Sven-Eric Jordt, PhD
Associate Professor of Anesthesiology, Pharmacology & Cancer Biology, University Program of Environmental Health (UPEH)
Research & Publications
Biography
News
Research Summary
In my laboratory we are interested in how humans and animals sense
touch and pain. These fundamental sensations originate in peripheral
sensory neurons which contain signaling pathways that translate
environmental stimuli into neural activity. Our aims are to identify
the molecular components of these pathways and to understand how
sensory neurons become sensitized during injury and chronic painful
conditions such as inflammation.
In our current studies we use pharmacological, molecular genetic and
physiological approaches as well as fluorescent imaging techniques to
investigate the properties of ion channel proteins that serve as
sensors for temperature and noxious stimuli in sensory neurons. These
proteins belong to the gene family of TRP (transient receptor
potential) ion channels, some of which are the targets of natural plant
products that activate the sensation of heat and pain (capsaicin,
mustard oil) or cold (menthol). We are using these compounds as
chemical probes to study how TRP channels are activated, how they
interact with endogenous ligands and how temperature sensing occurs.
Another goal in our lab is to understand how signaling pathways are
used to increase TRP channel activity in disease. TRP channels are
regulated by other receptor systems through membrane phospholipid
turnover, kinase pathways and endogenous ligands. Increased channel
activity results in neural sensitization that causes hypersensitivity
to sensory input and contributes to painful inflammation by a mechanism
known as neurogenic inflammation. This mechanism is important for
conditions such as arthritis, vasculitis, psoriasis, intra- and
postoperative pain, trauma, invading cancer and visceral and
musculoskeletal disorders. With our studies we hope to gain new
mechanistic insights into neurogenic inflammation, identify potential
pharmacological targets and reveal basic molecular and cellular
mechanisms of sensory transduction.
Coauthors
Selected Publications
- Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette BansJabba S, Erythropel H, Anastas P, Zimmerman J, Jordt S. Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans. JAMA 2023, 330: 1689-1691. PMID: 37812408, PMCID: PMC10562986, DOI: 10.1001/jama.2023.17134.
- Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.2.
- Synthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’Jabba S, Erythropel H, Woodrow J, Anastas P, O'Malley S, Krishnan-Sarin S, Zimmerman J, Jordt S. Synthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’. Tobacco Control 2023, tc-2023-058035. PMID: 37380351, PMCID: PMC10753027, DOI: 10.1136/tc-2023-058035.
- Soluble Epoxide Hydrolase Inhibitors and ACE Inhibitors Ameliorate Phosgene Inhalation InjuriesAchanta S, Marcus A, Caceres A, Jordt S. Soluble Epoxide Hydrolase Inhibitors and ACE Inhibitors Ameliorate Phosgene Inhalation Injuries. 2023, a1171-a1171. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1171.
- Synthetic Cooling Agents in California-Marketed "Non-menthol" Cigarette Brands Introduced After the State’s Menthol BanJordt S, Erythropel H, Yang A, O'Malley S, Krishnan-Sarin S, Zimmerman J, Jabba S. Synthetic Cooling Agents in California-Marketed "Non-menthol" Cigarette Brands Introduced After the State’s Menthol Ban. 2023, a2633-a2633. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2633.
- High Toxicity of Cinnamon-flavored Electronic Cigarette Liquids: A Lesson Not LearnedJordt S, Erythropel H, Zimmerman J, Jabba S. High Toxicity of Cinnamon-flavored Electronic Cigarette Liquids: A Lesson Not Learned. 2023, a2632-a2632. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2632.
- Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1Blair N, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.1.
- Effect Of Comt Genetic Background And Stress On Pain Following Tibial FractureChen J, Wu Y, Wang Y, Sandu C, Gu E, Jordt S, Terrando N, Nackley A. Effect Of Comt Genetic Background And Stress On Pain Following Tibial Fracture. Journal Of Pain 2023, 24: 30. DOI: 10.1016/j.jpain.2023.02.098.
- Vagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult MiceWu P, De Caceres A, Baht G, Terrando N, Jordt S. Vagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult Mice. Journal Of Pain 2023, 24: 10. DOI: 10.1016/j.jpain.2023.02.044.
