Peter S. Aronson, MD
Research & Publications
Biography
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Research Summary
The general goal of our research is to understand how the kidney regulates the composition of the urine, especially as needed to maintain the salt (NaCl) and acid-base balance of the body. To eliminate waste products from the body, the kidney filters gigantic quantities of the plasma (over 160 quarts per day) resulting in the flow of huge quantities of water, NaCl and the base bicarbonate through the renal tubules. The first portion of each renal tubule is called the proximal tubule, and the proximal tubules are collectively responsible for reabsorbing the vast majority of the filtered NaCl, bicarbonate and water, and secreting acid in the form of ammonium ions.
Our lab has specifically focused on identifying the proteins involved in mediating the transport of bicarbonate, NaCl and ammonium in the proximal tubule. We found that “knockout” mice lacking one of these transport proteins have a high incidence of calcium oxalate urinary stones, the same type that is most common in human patients with kidney stones. We showed that the cause of the calcium oxalate kidney stones is a very high concentration of oxalate in the urine. We found that this kidney transport protein also plays a very crucial role in the intestine, where it secretes oxalate and thereby limits how much of ingested oxalate is absorbed and then excreted in the urine. Based on this discovery, our laboratory has been devoting increasing effort to understanding the role of transporters in governing oxalate homeostasis and excretion. We have also been studying mechanisms by which oxalate crystals induce inflammation and thereby cause damage to the kidney and other tissues.
Extensive Research Description
Our general goal is to characterize the mechanisms regulating sodium, acid-base, and anion excretion by the kidney. Our work is primarily focused on membrane transport proteins mediating ion exchange, namely NHE isoforms mediating Na+-H+ exchange, and SLC26 isoforms mediating anion exchange. One approach involves the generation of isoform- and phospho-specific polyclonal and monoclonal antibodies to identify the cellular and subcellular sites of expression of ion exchangers in the kidney and other tissues, and to study their regulation. A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. For example, work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. This finding in turn has motivated studies on the mechanisms and regulation of oxalate transporters and their roles in oxalate homeostasis, urolithiasis, and crystal-induced inflammation in the kidney and other tissues.
Coauthors
Research Interests
Acid-Base Imbalance; Cell Membrane Permeability; Hyperoxaluria; Urinary Tract Physiological Phenomena; Water-Electrolyte Imbalance; Nephrolithiasis
Selected Publications
- SLC26A1 is a major determinant of sulfate homeostasis in humansPfau A, López-Cayuqueo K, Scherer N, Wuttke M, Wernstedt A, Fassrainer D, Smith D, van de Kamp J, Ziegeler K, Eckardt K, Luft F, Aronson P, Köttgen A, Jentsch T, Knauf F. SLC26A1 is a major determinant of sulfate homeostasis in humans Journal Of Clinical Investigation 2023, 133: e161849. PMID: 36719378, PMCID: PMC9888379, DOI: 10.1172/jci161849.
- Oxalate homeostasisErmer T, Nazzal L, Tio M, Waikar S, Aronson P, Knauf F. Oxalate homeostasis Nature Reviews Nephrology 2022, 19: 123-138. PMID: 36329260, PMCID: PMC10278040, DOI: 10.1038/s41581-022-00643-3.
- New Insights into the Pivotal Roles of Claudins in Proximal Tubule Electrolyte ReabsorptionAronson PS. New Insights into the Pivotal Roles of Claudins in Proximal Tubule Electrolyte Reabsorption Journal Of The American Society Of Nephrology 2022, 33: 659-661. PMID: 35264457, PMCID: PMC8970453, DOI: 10.1681/asn.2022020157.
- Dominant negative mutation in oxalate transporter SLC26A6 associated with enteric hyperoxaluria and nephrolithiasisCornière N, Thomson RB, Thauvin S, Villoutreix BO, Karp S, Dynia DW, Burlein S, Brinkmann L, Badreddine A, Dechaume A, Derhourhi M, Durand E, Vaillant E, Froguel P, Chambrey R, Aronson PS, Bonnefond A, Eladari D. Dominant negative mutation in oxalate transporter SLC26A6 associated with enteric hyperoxaluria and nephrolithiasis Journal Of Medical Genetics 2022, 59: 1035-1043. PMID: 35115415, PMCID: PMC9346097, DOI: 10.1136/jmedgenet-2021-108256.
