Yann Mineur, MS, PhD
Research Scientist in Psychiatry
Research & Publications
Biography
News
Coauthors
Selected Publications
- How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approachesMineur Y, Picciotto M. How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches. Journal Of Neurochemistry 2023, 167: 3-15. PMID: 37621094, PMCID: PMC10616967, DOI: 10.1111/jnc.15943.
- Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center ProgramsZakiniaeiz Y, Peltier M, Mineur Y, Gueorguieva R, Picciotto M, Petrakis I, Cosgrove K, McKee S. Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs. Journal Of Women's Health 2023, 32: 852-857. PMID: 37585509, PMCID: PMC10457604, DOI: 10.1089/jwh.2023.0015.
- Pathophysiology of nAChRs: Limbic circuits and related disordersMineur Y, Soares A, Etherington I, Abdulla Z, Picciotto M. Pathophysiology of nAChRs: Limbic circuits and related disorders. Pharmacological Research 2023, 191: 106745. PMID: 37011774, DOI: 10.1016/j.phrs.2023.106745.
- Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for rewardZhou WL, Kim K, Ali F, Pittenger ST, Calarco CA, Mineur YS, Ramakrishnan C, Deisseroth K, Kwan AC, Picciotto MR. Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward. Science Advances 2022, 8: eabm5217. PMID: 36260661, PMCID: PMC9581470, DOI: 10.1126/sciadv.abm5217.
- ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigmsMineur YS, Mose TN, Maibom KL, Pittenger ST, Soares AR, Wu H, Taylor SR, Huang Y, Picciotto MR. ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigms. Molecular Psychiatry 2022, 27: 4918-4927. PMID: 36050437, PMCID: PMC10718266, DOI: 10.1038/s41380-022-01749-7.
- Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathwaysMineur YS, Garcia-Rivas V, Thomas MA, Soares AR, McKee SA, Picciotto MR. Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. Psychopharmacology 2022, 239: 2041-2061. PMID: 35359158, PMCID: PMC9704113, DOI: 10.1007/s00213-022-06120-w.
- Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputsMineur YS, Mose TN, Vanopdenbosch L, Etherington IM, Ogbejesi C, Islam A, Pineda CM, Crouse RB, Zhou W, Thompson DC, Bentham MP, Picciotto MR. Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs. Molecular Psychiatry 2022, 27: 1829-1838. PMID: 34997190, PMCID: PMC9106825, DOI: 10.1038/s41380-021-01404-7.
- Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disordersPeltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.
- Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingencyCrouse RB, Kim K, Batchelor HM, Girardi EM, Kamaletdinova R, Chan J, Rajebhosale P, Pittenger ST, Role LW, Talmage DA, Jing M, Li Y, Gao XB, Mineur YS, Picciotto MR. Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency. ELife 2020, 9: e57335. PMID: 32945260, PMCID: PMC7529459, DOI: 10.7554/elife.57335.
- Origin and Function of Stress-Induced IL-6 in Murine ModelsQing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 2020, 182: 1660. PMID: 32946784, DOI: 10.1016/j.cell.2020.08.044.
- Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampusCope ZA, Lavadia ML, Joosen AJM, van de Cappelle CJA, Lara JC, Huval A, Kwiatkowski MK, Picciotto MR, Mineur YS, Dulcis D, Young JW. Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus. Cognitive, Affective, & Behavioral Neuroscience 2020, 20: 1173-1183. PMID: 32794101, PMCID: PMC7718303, DOI: 10.3758/s13415-020-00824-2.
- Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioningMineur YS, Ernstsen C, Islam A, Maibom KL, Picciotto MR. Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning. Genes Brain & Behavior 2020, 19: e12677. PMID: 32447811, PMCID: PMC8018799, DOI: 10.1111/gbb.12677.
- Origin and Function of Stress-Induced IL-6 in Murine ModelsQing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 2020, 182: 372-387.e14. PMID: 32610084, PMCID: PMC7384974, DOI: 10.1016/j.cell.2020.05.054.
- Cumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical ActivityBarthas F, Hu MY, Siniscalchi MJ, Ali F, Mineur YS, Picciotto MR, Kwan AC. Cumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical Activity. Biological Psychiatry 2020, 88: 541-553. PMID: 32276717, PMCID: PMC7434704, DOI: 10.1016/j.biopsych.2020.02.008.
- The role of acetylcholine in negative encoding bias: Too much of a good thing?Mineur YS, Picciotto MR. The role of acetylcholine in negative encoding bias: Too much of a good thing? European Journal Of Neuroscience 2019, 53: 114-125. PMID: 31821620, PMCID: PMC7282966, DOI: 10.1111/ejn.14641.
- Cholinergic modulation of circuits involved in stress-related behaviorsPicciotto M, Mineur Y. Cholinergic modulation of circuits involved in stress-related behaviors. IBRO Neuroscience Reports 2019, 6: s28. DOI: 10.1016/j.ibror.2019.07.080.
- Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacineLee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR. Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. Genes Brain & Behavior 2019, 19: e12601. PMID: 31364813, PMCID: PMC8045136, DOI: 10.1111/gbb.12601.
- Sex differences in stress-related alcohol usePeltier MR, Verplaetse TL, Mineur YS, Petrakis IL, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in stress-related alcohol use. Neurobiology Of Stress 2019, 10: 100149. PMID: 30949562, PMCID: PMC6430711, DOI: 10.1016/j.ynstr.2019.100149.
- The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain DevelopmentTebbenkamp ATN, Varela L, Choi J, Paredes MI, Giani AM, Song JE, Sestan-Pesa M, Franjic D, Sousa AMM, Liu ZW, Li M, Bichsel C, Koch M, Szigeti-Buck K, Liu F, Li Z, Kawasawa YI, Paspalas CD, Mineur YS, Prontera P, Merla G, Picciotto MR, Arnsten AFT, Horvath TL, Sestan N. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell 2018, 175: 1088-1104.e23. PMID: 30318146, PMCID: PMC6459420, DOI: 10.1016/j.cell.2018.09.014.
- Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamusCalarco CA, Li Z, Taylor SR, Lee S, Zhou W, Friedman JM, Mineur YS, Gotti C, Picciotto MR. Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus. European Journal Of Neuroscience 2018, 48: 1600-1619. PMID: 29791746, PMCID: PMC6251769, DOI: 10.1111/ejn.13966.
- Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in miceMineur YS, Cahuzac EL, Mose TN, Bentham MP, Plantenga ME, Thompson DC, Picciotto MR. Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice. Neuropsychopharmacology 2018, 43: 2118-2125. PMID: 29472646, PMCID: PMC6098039, DOI: 10.1038/s41386-018-0024-x.
- Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine ReceptorsLewis AS, Pittenger ST, Mineur YS, Stout D, Smith PH, Picciotto MR. Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology 2017, 43: 1267-1275. PMID: 29114104, PMCID: PMC5916354, DOI: 10.1038/npp.2017.276.
- Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J miceFait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS. Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. Behavioural Brain Research 2017, 334: 72-77. PMID: 28743602, PMCID: PMC5580257, DOI: 10.1016/j.bbr.2017.07.027.
- Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression‐like behaviour in C57BL/6J miceMineur YS, Mose TN, Blakeman S, Picciotto MR. Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression‐like behaviour in C57BL/6J mice. British Journal Of Pharmacology 2017, 175: 1903-1914. PMID: 28264149, PMCID: PMC5979617, DOI: 10.1111/bph.13769.
- CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and MemoryPark J, Chávez AE, Mineur YS, Morimoto-Tomita M, Lutzu S, Kim KS, Picciotto MR, Castillo PE, Tomita S. CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory. Neuron 2016, 92: 75-83. PMID: 27667007, PMCID: PMC5059846, DOI: 10.1016/j.neuron.2016.09.002.
- An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behaviorJung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR. An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nature Neuroscience 2016, 19: 905-914. PMID: 27239938, PMCID: PMC4925298, DOI: 10.1038/nn.4315.
