Leonard Kaczmarek, PhD
Research & Publications
Biography
News
Research Summary
Research in our laboratory is aimed at understanding the nature of the biochemical changes that occur in neurons and that result in prolonged changes in the behavior of an animal or in its ability to detect specific patterns of sensory inputs. It is known that alterations of the intrinsic electrical excitability of specific neurons are the key feature of such events, and that these are caused by the short-term and long-term regulation of proteins termed ion channels. Our laboratory has isolated the genes for multiple ion channels, and is studying both how these channels function to in the normal nervous system, and how human mutations in these channels give rise to several neurological conditions that produce severe intellectual disability.
Specialized Terms: Neuroscience; Learning and memory; Ion channels
Extensive Research Description
Our laboratory has investigates the role of potassium channels, as well as other classes of ion channels, in the short-term and long-term regulation of neuronal excitability. Our group was the first to demonstrate directly, using purified enzymes, that excitability of neurons is regulated by cyclic AMP-dependent protein kinase, protein kinase C and tyrosine phosphatases. As part of this work we isolated the genes for over fourteen novel ion channels and were the first to identify the “two-pore” family of potassium channels. Among the channels that our group cloned and characterized are Kv3.1b channel, which is required for high-frequency firing in many neurons and the Slack and Slick genes that underlie Na+-activated K+ channels. Our work was the first to show directly that rapid changes in the phosphorylation state of ion channels and in the synthesis of new channels occur in vivo in response to changes in an animal’s environment. Most recently, we have found that the Slack protein interacts with the Fragile X Mental Retardation Protein FMRP and that human mutations in Slack produce very severe epilepsy and developmental delay. This is now a major focus of our laboratory.
Coauthors
Research Interests
Ion Channels; Learning; Memory; Neurosciences; Pharmacology; Physiology
Selected Publications
- Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2023.1Aldrich R, Chandy K, Grissmer S, Gutman G, Kaczmarek L, Wei A, Wulff H. Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2023.1. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f69/2023.1.
- The Difficult Path to the Discovery of Novel Treatments in Psychiatric DisordersGribkoff V, Kaczmarek L. The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders. 2023, 30: 255-285. PMID: 36928854, DOI: 10.1007/978-3-031-21054-9_11.
- Modulation of potassium conductances optimizes fidelity of auditory informationKaczmarek L. Modulation of potassium conductances optimizes fidelity of auditory information. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2216440120. PMID: 36930599, PMCID: PMC10041146, DOI: 10.1073/pnas.2216440120.
- Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effectTakahashi T, Stoiljkovic M, Song E, Gao X, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu Z, Kristant A, Zhang Y, Sulkowski P, Glazer P, Kaczmarek L, Horvath T, Iwasaki A. Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effect. Neuron 2023, 111: 612-613. PMID: 36863323, DOI: 10.1016/j.neuron.2023.02.006.
- Modulation of potassium channels preserves temporal fidelity in auditory network modelsKaczmarek L. Modulation of potassium channels preserves temporal fidelity in auditory network models. Biophysical Journal 2023, 122: 245a. DOI: 10.1016/j.bpj.2022.11.1428.
- LINE-1 activation in the cerebellum drives ataxiaTakahashi T, Stoiljkovic M, Song E, Gao XB, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu ZW, Kristant A, Zhang Y, Sulkowski P, Glazer PM, Kaczmarek LK, Horvath TL, Iwasaki A. LINE-1 activation in the cerebellum drives ataxia. Neuron 2022, 110: 3278-3287.e8. PMID: 36070749, PMCID: PMC9588660, DOI: 10.1016/j.neuron.2022.08.011.
- Auditory brainstem development of naked mole-rats (Heterocephalus glaber)McCullagh EA, Peacock J, Lucas A, Poleg S, Greene NT, Gaut A, Lagestee S, Zhang Y, Kaczmarek LK, Park TJ, Tollin DJ, Klug A. Auditory brainstem development of naked mole-rats (Heterocephalus glaber). Proceedings Of The Royal Society B 2022, 289: 20220878. PMID: 35946148, PMCID: PMC9363996, DOI: 10.1098/rspb.2022.0878.
- Editorial: Alterations in the Sound Localization Pathway Related to Impaired Cocktail-Party PerformanceMcCullagh EA, Kaczmarek LK, Tollin DJ, Klug A. Editorial: Alterations in the Sound Localization Pathway Related to Impaired Cocktail-Party Performance. Frontiers In Neuroscience 2022, 16: 902197. PMID: 35546884, PMCID: PMC9082812, DOI: 10.3389/fnins.2022.902197.
- The role of altered translation in intellectual disability and epilepsyMalone TJ, Kaczmarek LK. The role of altered translation in intellectual disability and epilepsy. Progress In Neurobiology 2022, 213: 102267. PMID: 35364140, DOI: 10.1016/j.pneurobio.2022.102267.
- Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 miceZhang Y, Quraishi IH, McClure H, Williams LA, Cheng Y, Kale S, Dempsey GT, Agrawal S, Gerber DJ, McManus OB, Kaczmarek LK. Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice. The FASEB Journal 2021, 35: e22053. PMID: 34820911, PMCID: PMC8630780, DOI: 10.1096/fj.202101356r.
- THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channelsAlexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. British Journal Of Pharmacology 2021, 178: s157-s245. PMID: 34529831, DOI: 10.1111/bph.15539.
- Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3Aldrich R, Chandy K, Grissmer S, Gutman G, Kaczmarek L, Wei A, Wulff H. Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3. IUPHAR/BPS Guide To Pharmacology CITE 2021, 2021 DOI: 10.2218/gtopdb/f69/2021.3.
- The NaVy paradox: reducing sodium currents increases excitabilityKaczmarek LK. The NaVy paradox: reducing sodium currents increases excitability. Trends In Neurosciences 2021, 44: 767-768. PMID: 34373125, PMCID: PMC8813127, DOI: 10.1016/j.tins.2021.07.008.
- The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagenWright JR, Jones S, Parvathy S, Kaczmarek LK, Forsythe I, Farndale RW, Gibbins JM, Mahaut-Smith MP. The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen. Platelets 2021, 33: 1942818. PMID: 34348571, PMCID: PMC8935947, DOI: 10.1080/09537104.2021.1942818.
- A KCNC1 mutation in epilepsy of infancy with focal migrating seizures produces functional channels that fail to be regulated by PKC phosphorylationZhang Y, Ali SR, Nabbout R, Barcia G, Kaczmarek LK. A KCNC1 mutation in epilepsy of infancy with focal migrating seizures produces functional channels that fail to be regulated by PKC phosphorylation. Journal Of Neurophysiology 2021, 126: 532-539. PMID: 34232791, PMCID: PMC8409950, DOI: 10.1152/jn.00257.2021.
- Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D’Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK. Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. Nature Communications 2021, 12: 1731. PMID: 33741962, PMCID: PMC7979925, DOI: 10.1038/s41467-021-22003-8.
- Modulation of Neuronal Potassium Channels During Auditory ProcessingWu J, Kaczmarek LK. Modulation of Neuronal Potassium Channels During Auditory Processing. Frontiers In Neuroscience 2021, 15: 596478. PMID: 33613177, PMCID: PMC7887315, DOI: 10.3389/fnins.2021.596478.
- Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesiclesWu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG. Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles. Neuron 2021, 109: 938-946.e5. PMID: 33508244, PMCID: PMC7979485, DOI: 10.1016/j.neuron.2021.01.006.
- Excitable Membrane Properties of NeuronsKaczmarek L. Excitable Membrane Properties of Neurons. 2020, 3-32. DOI: 10.1093/oxfordhb/9780190669164.013.20.
- Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channelsQuraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P, Kaczmarek LK. Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels. Scientific Reports 2020, 10: 3213. PMID: 32081855, PMCID: PMC7035262, DOI: 10.1038/s41598-020-60028-z.
- Mechanisms underlying auditory processing deficits in Fragile X syndromeMcCullagh EA, Rotschafer SE, Auerbach BD, Klug A, Kaczmarek LK, Cramer KS, Kulesza RJ, Razak KA, Lovelace JW, Lu Y, Koch U, Wang Y. Mechanisms underlying auditory processing deficits in Fragile X syndrome. The FASEB Journal 2020, 34: 3501-3518. PMID: 32039504, PMCID: PMC7347277, DOI: 10.1096/fj.201902435r.
- Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1)Ali SR, Malone TJ, Zhang Y, Prechova M, Kaczmarek LK. Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1). The FASEB Journal 2019, 34: 1591-1601. PMID: 31914597, PMCID: PMC6956700, DOI: 10.1096/fj.201902366r.
- THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channelsAlexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, Armstrong J, Faccenda E, Harding S, Pawson A, Sharman J, Southan C, Davies J, Collaborators C, Aldrich R, Aldrich R, Becirovic E, Becirovic E, Biel M, Biel M, Catterall W, Catterall W, Conner A, Conner A, Davies P, Davies P, Delling M, Delling M, Di Virgilio F, Di Virgilio F, Falzoni S, Falzoni S, George C, George C, Goldstein S, Goldstein S, Grissmer S, Grissmer S, Ha K, Hammelmann V, Ha K, Hammelmann V, Hanukoglu I, Hanukoglu I, Jarvis M, Jarvis M, Jensen A, Jensen A, Kaczmarek L, Kaczmarek L, Kellenberger S, Kellenberger S, Kennedy C, Kennedy C, King B, King B, Lynch J, Lynch J, Perez-Reyes E, Perez-Reyes E, Plant L, Plant L, Rash L, Rash L, Ren D, Ren D, Sivilotti L, Sivilotti L, Smart T, Snutch T, Smart T, Snutch T, Tian J, Tian J, Van den Eynde C, Van den Eynde C, Vriens J, Vriens J, Wei A, Wei A, Winn B, Winn B, Wulff H, Wulff H, Xu H, Xu H, Yue L, Yue L, Zhang X, Zhang X, Zhu M, Zhu M. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels. British Journal Of Pharmacology 2019, 176: s142-s228. PMID: 31710715, PMCID: PMC6844578, DOI: 10.1111/bph.14749.
- Calcium- and sodium-activated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology DatabaseAldrich R, Chandy K, Grissmer S, Gutman G, Kaczmarek L, Wei A, Wulff H. Calcium- and sodium-activated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f69/2019.4.
- Loss of NaV1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual DisabilityKaczmarek LK. Loss of NaV1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability. Neuron 2019, 103: 551-553. PMID: 31437449, DOI: 10.1016/j.neuron.2019.07.032.
- An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa CurrentsQuraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. Journal Of Neuroscience 2019, 39: 7438-7449. PMID: 31350261, PMCID: PMC6759030, DOI: 10.1523/jneurosci.1628-18.2019.
- Role of KCNQ potassium channels in stress-induced deficit of working memoryArnsten AFT, Jin LE, Gamo NJ, Ramos B, Paspalas CD, Morozov YM, Kata A, Bamford NS, Yeckel MF, Kaczmarek LK, El-Hassar L. Role of KCNQ potassium channels in stress-induced deficit of working memory. Neurobiology Of Stress 2019, 11: 100187. PMID: 31832507, PMCID: PMC6889760, DOI: 10.1016/j.ynstr.2019.100187.
- Modulators of Kv3 potassium channels rescue the auditory function of Fragile X miceEl-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 potassium channels rescue the auditory function of Fragile X mice. Journal Of Neuroscience 2019, 39: 0839-18. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.
- Loss of HAX-1 May Contribute to the Neurodegeneration Caused by a Kv3.3 MutationZhang Y, Varela L, Szigeti-Buck K, Horvath T, Kaczmarek L. Loss of HAX-1 May Contribute to the Neurodegeneration Caused by a Kv3.3 Mutation. Biophysical Journal 2019, 116: 104a. DOI: 10.1016/j.bpj.2018.11.596.
