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Gilbert Moeckel

MD, PhD, FASN

Professor of Pathology; Director, Renal,Transplant Pathology and Electron Microscopy Laboratory, Pathology; Director, Renal & Genitourinary Fellowship Program, Pathology

Contact Information

Gilbert Moeckel, MD, PhD, FASN

Lab Location

Renal Pathology Laboratory
Brady Memorial Laboratory
310 Cedar Street, Ste LB20
New Haven, CT 06510

Office Location

Department of Pathology
Brady Memorial Laboratory
310 Cedar Street, Ste LB20
New Haven, CT 06510
Appointments:203.737.2803
Fax:203.785.3348

Moeckel Lab

Yale Medicine

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Research & Publications
Biography
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Research Summary

My lab studies the molecular mechanisms of acute kidney injury and tubular cell regeneration and the role of intrinsic progenitor cells in repair of acute kidney injury. Moreover, the lab studies the underlying factors that lead to progression of acute kidney injury to chronic kidney disease.

Extensive Research Description

The following projects are currently ongoing in the Moeckel lab:

1. Role of DDT/MIF2 in acute tubular injury repair and regeneration

2. Role of intrinsic progenitor cells/pericytes in tubular injury repair

3. Role of DDT/MIF2 in prevention of progression from AKI to CKD

Coauthors

Research Interests

Diabetic Nephropathies; Fibrosis; Kidney Failure, Chronic; Stem Cell Niche; Acute Kidney Injury

Public Health Interests

Biomarkers; Cardiovascular Diseases; Genetics, Genomics, Epigenetics; Nutrition

Research Image

Glomerulonephritis

This image shows a necrotizing lesion in a human glomerulus, which is the main filtration structure in the kidney. These lesions need to be treated promptly or the patient may loose all kidney function.