- The E-cigarette or Vaping Product Use–Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop ReportRebuli M, Rose J, Noël A, Croft D, Benowitz N, Cohen A, Goniewicz M, Larsen B, Leigh N, McGraw M, Melzer A, Penn A, Rahman I, Upson D, Alexander L, Ewart G, Jaspers I, Jordt S, Kligerman S, Loughlin C, McConnell R, Neptune E, Nguyen T, Pinkerton K, Witek T. The E-cigarette or Vaping Product Use–Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2023, 20: 1-17. PMID: 36584985, PMCID: PMC9819258, DOI: 10.1513/annalsats.202209-796st.
- Biomarkers and Drugs Targets for Phosgene Induced Pulmonary Inhalation InjuriesAchanta S, Marcus A, Caceres A, Merutka I, Jordt S. Biomarkers and Drugs Targets for Phosgene Induced Pulmonary Inhalation Injuries. 2022, a3834-a3834. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3834.
- Synthetic Cooling Agents in US-Marketed E-cigarette Refill Liquids and Disposable E-cigarettes: Chemical Analysis and Risk AssessmentJordt S, Erythropel H, Garcia Torres D, Delgado L, Anastas P, Zimmerman J, Jabba S. Synthetic Cooling Agents in US-Marketed E-cigarette Refill Liquids and Disposable E-cigarettes: Chemical Analysis and Risk Assessment. 2022, a1147-a1147. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1147.
- Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1Blair N, Carvacho I, Chaudhuri D, Clapham D, DeCaen P, Delling M, Doerner J, Fan L, Grimm C, Ha K, Jordt S, Julius D, Kahle K, Liu B, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Van den Eynde C, Vriens J, Wu L, Xu H, Yue L, Zhang X, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1. IUPHAR/BPS Guide To Pharmacology CITE 2022, 2022 DOI: 10.2218/gtopdb/f78/2022.1.
- Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3Blair N, Carvacho I, Chaudhuri D, Clapham D, DeCaen P, Delling M, Doerner J, Fan L, Ha K, Jordt S, Julius D, Kahle K, Liu B, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Van den Eynde C, Vriens J, Wu L, Xu H, Yue L, Zhang X, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3. IUPHAR/BPS Guide To Pharmacology CITE 2021, 2021 DOI: 10.2218/gtopdb/f78/2021.3.
- Chlorinated Tyrosine Adducts as Biomarkers of Chlorine Gas Exposure in a Swine ModelAchanta S, Pantazides B, Crow B, Quiñones-González J, Perez J, Blake T, Jordt S. Chlorinated Tyrosine Adducts as Biomarkers of Chlorine Gas Exposure in a Swine Model. 2021, a3072-a3072. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3072.
- The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung InflammationCaceres A, Kaelberer M, Jordt S. The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation. 2021, a1311-a1311. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1311.
- Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic CigarettesJabba S, Diaz A, Caceres A, Erythropel H, Kumar V, Varghese S, Zimmerman J, Jordt S. Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes. 2021, a4296-a4296. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4296.
- Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammationCaceres A, Kaelberer M, Jordt S. Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammation. 2020, 902. DOI: 10.1183/13993003.congress-2020.902.
- Exposure biomarkers in a pig model of chlorine inhalation injuryJordt S, Albert C, Schultz K, Ford D, Patel R, Achanta S. Exposure biomarkers in a pig model of chlorine inhalation injury. 2020, 1308. DOI: 10.1183/13993003.congress-2020.1308.
- Flavor-solvent reaction products in electronic cigarette liquids activate respiratory irritant receptors and elicit cytotoxic metabolic responses in airway epithelial cellJordt S, Caceres A, Erythropel H, Zimmerman J, Dewinter T, Jabba S. Flavor-solvent reaction products in electronic cigarette liquids activate respiratory irritant receptors and elicit cytotoxic metabolic responses in airway epithelial cell. 2020, 4384. DOI: 10.1183/13993003.congress-2020.4384.
