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INFORMATION FOR

Won Jae Huh, MD, PhD

Assistant Professor of Pathology

Contact Information

Won Jae Huh, MD, PhD

Lab Location

Office Location

Research Summary

My research focuses on cellular plasticity in pre-neoplastic lesions and mucosal injury of the stomach. My previous work showed that Notch signaling is downstream of epidermal growth factor receptor (EGFR) signaling in gastric premalignant condition Ménétrier’s disease (MD) and Notch signaling inhibition rescues biochemical and histological features of this disorder in a mouse model of MD. Preliminary data shows that parietal cells (acid secreting cells in stomach) can transdifferentiate into other cell types in MD and gastric mucosal injury mouse models. The goal of the laboratory is to investigate signaling networks that regulate cellular plasticity in pathologic conditions and normal homeostasis in the stomach. The results will form the basis for developing therapeutics.

An additional research direction is on the sexual difference of EGFR in liver. I have found that male mice express two- to three-fold higher EGFR protein in their livers compared to female mice. Notably, this sex difference in hepatic EGFR levels extends to humans. In mice, I have shown that EGFR levels in the liver are regulated by testosterone. My laboratory will investigate whether testosterone also regulates EGFR expression in human liver, the mechanism how testosterone regulates EGFR, and the effects of sex differential expression of hepatic EGFR on the male predominance of fatty liver disease and hepatocellular carcinoma (HCC).

Coauthors

Research Interests

Cell Differentiation; Liver; Metaplasia; Stem Cells; Stomach; Stomach Neoplasms; Cell Dedifferentiation; EGF Family of Proteins; Cell Plasticity