Selected Publications

Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritisChen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.
SUN-389 Collagenofibrotic glomerulopathy in kidney transplant recipient: A first reportAbu-Alfa A, Moeckel G, Kfrouy H, Jdiaa S. SUN-389 Collagenofibrotic glomerulopathy in kidney transplant recipient: A first report Kidney International Reports 2020, 5: s359-s360. DOI: 10.1016/j.ekir.2020.02.929.
Polycystin 2 is increased in disease to protect against stress-induced cell deathBrill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE. Polycystin 2 is increased in disease to protect against stress-induced cell death Scientific Reports 2020, 10: 386. PMID: 31941974, PMCID: PMC6962458, DOI: 10.1038/s41598-019-57286-x.
PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosusHan X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus Science Translational Medicine 2019, 11 PMID: 31826980, DOI: 10.1126/scitranslmed.aax1159.
Secretory Leukocyte Protease Inhibitor (SLPI)—A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational StudyAverdunk L, Fitzner C, Levkovich T, Leaf DE, Sobotta M, Vieten J, Ochi A, Moeckel G, Marx G, Stoppe C. Secretory Leukocyte Protease Inhibitor (SLPI)—A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study Journal Of Clinical Medicine 2019, 8: 1931. PMID: 31717603, PMCID: PMC6912354, DOI: 10.3390/jcm8111931.
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction patternRoy SF, Ko CJ, Moeckel GW, Mcniff JM. Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern Journal Of Cutaneous Pathology 2019, 46: 742-747. PMID: 31157457, DOI: 10.1111/cup.13522.
Development of a 2-dimensional atlas of the human kidney with imaging mass cytometrySingh N, Avigan ZM, Kliegel JA, Shuch BM, Montgomery RR, Moeckel GW, Cantley LG. Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry JCI Insight 2019, 4: e129477. PMID: 31217358, PMCID: PMC6629112, DOI: 10.1172/jci.insight.129477.
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritisMoledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.
Regulated necrosis and failed repair in cisplatin-induced chronic kidney diseaseLandau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease Kidney International 2019, 95: 797-814. PMID: 30904067, PMCID: PMC6543531, DOI: 10.1016/j.kint.2018.11.042.
Telavancin-associated acute kidney injury .Cavanaugh C, Moeckel GW, Perazella MA. Telavancin-associated acute kidney injury . Clinical Nephrology 2019, 91: 187-191. PMID: 30614441, DOI: 10.5414/cn109651.
Update on the Native Kidney Biopsy: Core Curriculum 2019Luciano RL, Moeckel GW. Update on the Native Kidney Biopsy: Core Curriculum 2019 American Journal Of Kidney Diseases 2019, 73: 404-415. PMID: 30661724, DOI: 10.1053/j.ajkd.2018.10.011.
Chapter 83 Adaptive Immunity and Critical IllnessSchulte W, Maerz L, Moeckel G, Bucala R. Chapter 83 Adaptive Immunity and Critical Illness 2019, 483-487. DOI: 10.1016/b978-0-323-44942-7.00083-2.
Reliability of deceased‐donor procurement kidney biopsy images uploaded in United Network for Organ SharingMansour SG, Hall IE, Reese PP, Jia Y, Thiessen‐Philbrook H, Moeckel G, Weng FL, Revelo MP, Khalighi MA, Trivedi A, Doshi MD, Schröppel B, Parikh CR. Reliability of deceased‐donor procurement kidney biopsy images uploaded in United Network for Organ Sharing Clinical Transplantation 2018, 32: e13441. PMID: 30387908, PMCID: PMC6317379, DOI: 10.1111/ctr.13441.
TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD—A Novel PresentationGulati A, Bale AE, Dykas DJ, Bia MJ, Danovitch GM, Moeckel GW, Somlo S, Dahl NK. TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD—A Novel Presentation American Journal Of Kidney Diseases 2018, 72: 895-899. PMID: 29941221, DOI: 10.1053/j.ajkd.2018.05.006.
The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgeryStoppe C, Averdunk L, Goetzenich A, Soppert J, Marlier A, Kraemer S, Vieten J, Coburn M, Kowark A, Kim BS, Marx G, Rex S, Ochi A, Leng L, Moeckel G, Linkermann A, El Bounkari O, Zarbock A, Bernhagen J, Djudjaj S, Bucala R, Boor P. The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery Science Translational Medicine 2018, 10 PMID: 29769287, DOI: 10.1126/scitranslmed.aan4886.
Granulomatosis With Polyangiitis in a Young Adult With Down SyndromeMensah KA, Pascha V, Moeckel G, Danve A. Granulomatosis With Polyangiitis in a Young Adult With Down Syndrome JCR Journal Of Clinical Rheumatology 2018, 24: 153-156. PMID: 29200025, DOI: 10.1097/rhu.0000000000000633.
Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatmentLee Y, Blount KL, Dai F, Thompson S, Scher JK, Bitterman S, Droher M, Herzog EL, Moeckel G, Karihaloo A, Dahl NK. Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment Clinical And Experimental Nephrology 2018, 22: 906-916. PMID: 29453607, DOI: 10.1007/s10157-018-1542-x.
Pathologic Perspectives on Acute Tubular Injury Assessment in the Kidney BiopsyMoeckel GW. Pathologic Perspectives on Acute Tubular Injury Assessment in the Kidney Biopsy Seminars In Nephrology 2018, 38: 21-30. PMID: 29291758, DOI: 10.1016/j.semnephrol.2017.09.003.
Severe Orthostatic Hypotension Complicating Multiple MyelomaSury K, Mutter M, Moeckel G, Perazella M. Severe Orthostatic Hypotension Complicating Multiple Myeloma Journal Of Onco-Nephrology 2017, 1: e8-e12. DOI: 10.5301/jo-n.5000029.
Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritisWilson PC, Kashgarian M, Moeckel G. Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis Clinical Kidney Journal 2017, 11: sfx093. PMID: 29644061, PMCID: PMC5888814, DOI: 10.1093/ckj/sfx093.
Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injuryZhou H, Tian X, Tufro A, Moeckel G, Ishibe S, Goodwin J. Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury Scientific Reports 2017, 7: 9833. PMID: 28852159, PMCID: PMC5575043, DOI: 10.1038/s41598-017-10490-z.
A case of severe nephrotoxicity associated with long-term dietary supplement useKoraishy FM, Moeckel GW, Geller DS. A case of severe nephrotoxicity associated with long-term dietary supplement use Clinical Nephrology 2017, 5: 42-47. PMID: 28766491, PMCID: PMC5642467, DOI: 10.5414/cncs109180.
Renal recovery following orthotopic liver transplant after prolonged kidney injury: Perspectives on diagnosing hepatorenal syndrome and determining which patients should undergo simultaneous liver kidney transplantationCard M, Moeckel G, Turner J. Renal recovery following orthotopic liver transplant after prolonged kidney injury: Perspectives on diagnosing hepatorenal syndrome and determining which patients should undergo simultaneous liver kidney transplantation Journal Of Renal And Hepatic Disorders 2017, 1: 25-28. DOI: 10.15586/jrenhep.2017.20.
MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanismsOchi A, Chen D, Schulte W, Leng L, Moeckel N, Piecychna M, Averdunk L, Stoppe C, Bucala R, Moeckel G. MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms American Journal Of Physiology. Renal Physiology 2017, 313: f767-f780. PMID: 28539339, PMCID: PMC6148305, DOI: 10.1152/ajprenal.00683.2016.
Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axisLi A, Fan S, Xu Y, Meng J, Shen X, Mao J, Zhang L, Zhang X, Moeckel G, Wu D, Wu G, Liang C. Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis Journal Of Cellular And Molecular Medicine 2017, 21: 1619-1635. PMID: 28244683, PMCID: PMC5543471, DOI: 10.1111/jcmm.13091.
Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKINakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, Kraft F, Lei Y, Fukasawa Y, Moeckel GW, Angelotti ML, Liapis H, Anders HJ. Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI Journal Of The American Society Of Nephrology 2017, 28: 1753-1768. PMID: 28073931, PMCID: PMC5461800, DOI: 10.1681/asn.2016080925.
Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled TrialKulkarni S, Kirkiles‐Smith N, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS. Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial American Journal Of Transplantation 2016, 17: 682-691. PMID: 27501352, DOI: 10.1111/ajt.14001.
Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse KidneyStankewich MC, Moeckel GW, Ji L, Ardito T, Morrow JS. Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney PLOS ONE 2016, 11: e0142687. PMID: 26727517, PMCID: PMC4703142, DOI: 10.1371/journal.pone.0142687.
Antiphospholipid Antibody SyndromeRudich DS, Yun SH, Liebling A, Silbert JE, Moeckel GW, Lesser RL. Antiphospholipid Antibody Syndrome Journal Of Neuro-Ophthalmology 2015, 35: 396-399. PMID: 26049680, DOI: 10.1097/wno.0000000000000277.
Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant MiceLi A, Tian X, Zhang X, Huang S, Ma Y, Wu D, Moeckel G, Somlo S, Wu G. Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice American Journal Of Pathology 2015, 185: 2843-2860. PMID: 26435415, PMCID: PMC4607765, DOI: 10.1016/j.ajpath.2015.06.014.
A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum CarbonateValika AK, Jain D, Jaffe PE, Moeckel G, Brewster UC. A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate American Journal Of Kidney Diseases 2015, 67: 128-132. PMID: 26385816, DOI: 10.1053/j.ajkd.2015.07.033.
Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKDTorres R, Velazquez H, Chang JJ, Levene MJ, Moeckel G, Desir GV, Safirstein R. Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD Journal Of The American Society Of Nephrology 2015, 27: 1102-1112. PMID: 26303068, PMCID: PMC4814184, DOI: 10.1681/asn.2015010079.
Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in PodocytesHassan H, Tian X, Inoue K, Chai N, Liu C, Soda K, Moeckel G, Tufro A, Lee AH, Somlo S, Fedeles S, Ishibe S. Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes Journal Of The American Society Of Nephrology 2015, 27: 1055-1065. PMID: 26303067, PMCID: PMC4814187, DOI: 10.1681/asn.2015020191.
Comparison of amyloid deposition in human kidney biopsies as predictor of poor patient outcomeCastano E, Palmer MB, Vigneault C, Luciano R, Wong S, Moeckel G. Comparison of amyloid deposition in human kidney biopsies as predictor of poor patient outcome BMC Nephrology 2015, 16: 64. PMID: 25924613, PMCID: PMC4424547, DOI: 10.1186/s12882-015-0046-0.
Podocyte-associated talin1 is critical for glomerular filtration barrier maintenanceTian X, Kim J, Monkley S, Gotoh N, Nandez R, Soda K, Inoue K, Balkin D, Hassan H, Son S, Lee Y, Moeckel G, Calderwood D, Holzman L, Critchley D, Zent R, Reiser J, Ishibe S. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance Journal Of Clinical Investigation 2015, 125: 882-882. PMCID: PMC4319418, DOI: 10.1172/jci80814.
