Andrew Wang, MD/PhD, AB

• Akiko Iwasaki
• Anna Eisenstein
• Carlos Fernandez-Hernando
• Carmen Jane Booth
• Erica Herzog
• Jean-Dominique Gallezot
• Lawrence Young
• Tamara Dlugos
• Tamas Horvath
• Vishwa Deep Dixit
• Yajaira Suarez
• Yann Mineur
• Yuki Yasumoto

Inflammation; Metabolism; Psychoneuroimmunology; Neuroimmunomodulation

• Immune sensing of food allergens promotes avoidance behaviourFlorsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.
• Dickkopf1 fuels inflammatory cytokine responsesJaschke N, Pählig S, Sinha A, Adolph T, Colunga M, Hofmann M, Wang A, Thiele S, Schwärzler J, Kleymann A, Gentzel M, Tilg H, Wielockx B, Hofbauer L, Rauner M, Göbel A, Rachner T. Dickkopf1 fuels inflammatory cytokine responses. Communications Biology 2022, 5: 1391. PMID: 36539532, PMCID: PMC9765382, DOI: 10.1038/s42003-022-04368-8.
• The matricellular protein SPARC induces inflammatory interferon-response in macrophages during agingRyu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A, Dixit VD. The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity 2022, 55: 1609-1626.e7. PMID: 35963236, PMCID: PMC9474643, DOI: 10.1016/j.immuni.2022.07.007.
• Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in miceRyu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. ELife 2021, 10: e66522. PMID: 34151773, PMCID: PMC8245129, DOI: 10.7554/elife.66522.
• 051 Non-steroidal anti-inflammatory drugs act as adjuvant in allergic sensitizationEisenstein A, Hilliard B, Wang A. 051 Non-steroidal anti-inflammatory drugs act as adjuvant in allergic sensitization. Journal Of Investigative Dermatology 2020, 140: s5. DOI: 10.1016/j.jid.2020.03.053.
• Origin and Function of Stress-Induced IL-6 in Murine ModelsQing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 2020, 182: 372-387.e14. PMID: 32610084, PMCID: PMC7384974, DOI: 10.1016/j.cell.2020.05.054.
• Less Pain, More Gain: Should Placebo Be a Clinical Therapeutic?Uchendu SN, Wang A. Less Pain, More Gain: Should Placebo Be a Clinical Therapeutic? Arthritis & Rheumatology 2020, 72: 511-514. PMID: 31729836, DOI: 10.1002/art.41168.
• GDF15 Is an Inflammation-Induced Central Mediator of Tissue ToleranceLuan HH, Wang A, Hilliard B, Carvalho F, Rosen CE, Ahasic A, Herzog E, Kang I, Pisani MA, Yu S, Zhang C, Ring A, Young L, Medzhitov R. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell 2019, 178: 1231-1244.e11. PMID: 31402172, PMCID: PMC6863354, DOI: 10.1016/j.cell.2019.07.033.
• Not the usual suspect: type I interferon–responsive T cells drive infection-induced cachexiaWang A, Medzhitov R. Not the usual suspect: type I interferon–responsive T cells drive infection-induced cachexia. Nature Immunology 2019, 20: 666-667. PMID: 31110313, DOI: 10.1038/s41590-019-0374-5.
• Counting Calories: The Cost of InflammationWang A, Medzhitov R. Counting Calories: The Cost of Inflammation. Cell 2019, 177: 223-224. PMID: 30951664, DOI: 10.1016/j.cell.2019.03.022.
• Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in miceWang A, Pope SD, Weinstein JS, Yu S, Zhang C, Booth CJ, Medzhitov R. Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 2200-2209. PMID: 30674681, PMCID: PMC6369774, DOI: 10.1073/pnas.1820704116.
• An evolutionary perspective on immunometabolismWang A, Luan HH, Medzhitov R. An evolutionary perspective on immunometabolism. Science 2019, 363 PMID: 30630899, PMCID: PMC6892590, DOI: 10.1126/science.aar3932.
• Glucose metabolism mediates disease tolerance in cerebral malariaWang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medzhitov R. Glucose metabolism mediates disease tolerance in cerebral malaria. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 11042-11047. PMID: 30291189, PMCID: PMC6205430, DOI: 10.1073/pnas.1806376115.
• Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral InflammationWang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell 2016, 166: 1512-1525.e12. PMID: 27610573, PMCID: PMC5555589, DOI: 10.1016/j.cell.2016.07.026.
• The expression of CXCR4/CXCL12 determines subsets of patients in systemic lupus erythematosusGuilpain P, Wang A, Chong B, Chouzenoux S, Guillevin L, Zhou X, Lin F, Fairhurst A, Boudreaux C, Roux C, Wakeland E, Davis L, Batteux F, Mohan C. The expression of CXCR4/CXCL12 determines subsets of patients in systemic lupus erythematosus. Journal Of Translational Medicine 2011, 9: p60. PMCID: PMC3242291, DOI: 10.1186/1479-5876-9-s2-p60.
• Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injuryLi L, Black R, Ma Z, Yang Q, Wang A, Lin F. Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. American Journal Of Physiology. Renal Physiology 2011, 302: f9-f19. PMID: 21937606, PMCID: PMC3251347, DOI: 10.1152/ajprenal.00377.2011.
• Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosusWang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst A, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis & Rheumatism 2010, 62: 3436-3446. PMID: 20722038, PMCID: PMC8972909, DOI: 10.1002/art.27685.
• CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of LupusWang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus. The Journal Of Immunology 2009, 182: 4448-4458. PMID: 19299746, PMCID: PMC2946082, DOI: 10.4049/jimmunol.0801920.
• Chapter 44 Genetic Susceptibility to Kidney Disease as a Consequence of Systemic AutoimmunityWang A, Mohan C, Wakeland E. Chapter 44 Genetic Susceptibility to Kidney Disease as a Consequence of Systemic Autoimmunity. 2009, 737-748. DOI: 10.1016/b978-0-12-449851-8.00044-9.
• Identification of the Yaa lupus gene as a Tlr-7 gene duplication eventWang A, Mohan C. Identification of the Yaa lupus gene as a Tlr-7 gene duplication event. International Journal Of Clinical Rheumatology 2006, 1: 563-565. DOI: 10.2217/17460816.1.5.563.