatric Nephrology 2021, 37: 127-128. PMID: 34633531, DOI: 10.1007/s00467-021-05247-w.
- Fanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? AnswersNugent JT, Reardon J, Crana C, Greenberg JH, Warejko JK, Goodwin JE. Fanconi syndrome, nephrotic-range proteinuria, and hypoalbuminemia in a newborn—Occam’s razor or Hickam’s dictum? Answers. Pediatric Nephrology 2021, 37: 129-132. PMID: 34633532, DOI: 10.1007/s00467-021-05255-w.
- Coronavirus Disease (COVID)-19 and Diabetic Kidney DiseaseSrivastava SP, Srivastava R, Chand S, Goodwin JE. Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease. Pharmaceuticals 2021, 14: 751. PMID: 34451848, PMCID: PMC8398861, DOI: 10.3390/ph14080751.
- Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes MellitusSrivastava SP, Zhou H, Setia O, Dardik A, Fernandez‐Hernando C, Goodwin J. Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus. Journal Of The American Heart Association 2021, 10: e019437. PMID: 34308664, PMCID: PMC8475689, DOI: 10.1161/jaha.120.019437.
- Editorial: Combating Diabetes and Diabetic Kidney DiseaseSrivastava SP, Kanasaki K, Goodwin JE. Editorial: Combating Diabetes and Diabetic Kidney Disease. Frontiers In Pharmacology 2021, 12: 716029. PMID: 34305620, PMCID: PMC8295890, DOI: 10.3389/fphar.2021.716029.
- Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney DiseaseSrivastava SP, Goodwin JE, Tripathi P, Kanasaki K, Koya D. Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease. International Journal Of Molecular Sciences 2021, 22: 6027. PMID: 34199672, PMCID: PMC8199750, DOI: 10.3390/ijms22116027.
- Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathySrivastava SP, Zhou H, Setia O, Liu B, Kanasaki K, Koya D, Dardik A, Fernandez-Hernando C, Goodwin J. Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy. Nature Communications 2021, 12: 2368. PMID: 33888696, PMCID: PMC8062600, DOI: 10.1038/s41467-021-22617-y.
- Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneysSrivastava SP, Li J, Takagaki Y, Kitada M, Goodwin JE, Kanasaki K, Koya D. Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys. IScience 2021, 24: 102390. PMID: 33981977, PMCID: PMC8086030, DOI: 10.1016/j.isci.2021.102390.
- Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathwayLiu B, Zhou H, Zhang T, Gao X, Tao B, Xing H, Zhuang Z, Dardik A, Kyriakides TR, Goodwin JE. Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway. Angiogenesis 2021, 24: 631-645. PMID: 33650028, PMCID: PMC8292305, DOI: 10.1007/s10456-021-09773-x.
- Loss of Mitochondrial Control Impacts Renal HealthSrivastava SP, Kanasaki K, Goodwin JE. Loss of Mitochondrial Control Impacts Renal Health. Frontiers In Pharmacology 2020, 11: 543973. PMID: 33362536, PMCID: PMC7756079, DOI: 10.3389/fphar.2020.543973.
- The Effect of Glucocorticoids on Angiogenesis in the Treatment of Solid Tumors.Liu B, Goodwin JE. The Effect of Glucocorticoids on Angiogenesis in the Treatment of Solid Tumors. Journal Of Cellular Signaling 2020, 1: 42-49. PMID: 32728672, PMCID: PMC7388649, DOI: 10.33696/signaling.1.011.
- Metabolic reprogramming by N‐acetyl‐seryl‐aspartyl‐lysyl‐proline protects against diabetic kidney diseaseSrivastava SP, Goodwin JE, Kanasaki K, Koya D. Metabolic reprogramming by N‐acetyl‐seryl‐aspartyl‐lysyl‐proline protects against diabetic kidney disease. British Journal Of Pharmacology 2020, 177: 3691-3711. PMID: 32352559, PMCID: PMC7393199, DOI: 10.1111/bph.15087.
- Cancer Biology and Prevention in DiabetesSrivastava SP, Goodwin JE. Cancer Biology and Prevention in Diabetes. Cells 2020, 9: 1380. PMID: 32498358, PMCID: PMC7349292, DOI: 10.3390/cells9061380.
- Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAsSrivastava SP, Goodwin JE, Kanasaki K, Koya D. Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs. Genes 2020, 11: 211. PMID: 32085655, PMCID: PMC7074526, DOI: 10.3390/genes11020211.
- Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signalingZhou H, Mehta S, Srivastava SP, Grabinska K, Zhang X, Wong C, Hedayat A, Perrotta P, Fernández-Hernando C, Sessa WC, Goodwin JE. Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling. JCI Insight 2020, 5: e131384. PMID: 32051336, PMCID: PMC7098785, DOI: 10.1172/jci.insight.131384.
- The Glucocorticoid Receptor in Cardiovascular Health and DiseaseLiu B, Zhang TN, Knight JK, Goodwin JE. The Glucocorticoid Receptor in Cardiovascular Health and Disease. Cells 2019, 8: 1227. PMID: 31601045, PMCID: PMC6829609, DOI: 10.3390/cells8101227.
- microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the KidneySrivastava SP, Hedayat A, Kanasaki K, Goodwin JE. microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney. Frontiers In Pharmacology 2019, 10: 904. PMID: 31474862, PMCID: PMC6707424, DOI: 10.3389/fphar.2019.00904.
- Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial DepressionZhang TN, Goodwin JE, Liu B, Li D, Wen R, Yang N, Xia J, Zhou H, Zhang T, Song WL, Liu CF. Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression. Molecular Therapy - Nucleic Acids 2019, 17: 852-866. PMID: 31472370, PMCID: PMC6722300, DOI: 10.1016/j.omtn.2019.07.020.
- Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: a Lipopolysaccharide-Induced Rat Septic Shock ModelZhang TN, Yang N, Goodwin JE, Mahrer K, Li D, Xia J, Wen R, Zhou H, Zhang T, Song WL, Liu CF. Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: a Lipopolysaccharide-Induced Rat Septic Shock Model. Inflammation 2019, 42: 1990-2002. PMID: 31332662, DOI: 10.1007/s10753-019-01060-8.
- Role of the glucocorticoid receptor in glomerular diseaseGoodwin JE. Role of the glucocorticoid receptor in glomerular disease. American Journal Of Physiology. Renal Physiology 2019, 317: f133-f136. PMID: 31166704, PMCID: PMC6692724, DOI: 10.1152/ajprenal.00217.2019.
- Diagnosis, Treatment, and Outcomes in Children With Congenital Nephrogenic Diabetes Insipidus: A Pediatric Nephrology Research Consortium Study.D'Alessandri-Silva C, Carpenter M, Ayoob R, Barcia J, Chishti A, Constantinescu A, Dell KM, Goodwin J, Hashmat S, Iragorri S, Kaspar C, Mason S, Misurac JM, Muff-Luett M, Sethna C, Shah S, Weng P, Greenbaum LA, Mahan JD. Diagnosis, Treatment, and Outcomes in Children With Congenital Nephrogenic Diabetes Insipidus: A Pediatric Nephrology Research Consortium Study. Frontiers In Pediatrics 2019, 7: 550. PMID: 32039113, PMCID: PMC6985429, DOI: 10.3389/fped.2019.00550.
- SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosisSrivastava SP, Li J, Kitada M, Fujita H, Yamada Y, Goodwin JE, Kanasaki K, Koya D. SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis. Cell Death & Disease 2018, 9: 997. PMID: 30250024, PMCID: PMC6155322, DOI: 10.1038/s41419-018-1057-0.
- Endothelial Dysfunction and Vascular Remodeling in HypertensionGoodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2018, 205-219. DOI: 10.1007/978-3-319-31107-4_41.
- Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injuryZhou H, Tian X, Tufro A, Moeckel G, Ishibe S, Goodwin J. Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury. Scientific Reports 2017, 7: 9833. PMID: 28852159, PMCID: PMC5575043, DOI: 10.1038/s41598-017-10490-z.
- Endothelial Dysfunction and Vascular Remodeling in HypertensionGoodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2017, 1-16. DOI: 10.1007/978-3-319-31420-4_41-1.
