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Daniel Tylee, MD/PhD

Associate Research Scientist; NRTP, Yale Department of Psychiatry

Research & Publications
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Selected Publications

A perspective on translating genomic discoveries into targets for brain‐machine interface and deep brain stimulation devicesValentim W, Tylee D, Polimanti R. A perspective on translating genomic discoveries into targets for brain‐machine interface and deep brain stimulation devices. WIREs Mechanisms Of Disease 2023, 16: e1635. PMID: 38059513, PMCID: PMC11163995, DOI: 10.1002/wsbm.1635.
Polysubstance addiction patterns among 7,989 individuals with cocaine use disorderStiltner B, Pietrzak R, Tylee D, Nunez Y, Adhikari K, Kranzler H, Gelernter J, Polimanti R. Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. IScience 2023, 26: 107336. PMID: 37554454, PMCID: PMC10405253, DOI: 10.1016/j.isci.2023.107336.
Sex differences in the polygenic architecture of hearing problems in adultsDe Angelis F, Zeleznik O, Wendt F, Pathak G, Tylee D, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford R, Maihofer A, Nievergelt C, Curhan G, Curhan S, Polimanti R. Sex differences in the polygenic architecture of hearing problems in adults. Genome Medicine 2023, 15: 36. PMID: 37165447, PMCID: PMC10173489, DOI: 10.1186/s13073-023-01186-3.
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating DisordersKoller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. Obstetrical & Gynecological Survey 2023, 78: 282-283. DOI: 10.1097/01.ogx.0000935848.53207.07.
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating DisordersKoller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.
A GENOME-WIDE CROSS-DISORDER ANALYSIS OF BIPOLAR DISORDER, SCHIZOPHRENIA, AND DEPRESSION REVEALS NOVEL PLEIOTROPIC LOCI AND PATHWAYSFriligkou E, Wendt F, Pathak G, Tylee D, De Angelis F, De Lillo A, Koller D, Cabrera-Mendoza B, Polimanti R. A GENOME-WIDE CROSS-DISORDER ANALYSIS OF BIPOLAR DISORDER, SCHIZOPHRENIA, AND DEPRESSION REVEALS NOVEL PLEIOTROPIC LOCI AND PATHWAYS. European Neuropsychopharmacology 2022, 63: e254-e255. DOI: 10.1016/j.euroneuro.2022.07.454.
T127. AUTOMATED PHENOTYPING OF DEPRESSIVE DISORDERS AND SYMPTOMS APPLIED TO THE ELECTRONIC MEDICAL RECORD OF THE YALE NEW HAVEN HEALTH SYSTEMTylee D, Hänsel K, Polimanti R, Schulz W. T127. AUTOMATED PHENOTYPING OF DEPRESSIVE DISORDERS AND SYMPTOMS APPLIED TO THE ELECTRONIC MEDICAL RECORD OF THE YALE NEW HAVEN HEALTH SYSTEM. European Neuropsychopharmacology 2022, 63: e237. DOI: 10.1016/j.euroneuro.2022.07.423.
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health recordsPolimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.
An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related PhenotypesTylee DS, Lee YK, Wendt FR, Pathak GA, Levey DF, De Angelis F, Gelernter J, Polimanti R. An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes. JAMA Psychiatry 2022, 79: 667-676. PMID: 35507366, PMCID: PMC9069342, DOI: 10.1001/jamapsychiatry.2022.0914.
Characterizing the Genetic Effects Linking Psychiatric and Immune-Related PhenotypesTylee D, Lee Y, Wendt F, Pathak G, Levey D, De Angelis F, Gelernter J, Polimanti R. Characterizing the Genetic Effects Linking Psychiatric and Immune-Related Phenotypes. Biological Psychiatry 2022, 91: s72-s73. DOI: 10.1016/j.biopsych.2022.02.200.
Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathwaysKasher M, Williams F, Freidin M, Malkin I, Cherny S, Benjamin E, Chasman D, Dehghan A, Ahluwalia T, Meigs J, Tracy R, Alizadeh B, Ligthart S, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Snieder H, Wilson J, Psaty B, Dupuis J, Prins B, Vaso U, Stathopoulou M, Franke L, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Abbasi A, Uitterlinden A, Abdollahi M, Schnabel R, Schick U, Nolte I, Kraja A, Hsu Y, Tylee D, Zwicker A, Uher R, Davey-Smith G, Morrison A, Hicks A, van Duijn C, Ward-Caviness C, Boerwinkle E, Rotter J, Rice K, Lange L, Perola M, de Geus E, Morris A, Makela K, Stacey D, Eriksson J, Frayling T, Slagboom E, Livshits G. Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways. Human Molecular Genetics 2022, 31: 2623-2632. PMID: 35349660, PMCID: PMC9402243, DOI: 10.1093/hmg/ddac061.
