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Francis Lee

MD, PhD, FAAOS, MBA

Wayne O. Southwick Professor of Orthopaedics and Rehabilitation; Professor, Biomedical Engineering; Professor, Graduate School of Arts and Sciences; with Tenure in Traditional Track; Professor in Department of Pathology, Secondary Appointment; Biological and Biomedical Science Program, YSM Postgraduate School; Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation

Research & Publications
Biography
News
Locations

Research Summary

Translational Musculoskeletal Research Programs (Tompkin 5 Orthopedic Translational Research Laboratory; Research Programs are supported by NIH and other research funding.)

Minimally Invasive Procedure for Metastatic Cancers to Bone; Ablation (Radiofreuqency, Microwave, Cryoablation); Percutaneous Cementoplasty; Spine, Pelvis, and Acetabular Fractures
Bone Inflammation: Biomaterials-Bone Interface Biology: Bio-implant related inflammation
Breast Cancer-Bone Interactions: Cancer-induced bone loss, Molecular imaging
Bone-Bacteria Interactions: Enhanced control of bone infection, Bone implant infection
Osteoclastogenesis; Novel regulators of osteoclastogenesis
Stem Cell, Tissue Engineering, Fracture Healing, and Tendon Regeneration
Fracture Healing
Bone Resorption
Orthopedic Translational Research
Sarcoma
Bone Metastasis
Orthobiologics
Orthopedics

Grants:

ERK Signaling in Inflammatory Bone Loss, NIH/NIAMS R01, PI: Francis Lee
Modification of Bone Grafts for Orthopaedic Procedures, NIH/NIAMS R01, PI: Francis Lee
Bone and Breast Cancer Molecular Interactions, NIH/NCI R01, PI: Francis Lee
Mechanobiological mechanism for inflammatory bone loss, NIH/NIBIB R01, PI: Francis Lee
Bio-Logical Modification of Structural Bone Allografts, Musculoskeletal Transplant Foundation, PI: Francis Lee
Inflammation in Rotator Cuff Tear and Repair, NIH/NIAMS K08, PI: David Kovacevic, Mentor: Francis Lee

Extensive Research Description

Clinical Research

Metastatic Cancers to Bone, Pathological Fractures, Minimally Invasive Reconstruction of Pathological Fractures, AORIF (Ablation - Osteoplasty - Reinforcement - Internal Fixation)

Translational Research

Tissue Engineering, Bone Regeneration, Fracture Healing (Diabetes, Chronic Smoking, Infection), Bone Inflammation, Bone Infection, Cancer-Induced Bone Loss

Please refer to NIH RePorter on Descriptions of NIH-funded Research Programs.

My research group is committed to engaging undergraduate students, Yale medical students for Thesis, M.D.-Ph.D. Students, other graduate students, and visiting fellows for research opportunities and career advancement. For inquires, please contact francis.lee@yale.edu. I am an Orthopaedic Surgeon in active clinical practice and a Scientist fostering research experience for future clinician scholars and clinically relevant translational research scientists. I focus on high impact orthopaedic research that is directly relevant to pathogenesis, diagnosis, and treatment of Orthopaedic disorders.

Coauthors

Research Interests

Bone and Bones; Bone Diseases, Infectious; Bone Marrow; Fracture Fixation; Musculoskeletal Diseases; Orthopedics; Osteoarthritis; Osteoblasts; Osteoclasts; Stem Cells; Oncology Service, Hospital; Tissue Engineering

