Sreeganga Chandra, PhD
Associate Professor of Neurology and Neuroscience
Research & Publications
Biography
News
Research Summary
My lab explores two related themes, those of synapse loss and neurodegeneration. Synapse loss is an early, defining event in neurodegenerative diseases, such as Parkinson's disease. In these prolonged diseases, decreases in synapse density are the best correlates of disease progression.Yet, little is known about the pathways that maintain synapses and their roles in aging and neurodegeneration. We are characterizing familial neurodegeneration genes that encode synaptic proteins to understand this important step in disease pathogenesis. Our lab uses mouse models as well as iPSC derived neuronal models in combination with biochemical, cell biological and in vivo approaches to tackle these important questions.
Specialized Terms:
- Presynaptic Biology
- Synapse Maintenance
- Parkinson's Disease
- Neuronal Ceroid Lipofuscinosis
- Neurodegeneration
Extensive Research Description
- Role of the endolysosomal pathway in Parkinson's disease
- Protein palmitoylation and neuronal ceroid lipofuscinosis
- Identification of the physiological function of synucleins
- Role of CSP alpha in synapse maintenance
- Identification of novel synapse maintenance genes
Coauthors
Research Interests
Neurology; Neuronal Ceroid-Lipofuscinoses; Parkinson Disease; Synapses; Receptors, Presynaptic; Neurodegenerative Diseases
Research Images
Selected Publications
- Impaired pre-synaptic plasticity and visual responses in auxilin-knockout miceCheng X, Tang Y, Vidyadhara D, Li B, Zimmerman M, Pak A, Nareddula S, Edens P, Chandra S, Chubykin A. Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice. IScience 2023, 26: 107842. PMID: 37766983, PMCID: PMC10520332, DOI: 10.1016/j.isci.2023.107842.
- α-Synuclein colocalizes with AP180 and affects the size of clathrin latticesVargas K, Colosi P, Girardi E, Park J, Harmon L, Chandra S. α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices. Journal Of Biological Chemistry 2023, 299: 105091. PMID: 37516240, PMCID: PMC10470054, DOI: 10.1016/j.jbc.2023.105091.
- Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s diseaseVidyadhara D, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam T, Sames D, Greene L, Sulzer D, Chandra S. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports 2023, 42: 112231. PMID: 36920906, PMCID: PMC10127800, DOI: 10.1016/j.celrep.2023.112231.
- α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease.Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.
- Pharmacological Mechanism of the Non-hallucinogenic 5‑HT2A Agonist Ariadne and AnalogsCunningham M, Bock H, Serrano I, Bechand B, Vidyadhara D, Bonniwell E, Lankri D, Duggan P, Nazarova A, Cao A, Calkins M, Khirsariya P, Hwu C, Katritch V, Chandra S, McCorvy J, Sames D. Pharmacological Mechanism of the Non-hallucinogenic 5‑HT2A Agonist Ariadne and Analogs. ACS Chemical Neuroscience 2022, 14: 119-135. PMID: 36521179, PMCID: PMC10147382, DOI: 10.1021/acschemneuro.2c00597.
- Subcellular Fractionation for the Isolation of Synaptic Components from the Murine BrainMassaro Tieze S, Chandra S, Vidyadhara D. Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain. Journal Of Visualized Experiments 2022 DOI: 10.3791/64574-v.
- Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's DiseaseTaguchi YV, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, Keutzer J, Mistry PK, Chandra SS. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. Journal Of Neuroscience 2017, 37: 9617-9631. PMID: 28847804, PMCID: PMC5628407, DOI: 10.1523/jneurosci.1525-17.2017.
- Synucleins Have Multiple Effects on Presynaptic ArchitectureVargas KJ, Schrod N, Davis T, Fernandez-Busnadiego R, Taguchi YV, Laugks U, Lucic V, Chandra SS. Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Reports 2017, 18: 161-173. PMID: 28052246, PMCID: PMC5510332, DOI: 10.1016/j.celrep.2016.12.023.
- Glucosylsphingosine accelerates α-synuclein pathology in GBA-associated Parkinson diseaseTaguchi Y, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, Keutzer J, Mistry P, Chandra S. Glucosylsphingosine accelerates α-synuclein pathology in GBA-associated Parkinson disease. Molecular Genetics And Metabolism 2017, 120: s129. DOI: 10.1016/j.ymgme.2016.11.338.
- Synucleins Regulate the Kinetics of Synaptic Vesicle EndocytosisVargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS. Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis. Journal Of Neuroscience 2014, 34: 9364-9376. PMID: 25009269, PMCID: PMC4087213, DOI: 10.1523/jneurosci.4787-13.2014.
- Synucleins☆Vargas K, Chandra S. Synucleins☆. 2014 DOI: 10.1016/b978-0-12-801238-3.04785-1.
- Identification of CSPα Clients Reveals a Role in Dynamin 1 RegulationZhang YQ, Henderson MX, Colangelo CM, Ginsberg SD, Bruce C, Wu T, Chandra SS. Identification of CSPα Clients Reveals a Role in Dynamin 1 Regulation. Neuron 2012, 74: 136-150. PMID: 22500636, PMCID: PMC3328141, DOI: 10.1016/j.neuron.2012.01.029.
- SynucleinsChandra S. Synucleins. 2009, 833-837. DOI: 10.1016/b978-008045046-9.01354-1.
- Chapter 22 α-Synuclein, CSPα, SNAREs and Neuroprotection in vivoChandra S, Südhof T. Chapter 22 α-Synuclein, CSPα, SNAREs and Neuroprotection in vivo. 2008, 295-308. DOI: 10.1016/b978-0-12-374028-1.00022-1.
- α-Synuclein Cooperates with CSPα in Preventing NeurodegenerationChandra S, Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC. α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration. Cell 2005, 123: 383-396. PMID: 16269331, DOI: 10.1016/j.cell.2005.09.028.