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traitsPathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic riskDe Angelis F, Wendt FR, Pathak GA, Tylee DS, Goswami A, Gelernter J, Polimanti R. Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk. Translational Psychiatry 2021, 11: 586. PMID: 34775470, PMCID: PMC8590689, DOI: 10.1038/s41398-021-01713-z.
Role of microbes in the pathogenesis of neuropsychiatric disordersGoswami A, Wendt FR, Pathak GA, Tylee DS, De Angelis F, De Lillo A, Polimanti R. Role of microbes in the pathogenesis of neuropsychiatric disorders. Frontiers In Neuroendocrinology 2021, 62: 100917. PMID: 33957173, PMCID: PMC8364482, DOI: 10.1016/j.yfrne.2021.100917.
Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidalityWendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
Characterizing the effect of background selection on the polygenicity of brain-related traitsWendt FR, Pathak GA, Overstreet C, Tylee DS, Gelernter J, Atkinson EG, Polimanti R. Characterizing the effect of background selection on the polygenicity of brain-related traits. Genomics 2020, 113: 111-119. PMID: 33278486, PMCID: PMC7855394, DOI: 10.1016/j.ygeno.2020.11.032.
Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular OutcomesGeorgakis M, Malik R, Gill D, Franceschini N, Sudlow C, Dichgans M, Lindstrom S, Wang L, Smith E, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody J, Pattee J, Haessler J, Brumpton B, Chasman D, Suchon P, Chen M, Turman C, Germain M, Wiggins K, MacDonald J, Braekkan S, Armasu S, Pankratz N, Jackson R, Nielsen J, Giulianini F, Puurunen M, Ibrahim M, Heckbert S, Damrauer S, Natarajan P, Klarin D, de Vries P, SabaterLleal M, Huffman J, Bammler T, Frazer K, McCauley B, Taylor K, Pankow J, Reiner A, Gabrielsen M, Deleuze J, O’Donnell C, Kim J, McKnight B, Kraft P, Hansen J, Rosendaal F, Heit J, Psaty B, Tang W, Kooperberg C, Hveem K, Ridker P, Morange P, Johnson A, Kabrhel C, Trégouët D, Smith N, Benjamin E, Chasman D, Dehghan A, Ahluwalia T, Meigs J, Tracy R, Alizadeh B, Ligthart S, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Snieder H, Wilson J, Psaty B, Dupuis J, Prins B, Vaso U, Stathopoulou M, Franke L, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Abbasi A, Uitterlinden A, Abdollahi M, Schnabel R, Schick U, Nolte I, Kraja A, Hsu Y, Tylee D, Zwicker A, Uher R, Davey-Smith G, Morrison A, Hicks A, van Duijn C, Ward-Caviness C, Boerwinkle E, Rotter J, Rice K, Lange L, Perola M, de Geus E, Morris A, Makela K, Stacey D, Eriksson J, Frayling T, Slagboom E. Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes. Circulation Genomic And Precision Medicine 2020, 13: e002872-e002872. PMID: 32397738, PMCID: PMC7299212, DOI: 10.1161/circgen.119.002872.
Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide PerspectiveWendt FR, Pathak GA, Tylee DS, Goswami A, Polimanti R. Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective. Chronic Stress 2020, 4: 2470547020924844. PMID: 32518889, PMCID: PMC7254587, DOI: 10.1177/2470547020924844.
M14 DISCRIMINATION OF MAJOR NEUROPSYCHIATRIC DISORDERS USING BLOOD-BASED TRANSCRIPTOMIC SIGNATURESHess J, Tylee D, Liu C, de Jong S, Ophoff R, Gardiner E, Sibille E, Turecki G, Tseng G, Tsuang M, Faraone S, Glatt S. M14 DISCRIMINATION OF MAJOR NEUROPSYCHIATRIC DISORDERS USING BLOOD-BASED TRANSCRIPTOMIC SIGNATURES. European Neuropsychopharmacology 2019, 29: s173. DOI: 10.1016/j.euroneuro.2019.08.114.