- Activation of Slack Potassium Channels (KCNT1) Triggers an Increase in mRNA TranslationMalone T, Licznerski P, Jonas E, Kaczmarek L. Activation of Slack Potassium Channels (KCNT1) Triggers an Increase in mRNA Translation. Biophysical Journal 2019, 116: 306a. DOI: 10.1016/j.bpj.2018.11.1658.
- C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticityKhare S, Galeano K, Zhang Y, Nick JA, Nick HS, Subramony SH, Sampson J, Kaczmarek LK, Waters MF. C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity. The Cerebellum 2018, 17: 692-697. PMID: 29949095, PMCID: PMC8299775, DOI: 10.1007/s12311-018-0950-5.
- Extraction of Auditory Information by Modulation of Neuronal Ion ChannelsKaczmarek L. Extraction of Auditory Information by Modulation of Neuronal Ion Channels. 2018, 273-300. DOI: 10.1093/oxfordhb/9780190849061.013.23.
- The Functional Modulation of Sodium-Activated Potassium (Slack) Channels by Phosphatase and Actin Regulator 1 (Phactr1)Ali S, Kaczmarek L. The Functional Modulation of Sodium-Activated Potassium (Slack) Channels by Phosphatase and Actin Regulator 1 (Phactr1). Biophysical Journal 2018, 114: 295a-296a. DOI: 10.1016/j.bpj.2017.11.1687.
- iPSC-Derived Neurons Harboring a Known Epilepsy Mutation Provide a ‘Disease-in-a-Dish’ Capability that Displays Established and Novel Epileptic PhenotypesMangan K, Quraishi I, Zhang Y, McLachlan M, Meline B, McMahon C, Enghofer E, Kannemeier C, Jones E, Kaczmarek L. iPSC-Derived Neurons Harboring a Known Epilepsy Mutation Provide a ‘Disease-in-a-Dish’ Capability that Displays Established and Novel Epileptic Phenotypes. Biophysical Journal 2018, 114: 487a. DOI: 10.1016/j.bpj.2017.11.2674.
- Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damageChambers AR, Pilati N, Balaram P, Large CH, Kaczmarek LK, Polley DB. Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage. Scientific Reports 2017, 7: 17496. PMID: 29235497, PMCID: PMC5727503, DOI: 10.1038/s41598-017-17406-x.
- Tuning Neuronal Potassium Channels to the Auditory EnvironmentKaczmarek L. Tuning Neuronal Potassium Channels to the Auditory Environment. 2017, 64: 133-159. DOI: 10.1007/978-3-319-21530-3_6.
- Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal EnduranceKaczmarek LK, Zhang Y. Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance. Physiological Reviews 2017, 97: 1431-1468. PMID: 28904001, PMCID: PMC6151494, DOI: 10.1152/physrev.00002.2017.
- A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR traffickingKhare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF. A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. PLOS ONE 2017, 12: e0173565. PMID: 28467418, PMCID: PMC5414954, DOI: 10.1371/journal.pone.0173565.
- Role of Tank-Binding Kinase in Neurodegeneration Produced by Spinocerebellar Ataxia Type 13Zhang Y, Varela L, Horvath T, Kaczmarek L. Role of Tank-Binding Kinase in Neurodegeneration Produced by Spinocerebellar Ataxia Type 13. Biophysical Journal 2017, 112: 405a. DOI: 10.1016/j.bpj.2016.11.2193.
- IPSC-Derived Neurons Harboring a Known Epilepsy Mutation Display Known and Novel Electrophysiological PhenotypesCarlson C, Quaraishi I, Zhang Y, McLachlan M, Meline B, McMahon C, Burke T, Jones E, Kaczmarek L, Mangan K. IPSC-Derived Neurons Harboring a Known Epilepsy Mutation Display Known and Novel Electrophysiological Phenotypes. Biophysical Journal 2017, 112: 547a. DOI: 10.1016/j.bpj.2016.11.2954.
- An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia NeuronsZhang Y, Ni W, Horwich AL, Kaczmarek LK. An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons. Journal Of Neuroscience 2017, 37: 2258-2265. PMID: 28119399, PMCID: PMC5338764, DOI: 10.1523/jneurosci.3102-16.2017.
- Chapter 16 Ion Channel Dysfunction and FXSFrick A, Ginger M, El-Hassar L, Kaczmarek L. Chapter 16 Ion Channel Dysfunction and FXS. 2017, 323-340. DOI: 10.1016/b978-0-12-804461-2.00016-0.
- International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium ChannelsKaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacological Reviews 2016, 69: 1-11. PMID: 28267675, DOI: 10.1124/pr.116.012864.
- Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial GliaOnorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell’Anno M, Gulden FO, Pochareddy S, Tebbenkamp AT, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 2016, 16: 2576-2592. PMID: 27568284, PMCID: PMC5135012, DOI: 10.1016/j.celrep.2016.08.038.
- Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory ComplexFleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK. Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex. Cell Reports 2016, 16: 2281-2288. PMID: 27545877, PMCID: PMC5123741, DOI: 10.1016/j.celrep.2016.07.024.
- Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neuronsBrown MR, El-Hassar L, Zhang Y, Alvaro G, Large CH, Kaczmarek LK. Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons. Journal Of Neurophysiology 2016, 116: 106-121. PMID: 27052580, PMCID: PMC4961756, DOI: 10.1152/jn.00174.2016.
- Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel GatingZhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK. Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell 2016, 165: 434-448. PMID: 26997484, PMCID: PMC4826296, DOI: 10.1016/j.cell.2016.02.009.
- The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomesGribkoff VK, Kaczmarek LK. The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes. Neuropharmacology 2016, 120: 11-19. PMID: 26979921, PMCID: PMC5820030, DOI: 10.1016/j.neuropharm.2016.03.021.
- T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 ChannelsMatza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA. T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. PLOS ONE 2016, 11: e0147379. PMID: 26815481, PMCID: PMC4729531, DOI: 10.1371/journal.pone.0147379.
- Kv3.3 potassium channels and spinocerebellar ataxiaZhang Y, Kaczmarek LK. Kv3.3 potassium channels and spinocerebellar ataxia. The Journal Of Physiology 2015, 594: 4677-4684. PMID: 26442672, PMCID: PMC4983625, DOI: 10.1113/jp271343.
- Signaling in the BrainLevitan I, Kaczmarek L. Signaling in the Brain. 2015, 3-22. DOI: 10.1093/med/9780199773893.003.0001.
- Electrical Signaling in NeuronsLevitan I, Kaczmarek L. Electrical Signaling in Neurons. 2015, 41-62. DOI: 10.1093/med/9780199773893.003.0003.
- Membrane Ion Channels and Ion CurrentsLevitan I, Kaczmarek L. Membrane Ion Channels and Ion Currents. 2015, 63-84. DOI: 10.1093/med/9780199773893.003.0004.
- Ion Channels Are Membrane ProteinsLevitan I, Kaczmarek L. Ion Channels Are Membrane Proteins. 2015, 85-102. DOI: 10.1093/med/9780199773893.003.0005.
- Ion Channels, Membrane Ion Currents, and the Action PotentialLevitan I, Kaczmarek L. Ion Channels, Membrane Ion Currents, and the Action Potential. 2015, 103-126. DOI: 10.1093/med/9780199773893.003.0006.
- How Neurons Communicate: Gap Junctions and NeurosecretionLevitan I, Kaczmarek L. How Neurons Communicate: Gap Junctions and Neurosecretion. 2015, 153-186. DOI: 10.1093/med/9780199773893.003.0008.
- Neurotransmitters and NeurohormonesLevitan I, Kaczmarek L. Neurotransmitters and Neurohormones. 2015, 213-238. DOI: 10.1093/med/9780199773893.003.0010.
- Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion ChannelsLevitan I, Kaczmarek L. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels. 2015, 239-262. DOI: 10.1093/med/9780199773893.003.0011.
- Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel SystemsLevitan I, Kaczmarek L. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems. 2015, 263-294. DOI: 10.1093/med/9780199773893.003.0012.
- Sensory ReceptorsLevitan I, Kaczmarek L. Sensory Receptors. 2015, 295-326. DOI: 10.1093/med/9780199773893.003.0013.
- Neuronal Growth and Trophic FactorsLevitan I, Kaczmarek L. Neuronal Growth and Trophic Factors. 2015, 353-386. DOI: 10.1093/med/9780199773893.003.0015.
- Adhesion Molecules and Axon PathfindingLevitan I, Kaczmarek L. Adhesion Molecules and Axon Pathfinding. 2015, 387-414. DOI: 10.1093/med/9780199773893.003.0016.
- Formation, Maintenance, and Plasticity of Chemical SynapsesLevitan I, Kaczmarek L. Formation, Maintenance, and Plasticity of Chemical Synapses. 2015, 415-456. DOI: 10.1093/med/9780199773893.003.0017.
- Intrinsic Neuronal Properties, Neural Networks, and BehaviorLevitan I, Kaczmarek L. Intrinsic Neuronal Properties, Neural Networks, and Behavior. 2015, 457-488. DOI: 10.1093/med/9780199773893.003.0018.
- The Birth and Death of a NeuronLevitan I, Kaczmarek L. The Birth and Death of a Neuron. 2015, 329-352. DOI: 10.1093/med/9780199773893.003.0014.
- Synaptic Release of NeurotransmittersLevitan I, Kaczmarek L. Synaptic Release of Neurotransmitters. 2015, 187-212. DOI: 10.1093/med/9780199773893.003.0009.
- Form and Function in Cells of the BrainLevitan I, Kaczmarek L. Form and Function in Cells of the Brain. 2015, 23-38. DOI: 10.1093/med/9780199773893.003.0002.
- Diversity in the Structure and Function of Ion ChannelsLevitan I, Kaczmarek L. Diversity in the Structure and Function of Ion Channels. 2015, 127-150. DOI: 10.1093/med/9780199773893.003.0007.
- Learning and MemoryLevitan I, Kaczmarek L. Learning and Memory. 2015, 489-528. DOI: 10.1093/med/9780199773893.003.0019.
- The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in miceBausch AE, Dieter R, Nann Y, Hausmann M, Meyerdierks N, Kaczmarek LK, Ruth P, Lukowski R. The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice. Learning & Memory 2015, 22: 323-335. PMID: 26077685, PMCID: PMC4478330, DOI: 10.1101/lm.037820.114.
- Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual ChannelsKim GE, Kronengold J, Barcia G, Quraishi IH, Martin HC, Blair E, Taylor JC, Dulac O, Colleaux L, Nabbout R, Kaczmarek LK. Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels. Cell Reports 2014, 9: 1661-1672. PMID: 25482562, PMCID: PMC4294418, DOI: 10.1016/j.celrep.2014.11.015.
- More Than a Pore: Ion Channel Signaling ComplexesLee A, Fakler B, Kaczmarek LK, Isom LL. More Than a Pore: Ion Channel Signaling Complexes. Journal Of Neuroscience 2014, 34: 15159-15169. PMID: 25392484, PMCID: PMC4228125, DOI: 10.1523/jneurosci.3275-14.2014.
- Emerging role of the KCNT1 Slack channel in intellectual disabilityKim GE, Kaczmarek LK. Emerging role of the KCNT1 Slack channel in intellectual disability. Frontiers In Cellular Neuroscience 2014, 8: 209. PMID: 25120433, PMCID: PMC4112808, DOI: 10.3389/fncel.2014.00209.
- Use of label-free optical biosensors to detect modulation of potassium channels by G-protein coupled receptors.Fleming MR, Shamah SM, Kaczmarek LK. Use of label-free optical biosensors to detect modulation of potassium channels by G-protein coupled receptors. Journal Of Visualized Experiments 2014, e51307. PMID: 24562095, PMCID: PMC4122194, DOI: 10.3791/51307.
- Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled ReceptorsFleming M, Shamah S, Kaczmarek L. Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors. Journal Of Visualized Experiments 2014 DOI: 10.3791/51307-v.
- Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosisMartin HC, Kim GE, Pagnamenta AT, Murakami Y, Carvill GL, Meyer E, Copley RR, Rimmer A, Barcia G, Fleming MR, Kronengold J, Brown MR, Hudspith KA, Broxholme J, Kanapin A, Cazier JB, Kinoshita T, Nabbout R, , Bentley D, McVean G, Heavin S, Zaiwalla Z, McShane T, Mefford HC, Shears D, Stewart H, Kurian MA, Scheffer IE, Blair E, Donnelly P, Kaczmarek LK, Taylor JC. Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. Human Molecular Genetics 2014, 23: 3200-3211. PMID: 24463883, PMCID: PMC4030775, DOI: 10.1093/hmg/ddu030.
- Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ ChannelsEl-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 2014, 76: 476-485. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.
- Activation of Slack Channels Alters their Interactions with the Pp1 Targeting Protein Phactr1Fleming M, Kaczmarek L. Activation of Slack Channels Alters their Interactions with the Pp1 Targeting Protein Phactr1. Biophysical Journal 2014, 106: 543a-544a. DOI: 10.1016/j.bpj.2013.11.3028.
- Expression of Kv1.3 potassium channels regulates density of cortical interneuronsDuque A, Gazula V, Kaczmarek LK. Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Developmental Neurobiology 2013, 73: 841-855. PMID: 23821603, PMCID: PMC3829632, DOI: 10.1002/dneu.22105.
- Slack, Slick, and Sodium-Activated Potassium ChannelsKaczmarek LK. Slack, Slick, and Sodium-Activated Potassium Channels. International Scholarly Research Notices 2013, 2013: 354262. PMID: 24319675, PMCID: PMC3850776, DOI: 10.1155/2013/354262.
- Gating modulation of the sodium‐activated potassium channel KCa4.1 (Slack) by bithionol and niclosamideFleming M, Singh V, Jenkins D, Wulff H, Kaczmarek L. Gating modulation of the sodium‐activated potassium channel KCa4.1 (Slack) by bithionol and niclosamide. The FASEB Journal 2013, 27: 913.24-913.24. DOI: 10.1096/fasebj.27.1_supplement.913.24.
- A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitudeMarkham MR, Kaczmarek LK, Zakon HH. A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude. Journal Of Neurophysiology 2013, 109: 1713-1723. PMID: 23324315, PMCID: PMC3628015, DOI: 10.1152/jn.00875.2012.
- The contribution of TWIK-1 channels to astrocyte K+ current is limited by retention in intracellular compartmentsWang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M. The contribution of TWIK-1 channels to astrocyte K+ current is limited by retention in intracellular compartments. Frontiers In Cellular Neuroscience 2013, 7: 246. PMID: 24368895, PMCID: PMC3856854, DOI: 10.3389/fncel.2013.00246.
- Use of Resonance-Wavelength Grating Optical Biosensors to Detect Channel-Protein Interaction in Slack KNa ChannelsFleming M, Barcia G, Colleaux L, Nabbout R, Kaczmarek L. Use of Resonance-Wavelength Grating Optical Biosensors to Detect Channel-Protein Interaction in Slack KNa Channels. Biophysical Journal 2013, 104: 131a. DOI: 10.1016/j.bpj.2012.11.750.
- Biogenesis of the Sodium-Activated Potassium Channel Slack-B is Controlled by the Dephosphorylation of N-Terminal SerinesKim G, Fleming M, Kronengold J, Kaczmarek L. Biogenesis of the Sodium-Activated Potassium Channel Slack-B is Controlled by the Dephosphorylation of N-Terminal Serines. Biophysical Journal 2013, 104: 131a. DOI: 10.1016/j.bpj.2012.11.751.
- An evolutionarily conserved mode of modulation of Shaw‐like K+ channelsCotella D, Hernandez‐Enriquez B, Duan Z, Wu X, Gazula V, Brown MR, Kaczmarek LK, Sesti F. An evolutionarily conserved mode of modulation of Shaw‐like K+ channels. The FASEB Journal 2012, 27: 1381-1393. PMID: 23233530, PMCID: PMC3606535, DOI: 10.1096/fj.12-222778.
- Regulation of Neuronal Excitability by Interaction of Fragile X Mental Retardation Protein with Slack Potassium ChannelsZhang Y, Brown MR, Hyland C, Chen Y, Kronengold J, Fleming MR, Kohn AB, Moroz LL, Kaczmarek LK. Regulation of Neuronal Excitability by Interaction of Fragile X Mental Retardation Protein with Slack Potassium Channels. Journal Of Neuroscience 2012, 32: 15318-15327. PMID: 23115170, PMCID: PMC3518385, DOI: 10.1523/jneurosci.2162-12.2012.
- De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancyBarcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J, Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R. De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nature Genetics 2012, 44: 1255-1259. PMID: 23086397, PMCID: PMC3687547, DOI: 10.1038/ng.2441.
- Gradients and Modulation of K+ Channels Optimize Temporal Accuracy in Networks of Auditory NeuronsKaczmarek LK. Gradients and Modulation of K+ Channels Optimize Temporal Accuracy in Networks of Auditory Neurons. PLOS Computational Biology 2012, 8: e1002424. PMID: 22438799, PMCID: PMC3305353, DOI: 10.1371/journal.pcbi.1002424.
- Use of Resonance-Wavelength Grating Optical Biosensors to Detect Channel-Protein Interaction in Slack KNa ChannelsFleming M, Brown M, Kaczmarek L. Use of Resonance-Wavelength Grating Optical Biosensors to Detect Channel-Protein Interaction in Slack KNa Channels. Biophysical Journal 2012, 102: 532a. DOI: 10.1016/j.bpj.2011.11.2908.
- Bcl-x L regulates mitochondrial energetics by stabilizing the inner membrane potentialChen Y, Aon M, Hsu Y, Soane L, Teng X, McCaffery J, Cheng W, Qi B, Li H, Alavian K, Dayhoff-Brannigan M, Zou S, Pineda F, O'Rourke B, Ko Y, Pedersen P, Kaczmarek L, Jonas E, Hardwick J. Bcl-x L regulates mitochondrial energetics by stabilizing the inner membrane potential. Journal Of Experimental Medicine 2011, 208: i29-i29. DOI: 10.1084/jem20811oia29.
- Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potentialChen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM. Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. Journal Of Cell Biology 2011, 195: 263-276. PMID: 21987637, PMCID: PMC3198165, DOI: 10.1083/jcb.201108059.
- Potassium channel modulation and auditory processingBrown MR, Kaczmarek LK. Potassium channel modulation and auditory processing. Hearing Research 2011, 279: 32-42. PMID: 21414395, PMCID: PMC3137660, DOI: 10.1016/j.heares.2011.03.004.
- Phosphorylation Regulates Gating and Channel-Protein Interaction in the Slack Kna ChannelFleming M, Kaczmarek L. Phosphorylation Regulates Gating and Channel-Protein Interaction in the Slack Kna Channel. Biophysical Journal 2011, 100: 284a. DOI: 10.1016/j.bpj.2010.12.1758.
- Fragile X Mental Retardation Protein Is Required for Rapid Experience-Dependent Regulation of the Potassium Channel Kv3.1bStrumbos JG, Brown MR, Kronengold J, Polley DB, Kaczmarek LK. Fragile X Mental Retardation Protein Is Required for Rapid Experience-Dependent Regulation of the Potassium Channel Kv3.1b. Journal Of Neuroscience 2010, 30: 10263-10271. PMID: 20685971, PMCID: PMC3485078, DOI: 10.1523/jneurosci.1125-10.2010.
- A Less Flexible BK Channel Opens More EasilyKronengold J, Kaczmarek LK. A Less Flexible BK Channel Opens More Easily. Neuron 2010, 66: 817-818. PMID: 20620867, PMCID: PMC3703916, DOI: 10.1016/j.neuron.2010.06.013.
- Fragile X mental retardation protein controls gating of the sodium-activated potassium channel SlackBrown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D, Kaczmarek LK. Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nature Neuroscience 2010, 13: 819-821. PMID: 20512134, PMCID: PMC2893252, DOI: 10.1038/nn.2563.
- Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neuronsGazula V, Strumbos JG, Mei X, Chen H, Rahner C, Kaczmarek LK. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. The Journal Of Comparative Neurology 2010, 518: 3205-3220. PMID: 20575068, PMCID: PMC2894291, DOI: 10.1002/cne.22393.
- Kv1.3 is the exclusive voltage‐gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet countMcCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut‐Smith M. Kv1.3 is the exclusive voltage‐gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count. The Journal Of Physiology 2010, 588: 1399-1406. PMID: 20308249, PMCID: PMC2876798, DOI: 10.1113/jphysiol.2010.188136.
- Controlling auditory excitability: the benefits of a cultured environmentKaczmarek LK. Controlling auditory excitability: the benefits of a cultured environment. The Journal Of Physiology 2010, 588: 1387-1388. PMID: 20436041, PMCID: PMC2876793, DOI: 10.1113/jphysiol.2010.189712.
- The Slack Sodium-Activated Potassium Channel Provides a Major Outward Current in Olfactory Neurons of Kv1.3−/− Super-Smeller MiceLu S, Das P, Fadool DA, Kaczmarek LK. The Slack Sodium-Activated Potassium Channel Provides a Major Outward Current in Olfactory Neurons of Kv1.3−/− Super-Smeller Mice. Journal Of Neurophysiology 2010, 103: 3311-3319. PMID: 20393063, PMCID: PMC2888249, DOI: 10.1152/jn.00607.2009.
- Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult ratStrumbos J, Polley D, Kaczmarek L. Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat. Neuroscience 2010, 167: 567-572. PMID: 20219640, PMCID: PMC2854512, DOI: 10.1016/j.neuroscience.2010.02.046.
- Identification of Regulatory Phosphorylation Sites in Slack and Slick Sodium Activated Potassium (KNa) ChannelsFleming M, Kronengold J, Yan Y, Lam T, Gulcicek E, Sigworth F, Nairn A, Kaczmarek L. Identification of Regulatory Phosphorylation Sites in Slack and Slick Sodium Activated Potassium (KNa) Channels. Biophysical Journal 2010, 98: 316a. DOI: 10.1016/j.bpj.2009.12.1714.
- Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptorsFleming MR, Kaczmarek LK. Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors. Journal Of Receptors And Signal Transduction 2009, 29: 173-181. PMID: 19640220, PMCID: PMC3727623, DOI: 10.1080/10799890903056883.
- The N-Terminal Domain of Slack Determines the Formation and Trafficking of Slick/Slack Heteromeric Sodium-Activated Potassium ChannelsChen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK. The N-Terminal Domain of Slack Determines the Formation and Trafficking of Slick/Slack Heteromeric Sodium-Activated Potassium Channels. Journal Of Neuroscience 2009, 29: 5654-5665. PMID: 19403831, PMCID: PMC3688047, DOI: 10.1523/jneurosci.5978-08.2009.
- Single channel studies of heteromer formation between Slick and Slack K(Na) subunitsKronengold J, Brown M, Chen H, Salkoff L, Kaczmarek L. Single channel studies of heteromer formation between Slick and Slack K(Na) subunits. Biophysical Journal 2009, 96: 482a. DOI: 10.1016/j.bpj.2008.12.2487.
- Amino-termini Isoforms Of Slack K(Na) Channel Differentially Influence The Rate Of Neuronal Adaptation.Brown M, Kronengold J, Bhattacharjee A, Kaczmarek L. Amino-termini Isoforms Of Slack K(Na) Channel Differentially Influence The Rate Of Neuronal Adaptation. Biophysical Journal 2009, 96: 482a. DOI: 10.1016/j.bpj.2008.12.2486.
- Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmissionNanou E, Kyriakatos A, Bhattacharjee A, Kaczmarek LK, Paratcha G, Manira A. Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 20941-20946. PMID: 19095801, PMCID: PMC2634910, DOI: 10.1073/pnas.0806403106.
- Amino‐termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptationBrown MR, Kronengold J, Gazula V, Spilianakis CG, Flavell RA, Von Hehn CA, Bhattacharjee A, Kaczmarek LK. Amino‐termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation. The Journal Of Physiology 2008, 586: 5161-5179. PMID: 18787033, PMCID: PMC2652154, DOI: 10.1113/jphysiol.2008.160861.
- Regulation of Neuronal Excitability by the Sodium‐Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2)Gribkoff V, Kaczmarek L. Regulation of Neuronal Excitability by the Sodium‐Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2). 2008, 193-215. DOI: 10.1002/9780470429907.ch7.
- Protein Kinase C Modulates Inactivation of Kv3.3 Channels*Desai R, Kronengold J, Mei J, Forman SA, Kaczmarek LK. Protein Kinase C Modulates Inactivation of Kv3.3 Channels*. Journal Of Biological Chemistry 2008, 283: 22283-22294. PMID: 18539595, PMCID: PMC2494927, DOI: 10.1074/jbc.m801663200.
- PKC-Induced Intracellular Trafficking of CaV2 Precedes Its Rapid Recruitment to the Plasma MembraneZhang Y, Helm JS, Senatore A, Spafford JD, Kaczmarek LK, Jonas EA. PKC-Induced Intracellular Trafficking of CaV2 Precedes Its Rapid Recruitment to the Plasma Membrane. Journal Of Neuroscience 2008, 28: 2601-2612. PMID: 18322103, PMCID: PMC2830008, DOI: 10.1523/jneurosci.4314-07.
- Repetitive Firing Triggers Clustering of Kv2.1 Potassium Channels in Aplysia Neurons*Zhang Y, McKay SE, Bewley B, Kaczmarek LK. Repetitive Firing Triggers Clustering of Kv2.1 Potassium Channels in Aplysia Neurons*. Journal Of Biological Chemistry 2008, 283: 10632-10641. PMID: 18276591, DOI: 10.1074/jbc.m800253200.
- Bcl-xL Inhibitor ABT-737 Reveals a Dual Role for Bcl-xL in Synaptic TransmissionHickman JA, Hardwick JM, Kaczmarek LK, Jonas EA. Bcl-xL Inhibitor ABT-737 Reveals a Dual Role for Bcl-xL in Synaptic Transmission. Journal Of Neurophysiology 2007, 99: 1515-1522. PMID: 18160428, PMCID: PMC2836590, DOI: 10.1152/jn.00598.2007.
- Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neuronsKnox RJ, Keen KL, Luchansky L, Terasawa E, Freyer H, Barbee SJ, Kaczmarek LK. Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons. Biochemical And Biophysical Research Communications 2007, 366: 48-53. PMID: 18053804, DOI: 10.1016/j.bbrc.2007.11.083.
- Sodium‐dependent potassium channels of a Slack‐like subtype contribute to the slow afterhyperpolarization in lamprey spinal neuronsWallén P, Robertson B, Cangiano L, Löw P, Bhattacharjee A, Kaczmarek LK, Grillner S. Sodium‐dependent potassium channels of a Slack‐like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons. The Journal Of Physiology 2007, 585: 75-90. PMID: 17884929, PMCID: PMC2375474, DOI: 10.1113/jphysiol.2007.138156.
- Slack and Slick KNa Channels Regulate the Accuracy of Timing of Auditory NeuronsYang B, Desai R, Kaczmarek LK. Slack and Slick KNa Channels Regulate the Accuracy of Timing of Auditory Neurons. Journal Of Neuroscience 2007, 27: 2617-2627. PMID: 17344399, PMCID: PMC6672517, DOI: 10.1523/jneurosci.5308-06.2007.
- Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymiaChen H, von Hehn C, Kaczmarek LK, Ment LR, Pober BR, Hisama FM. Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia. Neurogenetics 2006, 8: 131-135. PMID: 17136396, PMCID: PMC1820748, DOI: 10.1007/s10048-006-0071-z.
- Non-conducting functions of voltage-gated ion channelsKaczmarek LK. Non-conducting functions of voltage-gated ion channels. Nature Reviews Neuroscience 2006, 7: 761-771. PMID: 16988652, DOI: 10.1038/nrn1988.
- Mitochondrial factors with dual roles in death and survivalCheng WC, Berman SB, Ivanovska I, Jonas EA, Lee SJ, Chen Y, Kaczmarek LK, Pineda F, Hardwick JM. Mitochondrial factors with dual roles in death and survival. Oncogene 2006, 25: 4697-4705. PMID: 16892083, DOI: 10.1038/sj.onc.1209596.
- A Store-Operated Ca2+ Influx Pathway in the Bag Cell Neurons of AplysiaKachoei BA, Knox RJ, Uthuza D, Levy S, Kaczmarek LK, Magoski NS. A Store-Operated Ca2+ Influx Pathway in the Bag Cell Neurons of Aplysia. Journal Of Neurophysiology 2006, 96: 2688-2698. PMID: 16885525, PMCID: PMC2894935, DOI: 10.1152/jn.00118.2006.
- Pharmacological activation and inhibition of Slack (Slo2.2) channelsYang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK. Pharmacological activation and inhibition of Slack (Slo2.2) channels. Neuropharmacology 2006, 51: 896-906. PMID: 16876206, DOI: 10.1016/j.neuropharm.2006.06.003.
- Opposite Regulation of Slick and Slack K+ Channels by NeuromodulatorsSanti CM, Ferreira G, Yang B, Gazula VR, Butler A, Wei A, Kaczmarek LK, Salkoff L. Opposite Regulation of Slick and Slack K+ Channels by Neuromodulators. Journal Of Neuroscience 2006, 26: 5059-5068. PMID: 16687497, PMCID: PMC6674240, DOI: 10.1523/jneurosci.3372-05.2006.
- Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes*Song P, Kaczmarek LK. Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes*. Journal Of Biological Chemistry 2006, 281: 15582-15591. PMID: 16595659, DOI: 10.1074/jbc.m512866200.
- Policing the Ball: A New Potassium Channel Subunit Determines Inactivation RateKaczmarek LK. Policing the Ball: A New Potassium Channel Subunit Determines Inactivation Rate. Neuron 2006, 49: 642-644. PMID: 16504937, DOI: 10.1016/j.neuron.2006.02.011.
- Neuron DoctrineKaczmarek L. Neuron Doctrine. 2006 DOI: 10.1002/0470018860.s00341.
- RetractionFlavell RA, Kaczmarek LK, Abdallah B, Boulpaep EL, Desai R, Basavappa S, Matza D, Peng YQ, Mehal WZ. Retraction. Science 2005, 310: 1903-1903. PMID: 16373558, DOI: 10.1126/science.310.5756.1903b.
- Actions of BAX on Mitochondrial Channel Activity and on Synaptic TransmissionJonas EA, Hardwick JM, Kaczmarek LK. Actions of BAX on Mitochondrial Channel Activity and on Synaptic Transmission. Antioxidants & Redox Signaling 2005, 7: 1092-1100. PMID: 16115013, DOI: 10.1089/ars.2005.7.1092.
- Association/Dissociation of a Channel–Kinase Complex Underlies State-Dependent ModulationMagoski NS, Kaczmarek LK. Association/Dissociation of a Channel–Kinase Complex Underlies State-Dependent Modulation. Journal Of Neuroscience 2005, 25: 8037-8047. PMID: 16135761, PMCID: PMC2873328, DOI: 10.1523/jneurosci.1903-05.2005.
- Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neuronsSong P, Yang Y, Barnes-Davies M, Bhattacharjee A, Hamann M, Forsythe ID, Oliver DL, Kaczmarek LK. Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons. Nature Neuroscience 2005, 8: 1335-1342. PMID: 16136041, DOI: 10.1038/nn1533.
- Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channelsKaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing Research 2005, 206: 133-145. PMID: 16081004, DOI: 10.1016/j.heares.2004.11.023.
- For K+ channels, Na+ is the new Ca2+Bhattacharjee A, Kaczmarek LK. For K+ channels, Na+ is the new Ca2+. Trends In Neurosciences 2005, 28: 422-428. PMID: 15979166, DOI: 10.1016/j.tins.2005.06.003.
- Localization of the Na+‐activated K+ channel Slick in the rat central nervous systemBhattacharjee A, von Hehn CA, Mei X, Kaczmarek LK. Localization of the Na+‐activated K+ channel Slick in the rat central nervous system. The Journal Of Comparative Neurology 2005, 484: 80-92. PMID: 15717307, DOI: 10.1002/cne.20462.
- Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequenciesLiu S, Kaczmarek LK. Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies. Developmental Neurobiology 2005, 62: 439-452. PMID: 15547932, DOI: 10.1002/neu.20112.
- Requirement of Voltage-Gated Calcium Channel ß4 Subunit for T Lymphocyte FunctionsBadou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Requirement of Voltage-Gated Calcium Channel ß4 Subunit for T Lymphocyte Functions. Science 2005, 307: 117-121. PMID: 15637280, DOI: 10.1126/science.1100582.
- Exposure to Hypoxia Rapidly Induces Mitochondrial Channel Activity within a Living Synapse*Jonas EA, Hickman JA, Hardwick JM, Kaczmarek LK. Exposure to Hypoxia Rapidly Induces Mitochondrial Channel Activity within a Living Synapse*. Journal Of Biological Chemistry 2004, 280: 4491-4497. PMID: 15561723, DOI: 10.1074/jbc.m410661200.
- The Appearance of a Protein Kinase A-regulated Splice Isoform of slo Is Associated with the Maturation of Neurons That Control Reproductive Behavior*Zhang Y, Joiner WJ, Bhattacharjee A, Rassendren F, Magoski NS, Kaczmarek LK. The Appearance of a Protein Kinase A-regulated Splice Isoform of slo Is Associated with the Maturation of Neurons That Control Reproductive Behavior*. Journal Of Biological Chemistry 2004, 279: 52324-52330. PMID: 15375169, DOI: 10.1074/jbc.m408543200.
- Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of AplysiaKnox RJ, Magoski NS, Wing D, Barbee SJ, Kaczmarek LK. Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia. Developmental Neurobiology 2004, 60: 411-423. PMID: 15307146, DOI: 10.1002/neu.20029.
- Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminalsJonas EA, Hickman JA, Chachar M, Polster BM, Brandt TA, Fannjiang Y, Ivanovska I, Basañez G, Kinnally KW, Zimmerberg J, Hardwick JM, Kaczmarek LK. Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 13590-13595. PMID: 15342906, PMCID: PMC518799, DOI: 10.1073/pnas.0401372101.
- Genes for the Common ManKaczmarek L. Genes for the Common Man. Nature Medicine 2004, 10: 449-449. DOI: 10.1038/nm0504-449.
- Loss of Kv3.1 Tonotopicity and Alterations in cAMP Response Element-Binding Protein Signaling in Central Auditory Neurons of Hearing Impaired Micevon Hehn CA, Bhattacharjee A, Kaczmarek LK. Loss of Kv3.1 Tonotopicity and Alterations in cAMP Response Element-Binding Protein Signaling in Central Auditory Neurons of Hearing Impaired Mice. Journal Of Neuroscience 2004, 24: 1936-1940. PMID: 14985434, PMCID: PMC6730406, DOI: 10.1523/jneurosci.4554-03.2004.
- The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivityXu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 3112-3117. PMID: 14981264, PMCID: PMC365752, DOI: 10.1073/pnas.0308450100.