- Comparative mRNA analysis of behavioral and genetic mouse models of aggressionMalki K, Tosto MG, Pain O, Sluyter F, Mineur YS, Crusio WE, de Boer S, Sandnabba KN, Kesserwani J, Robinson E, Schalkwyk LC, Asherson P. Comparative mRNA analysis of behavioral and genetic mouse models of aggression. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 427-436. PMID: 26888158, DOI: 10.1002/ajmg.b.32424.
- Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social StressMineur YS, Fote GM, Blakeman S, Cahuzac EL, Newbold SA, Picciotto MR. Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress. Neuropsychopharmacology 2015, 41: 1579-1587. PMID: 26471256, PMCID: PMC4832019, DOI: 10.1038/npp.2015.316.
- Reduction of aggressive behavior in mouse models by the selective α7 nicotinic partial agonist GTS-21Lewis A, Garvey K, Mineur Y, Picciotto M. Reduction of aggressive behavior in mouse models by the selective α7 nicotinic partial agonist GTS-21. Biochemical Pharmacology 2015, 97: 632-633. DOI: 10.1016/j.bcp.2015.08.034.
- Modulation of aggressive behavior in mice by nicotinic receptor subtypesLewis AS, Mineur YS, Smith PH, Cahuzac EL, Picciotto MR. Modulation of aggressive behavior in mice by nicotinic receptor subtypes. Biochemical Pharmacology 2015, 97: 488-497. PMID: 26212554, PMCID: PMC4600457, DOI: 10.1016/j.bcp.2015.07.019.
- Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female miceMineur YS, Bentham MP, Zhou WL, Plantenga ME, McKee SA, Picciotto MR. Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice. Psychopharmacology 2015, 232: 3539-3549. PMID: 26146014, PMCID: PMC4561580, DOI: 10.1007/s00213-015-4001-3.
- Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strainsMalki K, Mineur YS, Tosto MG, Campbell J, Karia P, Jumabhoy I, Sluyter F, Crusio WE, Schalkwyk LC. Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains. BMC Genomics 2015, 16: 262. PMID: 25879669, PMCID: PMC4412144, DOI: 10.1186/s12864-015-1431-6.
- Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxideClément Y, Prut L, Saurini F, Mineur Y, Le Guisquet A, Védrine S, Andres C, Vodjdani G, Belzung C. Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide. Behavioural Brain Research 2012, 233: 474-482. PMID: 22677273, DOI: 10.1016/j.bbr.2012.05.041.
- Genetic Models of Alzheimer’s DiseaseMineur Y. Genetic Models of Alzheimer’s Disease. 2008, 539-544. DOI: 10.1007/978-1-59745-285-4_55.
- Effects of Chronic Alcohol Consumption on Hippocampal Anatomy and Associated Behaviors in Three Inbred Strains of MiceMineur Y, Marican C, Larue-Achagiotis C, Sluyter F, Crusio W. Effects of Chronic Alcohol Consumption on Hippocampal Anatomy and Associated Behaviors in Three Inbred Strains of Mice. The Open Behavioral Science Journal 2007, 1: 5-12. DOI: 10.2174/1874230000701010005.
- P.1.a.015 Strain differences in susceptibility to unpredictable chronic mild stress as assessed by hippocampal gene expression profilingPaya-Cano J, Sluyter F, Mineur Y, Fernandes C, Crusio W, Schalkwyk L. P.1.a.015 Strain differences in susceptibility to unpredictable chronic mild stress as assessed by hippocampal gene expression profiling. European Neuropsychopharmacology 2006, 16: s216-s217. DOI: 10.1016/s0924-977x(06)70154-7.
- Neuroanatomy of cerebellum and olfactory bulb in a substrain of C57BL/6J inbred mice carrying a spontaneous mutationPager J, Mineur Y, Pinoteau W, LeRoy I, Crusio W. Neuroanatomy of cerebellum and olfactory bulb in a substrain of C57BL/6J inbred mice carrying a spontaneous mutation. Physiology & Behavior 2001, 73: 827-831. PMID: 11566215, DOI: 10.1016/s0031-9384(01)00519-4.