- Endothelial Dysfunction and Vascular Remodeling in HypertensionGoodwin JE. (2017) Endothelial Dysfunction and Vascular Remodeling in Hypertension. In Flynn J, Ingelfinger JR, Redwine K (Eds.) Pediatric Hypertension, Springer International Publishing AG, DOI: 10.1007/978-3-319-31420-4_41-1
- Endothelial Glucocorticoid Receptor Suppresses Atherogenesis—Brief ReportGoodwin JE, Zhang X, Rotllan N, Feng Y, Zhou H, Fernández-Hernando C, Yu J, Sessa WC. Endothelial Glucocorticoid Receptor Suppresses Atherogenesis—Brief Report. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35: 779-782. PMID: 25810297, PMCID: PMC4375730, DOI: 10.1161/atvbaha.114.304525.
- Glucocorticoids and the Cardiovascular System. In: Glucocorticoid Signaling: from Molecules to Mice to ManGoodwin JE. Glucocorticoids and the Cardiovascular System. In: Glucocorticoid Signaling: from Molecules to Mice to Man. J Wang, C Harris eds; 2015: 299-314.
- Glucocorticoids and the Cardiovascular SystemGoodwin JE. Glucocorticoids and the Cardiovascular System. 2015, 872: 299-314. PMID: 26216000, DOI: 10.1007/978-1-4939-2895-8_13.
- Loss of the Endothelial Glucocorticoid Receptor Prevents the Therapeutic Protection Afforded by Dexamethasone after LPSGoodwin JE, Feng Y, Velazquez H, Zhou H, Sessa WC. Loss of the Endothelial Glucocorticoid Receptor Prevents the Therapeutic Protection Afforded by Dexamethasone after LPS. PLOS ONE 2014, 9: e108126. PMID: 25299055, PMCID: PMC4191990, DOI: 10.1371/journal.pone.0108126.
- Abdominal distention and renal failure in a neonateBedri B, Goodwin JE. Abdominal distention and renal failure in a neonate. BMJ Case Reports 2013, 2013: bcr2012007955. PMID: 23429016, PMCID: PMC3604299, DOI: 10.1136/bcr-2012-007955.
- A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemiaGoodwin JE, Palmer M, Pashankar F, Tufro A, Moeckel G. A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia. Clinical Nephrology 2013, 82: 205-210. PMID: 23391318, PMCID: PMC6990651, DOI: 10.5414/cn107767.
- Endothelial glucocorticoid receptor is required for protection against sepsisGoodwin JE, Feng Y, Velazquez H, Sessa WC. Endothelial glucocorticoid receptor is required for protection against sepsis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 110: 306-311. PMID: 23248291, PMCID: PMC3538225, DOI: 10.1073/pnas.1210200110.
- Glucocorticoid-induced hypertensionGoodwin JE, Geller DS. Glucocorticoid-induced hypertension. Pediatric Nephrology 2011, 27: 1059-1066. PMID: 21744056, DOI: 10.1007/s00467-011-1928-4.
- Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertensionGoodwin JE, Zhang J, Gonzalez D, Albinsson S, Geller DS. Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension. Journal Of Hypertension 2011, 29: 1347-1356. PMID: 21659825, PMCID: PMC3439131, DOI: 10.1097/hjh.0b013e328347da54.
- The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertensionGoodwin JE, Zhang J, Velazquez H, Geller DS. The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension. Biochemical And Biophysical Research Communications 2010, 394: 266-271. PMID: 20188070, PMCID: PMC2946623, DOI: 10.1016/j.bbrc.2010.02.123.
- Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*Zhang J, Ge R, Matte-Martone C, Goodwin J, Shlomchik WD, Mamula MJ, Kooshkabadi A, Hardy MP, Geller D. Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*. Journal Of Biological Chemistry 2008, 284: 6249-6259. PMID: 19017639, PMCID: PMC2649105, DOI: 10.1074/jbc.m807997200.
- A Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced HypertensionGoodwin JE, Zhang J, Geller DS. A Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced Hypertension. Journal Of The American Society Of Nephrology 2008, 19: 1291-1299. PMID: 18434569, PMCID: PMC2440298, DOI: 10.1681/asn.2007080911.
- Monogenic Disorders of Blood Pressure Regulation in Handbook of Hypertension Eds.Goodwin, David Geller. Monogenic Disorders of Blood Pressure Regulation in Handbook of Hypertension Eds.. A. F. Dominiczak and J. M. Connell Vol 24, 29-47. 2007.