Jaime Grutzendler, MD
Cards
About
Titles
Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Neuroscience
Vice-Chair for Research, Neurology; Director, Center for Experimental NeuroimagingBiography
Dr. Grutzendler obtained his MD from Universidad Javeriana in Bogota, Colombia, where he was born and raised. He completed a medical internship in Internal Medicine and a residency in Neurology at Washington University/Barnes-Jewish Hospital in St. Louis. Following that, he pursued a combined clinical and research fellowship in the Alzheimer Disease Research Center and the Department of Neurobiology at Washington University, with additional neurobiology research training at the Skirball Institute of New York University. Dr. Grutzendler's laboratory is dedicated to understanding the cellular and molecular mechanisms of normal brain function and neuropathology. They have a particular focus on elucidating mechanisms underlying neurodegeneration, such as those found in Alzheimer's disease. Additionally, they aim to advance the understanding of cell-cell interactions through the utilization of intravital optical imaging techniques, enabling them to study the brain in real-time and observe dynamic processes at the cellular and molecular levels. Moreover, their laboratory is interested in developing therapeutics for brain disorders. Leveraging their expertise in brain imaging, they work with chemists to develop novel small molecules to target specific brain cell types for drug delivery and as imaging probes. In addition to the research endeavors, Dr. Grutzendler is actively involved in clinical activities focused on dementia and Alzheimer's patients. He works closely with individuals affected by these neurodegenerative disorders, providing comprehensive care and support.
Appointments
Neurology
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
- Alzheimer's Disease Research Center (ADRC)
- Center for Brain & Mind Health
- Gold College Affiliates
- Grutzendler Lab
- Interdepartmental Neuroscience Program
- Memory Disorders & Cognitive Neurology
- Molecular Medicine, Pharmacology, and Physiology
- Neural Disorders
- Neurology
- Neuroscience
- Neuroscience Track
- Program in Translational Biomedicine (PTB)
- Vascular Biology and Therapeutics Program
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Ventures
Education & Training
- Postdoctoral Fellow
- Skirball Institute/New York University (2003)
- Research Fellow
- Washington University in St. Louis (2000)
- Clinical Fellow
- Washington University in St. Louis (2000)
- Resident
- Washington Univeristy in St. Louis (1998)
- Intern
- Washington University in St. Louis (1995)
- MD
- Universidad Javeriana School of Medicine (1991)
Research
Academic Achievements and Community Involvement
Clinical Care
Overview
Jaime Grutzendler, MD, works with patients in the Adler Memory Clinic at Yale, where he combines innovative therapies with his specialized expertise in dealing with dementia, and connects families to support groups and services. “In some ways, you are treating the family,” he says. The clinic works closely with the Yale Medicine Dorothy Adler Geriatric Assessment Program, an outpatient consultative service with a national reputation.
Dr. Grutzendler cares for patients with Alzheimer's disease, frontotemporal and vascular dementia, as well as behavioral and neurodegenerative disorders. He and his colleagues have access to innovative therapies—sometimes before they hit the market. “Scientists have been learning more about the role of genes in Alzheimer’s, and the Adler Memory Clinic utilizes genetic testing for some patients, he says.
A native of Bogotá, Colombia, Dr. Grutzendler is working toward improving care for patients through the Grutzendler Lab at Yale, where he works with researchers to understand brain function and the cellular basis of neurological diseases. In addition, he directs the Center for Experimental Neuroimaging at Yale, fostering interactions among Yale investigators who study the physiology and pathology of the central and peripheral nervous systems to better understand and treat a variety of neurological conditions.
Clinical Specialties
Fact Sheets
Alzheimer's Disease
Learn More on Yale MedicineDementia
Learn More on Yale MedicineSleep Study
Learn More on Yale MedicinePediatric Sleep Study
Learn More on Yale Medicine
Yale Medicine News
Links & Media
News
- July 11, 2024Source: Yale Ventures
11 Yale Projects Receive Awards from the Colton Center for Autoimmunity
- March 20, 2023
Jain Receives AHA Career Development Award
- November 29, 2022Source: YaleNews
Swelling Along Brain’s Axons May Be True Culprit in Alzheimer’s Disease
- January 14, 2022
Analyzing the aging brain offers hope for dementia
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