In-Hyun Park, PhD

Associate Professor of Genetics and Associate Professor in the Child Study Center; Yale Stem Cell Center

Research Departments & Organizations

Interdepartmental Neuroscience Program

Yale Stem Cell Center

Office of Cooperative Research

Research Interests

Cells; Central Nervous System Diseases; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Nervous System; Neural Stem Cells; Pluripotent Stem Cells; Psychiatry and Psychology; Stem Cells

Research Summary

Overexpression of four factors (Oct4, Sox2, Klf4, Myc, or Oct4, Sox2, Nanog, Lin28) reprogram somatic cells to become induced pluripotent stem (iPS) cells. Reprogramming accompanies genetic and epigenetic changes, and its molecular mechanism is still unknown. We recently showed that in iPS cells the global DNA methylation status is close to that of human embryonic stem (hES) cells, suggesting the epigenetic resetting during reprogramming. Furthermore, we have showed the possible dissection of stages in reprogramming through live cell imaging analysis.
We will investigate the molecular mechanism of genetic and epigenetic change during reprogramming. iPS cells show similar characteristics as hES cells, such as self-renewal and pluripotency, and provide an incredible resource for cell-based therapy, in vitro disease model and screening drugs.

Extensive Research Description

  • Investigation of genetic and epigenetic regulation of reprogramming
  • in vitro model of human neurodevelopmental disease

Selected Publications

See list of PubMed publications

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Contact Info

In-Hyun Park, PhD
Lab Location
The Park LabAmistad Street Building
10 Amistad Street, Ste 214J

New Haven, CT 06519
Mailing Address
Genetics10 Amistad 201B
New Haven, CT 06520

the Park Lab