Research Images

Minimally Invasive Pelvis Reconstruction for Osteolytic Metastases

Selected Publications

Emerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases.Ibe I, Dussik CM, Callan AK, Barr J, Lee FY. Emerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases. J Bone Joint Surg Am 2023 PMID: 36701566, DOI: 10.2106/JBJS.22.00694.
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2022 PMID: 36450109, DOI: 10.1165/rcmb.2022-0219oc.
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritisKwon H, Yu K, Cahill S, Alder K, Dussik C, Kim S, Sharma L, Back J, Oh I, Lee F. Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis EMBO Molecular Medicine 2022, 14: e15284. PMID: 36354099, PMCID: PMC9728052, DOI: 10.15252/emmm.202115284.
Enhancement of Impaired MRSA‐Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained InflammationYu KE, Kwon H, Dussik CM, Cahill SV, Back J, Alder KD, Lee FY. Enhancement of Impaired MRSA‐Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation Journal Of Bone And Mineral Research 2022, 37: 1352-1365. PMID: 35616626, DOI: 10.1002/jbmr.4570.
Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive InflammationKwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.
Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw?Morris MT, Alder KD, Moushey A, Munger AM, Milligan K, Toombs C, Conway D, Lee I, Chen F, Tommasini SM, Lee FY. Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw? Clinical Biomechanics 2022, 92: 105565. PMID: 34999389, DOI: 10.1016/j.clinbiomech.2021.105565.
Evolution of Surgical Management of Metastatic Disease of the Pelvis.Benevenia J, Guinand LA, Ippolito J, Neilson JC, Fabbri N, Lee FY, Yang R, Kurland AM. Evolution of Surgical Management of Metastatic Disease of the Pelvis. Instructional Course Lectures 2022, 71: 185-201. PMID: 35254782.
Ablation, Osteoplasty, Reinforcement, and Internal Fixation as a New Alternative First-Line Management for Osteolytic Pelvic Metastases.Lee FY. Ablation, Osteoplasty, Reinforcement, and Internal Fixation as a New Alternative First-Line Management for Osteolytic Pelvic Metastases. Instructional Course Lectures 2022, 71: 213-220. PMID: 35254784.
Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destructionBack J, Nguyen MN, Li L, Lee S, Lee I, Chen F, Gillinov L, Chung YH, Alder KD, Kwon HK, Yu KE, Dussik CM, Hao Z, Flores MJ, Kim Y, Ibe IK, Munger AM, Seo SW, Lee FY. Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction Bone Research 2021, 9: 43. PMID: 34588427, PMCID: PMC8481290, DOI: 10.1038/s41413-021-00158-w.
Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritisKwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis Science Advances 2021, 7: eabf2665. PMID: 34172438, PMCID: PMC8232912, DOI: 10.1126/sciadv.abf2665.
Biocompatibility of platinum-based bulk metallic glass in orthopedic applicationsLoye AM, Kwon HK, Dellal D, Ojeda R, Lee S, Davis R, Nagle N, Doukas PG, Schroers J, Lee FY, Kyriakides TR. Biocompatibility of platinum-based bulk metallic glass in orthopedic applications Biomedical Materials 2021, 16: 045018. PMID: 33873168, DOI: 10.1088/1748-605x/abf981.
Early success of the arthroscopic-assisted locked loop suprapectoral biceps tenodesisKahan J, Schneble C, Applonie R, Nicholson A, Whittall I, Talley-Bruns R, Jorgensen A, LaVette N, Moran J, Ware J, Lee F, Blaine T. Early success of the arthroscopic-assisted locked loop suprapectoral biceps tenodesis JSES Reviews Reports And Techniques 2021, 1: 96-101. DOI: 10.1016/j.xrrt.2021.02.003.
Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infectionCahill SV, Kwon H, Back J, Lee I, Lee S, Alder KD, Hao Z, Yu KE, Dussik CM, Kyriakides T, Lee F. Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection Journal Of Orthopaedic Research® 2021, 39: 402-414. PMID: 33336805, DOI: 10.1002/jor.24965.
Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases.Toombs C, Conway D, Munger AM, Alder KD, Latich I, Lee FY. Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases. Instructional Course Lectures 2021, 70: 503-514. PMID: 33438931.
Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine StrainsHao Z, Li J, Li B, Alder KD, Cahill SV, Munger AM, Lee I, Kwon H, Back J, Xu S, Kang M, Lee FY. Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains Journal Of Bone And Mineral Research 2020, 36: 186-198. PMID: 32866293, PMCID: PMC9057220, DOI: 10.1002/jbmr.4175.
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43: e498-e502. PMID: 32882054, DOI: 10.3928/01477447-20200827-05.
Intracellular Staphylococcus aureus in Bone and Joint Infections: A Mechanism of Disease Recurrence, Inflammation, and Bone and Cartilage DestructionAlder KD, Lee I, Munger AM, Kwon HK, Morris MT, Cahill SV, Back J, Yu KE, Lee FY. Intracellular Staphylococcus aureus in Bone and Joint Infections: A Mechanism of Disease Recurrence, Inflammation, and Bone and Cartilage Destruction Bone 2020, 141: 115568. PMID: 32745687, DOI: 10.1016/j.bone.2020.115568.
Avoiding Limb-Length Discrepancy with Reconstruction of a Massive Tibial Defect Using a Bone Allograft and a Minimally Invasive Lengthening System in a Pediatric Patient: A Case Report.Alder KD, Morris MT, Hao Z, Li L, Yu KE, Lee FY. Avoiding Limb-Length Discrepancy with Reconstruction of a Massive Tibial Defect Using a Bone Allograft and a Minimally Invasive Lengthening System in a Pediatric Patient: A Case Report. JBJS Case Connector 2020, 10: e0456. PMID: 32649132, DOI: 10.2106/jbjs.cc.19.00456.
Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes MellitusAlder KD, White AH, Chung Y, Lee I, Back J, Kwon H, Cahill SV, Hao Z, Li L, Chen F, Lee S, Riedel MD, Lee FY. Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus JBMR Plus 2020, 4: e10359. PMID: 32382692, PMCID: PMC7202418, DOI: 10.1002/jbm4.10359.
Stem cell-directed therapies for osteoarthritis: The promise and the practice.Ng J, Little CB, Woods S, Whittle S, Lee FY, Gronthos S, Mukherjee S, Hunter DJ, Worthley DL. Stem cell-directed therapies for osteoarthritis: The promise and the practice. Stem Cells (Dayton, Ohio) 2020, 38: 477-486. PMID: 31837053, DOI: 10.1002/stem.3139.