- Kv1.3 Channel Gene-Targeted Deletion Produces “Super-Smeller Mice” with Altered Glomeruli, Interacting Scaffolding Proteins, and BiophysicsFadool DA, Tucker K, Perkins R, Fasciani G, Thompson RN, Parsons AD, Overton JM, Koni PA, Flavell RA, Kaczmarek LK. Kv1.3 Channel Gene-Targeted Deletion Produces “Super-Smeller Mice” with Altered Glomeruli, Interacting Scaffolding Proteins, and Biophysics. Neuron 2004, 41: 389-404. PMID: 14766178, PMCID: PMC2737549, DOI: 10.1016/s0896-6273(03)00844-4.
- Ion channels on intracellular organellesKaczmarek L, Jonas E. Ion channels on intracellular organelles. 2004, 32: 433-458. DOI: 10.1016/s1569-2558(03)32018-1.
- Functional Specialization of Male and Female Vocal MotoneuronsYamaguchi A, Kaczmarek LK, Kelley DB. Functional Specialization of Male and Female Vocal Motoneurons. Journal Of Neuroscience 2003, 23: 11568-11576. PMID: 14684859, PMCID: PMC6740944, DOI: 10.1523/jneurosci.23-37-11568.2003.
- Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATPBhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK. Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP. Journal Of Neuroscience 2003, 23: 11681-11691. PMID: 14684870, PMCID: PMC6740956, DOI: 10.1523/jneurosci.23-37-11681.2003.
- Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xLJonas EA, Hoit D, Hickman JA, Brandt TA, Polster BM, Fannjiang Y, McCarthy E, Montanez MK, Hardwick JM, Kaczmarek LK. Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xL. Journal Of Neuroscience 2003, 23: 8423-8431. PMID: 12968005, PMCID: PMC6740692, DOI: 10.1523/jneurosci.23-23-08423.2003.
- How to Make a Relationship Last Release Sites with Different Levels of CommitmentKaczmarek LK. How to Make a Relationship Last Release Sites with Different Levels of Commitment. Neuron 2003, 40: 7-9. PMID: 14527428, DOI: 10.1016/s0896-6273(03)00599-3.
- Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes*Koni PA, Khanna R, Chang MC, Tang MD, Kaczmarek LK, Schlichter LC, Flavell R. Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes*. Journal Of Biological Chemistry 2003, 278: 39443-39451. PMID: 12878608, DOI: 10.1074/jbc.m304879200.
- Modulation of mitochondrial function by endogenous Zn2+ poolsSensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK, Weiss JH. Modulation of mitochondrial function by endogenous Zn2+ pools. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 6157-6162. PMID: 12724524, PMCID: PMC156342, DOI: 10.1073/pnas.1031598100.
- BAK Alters Neuronal Excitability and Can Switch from Anti- to Pro-Death Function during Postnatal DevelopmentFannjiang Y, Kim CH, Huganir RL, Zou S, Lindsten T, Thompson CB, Mito T, Traystman RJ, Larsen T, Griffin DE, Mandir AS, Dawson TM, Dike S, Sappington AL, Kerr DA, Jonas EA, Kaczmarek LK, Hardwick JM. BAK Alters Neuronal Excitability and Can Switch from Anti- to Pro-Death Function during Postnatal Development. Developmental Cell 2003, 4: 575-585. PMID: 12689595, DOI: 10.1016/s1534-5807(03)00091-1.
- The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weightXu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics 2003, 12: 551-559. PMID: 12588802, DOI: 10.1093/hmg/ddg049.
- The Sodium-Activated Potassium Channel Is Encoded by a Member of the Slo Gene FamilyYuan A, Santi CM, Wei A, Wang Z, Pollak K, Nonet M, Kaczmarek L, Crowder CM, Salkoff L. The Sodium-Activated Potassium Channel Is Encoded by a Member of the Slo Gene Family. Neuron 2003, 37: 765-773. PMID: 12628167, DOI: 10.1016/s0896-6273(03)00096-5.
- Modulation of the Kv3.1b Potassium Channel Isoform Adjusts the Fidelity of the Firing Pattern of Auditory NeuronsMacica CM, von Hehn CA, Wang LY, Ho CS, Yokoyama S, Joho RH, Kaczmarek LK. Modulation of the Kv3.1b Potassium Channel Isoform Adjusts the Fidelity of the Firing Pattern of Auditory Neurons. Journal Of Neuroscience 2003, 23: 1133-1141. PMID: 12598601, PMCID: PMC6742259, DOI: 10.1523/jneurosci.23-04-01133.2003.
- Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell NeuronsZhang Y, Magoski NS, Kaczmarek LK. Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell Neurons. Journal Of Neuroscience 2002, 22: 10134-10141. PMID: 12451114, PMCID: PMC6758731, DOI: 10.1523/jneurosci.22-23-10134.2002.
- Localization of the Slack potassium channel in the rat central nervous systemBhattacharjee A, Gan L, Kaczmarek LK. Localization of the Slack potassium channel in the rat central nervous system. The Journal Of Comparative Neurology 2002, 454: 241-254. PMID: 12442315, DOI: 10.1002/cne.10439.
- Act locally: new ways of regulating voltage-gated ion channels.McKay SE, Kaczmarek LK. Act locally: new ways of regulating voltage-gated ion channels. Molecular Interventions 2002, 2: 215-8. PMID: 14993392, DOI: 10.1124/mi.2.4.215.
- HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced NeuronsWhite BH, Cummins TR, Wolf DH, Waxman SG, Russell DS, Kaczmarek LK. HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons. Journal Of Neurophysiology 2002, 87: 2149-2157. PMID: 11929932, DOI: 10.1152/jn.00498.2001.
- Endogenous parathyroid hormone-related protein functions as a neuroprotective agentChatterjee O, Nakchbandi IA, Philbrick WM, Dreyer BE, Zhang J, Kaczmarek LK, Brines ML, Broadus AE. Endogenous parathyroid hormone-related protein functions as a neuroprotective agent. Brain Research 2002, 930: 58-66. PMID: 11879796, DOI: 10.1016/s0006-8993(01)03407-2.
- Protein Kinase Modulation of a Neuronal Cation Channel Requires Protein–Protein Interactions Mediated by an Src homology 3 DomainMagoski NS, Wilson GF, Kaczmarek LK. Protein Kinase Modulation of a Neuronal Cation Channel Requires Protein–Protein Interactions Mediated by an Src homology 3 Domain. Journal Of Neuroscience 2002, 22: 1-9. PMID: 11756482, PMCID: PMC6757624, DOI: 10.1523/jneurosci.22-01-00001.2002.
- Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ ChannelWhite B, Osterwalder T, Yoon K, Joiner W, Whim M, Kaczmarek L, Keshishian H. Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ Channel. Neuron 2001, 31: 699-711. PMID: 11567611, DOI: 10.1016/s0896-6273(01)00415-9.
- Presynaptic target of Ca2+ action on neuropeptide and acetylcholine release in Aplysia californicaOhnuma K, Whim M, Fetter R, Kaczmarek L, Zucker R. Presynaptic target of Ca2+ action on neuropeptide and acetylcholine release in Aplysia californica. The Journal Of Physiology 2001, 535: 647-662. PMID: 11559764, PMCID: PMC2278817, DOI: 10.1111/j.1469-7793.2001.00647.x.
- Localization of two high‐threshold potassium channel subunits in the rat central auditory systemLi W, Kaczmarek L, Perney T. Localization of two high‐threshold potassium channel subunits in the rat central auditory system. The Journal Of Comparative Neurology 2001, 437: 196-218. PMID: 11494252, DOI: 10.1002/cne.1279.
- Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels*Joiner W, Khanna R, Schlichter L, Kaczmarek L. Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels*. Journal Of Biological Chemistry 2001, 276: 37980-37985. PMID: 11495911, DOI: 10.1074/jbc.m104965200.
- Aplysia Ror Forms Clusters on the Surface of Identified Neuroendocrine CellsMcKay S, Hislop J, Scott D, Bulloch A, Kaczmarek L, Carew T, Sossin W. Aplysia Ror Forms Clusters on the Surface of Identified Neuroendocrine Cells. Molecular And Cellular Neuroscience 2001, 17: 821-841. PMID: 11358481, DOI: 10.1006/mcne.2001.0977.
- Casein Kinase 2 Determines the Voltage Dependence of the Kv3.1 Channel in Auditory Neurons and Transfected CellsMacica C, Kaczmarek L. Casein Kinase 2 Determines the Voltage Dependence of the Kv3.1 Channel in Auditory Neurons and Transfected Cells. Journal Of Neuroscience 2001, 21: 1160-1168. PMID: 11160386, PMCID: PMC6762230, DOI: 10.1523/jneurosci.21-04-01160.2001.
- Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brainMonteggia L, Eisch A, Tang M, Kaczmarek L, Nestler E. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Brain Research 2000, 81: 129-139. PMID: 11000485, DOI: 10.1016/s0169-328x(00)00155-8.
- Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunitRichardson F, Kaczmarek L. Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit. Hearing Research 2000, 147: 21-30. PMID: 10962170, DOI: 10.1016/s0378-5955(00)00117-9.
- Parathyroid‐Hormone‐Related Protein is a Neuroprotective Endogenous Regulator of L‐Type Calcium ChannelsChatterjee O, Nakchbandi I, Philbrick W, Kaczmarek L, Brines M, Broadus A. Parathyroid‐Hormone‐Related Protein is a Neuroprotective Endogenous Regulator of L‐Type Calcium Channels. CNS Neuroscience & Therapeutics 2000, 6: 42-42. DOI: 10.1111/j.1527-3458.2000.tb00185.x.
- Regulation of Synaptic Stability by Bcl‐2 Family ProteinsKaczmarek L, Jonas E. Regulation of Synaptic Stability by Bcl‐2 Family Proteins. CNS Neuroscience & Therapeutics 2000, 6: 30-31. DOI: 10.1111/j.1527-3458.2000.tb00175.x.
- Mitochondrial Memory BanksKaczmarek L. Mitochondrial Memory Banks. The Journal Of General Physiology 2000, 115: 347-350. PMID: 10694262, PMCID: PMC2217212, DOI: 10.1085/jgp.115.3.347.
- Exocytotic Insertion of Calcium Channels Constrains Compensatory Endocytosis to Sites of ExocytosisSmith R, Baibakov B, Ikebuchi Y, White B, Lambert N, Kaczmarek L, Vogel S. Exocytotic Insertion of Calcium Channels Constrains Compensatory Endocytosis to Sites of Exocytosis. Journal Of Cell Biology 2000, 148: 755-768. PMID: 10684256, PMCID: PMC2169375, DOI: 10.1083/jcb.148.4.755.
- Activation of a Ca2+‐permeable cation channel produces a prolonged attenuation of intracellular Ca2+ release in Aplysia bag cell neuronesMagoski N, Knox R, Kaczmarek L. Activation of a Ca2+‐permeable cation channel produces a prolonged attenuation of intracellular Ca2+ release in Aplysia bag cell neurones. The Journal Of Physiology 2000, 522: 271-283. PMID: 10639103, PMCID: PMC2269759, DOI: 10.1111/j.1469-7793.2000.t01-2-00271.x.
- 3L1100 神経前末端における、神経ペプチドとアセチルコリン放出機構のカルシウム依存性の違い清 大, Whim M, Fetter R, Kaczmarek L, Zucker R. 3L1100 神経前末端における、神経ペプチドとアセチルコリン放出機構のカルシウム依存性の違い. Seibutsu Butsuri 2000, 40: s211. DOI: 10.2142/biophys.40.s211_1.
