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Ann Haberman, PhD

she/her/hers
Associate Professor of Immunobiology
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Additional Titles

Director, In Vivo Imaging Facility, Yale School of Medicine

Scientific Director, Flow Cytometry Research Facility, YSM central core

About

Titles

Associate Professor of Immunobiology

Director, In Vivo Imaging Facility, Yale School of Medicine; Scientific Director, Flow Cytometry Research Facility, YSM central core

Biography

Ph.D., University of Pennsylvania (1992)

Appointments

Education & Training

PhD
University of Pennsylvania, Immunology (1992)

Research

Overview

My research has focused on the cellular and molecular interactions regulating the form and function of an inducible lymphoid tissue structure called germinal centers. Germinal centers (GC) are large aggregates of B cells specificially responding to a foreign substance. They develop in the center of B cell follicles in spleen and lymph nodes about one week after initial immunization or exposure to pathogens. GCs are sites of extreme metabolism, with very high proliferation and death rates, and evolve over time to form structures with phenotypically distinct zones. GC development requires intricate interactions of B cells with multiple other cell types to achieve both the affinity maturation of plasma cells producing antibodies and the generation of memory B cells that are key to long-term immune protection. The regional composition of other cell types can vary tremendously and can include CD4+ T cell subsets, dendritic cells and activated macrophages. Defining the impact of interactions with other adjacent cell types will be an essential component of advances in this field. My current research aims to tease apart the role that each may play in the cascade of events regulating both the expansion of GC B cells and the effector output of germinal centers.

Medical Subject Headings (MeSH)

Antibody Formation; Dendritic Cells, Follicular; Germinal Center; Immunity, Cellular; Immunological Synapses; Lymphocyte Activation; Lymphoid Tissue; Lymphoma, B-Cell

Research at a Glance

Yale Co-Authors

Frequent collaborators of Ann Haberman's published research.

Publications

2024

2019

2018

2017

2016

2015

Academic Achievements & Community Involvement

  • activity

    Yale Microscopy Workshop

Get In Touch

Contacts

Academic Office Number
Mailing Address

Yale School of Medicine

1 Gilbert Street, TAC Bldg S530

New Haven, CT 06525

United States

Administrative Support

Locations