- Late Breaking Abstract - Differences in flavorant levels and synthetic coolant use between USA, EU and Canadian Juul productsErythropel H, Anastas P, Krishnan-Sarin S, O'Malley S, Jordt S, Zimmerman J. Late Breaking Abstract - Differences in flavorant levels and synthetic coolant use between USA, EU and Canadian Juul products. 2020, 4382. DOI: 10.1183/13993003.congress-2020.4382.
- Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targetsAchanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.
- Activation of Respiratory Irritant Receptors by Pulegone, A Toxic Flavor Chemical in Mint- or Menthol-Flavored Electronic CigarettesJabba S, Jordt S. Activation of Respiratory Irritant Receptors by Pulegone, A Toxic Flavor Chemical in Mint- or Menthol-Flavored Electronic Cigarettes. 2020, a2767-a2767. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2767.
- Biomarkers of Chlorine Gas Exposure in a Swine ModelAchanta S, Albert C, Schultz K, Ford D, Patel R, Jordt S. Biomarkers of Chlorine Gas Exposure in a Swine Model. 2020, a4332-a4332. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4332.
- The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung InflammationCaceres A, Kaelberer M, Jordt S. The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation. 2020, a1794-a1794. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1794.
- The science of flavour in tobacco products.Krishnan-Sarin S, O'Malley S, Green B, Jordt S. The science of flavour in tobacco products. Technical Report Series 930 2019, 1015: 125-142. PMID: 36743396, PMCID: PMC9896977.
- The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injuryCaceres A, Jordt S. The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury. 2019, pa3885. DOI: 10.1183/13993003.congress-2019.pa3885.
- Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology DatabaseBlair N, Carvacho I, Chaudhuri D, Clapham D, DeCaen P, Delling M, Doerner J, Fan L, Ha K, Jordt S, Julius D, Kahle K, Liu B, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Van den Eynde C, Vriens J, Wu L, Xu H, Yue L, Zhang X, Zhu M. Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f78/2019.4.
- Flavorant–Solvent Reaction Products and Menthol in JUUL E-Cigarettes and AerosolErythropel HC, Davis LM, de Winter TM, Jordt SE, Anastas PT, O'Malley SS, Krishnan-Sarin S, Zimmerman JB. Flavorant–Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol. American Journal Of Preventive Medicine 2019, 57: 425-427. PMID: 31358341, PMCID: PMC6702051, DOI: 10.1016/j.amepre.2019.04.004.
- Flavor-Solvent Adducts In Electronic Cigarette Liquids Are Modulators of Respiratory Irritant Receptors with Distinct Toxicological Effects on Lung Epithelial CellsJordt S, Caceres A, Jabba S. Flavor-Solvent Adducts In Electronic Cigarette Liquids Are Modulators of Respiratory Irritant Receptors with Distinct Toxicological Effects on Lung Epithelial Cells. 2019, a7312-a7312. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7312.
- Propylene Glycol and Glycerin in E-Cigarettes Elicit Respiratory Irritation Responses and Modulate Human Sensory Irritant Receptor FunctionJordt S, Jabba S, Ghoreshi K, Smith G, Morris J. Propylene Glycol and Glycerin in E-Cigarettes Elicit Respiratory Irritation Responses and Modulate Human Sensory Irritant Receptor Function. 2019, a4169-a4169. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4169.
- TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung InjuryAchanta S, Liu B, Gentile M, Caceres A, Behm D, Burgert M, Costell M, Cheifetz I, Gunn M, Jordt S. TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury. 2019, a1017-a1017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1017.
- Sweeteners are added to modify consumer behaviourJordt S, Jabba S. Sweeteners are added to modify consumer behaviour. The BMJ 2019, 364: l366. PMID: 30683659, PMCID: PMC6890469, DOI: 10.1136/bmj.l366.
- Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids.Erythropel HC, Jabba SV, DeWinter TM, Mendizabal M, Anastas PT, Jordt SE, Zimmerman JB. Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. Nicotine & Tobacco Research 2018, 21: 1248-1258. PMID: 30335174, PMCID: PMC6698951, DOI: 10.1093/ntr/nty192.