- Shaw‐like potassium currents in the auditory rhombencephalon throughout embryogenesisHendriks R, Morest D, Kaczmarek L. Shaw‐like potassium currents in the auditory rhombencephalon throughout embryogenesis. Journal Of Neuroscience Research 1999, 58: 791-804. PMID: 10583910, DOI: 10.1002/(sici)1097-4547(19991215)58:6<791::aid-jnr6>3.0.co;2-3.
- Role in neuronal cell migration for high‐threshold potassium currents in the chicken hindbrainHendriks R, Morest D, Kaczmarek L. Role in neuronal cell migration for high‐threshold potassium currents in the chicken hindbrain. Journal Of Neuroscience Research 1999, 58: 805-814. PMID: 10583911, DOI: 10.1002/(sici)1097-4547(19991215)58:6<805::aid-jnr7>3.0.co;2-v.
- Prolonged Activation of Mitochondrial Conductances During Synaptic TransmissionJonas E, Buchanan J, Kaczmarek L. Prolonged Activation of Mitochondrial Conductances During Synaptic Transmission. Science 1999, 286: 1347-1350. PMID: 10558987, DOI: 10.1126/science.286.5443.1347.
- Cell Type‐Specific Expression of the Kv3.1 Gene Is Mediated by a Negative Element in the 5′ Untranslated Region of the Kv3.1 PromoterGan L, Hahn S, Kaczmarek L. Cell Type‐Specific Expression of the Kv3.1 Gene Is Mediated by a Negative Element in the 5′ Untranslated Region of the Kv3.1 Promoter. Journal Of Neurochemistry 1999, 73: 1350-1362. PMID: 10501178, DOI: 10.1046/j.1471-4159.1999.0731350.x.
- hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes ROLES IN PROLIFERATION AND VOLUME REGULATION*Khanna R, Chang M, Joiner W, Kaczmarek L, Schlichter L. hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes ROLES IN PROLIFERATION AND VOLUME REGULATION*. Journal Of Biological Chemistry 1999, 274: 14838-14849. PMID: 10329683, DOI: 10.1074/jbc.274.21.14838.
- Short and Long‐term Regulation of Potassium Channels and Their GenesKaczmarek L. Short and Long‐term Regulation of Potassium Channels and Their Genes. CNS Neuroscience & Therapeutics 1999, 5: 14-14. DOI: 10.1111/j.1527-3458.1999.tb00127.x.
- Expression of a foreign G-protein coupled receptor modulates the excitability of the peptidergic bag cell neurons of AplysiaWhim M, Kaczmarek L. Expression of a foreign G-protein coupled receptor modulates the excitability of the peptidergic bag cell neurons of Aplysia. Neuroscience Letters 1998, 258: 143-146. PMID: 9885951, DOI: 10.1016/s0304-3940(98)00850-7.
- Heterologous Expression of the Kv3.1 Potassium Channel Eliminates Spike Broadening and the Induction of a Depolarizing Afterpotential in the Peptidergic Bag Cell NeuronsWhim M, Kaczmarek L. Heterologous Expression of the Kv3.1 Potassium Channel Eliminates Spike Broadening and the Induction of a Depolarizing Afterpotential in the Peptidergic Bag Cell Neurons. Journal Of Neuroscience 1998, 18: 9171-9180. PMID: 9801357, PMCID: PMC6792887, DOI: 10.1523/jneurosci.18-22-09171.1998.
- Depolarization Selectively Increases the Expression of the Kv3.1 Potassium Channel in Developing Inferior Colliculus NeuronsLiu S, Kaczmarek L. Depolarization Selectively Increases the Expression of the Kv3.1 Potassium Channel in Developing Inferior Colliculus Neurons. Journal Of Neuroscience 1998, 18: 8758-8769. PMID: 9786983, PMCID: PMC6793528, DOI: 10.1523/jneurosci.18-21-08758.1998.
- Protein Kinase C Regulates a Vesicular Class of Calcium Channels in the Bag Cell Neurons of AplysiaWhite B, Nick T, Carew T, Kaczmarek L. Protein Kinase C Regulates a Vesicular Class of Calcium Channels in the Bag Cell Neurons of Aplysia. Journal Of Neurophysiology 1998, 80: 2514-2520. PMID: 9819259, DOI: 10.1152/jn.1998.80.5.2514.
- Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunitsJoiner W, Tang M, Wang L, Dworetzky S, Boissard C, Gan L, Gribkoff V, Kaczmarek L. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature Neuroscience 1998, 1: 462-469. PMID: 10196543, DOI: 10.1038/2176.
- When, where, and how much? Expression of the Kv3.1 potassium channel in high‐frequency firing neuronsGan L, Kaczmarek L. When, where, and how much? Expression of the Kv3.1 potassium channel in high‐frequency firing neurons. Developmental Neurobiology 1998, 37: 69-79. PMID: 9777733, DOI: 10.1002/(sici)1097-4695(199810)37:1<69::aid-neu6>3.0.co;2-6.
- Modulation of a calcium-sensitive nonspecific cation channel by closely associated protein kinase and phosphatase activitiesWilson G, Magoski N, Kaczmarek L. Modulation of a calcium-sensitive nonspecific cation channel by closely associated protein kinase and phosphatase activities. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10938-10943. PMID: 9724808, PMCID: PMC27999, DOI: 10.1073/pnas.95.18.10938.
- High-frequency firing helps replenish the readily releasable pool of synaptic vesiclesWang L, Kaczmarek L. High-frequency firing helps replenish the readily releasable pool of synaptic vesicles. Nature 1998, 394: 384-388. PMID: 9690475, DOI: 10.1038/28645.
- Direct and indirect regulation of a single ion channelMagoski N, Kaczmarek L. Direct and indirect regulation of a single ion channel. The Journal Of Physiology 1998, 509: 1-1. PMID: 9547374, PMCID: PMC2230943, DOI: 10.1111/j.1469-7793.1998.001bo.x.
- Contribution of the Kv3.1 potassium channel to high‐frequency firing in mouse auditory neuronesWang L, Gan L, Forsythe I, Kaczmarek L. Contribution of the Kv3.1 potassium channel to high‐frequency firing in mouse auditory neurones. The Journal Of Physiology 1998, 509: 183-194. PMID: 9547392, PMCID: PMC2230948, DOI: 10.1111/j.1469-7793.1998.183bo.x.
- The Expression of Two Splice Variants of the Kv3.1 Potassium Channel Gene Is Regulated by Different Signaling PathwaysLiu S, Kaczmarek L. The Expression of Two Splice Variants of the Kv3.1 Potassium Channel Gene Is Regulated by Different Signaling Pathways. Journal Of Neuroscience 1998, 18: 2881-2890. PMID: 9526005, PMCID: PMC6792597, DOI: 10.1523/jneurosci.18-08-02881.1998.
- Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletionWang L, Gan L, Perney T, Schwartz I, Kaczmarek L. Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1882-1887. PMID: 9465111, PMCID: PMC19207, DOI: 10.1073/pnas.95.4.1882.
- hSK4, a member of a novel subfamily of calcium-activated potassium channelsJoiner W, Wang L, Tang M, Kaczmarek L. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 11013-11018. PMID: 9380751, PMCID: PMC23566, DOI: 10.1073/pnas.94.20.11013.
- Localization of a high threshold potassium channel in the rat cochlear nucleusPerney T, Kaczmarek L. Localization of a high threshold potassium channel in the rat cochlear nucleus. The Journal Of Comparative Neurology 1997, 386: 178-202. PMID: 9295146, DOI: 10.1002/(sici)1096-9861(19970922)386:2<178::aid-cne2>3.0.co;2-z.
- Giga-Ohm Seals on Intracellular Membranes: A Technique for Studying Intracellular Ion Channels in Intact CellsJonas E, Knox R, Kaczmarek L. Giga-Ohm Seals on Intracellular Membranes: A Technique for Studying Intracellular Ion Channels in Intact Cells. Neuron 1997, 19: 7-13. PMID: 9247259, DOI: 10.1016/s0896-6273(00)80343-8.
- Properties and regulation of the minK potassium channel proteinKaczmarek L, Blumenthal E. Properties and regulation of the minK potassium channel protein. Physiological Reviews 1997, 77: 627-641. PMID: 9234960, DOI: 10.1152/physrev.1997.77.3.627.
- The Secretion of Classical and Peptide Cotransmitters from a Single Presynaptic Neuron Involves a Synaptobrevin-Like MoleculeWhim M, Niemann H, Kaczmarek L. The Secretion of Classical and Peptide Cotransmitters from a Single Presynaptic Neuron Involves a Synaptobrevin-Like Molecule. Journal Of Neuroscience 1997, 17: 2338-2347. PMID: 9065494, PMCID: PMC6573516, DOI: 10.1523/jneurosci.17-07-02338.1997.
- Identification of a Vesicular Pool of Calcium Channels in the Bag Cell Neurons of Aplysia californicaWhite B, Kaczmarek L. Identification of a Vesicular Pool of Calcium Channels in the Bag Cell Neurons of Aplysia californica. Journal Of Neuroscience 1997, 17: 1582-1595. PMID: 9030618, PMCID: PMC6573390, DOI: 10.1523/jneurosci.17-05-01582.1997.
- Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretionJonas E, Knox R, Smith T, Wayne N, Connor J, Kaczmarek L. Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion. Nature 1997, 385: 343-346. PMID: 9002519, DOI: 10.1038/385343a0.
- Ionic Currents Underlying Developmental Regulation of Repetitive Firing in Aplysia Bag Cell NeuronsNick T, Kaczmarek L, Carew T. Ionic Currents Underlying Developmental Regulation of Repetitive Firing in Aplysia Bag Cell Neurons. Journal Of Neuroscience 1996, 16: 7583-7598. PMID: 8922415, PMCID: PMC6579091, DOI: 10.1523/jneurosci.16-23-07583.1996.
- Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotidesRoy M, Saal D, Perney T, Sontheimer H, Waxman S, Kaczmarek L. Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotides. Glia 1996, 18: 177-184. PMID: 8915650, DOI: 10.1002/(sici)1098-1136(199611)18:3<177::aid-glia2>3.0.co;2-x.
- Developmental dissociation of excitability and secretory ability in Aplysia bag cell neuronsNick T, Moreira J, Kaczmarek L, Carew T, Wayne N. Developmental dissociation of excitability and secretory ability in Aplysia bag cell neurons. Journal Of Neurophysiology 1996, 76: 3351-3359. PMID: 8930278, DOI: 10.1152/jn.1996.76.5.3351.
- Ca2+ influx and activation of a cation current are coupled to intracellular Ca2+ release in peptidergic neurons of Aplysia californica.Knox RJ, Jonas EA, Kao LS, Smith PJ, Connor JA, Kaczmarek LK. Ca2+ influx and activation of a cation current are coupled to intracellular Ca2+ release in peptidergic neurons of Aplysia californica. The Journal Of Physiology 1996, 494: 627-639. PMID: 8865062, PMCID: PMC1160665, DOI: 10.1113/jphysiol.1996.sp021520.
- Regulation of potassium channels by protein kinasesJonas E, Kaczmarek L. Regulation of potassium channels by protein kinases. Current Opinion In Neurobiology 1996, 6: 318-323. PMID: 8794088, DOI: 10.1016/s0959-4388(96)80114-0.
- Identification and Characterization of a Ca2+-Sensitive Nonspecific Cation Channel Underlying Prolonged Repetitive Firing in Aplysia NeuronsWilson G, Richardson F, Fisher T, Olivera B, Kaczmarek L. Identification and Characterization of a Ca2+-Sensitive Nonspecific Cation Channel Underlying Prolonged Repetitive Firing in Aplysia Neurons. Journal Of Neuroscience 1996, 16: 3661-3671. PMID: 8642410, PMCID: PMC6578840, DOI: 10.1523/jneurosci.16-11-03661.1996.
- Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currentsJonas E, Knox R, Kaczmarek L, Schwartz J, Solomon D. Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currents. Journal Of Neuroscience 1996, 16: 1645-1658. PMID: 8774433, PMCID: PMC6578688, DOI: 10.1523/jneurosci.16-05-01645.1996.
- Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗)Gan L, Perney T, Kaczmarek L. Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗). Journal Of Biological Chemistry 1996, 271: 5859-5865. PMID: 8621457, DOI: 10.1074/jbc.271.10.5859.
- Inhibition by Nystatin of Kv1.3 Channels Expressed in Chinese Hamster Ovary CellsHAHN S, WANG L, KACZMAREK L. Inhibition by Nystatin of Kv1.3 Channels Expressed in Chinese Hamster Ovary Cells. Neuropharmacology 1996, 35: 895-901. PMID: 8938720, DOI: 10.1016/0028-3908(96)00094-9.
- A new family of outwardly rectifying potassium channel proteins with two pore domains in tandemKetchum K, Joiner W, Sellers A, Kaczmarek L, Goldstein S. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 1995, 376: 690-695. PMID: 7651518, DOI: 10.1038/376690a0.
- Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblastsKanemasa T, Gan L, Perney T, Wang L, Kaczmarek L. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. Journal Of Neurophysiology 1995, 74: 207-217. PMID: 7472324, DOI: 10.1152/jn.1995.74.1.207.
- Elimination of potassium channel expression by antisense oligonucleotides in a pituitary cell line.Chung S, Saal D, Kaczmarek L. Elimination of potassium channel expression by antisense oligonucleotides in a pituitary cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 5955-5959. PMID: 7597060, PMCID: PMC41620, DOI: 10.1073/pnas.92.13.5955.
- Modulation of the inactivation of voltage-dependent potassium channels by cAMPChung S, Kaczmarek L. Modulation of the inactivation of voltage-dependent potassium channels by cAMP. Journal Of Neuroscience 1995, 15: 3927-3935. PMID: 7751955, PMCID: PMC6578223, DOI: 10.1523/jneurosci.15-05-03927.1995.
- Cyclic AMP modulates fast axonal transport in aplysia bag cell neurons by increasing the probability of single organelle movementAzhderian EM, Hefner D, Lin C, Kaczmarek LK, Forscher P. Cyclic AMP modulates fast axonal transport in aplysia bag cell neurons by increasing the probability of single organelle movement. Neuron 1994, 12: 1223-1233. PMID: 7516686, DOI: 10.1016/0896-6273(94)90439-1.
- The minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytesBlumenthal E, Kaczmarek L. The minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytes. Journal Of Neuroscience 1994, 14: 3097-3105. PMID: 7514215, PMCID: PMC6577436, DOI: 10.1523/jneurosci.14-05-03097.1994.
- Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californicaFisher T, Levy S, Kaczmarek L. Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica. Journal Of Neurophysiology 1994, 71: 1254-1257. PMID: 8201416, DOI: 10.1152/jn.1994.71.3.1254.
- Autoactive peptides act at three distinct receptors to depolarize the bag cell neurons of AplysiaLoechner K, Kaczmarek L. Autoactive peptides act at three distinct receptors to depolarize the bag cell neurons of Aplysia. Journal Of Neurophysiology 1994, 71: 195-203. PMID: 8158229, DOI: 10.1152/jn.1994.71.1.195.
- A shab potassium channel contributes to action potential broadening in peptidergic neuronsQuattrocki E, Marshall J, Kaczmarek L. A shab potassium channel contributes to action potential broadening in peptidergic neurons. Neuron 1994, 12: 73-86. PMID: 8292361, DOI: 10.1016/0896-6273(94)90153-8.
- Mode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyrosine phosphataseWilson G, Kaczmarek L. Mode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyrosine phosphatase. Nature 1993, 366: 433-438. PMID: 8247151, DOI: 10.1038/366433a0.
- Inward rectification of the minK potassium channelBlumenthal E, Kaczmarek L. Inward rectification of the minK potassium channel. The Journal Of Membrane Biology 1993, 136: 23-29. PMID: 8271270, DOI: 10.1007/bf00241486.
- The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductancesFisher T, Lin C, Kaczmarek L. The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances. Journal Of Neurophysiology 1993, 69: 2164-2173. PMID: 7688803, DOI: 10.1152/jn.1993.69.6.2164.
- Expression and regulation of mammalian K+ channel genesPerney T, Kaczmarek L. Expression and regulation of mammalian K+ channel genes. Seminars In Neuroscience 1993, 5: 135-145. DOI: 10.1016/s1044-5765(05)80008-9.
- Expression of the mRNAs for the Kv3.1 potassium channel gene in the adult and developing rat brainPerney T, Marshall J, Martin K, Hockfield S, Kaczmarek L. Expression of the mRNAs for the Kv3.1 potassium channel gene in the adult and developing rat brain. Journal Of Neurophysiology 1992, 68: 756-766. PMID: 1432046, DOI: 10.1152/jn.1992.68.3.756.
- Structure and regulation of the MinK potassium channelBlumenthal E, Kaczmarek L. Structure and regulation of the MinK potassium channel. Neurochemical Research 1992, 17: 869-876. PMID: 1407274, DOI: 10.1007/bf00993262.
- Expression of the H-ras oncogene induces potassium conductance and neuron-specific potassium channel mRNAs in the AtT20 cell lineHemmick L, Perney T, Flamm R, Kaczmarek L, Birnberg N. Expression of the H-ras oncogene induces potassium conductance and neuron-specific potassium channel mRNAs in the AtT20 cell line. Journal Of Neuroscience 1992, 12: 2007-2014. PMID: 1607925, PMCID: PMC6575920, DOI: 10.1523/jneurosci.12-06-02007.1992.
- Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7Loechner K, Mattessich-Arrandale J, Azhderian E, Kaczmarek L. Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7. Brain Research 1992, 581: 315-318. PMID: 1393536, DOI: 10.1016/0006-8993(92)90724-n.
- Hyperosmotic media inhibit voltage-dependent calcium influx and peptide release in Aplysia neuronsLoechner K, Knox R, Connor J, Kaczmarek L. Hyperosmotic media inhibit voltage-dependent calcium influx and peptide release in Aplysia neurons. The Journal Of Membrane Biology 1992, 128: 41-52. PMID: 1323684, DOI: 10.1007/bf00231869.
- Recruitment of Ca2+ channels by protein kinase C during rapid formation of putative neuropeptide release sites in isolated Aplysia neuronsKnox R, Quattrocki E, Connor J, Kaczmarek L. Recruitment of Ca2+ channels by protein kinase C during rapid formation of putative neuropeptide release sites in isolated Aplysia neurons. Neuron 1992, 8: 883-889. PMID: 1316764, DOI: 10.1016/0896-6273(92)90202-o.
- Modulation by cAMP of a slowly activating potassium channel expressed in Xenopus oocytesBlumenthal E, Kaczmarek L. Modulation by cAMP of a slowly activating potassium channel expressed in Xenopus oocytes. Journal Of Neuroscience 1992, 12: 290-296. PMID: 1370322, PMCID: PMC6575684, DOI: 10.1523/jneurosci.12-01-00290.1992.
- The role of inositol phosphates in neuronal function.Perney T, Kaczmarek L. The role of inositol phosphates in neuronal function. 1992, 26: 311-33. PMID: 1419361.
- Potassium channels: structure, classification, function and therapeutic potential edited by Nigel S. Cook, Ellis Horwood, 1990. £59.95 (412 pages) ISBN 0 7458 0624 4Kaczmarek L. Potassium channels: structure, classification, function and therapeutic potential edited by Nigel S. Cook, Ellis Horwood, 1990. £59.95 (412 pages) ISBN 0 7458 0624 4. Trends In Neurosciences 1991, 14: 534-535. DOI: 10.1016/0166-2236(91)90009-j.
- Dexamethasone increases potassium channel messenger RNA and activity in clonal pituitary cells.Levitan E, Hemmick L, Birnberg N, Kaczmarek L. Dexamethasone increases potassium channel messenger RNA and activity in clonal pituitary cells. Endocrinology 1991, 5: 1903-8. PMID: 1791837, DOI: 10.1210/mend-5-12-1903.
- Identification and localization of a dogfish homolog of human cystic fibrosis transmembrane conductance regulator.Marshall J, Martin K, Picciotto M, Hockfield S, Nairn A, Kaczmarek L. Identification and localization of a dogfish homolog of human cystic fibrosis transmembrane conductance regulator. Journal Of Biological Chemistry 1991, 266: 22749-22754. PMID: 1718999, DOI: 10.1016/s0021-9258(18)54631-7.
- The molecular biology of K+ channelsPerney T, Kaczmarek L. The molecular biology of K+ channels. Current Opinion In Cell Biology 1991, 3: 663-670. PMID: 1772658, DOI: 10.1016/0955-0674(91)90039-2.
- Neuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calciumKramer R, Kaczmarek L, Levitan E. Neuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium. Neuron 1991, 6: 557-563. PMID: 1849723, DOI: 10.1016/0896-6273(91)90058-8.
- Phosphorylation of membrane‐associated proteins by phorbol esters in isolated bag cell neurons of AplysiaAzhderian E, Kaczmarek L. Phosphorylation of membrane‐associated proteins by phorbol esters in isolated bag cell neurons of Aplysia. Developmental Neurobiology 1991, 22: 105-115. PMID: 2030336, DOI: 10.1002/neu.480220202.
- Contributors to Volume 4Auerbach A, Baldwin B, Ballivet M, Bers D, Bertrand D, Boiron F, Bowers L, Boyle M, Büschges A, Cassagne C, Chang F, Connor J, Cooper E, Delcomyn F, De Weer P, Ebenezer I, Fields R, Fitzgerald S, Forsythe I, Gadsby D, Glossmann H, Heape A, Henigman F, Hirashima N, Horn R, Imaizumi Y, Isenberg G, Kaczmarek L, Kendrick K, Keung E, Kirino Y, Kordaš M, Korn S, Krüger J, Martin D, Marty A, Mason W, Melik Z, Millar J, Muraki K, Nadler J, Neale E, Neil J, Nelson P, Peterec D, Rakowski R, Rungger D, Saito Y, Schmitz J, Shattock M, Stamford J, Stephenson R, Striessnig J, Taylor W, Valera S, Wachtel R, Watanabe M, Wendt-Gallitelli M, Wilkison D, Xiang Z, Yu C, Zorec R. Contributors to Volume 4. 1991, 4: ix-xii. DOI: 10.1016/b978-0-12-185257-3.50003-3.
- Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neuronsLoechner K, Kaczmarek L. Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neurons. Brain Research 1990, 532: 1-6. PMID: 2178030, DOI: 10.1016/0006-8993(90)91733-w.
- Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brainSwanson R, Marshall J, Smith J, Williams J, Boyle M, Folander K, Luneau C, Antanavage J, Oliva C, Buhrow S, Bennet C, Stein R, Kaczmarek L. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron 1990, 4: 929-939. PMID: 2361015, DOI: 10.1016/0896-6273(90)90146-7.
- Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysiaAzhderian E, Kaczmarek L. Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia. Journal Of Molecular Neuroscience 1990, 2: 61-70. PMID: 1964064, DOI: 10.1007/bf02876912.
- Estrogen induction of a small, putative K+ channel mRNA in rat uterusPragnell M, Snay K, Trimmer J, MacLusky N, Naftolin F, Kaczmarek L, Boyle M. Estrogen induction of a small, putative K+ channel mRNA in rat uterus. Neuron 1990, 4: 807-812. PMID: 2344412, DOI: 10.1016/0896-6273(90)90207-v.
- Progressive potentiation of peptide release during a neuronal dischargeLoechner K, Azhderian E, Dreyer R, Kaczmarek L. Progressive potentiation of peptide release during a neuronal discharge. Journal Of Neurophysiology 1990, 63: 738-744. PMID: 2341872, DOI: 10.1152/jn.1990.63.4.738.
- Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium currentFlamm R, Birnberg N, Kaczmarek L. Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current. Pflügers Archiv - European Journal Of Physiology 1990, 416: 120-125. PMID: 2191273, DOI: 10.1007/bf00370232.
- The bag cell neurons ofAplysiaConn P, Kaczmarek L. The bag cell neurons ofAplysia. Molecular Neurobiology 1989, 3: 237-273. PMID: 2698177, DOI: 10.1007/bf02740607.
- Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neuronsConn P, Strong J, Azhderian E, Nairn A, Greengard P, Kaczmarek L. Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons. Journal Of Neuroscience 1989, 9: 473-479. PMID: 2537389, PMCID: PMC6569795, DOI: 10.1523/jneurosci.09-02-00473.1989.
- Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of AplysiaConn P, Strong J, Kaczmarek L. Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. Journal Of Neuroscience 1989, 9: 480-487. PMID: 2918372, PMCID: PMC6569798, DOI: 10.1523/jneurosci.09-02-00480.1989.
- THE ROLE OF PROTEIN KINASE C AND PHOSPHOINOSITIDE METABOLITES IN NEURONS THAT CONTROL PROLONGED REPRODUCTIVE BEHAVIORS IN APLYSIAKaczmarek L. THE ROLE OF PROTEIN KINASE C AND PHOSPHOINOSITIDE METABOLITES IN NEURONS THAT CONTROL PROLONGED REPRODUCTIVE BEHAVIORS IN APLYSIA. 1989, 129-141. DOI: 10.1016/b978-0-12-375655-8.50014-7.
- Regulation of ion channels in Aplysia neurons by autoactive peptides and second messengers.Loechner K, Kaczmarek L. Regulation of ion channels in Aplysia neurons by autoactive peptides and second messengers. Society Of General Physiologists Series 1989, 44: 69-82. PMID: 2476858.
- Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neuronsFink L, Connor J, Kaczmarek L. Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons. Journal Of Neuroscience 1988, 8: 2544-2555. PMID: 2470874, PMCID: PMC6569530, DOI: 10.1523/jneurosci.08-07-02544.1988.
- Inositol polyphosphates regulate excitabilityFink L, Kaczmarek L. Inositol polyphosphates regulate excitability. Trends In Neurosciences 1988, 11: 338-339. PMID: 2469190, DOI: 10.1016/0166-2236(88)90052-5.
- Steroidal Regulation of mRNA Coding for Potassium Channels in Uterine Smooth MuscleBoyle M, Kaczmarek L. Steroidal Regulation of mRNA Coding for Potassium Channels in Uterine Smooth Muscle. 1988, 359-368. DOI: 10.1007/978-1-4613-0975-8_29.
- The regulation of neuronal calcium and potassium channels by protein phosphorylation.Kaczmarek L. The regulation of neuronal calcium and potassium channels by protein phosphorylation. 1988, 22: 113-38. PMID: 2852021.
- Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neuronsForscher P, Kaczmarek L, Buchanan J, Smith S. Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons. Journal Of Neuroscience 1987, 7: 3600-3611. PMID: 2824715, PMCID: PMC6569040, DOI: 10.1523/jneurosci.07-11-03600.1987.
- Hormonal regulation of K+-channel messenger RNA in rat myometrium during oestrus cycle and in pregnancyBoyle M, MacLusky N, Naftolin F, Kaczmarek L. Hormonal regulation of K+-channel messenger RNA in rat myometrium during oestrus cycle and in pregnancy. Nature 1987, 330: 373-375. PMID: 2446134, DOI: 10.1038/330373a0.
- Alpha bag cell peptide directly modulates the excitability of the neurons that release itKauer J, Fisher T, Kaczmarek L. Alpha bag cell peptide directly modulates the excitability of the neurons that release it. Journal Of Neuroscience 1987, 7: 3623-3632. PMID: 2824716, PMCID: PMC6569037, DOI: 10.1523/jneurosci.07-11-03623.1987.
- Xenopus Oocytes Injected with Rat Uterine RNA Express Very Slowly Activating Potassium CurrentsBoyle M, Azhderian E, MacLusky N, Naftolin F, Kaczmarek L. Xenopus Oocytes Injected with Rat Uterine RNA Express Very Slowly Activating Potassium Currents. Science 1987, 235: 1221-1224. PMID: 2434999, DOI: 10.1126/science.2434999.
- Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neuronsStrong J, Fox A, Tsien R, Kaczmarek L. Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons. Nature 1987, 325: 714-717. PMID: 2434853, DOI: 10.1038/325714a0.
- The role of protein kinase C in the regulation of ion channels and neurotransmitter releaseKaczmarek L. The role of protein kinase C in the regulation of ion channels and neurotransmitter release. Trends In Neurosciences 1987, 10: 30-34. DOI: 10.1016/0166-2236(87)90122-6.
- Phorbol Esters, Protein Phosphorylation and the Regulation of Neuronal Ion ChannelsKaczmarek L. Phorbol Esters, Protein Phosphorylation and the Regulation of Neuronal Ion Channels. Journal Of Experimental Biology 1986, 124: 375-392. PMID: 2428907, DOI: 10.1242/jeb.124.1.375.
- Multiple components of delayed potassium current in peptidergic neurons of Aplysia: modulation by an activator of adenylate cyclaseStrong J, Kaczmarek L. Multiple components of delayed potassium current in peptidergic neurons of Aplysia: modulation by an activator of adenylate cyclase. Journal Of Neuroscience 1986, 6: 814-822. PMID: 2420948, PMCID: PMC6568473, DOI: 10.1523/jneurosci.06-03-00814.1986.
- Chapter 7 The role of protein kinases in the control of prolonged changes in neuronal excitabilityKaczmarek L, Strong J, Kauer J. Chapter 7 The role of protein kinases in the control of prolonged changes in neuronal excitability. 1986, 69: 77-90. PMID: 3328878, DOI: 10.1016/s0079-6123(08)61050-x.
- The Control of Long-Lasting Changes in Membrane Excitability by Protein Phosphorylation in Peptidergic NeuronsKaczmarek L. The Control of Long-Lasting Changes in Membrane Excitability by Protein Phosphorylation in Peptidergic Neurons. 1986, 421-439. DOI: 10.1007/978-1-4613-2115-6_29.
- Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous systemDeRiemer SA, Greengard P, Kaczmarek LK. Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous system. Journal Of Neuroscience 1985, 5: 2672-2676. PMID: 4045549, PMCID: PMC6565129, DOI: 10.1523/jneurosci.05-10-02672.1985.
- Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of AplysiaDeRiemer S, Schweitzer B, Kaczmarek L. Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of Aplysia. Brain Research 1985, 340: 175-180. PMID: 4027644, DOI: 10.1016/0006-8993(85)90790-5.
- Peptidergic neurons of Aplysia lose their response to cyclic adenosine 3':5'-monophosphate during a prolonged refractory periodKauer J, Kaczmarek L. Peptidergic neurons of Aplysia lose their response to cyclic adenosine 3':5'-monophosphate during a prolonged refractory period. Journal Of Neuroscience 1985, 5: 1339-1345. PMID: 2987438, PMCID: PMC6565048, DOI: 10.1523/jneurosci.05-05-01339.1985.
- Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase CDeRiemer SA, Strong JA, Albert KA, Greengard P, Kaczmarek LK. Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C. Nature 1985, 313: 313-316. PMID: 2578617, DOI: 10.1038/313313a0.
- A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of AplysiaKaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.
- Calcium/calmodulin-dependent protein phosphorylation in the nervous system of AplysiaDeRiemer SA, Kaczmarek LK, Lai Y, McGuinness TL, Greengard P. Calcium/calmodulin-dependent protein phosphorylation in the nervous system of Aplysia. Journal Of Neuroscience 1984, 4: 1618-1625. PMID: 6726349, PMCID: PMC6564979, DOI: 10.1523/jneurosci.04-06-01618.1984.
- Calcium entry causes a prolonged refractory period in peptidergic neurons of AplysiaKaczmarek L, Kauer J. Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia. Journal Of Neuroscience 1983, 3: 2230-2239. PMID: 6631477, PMCID: PMC6564640, DOI: 10.1523/jneurosci.03-11-02230.1983.
- Intracellular modulation of membrane channels by cyclic AMP-mediated protein phosphorylation in peptidergic neurons of Aplysia.Strumwasser F, Kaczmarek L, Jennings K. Intracellular modulation of membrane channels by cyclic AMP-mediated protein phosphorylation in peptidergic neurons of Aplysia. The FASEB Journal 1982, 41: 2933-9. PMID: 6292000.
- An early sodium and a late calcium phase in the afterdischarge of peptide-secreting neurons ofAplysiaKaczmarek L, Jennings K, Strumwasser F. An early sodium and a late calcium phase in the afterdischarge of peptide-secreting neurons ofAplysia. Brain Research 1982, 238: 105-115. PMID: 6282390, DOI: 10.1016/0006-8993(82)90774-0.
- Protein phosphorylation during afterdischarge in peptidergic neurons of AplysiaJennings K, Kaczmarek L, Hewick R, Dreyer W, Strumwasser F. Protein phosphorylation during afterdischarge in peptidergic neurons of Aplysia. Journal Of Neuroscience 1982, 2: 158-168. PMID: 6278103, PMCID: PMC6564306, DOI: 10.1523/jneurosci.02-02-00158.1982.
- Serotonergic inhibition of afterdischarge in peptidergic bag cellsJennings K, Host J, Kaczmarek L, Strumwasser F. Serotonergic inhibition of afterdischarge in peptidergic bag cells. Developmental Neurobiology 1981, 12: 579-590. PMID: 7310396, DOI: 10.1002/neu.480120606.
- The expression of long lasting afterdischarge by isolated Aplysia bag cell neuronsKaczmarek L, Strumwasser F. The expression of long lasting afterdischarge by isolated Aplysia bag cell neurons. Journal Of Neuroscience 1981, 1: 626-634. PMID: 6286900, PMCID: PMC6564181, DOI: 10.1523/jneurosci.01-06-00626.1981.
- Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell cultureKaczmarek LK, Jennings KR, Strumwasser F, Nairn AC, Walter U, Wilson FD, Greengard P. Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1980, 77: 7487-7491. PMID: 6261262, PMCID: PMC350530, DOI: 10.1073/pnas.77.12.7487.
- Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg-laying in AplysiaHeller E, Kaczmarek L, Hunkapiller M, Hood L, Strumwasser F. Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg-laying in Aplysia. Proceedings Of The National Academy Of Sciences Of The United States Of America 1980, 77: 2328-2332. PMID: 6929554, PMCID: PMC348708, DOI: 10.1073/pnas.77.4.2328.
- Peptides controlling behavior in Aplysia.Strumwasser F, Kaczmarek L, Chiu A, Heller E, Jennings K, Viele D. Peptides controlling behavior in Aplysia. Society Of General Physiologists Series 1980, 35: 197-218. PMID: 7414370.
- The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell cultureKaczmarek L, Finbow M, Revel J, Strumwasser F. The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell culture. Developmental Neurobiology 1979, 10: 535-550. PMID: 521813, DOI: 10.1002/neu.480100604.
- Neurotransmitter modulation, phosphodiesterase inhibitor effects, and cyclic AMP correlates of afterdischarge in peptidergic neuritesKaczmarek L, Jennings K, Strumwasser F. Neurotransmitter modulation, phosphodiesterase inhibitor effects, and cyclic AMP correlates of afterdischarge in peptidergic neurites. Proceedings Of The National Academy Of Sciences Of The United States Of America 1978, 75: 5200-5204. PMID: 217016, PMCID: PMC336293, DOI: 10.1073/pnas.75.10.5200.