A polygenic resilience score moderates the genetic risk for schizophreniaHess JL, Tylee DS, Mattheisen M, Børglum A, Als T, Grove J, Werge T, Mortensen P, Mors O, Nordentoft M, Hougaard D, Byberg-Grauholm J, Bækvad-Hansen M, Greenwood T, Tsuang M, Curtis D, Steinberg S, Sigurdsson E, Stefánsson H, Stefánsson K, Edenberg H, Holmans P, Faraone S, Glatt S. A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry 2019, 26: 800-815. PMID: 31492941, PMCID: PMC7058518, DOI: 10.1038/s41380-019-0463-8.
Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychosesHess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M, Unit T, Tsuang MT, Glatt SJ. Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses. Schizophrenia Research 2019, 217: 124-135. PMID: 31391148, PMCID: PMC6997041, DOI: 10.1016/j.schres.2019.07.036.
PTSD BLOOD TRANSCRIPTOME MEGA-ANALYSIS: INFLAMMATORY PATHWAYS ACROSS BIOLOGICAL SEX AND MODES OF TRAUMABreen M, Tylee D, Maihofer A, Tsuang M, Chandler S, Mehta D, Binder E, Hess J, Baker D, Risbrough V, Nievergelt C, Buxbaum J, Glatt S. PTSD BLOOD TRANSCRIPTOME MEGA-ANALYSIS: INFLAMMATORY PATHWAYS ACROSS BIOLOGICAL SEX AND MODES OF TRAUMA. European Neuropsychopharmacology 2019, 29: s1056-s1057. DOI: 10.1016/j.euroneuro.2018.07.073.
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex DisordersLigthart S, Vaez A, Võsa U, Stathopoulou M, de Vries P, Prins B, Van der Most P, Tanaka T, Naderi E, Rose L, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Macé A, Sidore C, Trompet S, Mangino M, Sabater-Lleal M, Kemp J, Abbasi A, Kacprowski T, Verweij N, Smith A, Huang T, Marzi C, Feitosa M, Lohman K, Kleber M, Milaneschi Y, Mueller C, Huq M, Vlachopoulou E, Lyytikäinen L, Oldmeadow C, Deelen J, Perola M, Zhao J, Feenstra B, Amini M, Lahti J, Schraut K, Fornage M, Suktitipat B, Chen W, Li X, Nutile T, Malerba G, Luan J, Bak T, Schork N, Del Greco M. F, Thiering E, Mahajan A, Marioni R, Mihailov E, Eriksson J, Ozel A, Zhang W, Nethander M, Cheng Y, Aslibekyan S, Ang W, Gandin I, Yengo L, Portas L, Kooperberg C, Hofer E, Rajan K, Schurmann C, Hollander W, Ahluwalia T, Zhao J, Draisma H, Ford I, Timpson N, Teumer A, Huang H, Wahl S, Liu Y, Huang J, Uh H, Geller F, Joshi P, Yanek L, Trabetti E, Lehne B, Vozzi D, Verbanck M, Biino G, Saba Y, Meulenbelt I, O’Connell J, Laakso M, Giulianini F, Magnusson P, Ballantyne C, Hottenga J, Montgomery G, Rivadineira F, Rueedi R, Steri M, Herzig K, Stott D, Menni C, Frånberg M, St. Pourcain B, Felix S, Pers T, Bakker S, Kraft P, Peters A, Vaidya D, Delgado G, Smit J, Großmann V, Sinisalo J, Seppälä I, Williams S, Holliday E, Moed M, Langenberg C, Räikkönen K, Ding J, Campbell H, Sale M, Chen Y, James A, Ruggiero D, Soranzo N, Hartman C, Smith E, Berenson G, Fuchsberger C, Hernandez D, Tiesler C, Giedraitis V, Liewald D, Fischer K, Mellström D, Larsson A, Wang Y, Scott W, Lorentzon M, Beilby J, Ryan K, Pennell C, Vuckovic D, Balkau B, Concas M, Schmidt R, de Leon C, Bottinger E, Kloppenburg M, Paternoster L, Boehnke M, Musk A, Willemsen G, Evans D, Madden P, Kähönen M, Kutalik Z, Zoledziewska M, Karhunen V, Kritchevsky S, Sattar N, Lachance G, Clarke R, Harris T, Raitakari O, Attia J, van Heemst D, Kajantie E, Sorice R, Gambaro G, Scott R, Hicks A, Ferrucci L, Standl M, Lindgren C, Starr J, Karlsson M, Lind L, Li J, Chambers J, Mori T, de Geus E, Heath A, Martin N, Auvinen J, Buckley B, de Craen A, Waldenberger M, Strauch K, Meitinger T, Scott R, McEvoy M, Beekman M, Bombieri C, Ridker P, Mohlke