A 25-Year-Old Man with Necrotizing IgA Nephropathy and Sub Epithelial Electron Dense DepositsFu LY and Moeckel GW. Austin J Clin Pathol 2015,2(2):1031.
C3 Glomerulonephritis and Plasma Cell Dyscrasia: Expanding the Etiologic SpectrumCooper D, Munday W, Moeckel G. C3 Glomerulonephritis and Plasma Cell Dyscrasia: Expanding the Etiologic Spectrum Biology And Medicine 2015, 2015 DOI: 10.4172/0974-8369.1000252.
Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectorsYuan A, Lee Y, Choi U, Moeckel G, Karihaloo A. Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors American Journal Of Physiology. Renal Physiology 2014, 308: f459-f472. PMID: 25537742, PMCID: PMC4346747, DOI: 10.1152/ajprenal.00146.2014.
Semaphorin3a Promotes Advanced Diabetic NephropathyAggarwal PK, Veron D, Thomas DB, Siegel D, Moeckel G, Kashgarian M, Tufro A. Semaphorin3a Promotes Advanced Diabetic Nephropathy Diabetes 2014, 64: 1743-1759. PMID: 25475434, PMCID: PMC4407856, DOI: 10.2337/db14-0719.
GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion InjuryHuen SC, Huynh L, Marlier A, Lee Y, Moeckel GW, Cantley LG. GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury Journal Of The American Society Of Nephrology 2014, 26: 1334-1345. PMID: 25388222, PMCID: PMC4446881, DOI: 10.1681/asn.2014060612.
Quantification and localization of M2 macrophages in human kidneys with acute tubular injuryPalmer MB, Vichot AA, Cantley LG, Moeckel GW. Quantification and localization of M2 macrophages in human kidneys with acute tubular injury International Journal Of Nephrology And Renovascular Disease 2014, Volume 7: 415-419. PMID: 25404860, PMCID: PMC4230184, DOI: 10.2147/ijnrd.s66936.
Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplantation: An Interim Assessment.Kulkarni S, Nancy K, Formica R, Moeckel G, Pober J. Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplantation: An Interim Assessment. Transplantation 2014, 98: 79. DOI: 10.1097/00007890-201407151-00247.
Bile Acid Nephropathy in a Bodybuilder Abusing an Anabolic Androgenic SteroidLuciano RL, Castano E, Moeckel G, Perazella MA. Bile Acid Nephropathy in a Bodybuilder Abusing an Anabolic Androgenic Steroid American Journal Of Kidney Diseases 2014, 64: 473-476. PMID: 24953892, DOI: 10.1053/j.ajkd.2014.05.010.
Role of medullary progenitor cells in epithelial cell migration and proliferationChen D, Chen Z, Zhang Y, Park C, Al-Omari A, Moeckel GW. Role of medullary progenitor cells in epithelial cell migration and proliferation American Journal Of Physiology. Renal Physiology 2014, 307: f64-f74. PMID: 24808539, PMCID: PMC4080159, DOI: 10.1152/ajprenal.00547.2013.
Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse DevelopmentLian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G. Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development PLOS ONE 2014, 9: e88816. PMID: 24594709, PMCID: PMC3940423, DOI: 10.1371/journal.pone.0088816.
Podocyte-Specific VEGF-A Gain of Function Induces Nodular Glomerulosclerosis in eNOS Null MiceVeron D, Aggarwal PK, Velazquez H, Kashgarian M, Moeckel G, Tufro A. Podocyte-Specific VEGF-A Gain of Function Induces Nodular Glomerulosclerosis in eNOS Null Mice Journal Of The American Society Of Nephrology 2014, 25: 1814-1824. PMID: 24578128, PMCID: PMC4116059, DOI: 10.1681/asn.2013070752.
Podocyte-associated talin1 is critical for glomerular filtration barrier maintenanceTian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance Journal Of Clinical Investigation 2014, 124: 1098-1113. PMID: 24531545, PMCID: PMC3934159, DOI: 10.1172/jci69778.
Renalase Prevents AKI Independent of Amine Oxidase ActivityWang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase Prevents AKI Independent of Amine Oxidase Activity Journal Of The American Society Of Nephrology 2014, 25: 1226-1235. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/asn.2013060665.
Mineralocorticoid Receptor Phosphorylation Regulates Ligand Binding and Renal Response to Volume Depletion and HyperkalemiaShibata S, Rinehart J, Zhang J, Moeckel G, Castañeda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, Lifton RP. Mineralocorticoid Receptor Phosphorylation Regulates Ligand Binding and Renal Response to Volume Depletion and Hyperkalemia Cell Metabolism 2013, 18: 660-671. PMID: 24206662, PMCID: PMC3909709, DOI: 10.1016/j.cmet.2013.10.005.
Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturationFretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC. Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation Kidney International 2013, 85: 1091-1102. PMID: 24172684, PMCID: PMC4006322, DOI: 10.1038/ki.2013.433.
Cytomegalovirus Glomerulopathy and Cytomegalovirus Interstitial Nephritis on Sequential Transplant Kidney BiopsiesVichot AA, Formica RN, Moeckel GW. Cytomegalovirus Glomerulopathy and Cytomegalovirus Interstitial Nephritis on Sequential Transplant Kidney Biopsies American Journal Of Kidney Diseases 2013, 63: 536-539. PMID: 24568687, PMCID: PMC7210789, DOI: 10.1053/j.ajkd.2013.08.021.
Met Activation Is Required for Early Cytoprotection after Ischemic Kidney InjuryMason S, Hader C, Marlier A, Moeckel G, Cantley LG. Met Activation Is Required for Early Cytoprotection after Ischemic Kidney Injury Journal Of The American Society Of Nephrology 2013, 25: 329-337. PMID: 24136921, PMCID: PMC3904569, DOI: 10.1681/asn.2013050473.
