Juan Arellano, PhD
Research Scientist in Neuroscience
Research & Publications
Biography
Coauthors
Selected Publications
- Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaquesBathla S, Datta D, Liang F, Barthelemy N, Wiseman R, Slusher B, Asher J, Zeiss C, Ekanayake‐Alper D, Holden D, Terwilliger G, Duque A, Arellano J, van Dyck C, Bateman R, Xie Z, Nairn A, Arnsten A. Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2023, 9: e12431. PMID: 37915375, PMCID: PMC10617575, DOI: 10.1002/trc2.12431.
- Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s diseaseDatta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.
- Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalonMicali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.
- Old Models Know Wrinkles BestArellano J, Rakic P. Old Models Know Wrinkles Best. 2023, 499-525. DOI: 10.1002/9781119860914.ch23.
- Role of intracortical neuropil growth in the gyrification of the primate cerebral cortexRash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.
- Neuroanatomical and psychological considerations in temporal lobe epilepsyDeFelipe J, DeFelipe-Oroquieta J, Furcila D, Muñoz-Alegre M, Maestú F, Sola R, Blázquez-Llorca L, Armañanzas R, Kastanaskaute A, Alonso-Nanclares L, Rockland K, Arellano J. Neuroanatomical and psychological considerations in temporal lobe epilepsy. Frontiers In Neuroanatomy 2022, 16: 995286. PMID: 36590377, PMCID: PMC9794593, DOI: 10.3389/fnana.2022.995286.
- P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOADDatta D, Morozov Y, Arellano J, van Dyck C, Arnsten A. P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD. Alzheimer's & Dementia 2019, 15: p1329-p1329. DOI: 10.1016/j.jalz.2019.06.3804.
- Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-neuronal CellsSarkisian M, Arellano J, Breunig J. Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-neuronal Cells. 2012, 105-129. DOI: 10.1007/978-94-007-5808-7_4.
- Development of the Primate Cerebral CortexRakic P, Arellano J, Breunig J. Development of the Primate Cerebral Cortex. 2009 DOI: 10.7551/mitpress/8029.003.0005.
- Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine MorphologiesArellano J, Benavides-Piccione R, DeFelipe J, Yuste R. Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine Morphologies. Frontiers In Neuroscience 2007, 1: 131-143. PMID: 18982124, PMCID: PMC2518053, DOI: 10.3389/neuro.01.1.1.010.2007.
- Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampusAndrioli A, Alonso-Nanclares L, Arellano J, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience 2007, 149: 131-143. PMID: 17850980, DOI: 10.1016/j.neuroscience.2007.07.029.
- Glowing Green Pyramids: A False Positive for Neocortical Neurogenesis Reveals a Novel Neuronal–Microglial Fusion in the Postnatal BrainBreunig J, Arellano J. Glowing Green Pyramids: A False Positive for Neocortical Neurogenesis Reveals a Novel Neuronal–Microglial Fusion in the Postnatal Brain. Journal Of Neuroscience 2007, 27: 1507-1508. PMID: 17304702, PMCID: PMC6673745, DOI: 10.1523/jneurosci.5475-06.2007.
- 4.12 Specializations of the Cortical Microstructure of HumansDeFelipe J, Alonso-Nanclares L, Arellano J, Ballesteros-Yáñez I, Benavides-Piccione R, Muñoz A. 4.12 Specializations of the Cortical Microstructure of Humans. 2007, 167-190. DOI: 10.1016/b0-12-370878-8/00043-4.
- Non-synaptic dendritic spines in neocortexArellano J, Espinosa A, Fairén A, Yuste R, DeFelipe J. Non-synaptic dendritic spines in neocortex. Neuroscience 2006, 145: 464-469. PMID: 17240073, DOI: 10.1016/j.neuroscience.2006.12.015.
- Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal CortexBenavides-Piccione R, Arellano J, DeFelipe J. Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex. Cerebral Cortex 2005, 15: 1584-1591. PMID: 15703259, DOI: 10.1093/cercor/bhi036.
- CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to EpilepsyVelez‐Pardo C, Arellano J, Cardona‐Gomez P, Del Rio M, Lopera F, De Felipe J. CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy. Epilepsia 2004, 45: 751-756. PMID: 15230697, DOI: 10.1111/j.0013-9580.2004.55403.x.
- Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampusArellano J, Muñoz A, Ballesteros‐Yáñez I, Sola R, DeFelipe J. Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain 2003, 127: 45-64. PMID: 14534159, DOI: 10.1093/brain/awh004.
- A Model of Human Cortical Microcircuits for the Study of the Development of EpilepsySánchez-Montañés M, Lago-Fernández L, Castellanos N, Merchán-Pérez Á, Arellano J, DeFelipe J. A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy. 2002, 2415: 248-253. DOI: 10.1007/3-540-46084-5_41.
- Spaceflight Induces Changes in the Synaptic Circuitry of the Postnatal Developing NeocortexDeFelipe J, Arellano J, Merchán-Pérez A, González-Albo M, Walton K, Llinás R. Spaceflight Induces Changes in the Synaptic Circuitry of the Postnatal Developing Neocortex. Cerebral Cortex 2002, 12: 883-891. PMID: 12122037, DOI: 10.1093/cercor/12.8.883.
- GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsyMuñoz A, Arellano J, Defelipe J. GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy. The Journal Of Comparative Neurology 2002, 449: 166-179. PMID: 12115687, DOI: 10.1002/cne.10287.
- PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal CortexArellano J, DeFelipe J, Muñoz A. PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex. Cerebral Cortex 2002, 12: 617-624. PMID: 12003861, DOI: 10.1093/cercor/12.6.617.
- Synaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal SlicesAraque A, Martín E, Perea G, Arellano J, Buño W. Synaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal Slices. Journal Of Neuroscience 2002, 22: 2443-2450. PMID: 11923408, PMCID: PMC6758296, DOI: 10.1523/jneurosci.22-07-02443.2002.
- Microstructure of the neocortex: Comparative aspectsDeFelipe J, Alonso-Nanclares L, Arellano J. Microstructure of the neocortex: Comparative aspects. Brain Cell Biology 2002, 31: 299-316. PMID: 12815249, DOI: 10.1023/a:1024130211265.
- The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity.DeFelipe Oroquieta J, Arellano J, Alonso L, Muñoz A. The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity. Revista De Neurologia 2002, 34: 401-8. PMID: 12040509, DOI: 10.33588/rn.3405.2001403.
- Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortexSánchez C, Arellano J, Rodríguez-Sánchez P, Avila J, DeFelipe J, Díez-Guerra F. Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex. Neuroscience 2001, 107: 25-33. PMID: 11744243, DOI: 10.1016/s0306-4522(01)00338-4.
- Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg SyndromeDeFelipe J, Segura T, Arellano J, Merchán A, DeFelipe‐Oroquieta J, Martín P, Maestú F, Cajal S, Sánchez A, Sola R. Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome. Epilepsia 2001, 42: 1198-1203. PMID: 11580770, DOI: 10.1046/j.1528-1157.2001.45800.x.
- Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine ReleasePersico A, Mengual E, Moessner R, Hall S, Revay R, Sora I, Arellano J, DeFelipe J, Giménez-Amaya J, Conciatori M, Marino R, Baldi A, Cabib S, Pascucci T, Uhl G, Murphy D, Lesch K, Keller F. Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release. Journal Of Neuroscience 2001, 21: 6862-6873. PMID: 11517274, PMCID: PMC6763105, DOI: 10.1523/jneurosci.21-17-06862.2001.
- Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortexDeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.
- Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortexElston G, DeFelipe J, Arellano J, del Carmen Gonzilez-Albo M, Rosa M. Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex. Neuroreport 1999, 10: 2975-2979. PMID: 10549808, DOI: 10.1097/00001756-199909290-00019.