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing BonesLee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.
Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategiesYu K, Song L, Kang HP, Kwon HK, Back J, Lee FY. Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies Bone And Joint Research 2020, 9: 49-59. PMID: 32435455, PMCID: PMC7229311, DOI: 10.1302/2046-3758.92.bjr-2019-0131.r1.
Stem Cell Therapy for Osteoarthritis: the promise and the practiceJia Ng, Christopher B. Little, Susan Woods, Samuel Whittle, Francis Y. Lee, Siddhartha Mukherjee, David J. Hunter, Daniel L Worthley. Stem Cells (Accepted)
Re-appraising the potential of naringin for natural, novel orthopedic biotherapiesYu KE, Alder KD, Morris MT, Munger AM, Lee I, Cahill SV, Kwon HK, Back J, Lee FY. Re-appraising the potential of naringin for natural, novel orthopedic biotherapies Therapeutic Advances In Musculoskeletal Disease 2020, 12: 1759720x20966135. PMID: 33343723, PMCID: PMC7727086, DOI: 10.1177/1759720x20966135.
Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report.Cahill SV, Yu KE, Dussik CM, Lee FY. Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report. JBJS Case Connector 2019, 9: e0404. PMID: 31703012, DOI: 10.2106/jbjs.cc.18.00404.
Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus.Henderson S, Ibe I, Cahill S, Chung YH, Lee FY. Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus. Journal Of Bone And Joint Surgery 2019, 101: 1399-1410. PMID: 31393433, DOI: 10.2106/jbjs.18.01297.
Excisional Curettage of Benign Cystic Lesions.Ibe IK, Alder KD, Henderson SE, Yu KE, Lee FY. Excisional Curettage of Benign Cystic Lesions. JBJS Essential Surgical Techniques 2019, 9: e24. PMID: 32021719, PMCID: PMC6948994, DOI: 10.2106/jbjs.st.18.00036.
Excisional Curettage of Benign Cystic Lesions.Ibe IK, Alder KD, Henderson SE, Yu KE, Lee FY. Excisional Curettage of Benign Cystic Lesions. JBJS Essential Surgical Techniques 2019, 9: e24. PMID: 32021718, PMCID: PMC6948984, DOI: 10.2106/JBJS.ST.18.00036.
A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in miceKwon HK, Patra MC, Shin HJ, Gui X, Achek A, Panneerselvam S, Kim DJ, Song SJ, Hong R, Kim KS, Kim YG, Lee FY, Hahm DH, Lee SH, Choi S. A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice Experimental & Molecular Medicine 2019, 51: 1-19. PMID: 31028244, PMCID: PMC6486608, DOI: 10.1038/s12276-019-0244-0.
Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of BoneGreenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.
Defining preoperative imaging findings of sacral chordomas associated with decreased overall survival and local recurrenceMunger AM, Geddes BJ, Lee FY. Defining preoperative imaging findings of sacral chordomas associated with decreased overall survival and local recurrence Journal Of Spine Surgery 2019, 5: 171-173. PMID: 31032452, PMCID: PMC6465459, DOI: 10.21037/jss.2019.03.04.
Excisional Curettage of Benign Cystic LesionsJournal of Bone Joint Surg Am. Essential Surgical Techniques: July-September 2019 - Volume 9 - Issue 3 - p e24 doi: 10.2106/JBJS.ST.18.00036
Rotation Tibio-Pelvic Arthroplasty for a recalcitrant infectionSean Cahill, Kristin Yu, Christopher Dusik, Francis Y. Lee. Journal of Bone and Joint Surgery. Case Connector, 2019
Section 8 – Orthopaedic Oncology. Section Editor: Francis Y. Lee, M.D., Ph.D.* Chapter 41: Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss. Izuchuku Ibe,,, Francis Y. Lee, M.D., Ph.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
Chapter 42: Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss. Izuchuku Ibe,,, Francis Y. Lee, M.D., Ph.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
Chapter 47: Femoral and Tibial Reconstruction for Skeletal Metastases and Pathological Fractures. Izuchuku Ibe,,, Francis Y. Lee, M.D., Ph.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
Chapter 48: Bone Tumors and Reconstructive Options in Pediatric and Young Adult Patients. Izuchuku Ibe M.D., , Francis Y. Lee, M.D., Ph.D., Dieter Lindskog, M.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss.Henderson SE, Dussik C, Brand J, Ibe IK, Lee FY. Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss. Instructional Course Lectures 2019, 68: 557-566. PMID: 32032067.
Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss.Ibe IK, Sahlstrom A, White A, Henderson SE, Lee FY. Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss. Instructional Course Lectures 2019, 68: 547-556. PMID: 32032068.
Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures.Henderson SE, Yu K, Alder KD, Ibe IK, Lee FY, Lindskog DM. Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures. Instructional Course Lectures 2019, 68: 607-612. PMID: 32032089.
Molecular Targeted Therapy Approach to Musculoskeletal TumorsIbe I, Haynes M, Koo A, Lindskog D, Friedlaender GE, Lee FY. Molecular Targeted Therapy Approach to Musculoskeletal Tumors Techniques In Orthopaedics 2018, 33: 135-139. PMID: 36186916, PMCID: PMC9524233, DOI: 10.1097/bto.0000000000000298.
Immuno-oncologic Approach to Musculoskeletal TumorsIbe I, Sahlstrom A, Nguyen M, Lindskog D, Friedlaender G, Lee F. Immuno-oncologic Approach to Musculoskeletal Tumors Techniques In Orthopaedics 2018, 33: 140-147. DOI: 10.1097/bto.0000000000000305.
Targeted Therapies in Sarcomas6. Ibe, Izuchukwu; Haynes, Monique; Koo, Andrew; Lindskog, Dieter; Friedlaender, Gary E.; Lee, Francis Y. Techniques in Orthopaedics, 33(3):135-139, September, 2019.
Immunooncology in SarcomaIbe, Izuchukwu; Sahlstrom, Adam; Nguyen, Minh N.; Lindskog, Dieter; Friedlaender, Gary E.; Lee, Francis Y. Techniques in Orthopaedics, 33(3):140-147, September, 2019.
Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic miceMirza F, Lorenzo J, Drissi H, Lee FY, Soung DY. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice The Journal Of Nutritional Biochemistry 2017, 52: 54-61. PMID: 29149648, DOI: 10.1016/j.jnutbio.2017.10.002.
Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signalingTarafder S, Chen E, Jun Y, Kao K, Sim KH, Back J, Lee FY, Lee CH. Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling The FASEB Journal 2017, 31: 3991-3998. PMID: 28533328, PMCID: PMC5572690, DOI: 10.1096/fj.201700071r.
Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factorStamer D, Nizami S, Lee F, Do Y. Soung. Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor Journal Of Functional Foods 2017, 35: 458-465. DOI: 10.1016/j.jff.2017.06.018.
Calreticulin inhibits inflammation‐induced osteoclastogenesis and bone resorptionFischer CR, Mikami M, Minematsu H, Nizami S, Goo Lee H, Stamer D, Patel N, Yu Soung D, Back JH, Song L, Drissi H, Lee FY. Calreticulin inhibits inflammation‐induced osteoclastogenesis and bone resorption Journal Of Orthopaedic Research® 2017, 35: 2658-2666. PMID: 28460421, PMCID: PMC8996436, DOI: 10.1002/jor.23587.
Additive manufacturing of hydrogel-based materials for next-generation implantable medical devicesYin Chin S, Cheung Poh Y, Kohler AC, Compton JT, Hsu LL, Lau KM, Kim S, Lee BW, Lee FY, Sia SK. Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices Science Robotics 2017, 2 PMID: 31289767, PMCID: PMC6615760, DOI: 10.1126/scirobotics.aah6451.
Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices.Sau Yin Chin, Yukkee Cheung Poh, Anne-Céline Kohler, Jocelyn T. Compton, Lauren L. Hsu, Kathryn M. Lau, Sohyun Kim, Benjamin W. Lee, Francis Y. Lee, Samuel K. Science Robotics. 04 Jan 2017: Vol. 2, Issue 2, eaah645.
Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor.Journal of Functional Foods, Volume 35: 458-465, 2017
Tissue engineering advances in spine surgeryMakhni MC, Caldwell JM, Saifi C, Fischer CR, Lehman RA, Lenke LG, Lee FY. Tissue engineering advances in spine surgery Regenerative Medicine 2016, 11: 211-222. PMID: 26877156, DOI: 10.2217/rme.16.3.
Please see NIH Format Biosketches (Selected out of 110 Publications)JBJS, JCI, Cell, JOR, and others
Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic ResponseTascau L, Gardner T, Anan H, Yongpravat C, Cardozo CP, Bauman WA, Lee FY, Oh DS, Tawfeek HA. Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response Endocrinology 2015, 157: 112-126. PMID: 26488807, DOI: 10.1210/en.2015-1614.
Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bonesVorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones Clinical Biomechanics 2015, 30: 1114-1118. PMID: 26386637, PMCID: PMC9004608, DOI: 10.1016/j.clinbiomech.2015.08.016.
CA‐074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c‐FOS signaling pathwaysPatel N, Nizami S, Song L, Mikami M, Hsu A, Hickernell T, Chandhanayingyong C, Rho S, Compton JT, Caldwell J, Kaiser PB, Bai H, Lee HG, Fischer CR, Lee FY. CA‐074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c‐FOS signaling pathways Journal Of Orthopaedic Research® 2015, 33: 1474-1486. PMID: 25428830, DOI: 10.1002/jor.22795.
Harnessing endogenous stem/progenitor cells for tendon regenerationLee CH, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ. Harnessing endogenous stem/progenitor cells for tendon regeneration Journal Of Clinical Investigation 2015, 125: 2690-2701. PMID: 26053662, PMCID: PMC4563693, DOI: 10.1172/jci81589.
3D printing for regenerative medicine: From bench to bedsideLi J, He L, Zhou C, Zhou Y, Bai Y, Lee F, Mao J. 3D printing for regenerative medicine: From bench to bedside MRS Bulletin 2015, 40: 145-154. DOI: 10.1557/mrs.2015.5.
3D printing for regenerative medicine: From bench to bedside.Juan Li, Ling He, Chen Zhou, Yue Zhou, Hanying Bai, Francis Y. Lee, Jeremy Mao. Materials Research Society Bulletin, 2015 Feb, Vol. 40: 145-154.
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal PotentialWorthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential Cell 2015, 160: 269-284. PMID: 25594183, PMCID: PMC4436082, DOI: 10.1016/j.cell.2014.11.042.
A Review of Osteocyte Function and the Emerging Importance of SclerostinCompton JT, Lee FY. A Review of Osteocyte Function and the Emerging Importance of Sclerostin Journal Of Bone And Joint Surgery 2014, 96: 1659-1668. PMID: 25274791, PMCID: PMC4179450, DOI: 10.2106/jbjs.m.01096.
Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisitionLee JH, Kim HK, Chandhanayingyong C, Lee FY, Hielscher AH. Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition Biomedical Optics Express 2014, 5: 2301-16. PMID: 25071965, PMCID: PMC4102365, DOI: 10.1364/boe.5.002301.
Effects of biomechanical forces on signaling in the cortical collecting duct (CCD)Carrisoza-Gaytan R, Liu Y, Flores D, Else C, Lee HG, Rhodes G, Sandoval RM, Kleyman TR, Lee FY, Molitoris B, Satlin LM, Rohatgi R. Effects of biomechanical forces on signaling in the cortical collecting duct (CCD) American Journal Of Physiology. Renal Physiology 2014, 307: f195-f204. PMID: 24872319, PMCID: PMC4152160, DOI: 10.1152/ajprenal.00634.2013.
Tumor-Induced Osteomalacia Secondary to a Fibroblast Growth Factor 23-Secreting Phosphaturic Mesenchymal Tumor in the FootKim Y, Stein E, Remotti F, Lee FY. Tumor-Induced Osteomalacia Secondary to a Fibroblast Growth Factor 23-Secreting Phosphaturic Mesenchymal Tumor in the Foot JBJS Case Connector 2014, 4: e22. PMID: 29252581, DOI: 10.2106/jbjs.cc.l.00202.
Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cellsKim KO, Hsu AC, Lee HG, Patel N, Chandhanayingyong C, Hickernell T, Lee F. Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells Journal Of Orthopaedic Research® 2014, 32: 848-854. PMID: 24536031, DOI: 10.1002/jor.22598.
Systemic Therapy in Patients with Resectable and Unresectable Cases of Giant Cell Tumor: A Systematic ReviewKaiser P, Compton J, Caldwell J, Hickernell T, Lee F. Systemic Therapy in Patients with Resectable and Unresectable Cases of Giant Cell Tumor: A Systematic Review Journal Of Cancer Therapy 2014, 2014: 339-353. DOI: 10.4236/jct.2014.54041.
Bone marrow absorption and retention properties of engineered scaffolds with micro-channels and nano-pores for tissue engineering: A proof of conceptOh D, Kim Y, Ganbat D, Han M, Lim P, Back J, Lee F, Tawfeek H. Bone marrow absorption and retention properties of engineered scaffolds with micro-channels and nano-pores for tissue engineering: A proof of concept Ceramics International 2013, 39: 8401-8410. DOI: 10.1016/j.ceramint.2013.04.021.
Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental studyAmorosa L, Lee C, Aydemir, Nizami S, Hsu A, Patel N, Gardner T, Navalgund A, Kim DG, Park S, Mao J, Lee F. Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study International Journal Of Nanomedicine 2013, Volume 8: 1637-1643. PMID: 23637532, PMCID: PMC3639117, DOI: 10.2147/ijn.s42855.
Biomechanical forces differentially regulate signaling in the cortical collecting duct (CCD)Carrisoza R, Else C, Flores D, Lee H, Lee F, Rohatgi R, Satlin L. Biomechanical forces differentially regulate signaling in the cortical collecting duct (CCD) The FASEB Journal 2013, 27: 1148.10-1148.10. DOI: 10.1096/fasebj.27.1_supplement.1148.10.
Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cellsLee HG, Hsu A, Goto H, Nizami S, Lee JH, Cadet ER, Tang P, Shaji R, Chandhanayinyong C, Kweon SH, Oh DS, Tawfeek H, Lee FY. Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cells American Journal Of Physiology - Cell Physiology 2012, 304: c431-c439. PMID: 23255578, PMCID: PMC3602649, DOI: 10.1152/ajpcell.00202.2012.
Efficient differentiation of human iPSC‐derived mesenchymal stem cells to chondroprogenitor cellsGuzzo RM, Gibson J, Xu R, Lee FY, Drissi H. Efficient differentiation of human iPSC‐derived mesenchymal stem cells to chondroprogenitor cells Journal Of Cellular Biochemistry 2012, 114: 480-490. PMID: 22961870, DOI: 10.1002/jcb.24388.
Atrial Myxoma with Disseminated Osteolytic Embolic Lesions: A Case Report.Chandhanayingyong C, Thompson SA, Remotti F, Young-In Lee F. Atrial Myxoma with Disseminated Osteolytic Embolic Lesions: A Case Report. JBJS Case Connector 2012, 2: e36. PMID: 29252534, DOI: 10.2106/JBJS.CC.L.00012.
Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal TumorKim Y, Nizami S, Goto H, Lee FY. Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor Clinics In Orthopedic Surgery 2012, 4: 107-116. PMID: 22662295, PMCID: PMC3360182, DOI: 10.4055/cios.2012.4.2.107.
Osteoid osteoma is an osteocalcinoma affecting glucose metabolism.Confavreux CB, Borel O, Lee F, Vaz G, Guyard M, Fadat C, Carlier MC, Chapurlat R, Karsenty G. Osteoid osteoma is an osteocalcinoma affecting glucose metabolism. Osteoporosis International : A Journal Established As Result Of Cooperation Between The European Foundation For Osteoporosis And The National Osteoporosis Foundation Of The USA 2012, 23: 1645-50. PMID: 21681611, DOI: 10.1007/s00198-011-1684-0.
MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future DirectionsChandhanayingyong C, Kim Y, Staples JR, Hahn C, Lee FY. MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions Sarcoma 2012, 2012: 404810. PMID: 22577336, PMCID: PMC3345255, DOI: 10.1155/2012/404810.
New application of optical agent to image angiogenesis in hindlimb ischemiaTekabe Y, Klose A, Nizami S, Luma J, Lee FY, Johnson L. New application of optical agent to image angiogenesis in hindlimb ischemia Journal Of Biophotonics 2011, 4: 859-865. PMID: 22031282, DOI: 10.1002/jbio.201100038.
Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cellsLee HG, Minematsu H, Kim KO, Aydemir A, Shin MJ, Nizami SA, Chung KJ, Hsu AC, Jacobs CR, Lee FY. Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells Biomaterials 2011, 32: 9197-9206. PMID: 21899882, PMCID: PMC3193180, DOI: 10.1016/j.biomaterials.2011.08.059.
Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophagesMinematsu H, Shin MJ, Aydemir A, Kim KO, Nizami SA, Chung GJ, Lee FY. Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages Cellular Signalling 2011, 23: 1785-1793. PMID: 21726630, PMCID: PMC3169434, DOI: 10.1016/j.cellsig.2011.06.013.
Interleukin‐1β stimulates stromal‐derived factor‐1α expression in human subacromial bursaBlaine TA, Cote MA, Proto A, Mulcahey M, Lee FY, Bigliani LU. Interleukin‐1β stimulates stromal‐derived factor‐1α expression in human subacromial bursa Journal Of Orthopaedic Research® 2011, 29: 1695-1699. PMID: 21484857, DOI: 10.1002/jor.21416.
Targeting Inflammatory Kinase as an Adjuvant Treatment for OsteosarcomasNoh K, Kim KO, Patel NR, Staples JR, Minematsu H, Nair K, Lee FY. Targeting Inflammatory Kinase as an Adjuvant Treatment for Osteosarcomas Journal Of Bone And Joint Surgery 2011, 93: 723-732. PMID: 21508279, PMCID: PMC6882535, DOI: 10.2106/jbjs.j.00302.
Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot StudySon J, Kim JM, Han M, Choi S, Lee F, Oh D. Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot Study Journal Of Long-Term Effects Of Medical Implants 2011, 21: 159-167. PMID: 22043974, DOI: 10.1615/jlongtermeffmedimplants.v21.i2.60.
Surmounting Chemotherapy and Radioresistance in Chondrosarcoma: Molecular Mechanisms and Therapeutic TargetsOnishi AC, Hincker AM, Lee FY. Surmounting Chemotherapy and Radioresistance in Chondrosarcoma: Molecular Mechanisms and Therapeutic Targets Sarcoma 2010, 2011: 381564. PMID: 21234363, PMCID: PMC3018623, DOI: 10.1155/2011/381564.
Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysisSeo SW, Lee D, Minematsu H, Kim AD, Shin M, Cho SK, Kim DW, Yang J, Lee FY. Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis Bone 2009, 46: 695-702. PMID: 19895919, PMCID: PMC2823832, DOI: 10.1016/j.bone.2009.10.032.
Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cellsAydemir A, Minematsu H, Gardner TR, Kim KO, Ahn JM, Lee FY. Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells Bone 2009, 46: 167-175. PMID: 19748606, PMCID: PMC2818272, DOI: 10.1016/j.bone.2009.08.061.
Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat modelCadet ER, Vorys GC, Rahman R, Park S, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model Journal Of Orthopaedic Research® 2009, 28: 308-314. PMID: 19743506, DOI: 10.1002/jor.20972.
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cellsKim DW, Kim KO, Shin MJ, Ha JH, Seo SW, Yang J, Lee FY. siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells Molecular Cancer 2009, 8: 28. PMID: 19445670, PMCID: PMC2689171, DOI: 10.1186/1476-4598-8-28.
Zoledronate reduces unwanted bone resorption in intercalary bone allograftsSeo SW, Cho SK, Storer SK, Lee FY. Zoledronate reduces unwanted bone resorption in intercalary bone allografts International Orthopaedics 2009, 34: 599-603. PMID: 19343345, PMCID: PMC2903128, DOI: 10.1007/s00264-009-0748-7.