Alloantibody and Complement Promote T Cell–Mediated Cardiac Allograft Vasculopathy Through Noncanonical Nuclear Factor-&kgr;B Signaling in Endothelial CellsJane-wit D, Manes TD, Yi T, Qin L, Clark P, Kirkiles-Smith NC, Abrahimi P, Devalliere J, Moeckel G, Kulkarni S, Tellides G, Pober JS. Alloantibody and Complement Promote T Cell–Mediated Cardiac Allograft Vasculopathy Through Noncanonical Nuclear Factor-&kgr;B Signaling in Endothelial Cells Circulation 2013, 128: 2504-2516. PMID: 24045046, PMCID: PMC3885874, DOI: 10.1161/circulationaha.113.002972.
Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirinMoeckel GW, Luciano RL, Brewster UC. Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin Clinical Kidney Journal 2013, 6: 507-509. PMID: 26120444, PMCID: PMC4438392, DOI: 10.1093/ckj/sft076.
Hypertonic stress and cell death. Focus on “Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells”Moeckel GW. Hypertonic stress and cell death. Focus on “Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells” American Journal Of Physiology - Cell Physiology 2013, 305: c1009-c1010. PMID: 24005043, DOI: 10.1152/ajpcell.00263.2013.
Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanismsChen D, Chen Z, Park C, Centrella M, McCarthy T, Chen L, Al-Omari A, Moeckel GW. Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms Gene 2013, 531: 23-30. PMID: 23994292, DOI: 10.1016/j.gene.2013.08.047.
Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition.Manjunath V, Moeckel G, Dahl NK. Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition. Clinical Nephrology 2013, 80: 151-5. PMID: 23845267, DOI: 10.5414/cn107258.
Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injuryHuen SC, Moeckel GW, Cantley LG. Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury American Journal Of Physiology. Renal Physiology 2013, 305: f477-f484. PMID: 23761668, PMCID: PMC3891258, DOI: 10.1152/ajprenal.00624.2012.
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathyKnauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.
Babesiosis-Induced Acute Kidney Injury With Prominent Urinary MacrophagesLuciano RL, Moeckel G, Palmer M, Perazella MA. Babesiosis-Induced Acute Kidney Injury With Prominent Urinary Macrophages American Journal Of Kidney Diseases 2013, 62: 801-805. PMID: 23643302, DOI: 10.1053/j.ajkd.2013.02.376.
Renalase protects against cisplatin acute kidney injury in miceDesir G, Wang L, Velazquez H, Moeckel G, Safirstein R. Renalase protects against cisplatin acute kidney injury in mice The FASEB Journal 2013, 27: 910.7-910.7. DOI: 10.1096/fasebj.27.1_supplement.910.7.
Recessive mutations in DGKE cause atypical hemolytic-uremic syndromeLemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome Nature Genetics 2013, 45: 531-536. PMID: 23542698, PMCID: PMC3719402, DOI: 10.1038/ng.2590.
A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemiaGoodwin JE, Palmer M, Pashankar F, Tufro A, Moeckel G. A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia Clinical Nephrology 2013, 82: 205-210. PMID: 23391318, PMCID: PMC6990651, DOI: 10.5414/cn107767.
Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft FunctionSchmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR, Cantley LG. Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft Function Journal Of The American Society Of Nephrology 2013, 24: 309-319. PMID: 23291472, PMCID: PMC3559482, DOI: 10.1681/asn.2012060579.
Role of dynamin, synaptojanin, and endophilin in podocyte foot processesSoda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S. Role of dynamin, synaptojanin, and endophilin in podocyte foot processes Journal Of Clinical Investigation 2012, 122: 4401-4411. PMID: 23187129, PMCID: PMC3533561, DOI: 10.1172/jci65289.
Intrarenal Dopamine Inhibits Progression of Diabetic NephropathyZhang MZ, Yao B, Yang S, Yang H, Wang S, Fan X, Yin H, Fogo AB, Moeckel GW, Harris RC. Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy Diabetes 2012, 61: 2575-2584. PMID: 22688335, PMCID: PMC3447896, DOI: 10.2337/db12-0046.
Acute Podocyte Vascular Endothelial Growth Factor (VEGF-A) Knockdown Disrupts alphaVbeta3 Integrin Signaling in the GlomerulusVeron D, Villegas G, Aggarwal PK, Bertuccio C, Jimenez J, Velazquez H, Reidy K, Abrahamson DR, Moeckel G, Kashgarian M, Tufro A. Acute Podocyte Vascular Endothelial Growth Factor (VEGF-A) Knockdown Disrupts alphaVbeta3 Integrin Signaling in the Glomerulus PLOS ONE 2012, 7: e40589. PMID: 22808199, PMCID: PMC3396653, DOI: 10.1371/journal.pone.0040589.
Inorganic Phosphate Stimulates Fibronectin Expression in Renal FibroblastsChen Z, Chen D, McCarthy TL, Centrella M, Zhang Y, Moeckel GW. Inorganic Phosphate Stimulates Fibronectin Expression in Renal Fibroblasts Cellular Physiology And Biochemistry 2012, 30: 151-159. PMID: 22759963, DOI: 10.1159/000339054.
Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome.Hall IE, Kashgarian M, Moeckel GW, Dahl NK. Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome. Clinical Nephrology 2012, 77: 62-5. PMID: 22185970, DOI: 10.5414/cn106859.
Proteinuria and glomerular injury associated with the anti-angiogenesis drug Vargatef™Manjunath V, Moeckel GW, Mahnensmith R, Perazella MA. Proteinuria and glomerular injury associated with the anti-angiogenesis drug Vargatef™ Clinical Kidney Journal 2011, 4: 430-433. PMID: 25984216, PMCID: PMC4421682, DOI: 10.1093/ndtplus/sfr064.
