Vidyadhara D J, MSc, PhD
Associate Research Scientist
Research & Publications
Biography
Coauthors
Selected Publications
- Impaired pre-synaptic plasticity and visual responses in auxilin-knockout miceCheng X, Tang Y, Vidyadhara D, Li B, Zimmerman M, Pak A, Nareddula S, Edens P, Chandra S, Chubykin A. Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice. IScience 2023, 26: 107842. PMID: 37766983, PMCID: PMC10520332, DOI: 10.1016/j.isci.2023.107842.
- Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP.Yarreiphang H, Vidyadhara DJ, Nambisan AK, Raju TR, Sagar BKC, Alladi PA. Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP. Mol Neurobiol 2023, 60: 4778-4794. PMID: 37162724, DOI: 10.1007/s12035-023-03372-1.
- Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s diseaseVidyadhara D, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam T, Sames D, Greene L, Sulzer D, Chandra S. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports 2023, 42: 112231. PMID: 36920906, PMCID: PMC10127800, DOI: 10.1016/j.celrep.2023.112231.
- α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease.Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.
- Pharmacological Mechanism of the Non-hallucinogenic 5‑HT2A Agonist Ariadne and AnalogsCunningham M, Bock H, Serrano I, Bechand B, Vidyadhara D, Bonniwell E, Lankri D, Duggan P, Nazarova A, Cao A, Calkins M, Khirsariya P, Hwu C, Katritch V, Chandra S, McCorvy J, Sames D. Pharmacological Mechanism of the Non-hallucinogenic 5‑HT2A Agonist Ariadne and Analogs. ACS Chemical Neuroscience 2022, 14: 119-135. PMID: 36521179, PMCID: PMC10147382, DOI: 10.1021/acschemneuro.2c00597.
- Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain.Massaro Tieze S, Chandra SS, Vidyadhara DJ. Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain. Journal Of Visualized Experiments 2022 PMID: 36190269, PMCID: PMC10936730, DOI: 10.3791/64574.
- Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapyBoddupalli CS, Nair S, Belinsky G, Gans J, Teeple E, Nguyen TH, Mehta S, Guo L, Kramer ML, Ruan J, Wang H, Davison M, Kumar D, Vidyadhara D, Zhang B, Klinger K, Mistry PK. Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy. ELife 2022, 11: e79830. PMID: 35972072, PMCID: PMC9381039, DOI: 10.7554/elife.79830.
- Differences in Neuronal Numbers, Morphology, and Developmental Apoptosis in Mice Nigra Provide Experimental Evidence of Ontogenic Origin of Vulnerability to Parkinson's Disease.Vidyadhara DJ, Yarreiphang H, Raju TR, Alladi PA. Differences in Neuronal Numbers, Morphology, and Developmental Apoptosis in Mice Nigra Provide Experimental Evidence of Ontogenic Origin of Vulnerability to Parkinson's Disease. Neurotoxicity Research 2021, 39: 1892-1907. PMID: 34762290, DOI: 10.1007/s12640-021-00439-6.
- Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration.Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, Rai S, Paul A, Yarreiphang H, Pillai MS, Giridharan M, Clement JP, Alladi PA, Saiyed T, Manjithaya R. Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. EBioMedicine 2019, 50: 260-273. PMID: 31727601, PMCID: PMC6921191, DOI: 10.1016/j.ebiom.2019.10.036.
- Role of the endolysosomal system in Parkinson’s diseaseVidyadhara DJ, Lee JE, Chandra SS. Role of the endolysosomal system in Parkinson’s disease. Journal Of Neurochemistry 2019, 150: 487-506. PMID: 31287913, PMCID: PMC6707858, DOI: 10.1111/jnc.14820.
- Admixing MPTP-resistant and MPTP-vulnerable mice enhances striatal field potentials and calbindin-D28K expression to avert motor behaviour deficits.Vidyadhara DJ, Sasidharan A, Kutty BM, Raju TR, Alladi PA. Admixing MPTP-resistant and MPTP-vulnerable mice enhances striatal field potentials and calbindin-D28K expression to avert motor behaviour deficits. Behavioural Brain Research 2019, 360: 216-227. PMID: 30529402, DOI: 10.1016/j.bbr.2018.12.015.
- Pluchea lanceolata protects hippocampal neurons from endothelin-1 induced ischemic injury to ameliorate cognitive deficits.Mundugaru R, Sivanesan S, Popa-Wagner A, Udaykumar P, Kirubagaran R, Kp G, Vidyadhara DJ. Pluchea lanceolata protects hippocampal neurons from endothelin-1 induced ischemic injury to ameliorate cognitive deficits. Journal Of Chemical Neuroanatomy 2018, 94: 75-85. PMID: 30273663, DOI: 10.1016/j.jchemneu.2018.09.002.
- Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective.Suresh SN, Chavalmane AK, Pillai M, Ammanathan V, Vidyadhara DJ, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R. Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective. Frontiers In Molecular Neuroscience 2018, 11: 109. PMID: 29686608, PMCID: PMC5900053, DOI: 10.3389/fnmol.2018.00109.
- Admixing of MPTP-Resistant and Susceptible Mice Strains Augments Nigrostriatal Neuronal Correlates to Resist MPTP-Induced Neurodegeneration.Vidyadhara DJ, Yarreiphang H, Raju TR, Alladi PA. Admixing of MPTP-Resistant and Susceptible Mice Strains Augments Nigrostriatal Neuronal Correlates to Resist MPTP-Induced Neurodegeneration. Molecular Neurobiology 2017, 54: 6148-6162. PMID: 27704331, DOI: 10.1007/s12035-016-0158-y.
- A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.Suresh SN, Chavalmane AK, Dj V, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R. A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity. Autophagy 2017, 13: 1221-1234. PMID: 28350199, PMCID: PMC5529071, DOI: 10.1080/15548627.2017.1302045.
- Differential expression of calbindin in nigral dopaminergic neurons in two mice strains with differential susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Vidyadhara DJ, Yarreiphang H, Abhilash PL, Raju TR, Alladi PA. Differential expression of calbindin in nigral dopaminergic neurons in two mice strains with differential susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal Of Chemical Neuroanatomy 2016, 76: 82-89. PMID: 26775762, DOI: 10.1016/j.jchemneu.2016.01.001.
- Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta.Jyothi HJ, Vidyadhara DJ, Mahadevan A, Philip M, Parmar SK, Manohari SG, Shankar SK, Raju TR, Alladi PA. Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta. Neurobiology Of Aging 2015, 36: 3321-3333. PMID: 26433682, DOI: 10.1016/j.neurobiolaging.2015.08.024.