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Alvaro Duque, PhD

Director MacBrain Resource Center and Research Scientist, Department of Neuroscience; Research Scientist, Neuroscience

Research & Publications
Biography

Coauthors

Selected Publications

Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaquesBathla S, Datta D, Liang F, Barthelemy N, Wiseman R, Slusher B, Asher J, Zeiss C, Ekanayake‐Alper D, Holden D, Terwilliger G, Duque A, Arellano J, van Dyck C, Bateman R, Xie Z, Nairn A, Arnsten A. Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2023, 9: e12431. PMID: 37915375, PMCID: PMC10617575, DOI: 10.1002/trc2.12431.
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s diseaseDatta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.
Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalonMicali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.
Origin and development of the claustrum in rhesus macaqueLi H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.
Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealizationJunaković A, Kopić J, Duque A, Rakic P, Krsnik Ž, Kostović I. Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure And Function 2023, 228: 613-633. PMID: 36592215, PMCID: PMC9944618, DOI: 10.1007/s00429-022-02606-7.
Fostering nonhuman primate (NHP) brain researchwithout animal sacrificeDuque A. Fostering nonhuman primate (NHP) brain research without animal sacrifice, Open Access Government (2023), https://doi.org/10.56367/OAG-038-10792
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortexRash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.
Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortexDatta D, Leslie SN, Morozov YM, Duque A, Rakic P, van Dyck CH, Nairn AC, Arnsten AFT. Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex. Journal Of Neuroinflammation 2020, 17: 8. PMID: 31906973, PMCID: PMC6945481, DOI: 10.1186/s12974-019-1683-1.
A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disordersDuque A, Spector R. A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders. Brain Structure And Function 2019, 224: 2281-2295. PMID: 31278571, PMCID: PMC6852840, DOI: 10.1007/s00429-019-01917-6.
MacBrainResource: Virtual access to decades-old primate brainsSelemon L, Duque A. MacBrainResource: Virtual access to decades-old primate brains. Research Outreach 2019, 94-97. DOI: 10.32907/ro-106-9497.
Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrumRash BG, Duque A, Morozov YM, Arellano JI, Micali N, Rakic P. Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 7089-7094. PMID: 30894491, PMCID: PMC6452694, DOI: 10.1073/pnas.1822169116.
Noradrenergic α1-Adrenoceptor Actions in the Primate Dorsolateral Prefrontal CortexDatta D, Yang ST, Galvin VC, Solder J, Luo F, Morozov YM, Arellano J, Duque A, Rakic P, Arnsten A, Wang M. Noradrenergic α1-Adrenoceptor Actions in the Primate Dorsolateral Prefrontal Cortex. Journal Of Neuroscience 2019, 39: 2722-2734. PMID: 30755491, PMCID: PMC6445993, DOI: 10.1523/jneurosci.2472-18.2019.
Seizures and Sleep in the Thalamus: Focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic NucleiFeng L, Motelow JE, Ma C, Biche W, McCafferty C, Smith N, Liu M, Zhan Q, Jia R, Xiao B, Duque A, Blumenfeld H. Seizures and Sleep in the Thalamus: Focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic Nuclei. Journal Of Neuroscience 2017, 37: 11441-11454. PMID: 29066556, PMCID: PMC5700426, DOI: 10.1523/jneurosci.1011-17.2017.
Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primatesDuque A, Krsnik Z, Kostović I, Rakic P. Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 9892-9897. PMID: 27503885, PMCID: PMC5024589, DOI: 10.1073/pnas.1610078113.
Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells.Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Cerebral Cortex 2016, 27: 3186-3207. PMID: 27269961, PMCID: PMC6059165, DOI: 10.1093/cercor/bhw143.
Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and LimitationsDuque A, Rakic P. Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations. 2015, 101: 123-139. DOI: 10.1007/978-1-4939-2313-7_7.
Chapter 19 Organization of the Basal Forebrain Cholinergic Projection System Specific or Diffuse?Zaborszky L, Duque A, Gielow M, Gombkoto P, Nadasdy Z, Somogyi J. Chapter 19 Organization of the Basal Forebrain Cholinergic Projection System Specific or Diffuse? 2015, 491-507. DOI: 10.1016/b978-0-12-374245-2.00019-x.
Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ ChannelsEl-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 2014, 76: 476-485. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.
Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunctionGamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF. Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Translational Psychiatry 2013, 3: e328-e328. PMID: 24301646, PMCID: PMC4030323, DOI: 10.1038/tp.2013.104.
Expression of Kv1.3 potassium channels regulates density of cortical interneuronsDuque A, Gazula V, Kaczmarek LK. Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Developmental Neurobiology 2013, 73: 841-855. PMID: 23821603, PMCID: PMC3829632, DOI: 10.1002/dneu.22105.
Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficitsCarlyle BC, Duque A, Kitchen RR, Bordner KA, Coman D, Doolittle E, Papademetris X, Hyder F, Taylor JR, Simen AA. Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficits. Development And Psychopathology 2012, 24: 1401-1416. PMID: 23062306, PMCID: PMC3681803, DOI: 10.1017/s095457941200079x.
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow OscillationTahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.
Different Effects of Bromodeoxyuridine and [3H]Thymidine Incorporation into DNA on Cell Proliferation, Position, and FateDuque A, Rakic P. Different Effects of Bromodeoxyuridine and [3H]Thymidine Incorporation into DNA on Cell Proliferation, Position, and Fate. Journal Of Neuroscience 2011, 31: 15205-15217. PMID: 22016554, PMCID: PMC3225276, DOI: 10.1523/jneurosci.3092-11.2011.
Neuroanatomical changes in a mouse model of early life neglectDuque A, Coman D, Carlyle BC, Bordner KA, George ED, Papademetris X, Hyder F, Simen AA. Neuroanatomical changes in a mouse model of early life neglect. Brain Structure And Function 2011, 217: 459-472. PMID: 21984312, PMCID: PMC3664301, DOI: 10.1007/s00429-011-0350-9.
Functional Genomic and Proteomic Analysis Reveals Disruption of Myelin-Related Genes and Translation in a Mouse Model of Early Life NeglectBordner KA, George ED, Carlyle BC, Duque A, Kitchen RR, Lam TT, Colangelo CM, Stone KL, Abbott TB, Mane SM, Nairn AC, Simen AA. Functional Genomic and Proteomic Analysis Reveals Disruption of Myelin-Related Genes and Translation in a Mouse Model of Early Life Neglect. Frontiers In Psychiatry 2011, 2: 18. PMID: 21629843, PMCID: PMC3098717, DOI: 10.3389/fpsyt.2011.00018.
Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field StimulationHaider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.
Circuit-based Localization of Ferret Prefrontal CortexDuque A, McCormick DA. Circuit-based Localization of Ferret Prefrontal Cortex. Cerebral Cortex 2009, 20: 1020-1036. PMID: 19737780, PMCID: PMC2852501, DOI: 10.1093/cercor/bhp164.
Morphological characterization of electrophysiologically and immunohistochemically identified basal forebrain cholinergic and neuropeptide Y-containing neuronsDuque A, Tepper JM, Detari L, Ascoli GA, Zaborszky L. Morphological characterization of electrophysiologically and immunohistochemically identified basal forebrain cholinergic and neuropeptide Y-containing neurons. Brain Structure And Function 2007, 212: 55-73. PMID: 17717698, DOI: 10.1007/s00429-007-0143-3.
Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In VivoHaider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.
α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal CortexWang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex. Cell 2007, 129: 397-410. PMID: 17448997, DOI: 10.1016/j.cell.2007.03.015.
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon RecordingsShu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.
Prenatal exposure to ultrasound waves impacts neuronal migration in miceAng ES, Gluncic V, Duque A, Schafer ME, Rakic P. Prenatal exposure to ultrasound waves impacts neuronal migration in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 12903-12910. PMID: 16901978, PMCID: PMC1538990, DOI: 10.1073/pnas.0605294103.
Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and InhibitionHaider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.
Modulation of intracortical synaptic potentials by presynaptic somatic membrane potentialShu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.
Juxtacellular Labeling of Individual Neurons In Vivo: From Electrophysiology to SynaptologyDuque A, Zaborszky L. Juxtacellular Labeling of Individual Neurons In Vivo: From Electrophysiology to Synaptology. 2006, 197-236. DOI: 10.1007/0-387-28942-9_7.
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical NetworksHasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.
Sleep-wake mechanisms and basal forebrain circuitry.Zaborszky L, Duque A. Sleep-wake mechanisms and basal forebrain circuitry. Frontiers In Bioscience-Landmark 2003, 8: d1146-69. PMID: 12957822, DOI: 10.2741/1112.
Computational Anatomical Analysis of the Basal Forebrain Corticopetal SystemZaborszky L, Csordas A, Buhl D, Duque A, Somogyi J, Nadasdy Z. Computational Anatomical Analysis of the Basal Forebrain Corticopetal System. 2002, 0: 171-198. DOI: 10.1385/1-59259-275-9:171.
Local synaptic connections of basal forebrain neuronsZaborszky L, Duque A. Local synaptic connections of basal forebrain neurons. Behavioural Brain Research 2000, 115: 143-158. PMID: 11000417, DOI: 10.1016/s0166-4328(00)00255-2.
EEG Correlation of the Discharge Properties of Identified Neurons in the Basal ForebrainDuque A, Balatoni B, Detari L, Zaborszky L. EEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain. Journal Of Neurophysiology 2000, 84: 1627-1635. PMID: 10980032, DOI: 10.1152/jn.2000.84.3.1627.

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Selected Publications