Podocyte COX-2 Exacerbates Diabetic Nephropathy by Increasing Podocyte (Pro)renin Receptor ExpressionCheng H, Fan X, Moeckel GW, Harris RC. Podocyte COX-2 Exacerbates Diabetic Nephropathy by Increasing Podocyte (Pro)renin Receptor Expression Journal Of The American Society Of Nephrology 2011, 22: 1240-1251. PMID: 21737546, PMCID: PMC3137572, DOI: 10.1681/asn.2010111149.
365 Acute Tubulo-Intersttial Nephritis in a Patient With Hepatitis B on TenofovirYalamanchili H, Ravi S, Moeckel G, Abdelsayed G, Feintzeig I. 365 Acute Tubulo-Intersttial Nephritis in a Patient With Hepatitis B on Tenofovir American Journal Of Kidney Diseases 2011, 57: b108. DOI: 10.1053/j.ajkd.2011.02.368.
SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell FunctionJurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function Diabetes 2011, 60: 890-898. PMID: 21357472, PMCID: PMC3046850, DOI: 10.2337/db10-1328.
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetesVeron D, Bertuccio CA, Marlier A, Reidy K, Garcia AM, Jimenez J, Velazquez H, Kashgarian M, Moeckel GW, Tufro A. Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes Diabetologia 2011, 54: 1227-1241. PMID: 21318407, PMCID: PMC3397150, DOI: 10.1007/s00125-010-2034-z.
LATE‐ONSET OMEPRAZOLE‐ASSOCIATED ACUTE INTERSTITIAL NEPHRITISNi N, Moeckel GW, Kumar C. LATE‐ONSET OMEPRAZOLE‐ASSOCIATED ACUTE INTERSTITIAL NEPHRITIS Journal Of The American Geriatrics Society 2010, 58: 2443-2444. PMID: 21143456, DOI: 10.1111/j.1532-5415.2010.03194.x.
Hematuria and Decreased Kidney Function as Initial Signs of Acute B-Cell Lymphoblastic LeukemiaSeo-Mayer P, Kenney B, McNamara J, Stein J, Moeckel GW. Hematuria and Decreased Kidney Function as Initial Signs of Acute B-Cell Lymphoblastic Leukemia American Journal Of Kidney Diseases 2010, 56: 1001-1005. PMID: 20599308, DOI: 10.1053/j.ajkd.2010.03.029.
Nephrotoxicity From Chemotherapeutic Agents: Clinical Manifestations, Pathobiology, and Prevention/TherapyPerazella MA, Moeckel GW. Nephrotoxicity From Chemotherapeutic Agents: Clinical Manifestations, Pathobiology, and Prevention/Therapy Seminars In Nephrology 2010, 30: 570-581. PMID: 21146122, DOI: 10.1016/j.semnephrol.2010.09.005.
Identification and Regulation of Reticulon 4B (Nogo-B) in Renal Tubular Epithelial CellsMarin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC. Identification and Regulation of Reticulon 4B (Nogo-B) in Renal Tubular Epithelial Cells American Journal Of Pathology 2010, 177: 2765-2773. PMID: 20971739, PMCID: PMC2993268, DOI: 10.2353/ajpath.2010.100199.
TGF-β Receptor Deletion in the Renal Collecting System Exacerbates FibrosisGewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. TGF-β Receptor Deletion in the Renal Collecting System Exacerbates Fibrosis Journal Of The American Society Of Nephrology 2010, 21: 1334-1343. PMID: 20576806, PMCID: PMC2938601, DOI: 10.1681/asn.2010020147.
Hypertonicity-induced Mitochondrial Membrane Permeability in Renal Medullary Interstitial Cells: Protective Role of OsmolytesZhang L, Chen D, Chen Z, Moeckel GW. Hypertonicity-induced Mitochondrial Membrane Permeability in Renal Medullary Interstitial Cells: Protective Role of Osmolytes Cellular Physiology And Biochemistry 2010, 25: 753-760. PMID: 20511721, PMCID: PMC3030460, DOI: 10.1159/000315095.
Second Prize: A Sealed Bladder Cuff Technique During Laparoscopic Nephroureterectomy Utilizing the LigaSure™ Electrosurgical Device: Laboratory and Clinical ExperienceLambert EH, Schachter LR, Altamar HO, Tikhonenkov S, Moeckel G, Miller NL, Herrell SD. Second Prize: A Sealed Bladder Cuff Technique During Laparoscopic Nephroureterectomy Utilizing the LigaSure™ Electrosurgical Device: Laboratory and Clinical Experience Journal Of Endourology 2010, 24: 327-332. PMID: 20078234, DOI: 10.1089/end.2009.0187.
Anti-phospholipid antibody syndrome in the kidneyNikiforow S, Moeckel G, Brewster UC. Anti-phospholipid antibody syndrome in the kidney Kidney International 2010, 77: 473. PMID: 20150948, DOI: 10.1038/ki.2009.484.
Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstructionMa H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG, Ishibe S. Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction Kidney International 2009, 76: 868-876. PMID: 19675527, DOI: 10.1038/ki.2009.304.
Distinct Roles for Basal and Induced COX-2 in Podocyte InjuryCheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC. Distinct Roles for Basal and Induced COX-2 in Podocyte Injury Journal Of The American Society Of Nephrology 2009, 20: 1953-1962. PMID: 19643929, PMCID: PMC2736764, DOI: 10.1681/asn.2009010039.
Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicityKwon MS, Na KY, Moeckel G, Lee SD, Kwon HM. Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity Pflügers Archiv - European Journal Of Physiology 2009, 459: 183. PMID: 19585141, DOI: 10.1007/s00424-009-0696-5.
Resolution of renal inflammation: a new role for NF-κB1 (p50) in inflammatory kidney diseasesPanzer U, Steinmetz OM, Turner JE, Meyer-Schwesinger C, von Ruffer C, Meyer TN, Zahner G, Gómez-Guerrero C, Schmid RM, Helmchen U, Moeckel GW, Wolf G, Stahl RA, Thaiss F. Resolution of renal inflammation: a new role for NF-κB1 (p50) in inflammatory kidney diseases American Journal Of Physiology. Renal Physiology 2009, 297: f429-f439. PMID: 19458123, DOI: 10.1152/ajprenal.90435.2008.