K, Pedersen N, Morrison A, Boomsma D, Whitfield J, Strachan D, Hofman A, Vollenweider P, Cucca F, Jarvelin M, Jukema J, Spector T, Hamsten A, Zeller T, Uitterlinden A, Nauck M, Gudnason V, Qi L, Grallert H, Borecki I, Rotter J, März W, Wild P, Lokki M, Boyle M, Salomaa V, Melbye M, Eriksson J, Wilson J, Penninx B, Becker D, Worrall B, Gibson G, Krauss R, Ciullo M, Zaza G, Wareham N, Oldehinkel A, Palmer L, Murray S, Pramstaller P, Bandinelli S, Heinrich J, Ingelsson E, Deary I, Mägi R, Vandenput L, van der Harst P, Desch K, Kooner J, Ohlsson C, Hayward C, Lehtimäki T, Shuldiner A, Arnett D, Beilin L, Robino A, Froguel P, Pirastu M, Jess T, Koenig W, Loos R, Evans D, Schmidt H, Smith G, Slagboom E, Eiriksdottir G, Morris A, Psaty B, Tracy R, Nolte I, Boerwinkle E, Visvikis-Siest S, Reiner A, Gross M, Bis J, Franke L, Franco O, Benjamin E, Chasman D, Dupuis J, Snieder H, Dehghan A, Alizadeh B, Alizadeh B, Boezen H, Franke L, van der Harst P, Navis G, Rots M, Snieder H, Swertz M, Wolffenbuttel B, Wijmenga C, Benjamin E, Chasman D, Dehghan A, Ahluwalia T, Meigs J, Tracy R, Alizadeh B, Ligthart S, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Snieder H, Wilson J, Psaty B, Dupuis J, Prins B, Vaso U, Stathopoulou M, Franke L, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Abbasi A, Uitterlinden A, Abdollahi M, Schnabel R, Schick U, Nolte I, Kraja A, Hsu Y, Tylee D, Zwicker A, Uher R, Davey-Smith G, Morrison A, Hicks A, van Duijn C, Ward-Caviness C, Boerwinkle E, Rotter J, Rice K, Lange L, Perola M, de Geus E, Morris A, Makela K, Stacey D, Eriksson J, Frayling T, Slagboom P. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American Journal Of Human Genetics 2018, 103: 691-706. PMID: 30388399, PMCID: PMC6218410, DOI: 10.1016/j.ajhg.2018.09.009.
Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association dataTylee DS, Sun J, Hess JL, Tahir MA, Sharma E, Malik R, Worrall BB, Levine AJ, Martinson JJ, Nejentsev S, Speed D, Fischer A, Mick E, Walker BR, Crawford A, Grant SFA, Polychronakos C, Bradfield JP, Sleiman PMA, Hakonarson H, Ellinghaus E, Elder JT, Tsoi LC, Trembath RC, Barker JN, Franke A, Dehghan A, Team T, Consortium T, Consortium T, Registry T, Group T, Consortium T, Faraone SV, Glatt SJ. Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 177: 641-657. PMID: 30325587, PMCID: PMC6230304, DOI: 10.1002/ajmg.b.32652.
exprso: an R-package for the rapid implementation of machine learning algorithmsQuinn T, Tylee D, Glatt S. exprso: an R-package for the rapid implementation of machine learning algorithms. F1000Research 2017, 5: 2588. PMID: 29560250, PMCID: PMC5832912, DOI: 10.12688/f1000research.9893.2.
PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of TraumaBreen MS, Tylee DS, Maihofer AX, Neylan TC, Mehta D, Binder EB, Chandler SD, Hess JL, Kremen WS, Risbrough VB, Woelk CH, Baker DG, Nievergelt CM, Tsuang MT, Buxbaum JD, Glatt SJ. PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma. Neuropsychopharmacology 2017, 43: 469-481. PMID: 28925389, PMCID: PMC5770765, DOI: 10.1038/npp.2017.220.
Machine-learning classification of 22q11.2 deletion syndrome: A diffusion tensor imaging studyTylee DS, Kikinis Z, Quinn TP, Antshel KM, Fremont W, Tahir MA, Zhu A, Gong X, Glatt SJ, Coman IL, Shenton ME, Kates WR, Makris N. Machine-learning classification of 22q11.2 deletion syndrome: A diffusion tensor imaging study. NeuroImage Clinical 2017, 15: 832-842. PMID: 28761808, PMCID: PMC5522376, DOI: 10.1016/j.nicl.2017.04.029.
