my lab is interested in identifying central hubs that modulate large scale brain networks and are critical for various arousal states (e.g., sleep, selective attention, hyper-arousal)
We use methodologies such as single and multi-unit neuron recordings, intracranial electroencephalogram, closed loop recording and stimulating devices such as DBS, RNS, measures of the autonomic nervous system (heart rate, pupillometry). This invasive human electrophysiology-centric approach is combined with behavioral tasks, naturalistic behaviors, and computational modeling to ask fundamental questions related to identifying:
1. central hubs that modulate large scale brain networks and are critical for various arousal states (e.g., deep sleep, selective attention, hyperarousal)
2. the neural correlates of interoceptive feedback during periods of heightened states of arousal
3. neural correlates of emotional valence in the humans
We also have projects aimed at the understating and developing potential therapies for neurodegenerative and neuropsychiatric pathologies. In collaboration with Dr. Alfred Kaye, we record intracranial EEG in human epilepsy patients during task-based threat avoidance behaviors. These projects involve computational modeling of behavior, time series analysis of human electrophysiology/or brain tissue analysis after resective brain surgery. Our goal is to define circuit-level signatures of threat processing across the continuum of threat proximity.
Alzheimer Disease; Anxiety; Epilepsy; Memory Disorders; Psychological Distress