- Presence of High-Intensity Sweeteners in Popular Cigarillos of Varying Flavor Profiles.Erythropel HC, Kong G, deWinter TM, O'Malley SS, Jordt SE, Anastas PT, Zimmerman JB. Presence of High-Intensity Sweeteners in Popular Cigarillos of Varying Flavor Profiles. JAMA 2018, 320: 1380-1383. PMID: 30285168, PMCID: PMC6233844, DOI: 10.1001/jama.2018.11187.
- Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J miceFait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS. Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. Behavioural Brain Research 2017, 334: 72-77. PMID: 28743602, PMCID: PMC5580257, DOI: 10.1016/j.bbr.2017.07.027.
- Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptolCaceres AI, Liu B, Jabba SV, Achanta S, Morris JB, Jordt S. Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol. British Journal Of Pharmacology 2017, 174: 867-879. PMID: 28240768, PMCID: PMC5387001, DOI: 10.1111/bph.13760.
- Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neuronsPeter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg F, Schwede F, Stein C, Jordt S, Brackmann M, Spahn V. Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons. European Journal Of Pain 2017, 21: 1072-1086. PMID: 28182310, PMCID: PMC5504413, DOI: 10.1002/ejp.1008.
- The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8de Caceres Bustos A, Liu B, Jabba S, Morris J, Jordt S. The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8. 2016, oa4541. DOI: 10.1183/13993003.congress-2016.oa4541.
- Tear gas: an epidemiological and mechanistic reassessmentRothenberg C, Achanta S, Svendsen ER, Jordt S. Tear gas: an epidemiological and mechanistic reassessment. Annals Of The New York Academy Of Sciences 2016, 1378: 96-107. PMID: 27391380, PMCID: PMC5096012, DOI: 10.1111/nyas.13141.
- A Method to Target and Isolate Airway-innervating Sensory Neurons in MiceKaelberer M, Jordt S. A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice. Journal Of Visualized Experiments 2016 DOI: 10.3791/53917-v.
- TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitisLiu B, Escalera J, Balakrishna S, Fan L, Caceres A, Robinson E, Sui A, McKay M, McAlexander M, Herrick C, Jordt S. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. The FASEB Journal 2013, 27: 3549-3563. PMID: 23722916, PMCID: PMC3752543, DOI: 10.1096/fj.13-229948.
- TRPV1, Regulation by ProtonsJordt S. TRPV1, Regulation by Protons. 2013, 4112-4115. DOI: 10.1007/978-3-642-28753-4_4653.
- TRPV1, Regulation by Nerve Growth FactorJordt S. TRPV1, Regulation by Nerve Growth Factor. 2013, 4109-4112. DOI: 10.1007/978-3-642-28753-4_4652.
- Menthol Attenuates Respiratory Irritation Responses To Multiple Cigarette Smoke IrritantsJordt S, Willis D, Liu B, Morris J. Menthol Attenuates Respiratory Irritation Responses To Multiple Cigarette Smoke Irritants. 2012, a6745-a6745. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6745.
- Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritantsWillis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.
- Screening Spider Toxin Libraries for TRP Channel InhibitorsGui J, Zhou Y, Jordt S, Nitabach M. Screening Spider Toxin Libraries for TRP Channel Inhibitors. Biophysical Journal 2011, 100: 108a. DOI: 10.1016/j.bpj.2010.12.798.
- Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and NaphthaleneLanosa M, Willis D, Jordt S, Morris J. Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene. Toxicological Sciences 2010, 115: 589-595. PMID: 20176620, PMCID: PMC2948824, DOI: 10.1093/toxsci/kfq057.
- A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthmaCaceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
- Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1Caceres A, Brackmann M, Bessac B, Cohn L, Jordt S. Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. The FASEB Journal 2009, 23: 580.10-580.10. DOI: 10.1096/fasebj.23.1_supplement.580.10.
- TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear GasesBessac B, Sivula M, von Hehn C, Caceres A, Escalera J, Jordt S. TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases. The FASEB Journal 2009, 23: 580.11-580.11. DOI: 10.1096/fasebj.23.1_supplement.580.11.
- Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex ControlBessac BF, Jordt SE. Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control. Physiology 2008, 23: 360-370. PMID: 19074743, PMCID: PMC2735846, DOI: 10.1152/physiol.00026.2008.