Evaluation of the reconsolidation of traumatic memories protocol for the treatment of PTSD: a randomized, wait-list-controlled trialTylee D, Gray R, Glatt S, Bourke F. Evaluation of the reconsolidation of traumatic memories protocol for the treatment of PTSD: a randomized, wait-list-controlled trial. Journal Of Military Veteran And Family Health 2017, 3: 21-33. DOI: 10.3138/jmvfh.4120.
Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined‐samples mega‐analysisTylee DS, Hess JL, Quinn TP, Barve R, Huang H, Zhang‐James Y, Chang J, Stamova BS, Sharp FR, Hertz‐Picciotto I, Faraone SV, Kong SW, Glatt SJ. Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined‐samples mega‐analysis. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 181-201. PMID: 27862943, PMCID: PMC5499528, DOI: 10.1002/ajmg.b.32511.
exprso: an R-package for the rapid implementation of machine learning algorithmsQuinn T, Tylee D, Glatt S. exprso: an R-package for the rapid implementation of machine learning algorithms. F1000Research 2016, 5: 2588. DOI: 10.12688/f1000research.9893.1.
RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex‐specific effectsTylee DS, Espinoza AJ, Hess JL, Tahir MA, McCoy SY, Rim JK, Dhimal T, Cohen OS, Glatt SJ. RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex‐specific effects. Autism Research 2016, 10: 439-455. PMID: 27529825, DOI: 10.1002/aur.1679.
Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophreniaHess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M, Unit T, Tsuang MT, Glatt SJ. Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia. Schizophrenia Research 2016, 176: 114-124. PMID: 27450777, PMCID: PMC5026943, DOI: 10.1016/j.schres.2016.07.006.
Gene networks specific for innate immunity define post-traumatic stress disorderBreen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT, Risbrough VB, Baker DG, O'Connor DT, Nievergelt CM, Woelk CH. Gene networks specific for innate immunity define post-traumatic stress disorder. Molecular Psychiatry 2015, 20: 1538-1545. PMID: 25754082, PMCID: PMC4565790, DOI: 10.1038/mp.2015.9.
Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot studyTylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, Lohr JB, Kremen WS, Investigators M, Baker D, Glatt S, Tsuang M. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study. Psychoneuroendocrinology 2014, 51: 472-494. PMID: 25311155, PMCID: PMC4199086, DOI: 10.1016/j.psyneuen.2014.09.024.
On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”Tylee DS, Kawaguchi DM, Glatt SJ. On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 162: 595-603. PMID: 24132893, DOI: 10.1002/ajmg.b.32150.
Blood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot studyGlatt SJ, Tylee DS, Chandler SD, Pazol J, Nievergelt CM, Woelk CH, Baker DG, Lohr JB, Kremen WS, Litz BT, Tsuang MT, Investigators M. Blood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot study. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 162: 313-326. PMID: 23650250, DOI: 10.1002/ajmg.b.32167.
Active behavioral coping alters the behavioral but not the endocrine response to stress.Helmreich DL, Tylee D, Christianson JP, Kubala KH, Govindarajan ST, O'Neill WE, Becoats K, Watkins L, Maier SF. Active behavioral coping alters the behavioral but not the endocrine response to stress. Psychoneuroendocrinology 2012, 37: 1941-8. PMID: 22578266, PMCID: PMC3358794, DOI: 10.1016/j.psyneuen.2012.04.005.
Long-term behavioral consequences of stress exposure in adolescent versus young adult rats.Saul ML, Tylee D, Becoats KT, Guerrero BG, Sweeney P, Helmreich DL, Fudge JL. Long-term behavioral consequences of stress exposure in adolescent versus young adult rats. Behavioural Brain Research 2012, 229: 226-34. PMID: 22281462, DOI: 10.1016/j.bbr.2012.01.022.
Thyroid hormone regulation by stress and behavioral differences in adult male rats.Helmreich DL, Tylee D. Thyroid hormone regulation by stress and behavioral differences in adult male rats. Hormones And Behavior 2011, 60: 284-91. PMID: 21689656, PMCID: PMC3148770, DOI: 10.1016/j.yhbeh.2011.06.003.

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Daniel Tylee, MD/PhD

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