Placental Insufficiency Associated with Loss of Cited1 Causes Renal Medullary DysplasiaSparrow DB, Boyle SC, Sams RS, Mazuruk B, Zhang L, Moeckel GW, Dunwoodie SL, de Caestecker MP. Placental Insufficiency Associated with Loss of Cited1 Causes Renal Medullary Dysplasia Journal Of The American Society Of Nephrology 2009, 20: 777-786. PMID: 19297558, PMCID: PMC2663829, DOI: 10.1681/asn.2008050547.
NFATc1 Identifies a Population of Proximal Tubule Cell ProgenitorsLangworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS. NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors Journal Of The American Society Of Nephrology 2008, 20: 311-321. PMID: 19118153, PMCID: PMC2637056, DOI: 10.1681/asn.2008010094.
Apoptosis of the Thick Ascending Limb Results in Acute Kidney InjurySrichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD. Apoptosis of the Thick Ascending Limb Results in Acute Kidney Injury Journal Of The American Society Of Nephrology 2008, 19: 1538-1546. PMID: 18495962, PMCID: PMC2488270, DOI: 10.1681/asn.2007101101.
β1 integrin expression by podocytes is required to maintain glomerular structural integrityPozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. β1 integrin expression by podocytes is required to maintain glomerular structural integrity Developmental Biology 2008, 316: 288-301. PMID: 18328474, PMCID: PMC2396524, DOI: 10.1016/j.ydbio.2008.01.022.
Fibrocystin/Polyductin Modulates Renal Tubular Formation by Regulating Polycystin-2 Expression and FunctionKim I, Fu Y, Hui K, Moeckel G, Mai W, Li C, Liang D, Zhao P, Ma J, Chen XZ, George AL, Coffey RJ, Feng ZP, Wu G. Fibrocystin/Polyductin Modulates Renal Tubular Formation by Regulating Polycystin-2 Expression and Function Journal Of The American Society Of Nephrology 2008, 19: 455-468. PMID: 18235088, PMCID: PMC2391052, DOI: 10.1681/asn.2007070770.
Puromycin Induces Reversible Proteinuric Injury in Transgenic Mice Expressing Cyclooxygenase-2 in PodocytesJo YI, Cheng H, Wang S, Moeckel GW, Harris RC. Puromycin Induces Reversible Proteinuric Injury in Transgenic Mice Expressing Cyclooxygenase-2 in Podocytes Nephron 2007, 107: e87-e94. PMID: 17890881, DOI: 10.1159/000108653.
Overexpression of Cyclooxygenase-2 Predisposes to Podocyte InjuryCheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC. Overexpression of Cyclooxygenase-2 Predisposes to Podocyte Injury Journal Of The American Society Of Nephrology 2007, 18: 551-559. PMID: 17202413, DOI: 10.1681/asn.2006090990.
Beta1 integrin is required for ureteric bud branching developmentZhang X, Mernaugh G, Coffa S, Moeckel G, Brackebusch C, Fassler R, Pozzi A, Zent R. Beta1 integrin is required for ureteric bud branching development Matrix Biology 2006, 25: s51. DOI: 10.1016/j.matbio.2006.08.142.
The role of MT1_MMP in renal developmentRiggins K, Mernaugh G, Moeckel G, Quaranta V, Seiki M, Koshikawa N, Pozzi A, Zent R. The role of MT1_MMP in renal development Matrix Biology 2006, 25: s28. DOI: 10.1016/j.matbio.2006.08.079.
THE UTILITY OF IMMUNOFLUORESCENCE AND ELECTRON MICROSCOPY IN RENAL TRANSPLANT BIOPSIES.Langone A, Nitschke A, Helderman J, Schaefer H, Nylander W, Shaffer D, Kizilisik T, Chuang P, Moeckel G, Fogo A. THE UTILITY OF IMMUNOFLUORESCENCE AND ELECTRON MICROSCOPY IN RENAL TRANSPLANT BIOPSIES. Transplantation 2006, 82: 934-935. DOI: 10.1097/00007890-200607152-02645.
Glomerular injury is exacerbated in diabetic integrin α1-null miceZent R, Yan X, Su Y, Hudson B, Borza D, Moeckel G, Qi Z, Sado Y, Breyer M, Voziyan P, Pozzi A. Glomerular injury is exacerbated in diabetic integrin α1-null mice Kidney International 2006, 70: 460-470. PMID: 16775606, DOI: 10.1038/sj.ki.5000359.
Second Prize: Simple Method for Achieving Renal Parenchymal Hypothermia for Pure Laparoscopic Partial NephrectomyWebster TM, Moeckel GW, Herrell SD. Second Prize: Simple Method for Achieving Renal Parenchymal Hypothermia for Pure Laparoscopic Partial Nephrectomy Journal Of Endourology 2005, 19: 1075-1081. PMID: 16283843, DOI: 10.1089/end.2005.19.1075.
Role of integrin α1β1 in the regulation of renal medullary osmolyte concentrationMoeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A. Role of integrin α1β1 in the regulation of renal medullary osmolyte concentration American Journal Of Physiology. Renal Physiology 2005, 290: f223-f231. PMID: 16106035, DOI: 10.1152/ajprenal.00371.2004.
Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 InhibitionCheng H, Zhang M, Moeckel GW, Zhao Y, Wang S, Qi Z, Breyer MD, Harris RC. Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 Inhibition Nephron 2005, 101: e75-e85. PMID: 15995341, DOI: 10.1159/000086645.
52: New Pure Laparoscopic Renal Hypothermia Method Simplifies Laparoscopic Partial NephrectomyHerrell S, Moeckel G, Webster T. 52: New Pure Laparoscopic Renal Hypothermia Method Simplifies Laparoscopic Partial Nephrectomy Investigative Urology 2005, 173: 15. DOI: 10.1016/s0022-5347(18)34317-9.
Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2) IMPLICATIONS FOR ALTERED DRUG DISPOSITION AND CENTRAL NERVOUS SYSTEM DRUG ENTRY*Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB. Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2) IMPLICATIONS FOR ALTERED DRUG DISPOSITION AND CENTRAL NERVOUS SYSTEM DRUG ENTRY* Journal Of Biological Chemistry 2005, 280: 9610-9617. PMID: 15632119, DOI: 10.1074/jbc.m411092200.