- The menthol receptor TRPM8 is the principal detector of environmental coldBautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 2007, 448: 204-208. PMID: 17538622, DOI: 10.1038/nature05910.
- Trp Channels In DiseaseJORDT SE, EHRLICH BE. Trp Channels In Disease. 2007, 45: 253-271. PMID: 18193640, DOI: 10.1007/978-1-4020-6191-2_9.
- TRPV1, Regulation by Nerve Growth FactorJordt S. TRPV1, Regulation by Nerve Growth Factor. 2007, 2574-2575. DOI: 10.1007/978-3-540-29805-2_4652.
- TRPV1, Regulation by ProtonsJordt S. TRPV1, Regulation by Protons. 2007, 2575-2578. DOI: 10.1007/978-3-540-29805-2_4653.
- TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic AgentsBautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents. Cell 2006, 124: 1269-1282. PMID: 16564016, DOI: 10.1016/j.cell.2006.02.023.
- Pungent products from garlic activate the sensory ion channel TRPA1Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. Pungent products from garlic activate the sensory ion channel TRPA1. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12248-12252. PMID: 16103371, PMCID: PMC1189336, DOI: 10.1073/pnas.0505356102.
- Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427: 260-265. PMID: 14712238, DOI: 10.1038/nature02282.
- Lessons from peppers and peppermint: the molecular logic of thermosensationJordt SE, McKemy DD, Julius D. Lessons from peppers and peppermint: the molecular logic of thermosensation. Current Opinion In Neurobiology 2003, 13: 487-492. PMID: 12965298, DOI: 10.1016/s0959-4388(03)00101-6.
- Molecular determinants of ligand interaction with the capsaicin receptorJordt S, Julius D. Molecular determinants of ligand interaction with the capsaicin receptor. Journal Of Neurochemistry 2003, 85: 4-4. DOI: 10.1046/j.1471-4159.85.s2.4_3.x.
- Acid potentiation of the capsaicin receptor determined by a key extracellular siteJordt S. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Journal Of Neurochemistry 2003, 85: 6-6. DOI: 10.1046/j.1471-4159.85.s2.6_3.x.
- Molecular Basis for Species-Specific Sensitivity to “Hot” Chili PeppersJordt SE, Julius D. Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers. Cell 2002, 108: 421-430. PMID: 11853675, DOI: 10.1016/s0092-8674(02)00637-2.
- Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibitionChuang H, Prescott E, Kong H, Shields S, Jordt S, Basbaum A, Chao M, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001, 411: 957-962. PMID: 11418861, DOI: 10.1038/35082088.
- Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruptionBösl M, Stein V, Hübner C, Zdebik A, Jordt S, Mukhopadhyay A, Davidoff M, Holstein A, Jentsch T. Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruption. The EMBO Journal 2001, 20: 1289-1299. PMID: 11250895, PMCID: PMC145530, DOI: 10.1093/emboj/20.6.1289.
- Acid potentiation of the capsaicin receptor determined by a key extracellular siteJordt S, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 8134-8139. PMID: 10859346, PMCID: PMC16682, DOI: 10.1073/pnas.100129497.
- Chloride dependence of hyperpolarization‐activated chloride channel gatesPusch M, Jordt S, Stein V, Jentsch T. Chloride dependence of hyperpolarization‐activated chloride channel gates. The Journal Of Physiology 1999, 515: 341-353. PMID: 10050002, PMCID: PMC2269146, DOI: 10.1111/j.1469-7793.1999.341ac.x.
- Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neuronsClark S, Jordt S, Jentsch T, Mathie A. Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons. The Journal Of Physiology 1998, 506: 665-678. PMID: 9503329, PMCID: PMC2230754, DOI: 10.1111/j.1469-7793.1998.665bv.x.
- Molecular dissection of gating in the ClC‐2 chloride channelJordt S, Jentsch T. Molecular dissection of gating in the ClC‐2 chloride channel. The EMBO Journal 1997, 16: 1582-1592. PMID: 9130703, PMCID: PMC1169762, DOI: 10.1093/emboj/16.7.1582.