Enhancement of Periprosthetic Bone Quality with Topical Hydroxyapatite-Bisphosphonate CompositeSuratwala SJ, Cho SK, van Raalte JJ, Park SH, Seo SW, Chang SS, Gardner TR, Lee FY. Enhancement of Periprosthetic Bone Quality with Topical Hydroxyapatite-Bisphosphonate Composite Journal Of Bone And Joint Surgery 2008, 90: 2189-2196. PMID: 18829917, PMCID: PMC2657477, DOI: 10.2106/jbjs.g.00409.
What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?Tuan RS, Lee FY, T Konttinen Y, Wilkinson JM, Smith RL. What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? Journal Of The American Academy Of Orthopaedic Surgeons 2008, 16 Suppl 1: s42-8. PMID: 18612013, PMCID: PMC2714366, DOI: 10.5435/00124635-200800001-00010.
Orthopedic Implant Particle‐Induced Tumor Necrosis Factor‐α Production in Macrophage–Monocyte Lineage Cells Is Mediated by Nuclear Factor of Activated T CellsMINEMATSU H, SHIN MJ, AYDEMIR A, SEO SW, KIM DW, BLAINE TA, MACIÁN F, YANG J, LEE F. Orthopedic Implant Particle‐Induced Tumor Necrosis Factor‐α Production in Macrophage–Monocyte Lineage Cells Is Mediated by Nuclear Factor of Activated T Cells Annals Of The New York Academy Of Sciences 2007, 1117: 143-150. PMID: 18056040, DOI: 10.1196/annals.1402.026.
ERK Signaling Regulates Macrophage Colony‐Stimulating Factor Expression Induced by Titanium Particles in MC3T3.E1 Murine Calvarial Preosteoblastic CellsSEO SW, LEE D, CHO SK, KIM AD, MINEMATSU H, AYDEMIR A, GELLER JA, MACAULAY W, YANG J, LEE F. ERK Signaling Regulates Macrophage Colony‐Stimulating Factor Expression Induced by Titanium Particles in MC3T3.E1 Murine Calvarial Preosteoblastic Cells Annals Of The New York Academy Of Sciences 2007, 1117: 151-158. PMID: 18056041, DOI: 10.1196/annals.1402.027.
Nuclear Factor of Activated T Cell Mediates Proinflammatory Gene Expression in Response to MechanotransductionAYDEMIR A, LEE S, KIM D, GARDNER TR, PRINCE D, AHN J, LEE F. Nuclear Factor of Activated T Cell Mediates Proinflammatory Gene Expression in Response to Mechanotransduction Annals Of The New York Academy Of Sciences 2007, 1117: 138-142. PMID: 17584983, DOI: 10.1196/annals.1402.004.
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cellsKim DW, Seo SW, Cho SK, Chang SS, Lee HW, Lee E, Block JA, Hei TK, Lee FY. Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells Journal Of Orthopaedic Research® 2007, 25: 820-828. PMID: 17343283, DOI: 10.1002/jor.20377.
Coronal and Sagittal Plane Correction in Adolescent Idiopathic ScoliosisLowenstein JE, Matsumoto H, Vitale MG, Weidenbaum M, Gomez JA, Lee FY, Hyman JE, Roye DP. Coronal and Sagittal Plane Correction in Adolescent Idiopathic Scoliosis Spine 2007, 32: 448-452. PMID: 17304136, DOI: 10.1097/01.brs.0000255030.78293.fd.
Pour avoir le bras long…Lee F, Schoeb J, Yu J, Christiansen B, Dick H. Pour avoir le bras long… Revue De Chirurgie Orthopédique Et Traumatologique 2006, 92: 732. DOI: 10.1016/s0035-1040(06)77671-1.
Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agentsKim Y, Bigliani LU, Fujisawa M, Murakami K, Chang S, Lee H, Lee FY, Blaine TA. Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents Journal Of Orthopaedic Research® 2006, 24: 1756-1764. PMID: 16779827, DOI: 10.1002/jor.20197.
Mechanical Loading Differentially Regulates Membrane‐Bound and Soluble RANKL Availability in MC3T3‐E1 CellsKIM DW, LEE H, KARMIN JA, LEE E, CHANG S, TOLCHIN B, LIN S, CHO SK, KWON A, AHN JM, LEE F. Mechanical Loading Differentially Regulates Membrane‐Bound and Soluble RANKL Availability in MC3T3‐E1 Cells Annals Of The New York Academy Of Sciences 2006, 1068: 568-572. PMID: 16831954, DOI: 10.1196/annals.1346.054.
Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7). A report of five cases.Lee FY, Sinicropi SM, Lee FS, Vitale MG, Roye DP, Choi IH. Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7). A report of five cases. Journal Of Bone And Joint Surgery 2006, 88: 627-33. PMID: 16510831, DOI: 10.2106/00004623-200603000-00023.
Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7)Lee F, Sinicropi S, Lee F, Vitale M, Roye D, Choi I. Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7) Journal Of Bone And Joint Surgery 2006, 88: 627-633. DOI: 10.2106/jbjs.d.02201.
The effect of limb length discrepancy on health-related quality of life: is the ‘2 cm rule’ appropriate?Vitale MA, Choe JC, Sesko AM, Hyman JE, Lee FY, Roye DP, Vitale MG. The effect of limb length discrepancy on health-related quality of life: is the ‘2 cm rule’ appropriate? Journal Of Pediatric Orthopaedics B 2006, 15: 1-5. PMID: 16280711, DOI: 10.1097/01202412-200601000-00001.
Assessment of Health Status in Patients With Cerebral PalsyVitale MG, Roye EA, Choe JC, Hyman JE, Lee FY, Roye DP. Assessment of Health Status in Patients With Cerebral Palsy Journal Of Pediatric Orthopaedics 2005, 25: 792-797. PMID: 16294138, DOI: 10.1097/01.bpo.0000164870.26632.6b.
Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa with a review of its pathogenesis.Yoon AJ, Parisien M, Feldman F, Young-In Lee F. Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa with a review of its pathogenesis. Skeletal Radiology 2005, 34: 653-7. PMID: 16096753, DOI: 10.1007/s00256-005-0953-4.
Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC)Yu J, Chang S, Suratwala S, Chung W, Abdelmessieh P, Lee H, Yang J, Lee F. Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC) Journal Of Orthopaedic Research® 2005, 23: 1004-1012. PMID: 15921873, DOI: 10.1016/j.orthres.2005.02.012.
Operative Lengthening of the HumerusLee FY, Schoeb JS, Yu J, Christiansen BD, Dick HM. Operative Lengthening of the Humerus Journal Of Pediatric Orthopaedics 2005, 25: 613-616. PMID: 16199941, DOI: 10.1097/01.bpo.0000164868.97060.bb.
Correction of Adolescent Idiopathic Scoliosis Using Thoracic Pedicle Screw Fixation Versus Hook ConstructsStorer SK, Vitale MG, Hyman JE, Lee FY, Choe JC, Roye DP. Correction of Adolescent Idiopathic Scoliosis Using Thoracic Pedicle Screw Fixation Versus Hook Constructs Journal Of Pediatric Orthopaedics 2005, 25: 415-419. PMID: 15958886, DOI: 10.1097/01.mph.0000165134.38120.87.