A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapyFisher ME, Rossini M, Simmons E, Harris RC, Moeckel G, Zent R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy American Journal Of Kidney Diseases 2004, 44: 567-573. PMID: 15332232, DOI: 10.1053/j.ajkd.2004.04.051.
Lack of Integrin α1β1 Leads to Severe Glomerulosclerosis after Glomerular InjuryChen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A. Lack of Integrin α1β1 Leads to Severe Glomerulosclerosis after Glomerular Injury American Journal Of Pathology 2004, 165: 617-630. PMID: 15277235, PMCID: PMC1618576, DOI: 10.1016/s0002-9440(10)63326-3.
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cellsZhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 2311-2316. PMID: 14983006, PMCID: PMC356947, DOI: 10.1073/pnas.0400073101.
Proteolytic processing of laminin‐5 by MT1‐MMP in tissues and its effects on epithelial cell morphologyKoshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V. Proteolytic processing of laminin‐5 by MT1‐MMP in tissues and its effects on epithelial cell morphology The FASEB Journal 2003, 18: 1-22. PMID: 14688206, DOI: 10.1096/fj.03-0584fje.
Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stressLamitina ST, Morrison R, Moeckel GW, Strange K. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress American Journal Of Physiology - Cell Physiology 2003, 286: c785-c791. PMID: 14644776, DOI: 10.1152/ajpcell.00381.2003.
Importance of Functional EGF Receptors in Recovery from Acute Nephrotoxic InjuryWang Z, Chen JK, Wang SW, Moeckel G, Harris RC. Importance of Functional EGF Receptors in Recovery from Acute Nephrotoxic Injury Journal Of The American Society Of Nephrology 2003, 14: 3147-3154. PMID: 14638913, DOI: 10.1097/01.asn.0000098681.56240.1a.
COX2 Activity Promotes Organic Osmolyte Accumulation and Adaptation of Renal Medullary Interstitial Cells to Hypertonic Stress*Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD. COX2 Activity Promotes Organic Osmolyte Accumulation and Adaptation of Renal Medullary Interstitial Cells to Hypertonic Stress* Journal Of Biological Chemistry 2003, 278: 19352-19357. PMID: 12637551, DOI: 10.1074/jbc.m302209200.
Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPasesMoeckel GW, Shadman R, Fogel JM, Sadrzadeh SM. Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases Life Sciences 2002, 71: 2413-2424. PMID: 12231402, DOI: 10.1016/s0024-3205(02)02035-0.
Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension1Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, Mckanna JA, Harris RC. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension1 Kidney International 2002, 62: 929-939. PMID: 12164875, DOI: 10.1046/j.1523-1755.2002.00520.x.
A Novel Gene Encoding a TIG Multiple Domain Protein Is a Positional Candidate for Autosomal Recessive Polycystic Kidney DiseaseXiong H, Chen Y, Yi Y, Tsuchiya K, Moeckel G, Cheung J, Liang D, Tham K, Xu X, Chen XZ, Pei Y, Zhao ZJ, Wu G. A Novel Gene Encoding a TIG Multiple Domain Protein Is a Positional Candidate for Autosomal Recessive Polycystic Kidney Disease Genomics 2002, 80: 96-104. PMID: 12079288, DOI: 10.1006/geno.2002.6802.
An 11-year-old African-American girl with systemic lupus erythematosus and ANCA-negative renal vasculitisMoeckel GW, Jabs K, Fogo AB. An 11-year-old African-American girl with systemic lupus erythematosus and ANCA-negative renal vasculitis American Journal Of Kidney Diseases 2002, 39: 433-438. PMID: 11840389, DOI: 10.1053/ajkd.2002.30568.
Reabsorption of betaine in Henle's loops of rat kidney in vivoPummer S, Dantzler W, Lien Y, Moeckel G, Völker K, Silbernagl S. Reabsorption of betaine in Henle's loops of rat kidney in vivo American Journal Of Physiology. Renal Physiology 2000, 278: f434-f439. PMID: 10710548, DOI: 10.1152/ajprenal.2000.278.3.f434.
Kidney-targeted liposome-mediated gene transfer in miceLai L, Moeckel G, Lien Y. Kidney-targeted liposome-mediated gene transfer in mice Gene Therapy 1997, 4: 426-431. PMID: 9274719, DOI: 10.1038/sj.gt.3300406.
Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulationMoeckel G, Lien Y. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation American Journal Of Physiology 1997, 272: f94-f99. PMID: 9039054, DOI: 10.1152/ajprenal.1997.272.1.f94.
Kinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medullaMoeckel G, Lai L, Guder W, Kwon H, Lien Y. Kinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medulla American Journal Of Physiology 1997, 272: f100-f106. PMID: 9039055, DOI: 10.1152/ajprenal.1997.272.1.f100.
Purification of Human and Rat Kidney Aldose ReductaseMoeckel G, Hallbach J, Guder W. Purification of Human and Rat Kidney Aldose Reductase Enzyme And Protein 1994, 48: 45-50. PMID: 7787970, DOI: 10.1159/000474968.
Bicarbonate dependency of betaine synthesis in cultured LLC-PK1 cellsMoeckel G, Lien Y. Bicarbonate dependency of betaine synthesis in cultured LLC-PK1 cells American Journal Of Physiology 1994, 266: f512-f515. PMID: 8160802, DOI: 10.1152/ajprenal.1994.266.3.f512.
Bicarbonate-Dependent Betaine Synthesis in Rat Kidney1Moeckel G, Dasser H, Chen T, Schmolke M, Guder W. Bicarbonate-Dependent Betaine Synthesis in Rat Kidney1 1994, 110: 46-53. PMID: 7956256, DOI: 10.1159/000423397.

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