Selected Publications

  • Mo1343: TESTOSTERONE-DEPENDENT DIFFERENTIAL EXPRESSION OF EGFR IN MALE AND FEMALE LIVERS AND ITS IMPLICATIONS FOR CARCINOGENESISHuh W, Alexopoulos S, Coffey R. Mo1343: TESTOSTERONE-DEPENDENT DIFFERENTIAL EXPRESSION OF EGFR IN MALE AND FEMALE LIVERS AND ITS IMPLICATIONS FOR CARCINOGENESIS Gastroenterology 2022, 162: s-1225. DOI: 10.1016/s0016-5085(22)63622-9.
  • Sa1113: A SINGLE-CELL RESOLUTION, MULTI-OMIC SPATIAL ATLAS OF COLONIC TUMORIGENESIS DRIVEN BY C. DIFFICILE FROM HUMAN COLORECTAL CANCER-ASSOCIATED BIOFILMSMarkham N, Drewes J, Domingue J, Chen B, Heiser C, Bingham M, Simmons A, Ramirez M, Kotrannavar S, Lunnemann H, Laubacher E, Huh W, Shrubsole M, Liu Q, Coffey R, Sears C, Lau K. Sa1113: A SINGLE-CELL RESOLUTION, MULTI-OMIC SPATIAL ATLAS OF COLONIC TUMORIGENESIS DRIVEN BY C. DIFFICILE FROM HUMAN COLORECTAL CANCER-ASSOCIATED BIOFILMS Gastroenterology 2022, 162: s-310-s-311. DOI: 10.1016/s0016-5085(22)60740-6.
  • 665 HUMAN COLON CANCER-ASSOCIATED BIOFILMS ALTER HOST IMMUNE POPULATIONS AND PROMOTE TUMORIGENESISMarkham N, Drewes J, Domingue J, Chen B, Heiser C, Bingham M, Simmons A, Southard-Smith A, Macedonia M, Ramirez M, Laubacher E, Huh W, Shrubsole M, Liu Q, Coffey R, Sears C, Lau K. 665 HUMAN COLON CANCER-ASSOCIATED BIOFILMS ALTER HOST IMMUNE POPULATIONS AND PROMOTE TUMORIGENESIS Gastroenterology 2021, 160: s-128. DOI: 10.1016/s0016-5085(21)01059-3.
  • Abstract 1624: Lrig1 is an Egfr-dependent tumor suppressor in mouse duodenal and colonic neoplasiaCoffey R, Niitsu H, Lu Y, Huh W, Franklin J. Abstract 1624: Lrig1 is an Egfr-dependent tumor suppressor in mouse duodenal and colonic neoplasia Cancer Research 2020, 80: 1624-1624. DOI: 10.1158/1538-7445.am2020-1624.
  • Tu1204 BETTER UNDERSTANDING OF MENETRIER'S DISEASE ANDJUVENILE POLYPOSIS SYNDROME BY RNA SEQUENCINGRezanejad S, Ramirez M, Liu Q, Coffey R, Huh W. Tu1204 BETTER UNDERSTANDING OF MENETRIER'S DISEASE ANDJUVENILE POLYPOSIS SYNDROME BY RNA SEQUENCING Gastroenterology 2020, 158: s-1017-s-1018. DOI: 10.1016/s0016-5085(20)33215-7.
  • Tu1191 DISTRIBUTION OF DUODENAL TUFT CELLS IS ALTERED IN PEDIATRIC PATIENTS WITH ACUTE AND CHRONIC ENTEROPATHYHuh W, Roland J, Asai M, kaji I. Tu1191 DISTRIBUTION OF DUODENAL TUFT CELLS IS ALTERED IN PEDIATRIC PATIENTS WITH ACUTE AND CHRONIC ENTEROPATHY Gastroenterology 2020, 158: s-1013. DOI: 10.1016/s0016-5085(20)33202-9.
  • 2357 Drug-Induced Liver Injury (DILI) Does Not Always Follow the TextbookAjayi T, Dawodu E, Huh W, Scanga A, Izzy M. 2357 Drug-Induced Liver Injury (DILI) Does Not Always Follow the Textbook The American Journal Of Gastroenterology 2019, 114: s1312-s1313. DOI: 10.14309/01.ajg.0000598960.07963.76.
  • Sa1741 – Identification and Characterization of the First Neutralizing Antibody to Mouse EgfrHuh W, Niitsu H, McKinley E, Carney B, Houghton J, Coffey R. Sa1741 – Identification and Characterization of the First Neutralizing Antibody to Mouse Egfr Gastroenterology 2019, 156: s-383. DOI: 10.1016/s0016-5085(19)37808-4.
  • Sa1117 – Tnks2 Promotes Wnt/Β-Catenin Signaling Through Degredation of Nkd2 in Colon Cancer CellsMarkham N, Cao Z, Kasturi S, Fry W, Huh W, Coffey R. Sa1117 – Tnks2 Promotes Wnt/Β-Catenin Signaling Through Degredation of Nkd2 in Colon Cancer Cells Gastroenterology 2019, 156: s-275. DOI: 10.1016/s0016-5085(19)37500-6.
  • Abstract A34: EGF receptor-activated Notch signaling contributes to pathogenesis of premalignant gastric lesionsHuh W, Coffey R. Abstract A34: EGF receptor-activated Notch signaling contributes to pathogenesis of premalignant gastric lesions Cancer Research 2018, 78: a34-a34. DOI: 10.1158/1538-7445.mousemodels17-a34.
  • Su2036 - TNKS2 Promotes WNT/β-Catenin Signaling through Parylation of NKD2 in Colon Cancer CellsMarkham N, Fry W, Cao Z, Huh W, Coffey R. Su2036 - TNKS2 Promotes WNT/β-Catenin Signaling through Parylation of NKD2 in Colon Cancer Cells Gastroenterology 2018, 154: s-1365. DOI: 10.1016/s0016-5085(18)34460-3.
  • Sa1629 - Testosterone-Dependent Differential Expression of Egfr in Male and Female Mice and Its Implications for Carcinogenesis and Treatment ResponseHuh W, Rhoades K, Coffey R. Sa1629 - Testosterone-Dependent Differential Expression of Egfr in Male and Female Mice and Its Implications for Carcinogenesis and Treatment Response Gastroenterology 2018, 154: s-333-s-334. DOI: 10.1016/s0016-5085(18)31453-7.
  • 987 EGFR-Activated Notch Signaling Contributes to Pathogenesis of Ménétrier's DiseaseHuh W, Coffey R. 987 EGFR-Activated Notch Signaling Contributes to Pathogenesis of Ménétrier's Disease Gastroenterology 2017, 152: s187. DOI: 10.1016/s0016-5085(17)30936-8.
  • 804 Hepatic Zonation in a Nonalcoholic Steatohepatitis Mouse ModelHuh W, Albanese J, Salavaggione L, Liu Q, Neuschwander-Tetri B, Brunt E. 804 Hepatic Zonation in a Nonalcoholic Steatohepatitis Mouse Model Gastroenterology 2013, 144: s-963. DOI: 10.1016/s0016-5085(13)63578-7.
  • The presumptive gastric corpus stem cell population is CD44‐positive and expands during metaplasia via increased ERK‐MAPK signalingKhurana S, Huh W, Moore B, Riehl T, Stenson W, Mills J. The presumptive gastric corpus stem cell population is CD44‐positive and expands during metaplasia via increased ERK‐MAPK signaling The FASEB Journal 2012, 26: 1160.3-1160.3. DOI: 10.1096/fasebj.26.1_supplement.1160.3.
  • 863 XBP1 Is Required for the Maturation and the Maintenance of Digestive-Enzyme Secreting Zymogenic (Chief) CellsHuh W, Esen E, Bredemeyer A, Shi G, Lee A, Konieczny S, Glimcher L, Mills J. 863 XBP1 Is Required for the Maturation and the Maintenance of Digestive-Enzyme Secreting Zymogenic (Chief) Cells Gastroenterology 2009, 136: a-132. DOI: 10.1016/s0016-5085(09)60592-8.