Patient-Based Outcomes Following Clubfoot SurgeryVitale MG, Choe JC, Vitale MA, Lee FY, Hyman JE, Roye DP. Patient-Based Outcomes Following Clubfoot Surgery Journal Of Pediatric Orthopaedics 2005, 25: 533-538. PMID: 15958910, DOI: 10.1097/01.bpo.0000157999.38424.ba.
9:43210. Correction of adolescent idiopathic scoliosis using thoracic pedicle screw fixation vs. traditional hook constructs: a single surgeon retrospective reviewStorer S, Choe J, Hyman J, Lee F, Vitale M, Roye D. 9:43210. Correction of adolescent idiopathic scoliosis using thoracic pedicle screw fixation vs. traditional hook constructs: a single surgeon retrospective review The Spine Journal 2005, 5: s108-s109. DOI: 10.1016/j.spinee.2005.05.213.
μ-Calpain Regulates Receptor Activator of NF-κB Ligand (RANKL)-supported Osteoclastogenesis via NF-κB Activation in RAW 264.7 Cells*Lee FY, Kim DW, Karmin JA, Hong D, Chang SS, Fujisawa M, Takayanagi H, Bigliani LU, Blaine TA, Lee HJ. μ-Calpain Regulates Receptor Activator of NF-κB Ligand (RANKL)-supported Osteoclastogenesis via NF-κB Activation in RAW 264.7 Cells* Journal Of Biological Chemistry 2005, 280: 29929-29936. PMID: 15955824, DOI: 10.1074/jbc.m414600200.
Recruitment of osteoclast precursors by stromal cell derived factor‐1 (SDF‐1) in giant cell tumor of boneLiao TS, Yurgelun MB, Chang S, Zhang H, Murakami K, Blaine TA, Parisian M, Kim W, Winchester RJ, Lee F. Recruitment of osteoclast precursors by stromal cell derived factor‐1 (SDF‐1) in giant cell tumor of bone Journal Of Orthopaedic Research® 2005, 23: 203-209. PMID: 15607894, DOI: 10.1016/j.orthres.2004.06.018.
The molecular pathophysiology of subacromial bursitis in rotator cuff diseaseBlaine TA, Kim YS, Voloshin I, Chen D, Murakami K, Chang SS, Winchester R, Lee FY, O’Keefe R, Bigliani LU. The molecular pathophysiology of subacromial bursitis in rotator cuff disease Journal Of Shoulder And Elbow Surgery 2005, 14: s84-s89. PMID: 15726092, DOI: 10.1016/j.jse.2004.09.022.
Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone.Lee FY, Yu J, Chang SS, Fawwaz R, Parisien MV. Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone. Journal Of Bone And Joint Surgery 2004, 86: 2677-85. PMID: 15590853, DOI: 10.2106/00004623-200412000-00014.
Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP).Delloye C, Suratwala SJ, Cornu O, Lee FY. Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP). Acta Orthopaedica Belgica 2004, 70: 591-7. PMID: 15669462.
Bisphosphonates May Reduce Recurrence in Giant Cell Tumor by Inducing ApoptosisChang SS, Suratwala SJ, Jung KM, Doppelt JD, Zhang HZ, Blaine TA, Kim TW, Winchester RJ, Lee FY. Bisphosphonates May Reduce Recurrence in Giant Cell Tumor by Inducing Apoptosis Clinical Orthopaedics And Related Research® 2004, 426: 103-109. PMID: 15346059, DOI: 10.1097/01.blo.0000141372.54456.80.
Synovial Chondromatosis of the FootLee F, Hornicek FJ, Dick HM, Mankin HJ. Synovial Chondromatosis of the Foot Clinical Orthopaedics And Related Research® 2004, 423: 186-190. PMID: 15232447, DOI: 10.1097/01.blo.0000127133.89704.86.
Effect of bracing on the quality of life of adolescents with idiopathic scoliosisUgwonali OF, Lomas G, Choe JC, Hyman JE, Lee FY, Vitale MG, Roye DP. Effect of bracing on the quality of life of adolescents with idiopathic scoliosis The Spine Journal 2004, 4: 254-260. PMID: 15125845, DOI: 10.1016/j.spinee.2003.12.001.
Microarray analysis of gene expression in the subacromial bursa in patients with rotator cuff disease (SS-74)Blaine T, Kim Y, Chen D, Patel M, Nadell C, Sil C, Murakami K, Ilya V, Lee F, Bigliani L. Microarray analysis of gene expression in the subacromial bursa in patients with rotator cuff disease (SS-74) Arthroscopy The Journal Of Arthroscopic And Related Surgery 2004, 20: e34-e35. DOI: 10.1016/j.arthro.2004.02.067.
Orthopaedic manifestations of Brachmann-de Lange syndrome: a report of 34 patients.Roposch A, Bhaskar AR, Lee F, Adedapo S, Mousny M, Alman BA. Orthopaedic manifestations of Brachmann-de Lange syndrome: a report of 34 patients. Journal Of Pediatric Orthopedics. Part B 2004, 13: 118-22. PMID: 15076591, DOI: 10.1097/00009957-200403000-00011.
In Situ Pinning of Hip for Stable Slipped Capital Femoral Epiphysis on a Radiolucent Operating TableLee FY, Chapman CB. In Situ Pinning of Hip for Stable Slipped Capital Femoral Epiphysis on a Radiolucent Operating Table Journal Of Pediatric Orthopaedics 2003, 23: 27. PMID: 12499938, DOI: 10.1097/01241398-200301000-00005.
Use of ketorolac tromethamine in children undergoing scoliosis surgery an analysis of complicationsVitale MG, Choe JC, Hwang MW, Bauer RM, Hyman JE, Lee FY, Roye DP. Use of ketorolac tromethamine in children undergoing scoliosis surgery an analysis of complications The Spine Journal 2003, 3: 55-62. PMID: 14589246, DOI: 10.1016/s1529-9430(02)00446-1.
In Situ Pinning of Hip for Stable Slipped Capital Femoral Epiphysis on a Radiolucent Operating TableLee F, Chapman C. In Situ Pinning of Hip for Stable Slipped Capital Femoral Epiphysis on a Radiolucent Operating Table Journal Of Pediatric Orthopaedics 2003, 23: 27-29. DOI: 10.1097/00004694-200301000-00005.
Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2Lee FY, Storer S, Hazan EJ, Gebhardt MC, Mankin HJ. Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2 Clinical Orthopaedics And Related Research® 2002, 397: 119-126. PMID: 11953604, DOI: 10.1097/00003086-200204000-00017.
Novel translocation (9;12)(q22;q24) in secondardy chondrosarcoma arising from hereditary multiple exostosisLee FY, Zawadsky M, Parisien M, Ho M, Murty VV, Jayaraman T, Dick HM. Novel translocation (9;12)(q22;q24) in secondardy chondrosarcoma arising from hereditary multiple exostosis Cancer Genetics 2002, 132: 68-70. PMID: 11801313, DOI: 10.1016/s0165-4608(01)00524-6.
Magnetic resonance imaging depiction of tight iliotibial band in melorheostosis associated with severe external rotation deformity, limb shortening and patellar dislocation in planning surgical correctionOsgood GM, Lee F, Parisien MV, Ruzal-Shapiro C. Magnetic resonance imaging depiction of tight iliotibial band in melorheostosis associated with severe external rotation deformity, limb shortening and patellar dislocation in planning surgical correction Skeletal Radiology 2001, 31: 49-52. PMID: 11807595, DOI: 10.1007/s00256-001-0443-2.
Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture PatternPatari S, Lee F, Behrens F. Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture Pattern Journal Of Pediatric Orthopaedics 2001, 21: 451. PMID: 11433155, DOI: 10.1097/01241398-200107000-00007.
Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture PatternPatari S, Lee F, Behrens F. Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture Pattern Journal Of Pediatric Orthopaedics 2001, 21: 451-455. DOI: 10.1097/00004694-200107000-00007.
An all-arthroscopic soft-tissue balancing technique for lateral patellar instabilityAhmad C, Lee F. An all-arthroscopic soft-tissue balancing technique for lateral patellar instability Arthroscopy The Journal Of Arthroscopic And Related Surgery 2001, 17: 555-557. PMID: 11337729, DOI: 10.1053/jars.2001.20667.
Intra-articular lipoma with osteochondroid metaplasia in the knee jointLee F, Keel S, Gebhardt M, Rosenthal D. Intra-articular lipoma with osteochondroid metaplasia in the knee joint Skeletal Radiology 2001, 30: 230-233. PMID: 11392299, DOI: 10.1007/s002560100339.
Local Recurrence of ChondroblastomaMankin H, Ramappa A, Lee F, Tang P, Carlson J, Gebhardt M. Local Recurrence of Chondroblastoma Journal Of Bone And Joint Surgery 2001, 83: 624. DOI: 10.2106/00004623-200104000-00033.
Chondroblastoma of bone.Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ. Chondroblastoma of bone. Journal Of Bone And Joint Surgery 2000, 82: 1140-5. PMID: 10954104, DOI: 10.2106/00004623-200008000-00011.
Experimental Model for Allograft Incorporation and Allograft Fracture RepairLee F, Hazan E, Gebhardt M, Mankin H. Experimental Model for Allograft Incorporation and Allograft Fracture Repair Journal Of Bone And Joint Surgery 2000, 82: 58. DOI: 10.2106/00004623-200006000-00046.
Experimental model for allograft incorporation and allograft fracture repairLee F, Hazan E, Gebhardt M, Mankin H. Experimental model for allograft incorporation and allograft fracture repair Journal Of Orthopaedic Research® 2000, 18: 303-306. PMID: 10815832, DOI: 10.1002/jor.1100180219.
Recurrent giant-cell tumor presenting as a soft-tissue mass. A report of four cases.Lee FY, Montgomery M, Hazan EJ, Keel SB, Mankin HJ, Kattapuram S. Recurrent giant-cell tumor presenting as a soft-tissue mass. A report of four cases. Journal Of Bone And Joint Surgery 1999, 81: 703-7. PMID: 10360699, DOI: 10.2106/00004623-199905000-00012.
Chondrosarcoma of bone: an assessment of outcome.Lee FY, Mankin HJ, Fondren G, Gebhardt MC, Springfield DS, Rosenberg AE, Jennings LC. Chondrosarcoma of bone: an assessment of outcome. Journal Of Bone And Joint Surgery 1999, 81: 326-38. PMID: 10199270, DOI: 10.2106/00004623-199903000-00004.
Letters to the editorsOni O, Lee F, Choi Y, Beherens F, DeFouw D, Einhorn T. Letters to the editors Journal Of Orthopaedic Research® 1999, 17: 149-150. PMID: 10073659, DOI: 10.1002/jor.1100170121.
Reconstruction Of The Shoulder Joint Using An Acetabular AllograftLee FY, Hornicek FJ, Hazan EJ, Kloen P, Wolfe MA, Mankin HJ. Reconstruction Of The Shoulder Joint Using An Acetabular Allograft Clinical Orthopaedics And Related Research® 1998, 357: 120-121. PMID: 9917707, DOI: 10.1097/00003086-199812000-00015.
A Discrete Soft Tissue Mass in the Distal Thigh of a 29-Year-Old ManLee F, Gebhardt M, Keel S, Rosenthal D. A Discrete Soft Tissue Mass in the Distal Thigh of a 29-Year-Old Man Clinical Orthopaedics And Related Research® 1998, 357: 255. PMID: 9917723, DOI: 10.1097/00003086-199812000-00031.
Micromechanical Properties of Epiphyseal Trabecular Bone and Primary Spongiosa Around the Physis: An In Situ Nanoindentation StudyLee F, Rho J, Harten R, Parsons J, Behrens F. Micromechanical Properties of Epiphyseal Trabecular Bone and Primary Spongiosa Around the Physis: An In Situ Nanoindentation Study Journal Of Pediatric Orthopaedics 1998, 18: 582-585. PMID: 9746404, DOI: 10.1097/00004694-199809000-00004.
Programmed removal of chondrocytes during endochondral fracture healingLee F, Choi Y, Behrens F, DeFouw D, Einhorn T. Programmed removal of chondrocytes during endochondral fracture healing Journal Of Orthopaedic Research® 1998, 16: 144-150. PMID: 9565087, DOI: 10.1002/jor.1100160124.
Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacementBenevenia J, Lee F, Buechel F, Parsons J. Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacement Journal Of Biomedical Materials Research 1998, 43: 473-477. PMID: 9855207, DOI: 10.1002/(sici)1097-4636(199824)43:4<473::aid-jbm16>3.0.co;2-9.
Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healingHarten R, Lee F, Zimmerman M, Hurowitz E, Arakal R, Behrens F. Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing Journal Of Orthopaedic Research® 1997, 15: 570-576. PMID: 9379267, DOI: 10.1002/jor.1100150413.
The acoustic properties of healing rat fracturesHarten R, Lee F, Zimmer M. The acoustic properties of healing rat fractures 1996, 21-22. DOI: 10.1109/nebc.1996.503197.
Insulin-like Growth Factor I Regulation of Swarm Rat Chondrosarcoma Chondrocytes in CultureSeong S, Matsumura T, Lee F, Whelan M, Li X, Trippel S. Insulin-like Growth Factor I Regulation of Swarm Rat Chondrosarcoma Chondrocytes in Culture Experimental Cell Research 1994, 211: 238-244. PMID: 8143769, DOI: 10.1006/excr.1994.1083.
Morphologic and biomechanical study of avascular necrosis of the femoral head.Kim YM, Lee SH, Lee FY, Koo KH, Cho KH. Morphologic and biomechanical study of avascular necrosis of the femoral head. Orthopedics 1991, 14: 1111-6. PMID: 1946047, DOI: 10.3928/0147-7447-19911001-10.

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Francis Lee

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Minimally Invasive Pelvis Reconstruction for Osteolytic Metastases

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Cancer-Induced Bone Loss

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