- High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis PatientsPfau A, Ermer T, Coca S, Tio MC, Genser B, Reichel M, Finkelstein FO, März W, Wanner C, Waikar SS, Eckardt KU, Aronson P, Drechsler C, Knauf F. High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients Journal Of The American Society Of Nephrology 2021, 32: 2375-2385. PMID: 34281958, PMCID: PMC8729829, DOI: 10.1681/asn.2020121793.
- Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouseThomson R, Dynia DW, Burlein S, Thomson BR, Booth C, Knauf F, Wang T, Aronson P. Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse American Journal Of Physiology. Renal Physiology 2021, 320: f1106-f1122. PMID: 33938239, PMCID: PMC8285649, DOI: 10.1152/ajprenal.00556.2020.
- Author Reply to Comment on “Assessment of Plasma Oxalate Concentration in Patients With CKD” by Oka et al.Pfau A, Wytopil M, Chauhan K, Reichel M, Coca S, Aronson PS, Eckardt KU, Knauf F. Author Reply to Comment on “Assessment of Plasma Oxalate Concentration in Patients With CKD” by Oka et al. Kidney International Reports 2021, 6: 1194-1195. PMID: 33912771, PMCID: PMC8071653, DOI: 10.1016/j.ekir.2021.02.027.
- Gerhard Giebisch and the Gift of Mentorship.Aronson PS. Gerhard Giebisch and the Gift of Mentorship. Kidney360 2020, 1: 977-981. PMID: 35369559, PMCID: PMC8815600, DOI: 10.34067/kid.0004402020.
- Assessment of Plasma Oxalate Concentration in Patients With CKDPfau A, Wytopil M, Chauhan K, Reichel M, Coca SG, Aronson PS, Eckardt KU, Knauf F. Assessment of Plasma Oxalate Concentration in Patients With CKD Kidney International Reports 2020, 5: 2013-2020. PMID: 33163722, PMCID: PMC7609998, DOI: 10.1016/j.ekir.2020.08.029.
- Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney DiseaseNeumeier LI, Thomson RB, Reichel M, Eckardt KU, Aronson PS, Knauf F. Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease Journal Of The American Society Of Nephrology 2020, 31: 1987-1995. PMID: 32660969, PMCID: PMC7461683, DOI: 10.1681/asn.2020010105.
- In memoriam: Gerhard Giebisch, MD, 1927–2020Aronson P. In memoriam: Gerhard Giebisch, MD, 1927–2020 Kidney International 2020, 98: 2-5. DOI: 10.1016/j.kint.2020.04.023.
- Characterization of renal NaCl and oxalate transport in Slc26a6−/− miceKnauf F, Velazquez H, Pfann V, Jiang Z, Aronson PS. Characterization of renal NaCl and oxalate transport in Slc26a6−/− mice American Journal Of Physiology. Renal Physiology 2018, 316: f128-f133. PMID: 30427220, PMCID: PMC6383200, DOI: 10.1152/ajprenal.00309.2018.
- Impact of Regular or Extended Hemodialysis and Hemodialfiltration on Plasma Oxalate Concentrations in Patients With End-Stage Renal DiseaseErmer T, Kopp C, Asplin JR, Granja I, Perazella MA, Reichel M, Nolin TD, Eckardt KU, Aronson PS, Finkelstein FO, Knauf F. Impact of Regular or Extended Hemodialysis and Hemodialfiltration on Plasma Oxalate Concentrations in Patients With End-Stage Renal Disease Kidney International Reports 2017, 2: 1050-1058. PMID: 29270514, PMCID: PMC5733827, DOI: 10.1016/j.ekir.2017.06.002.
- N-glycosylation critically regulates function of oxalate transporter SLC26A6Thomson RB, Thomson CL, Aronson PS. N-glycosylation critically regulates function of oxalate transporter SLC26A6 American Journal Of Physiology - Cell Physiology 2016, 311: c866-c873. PMID: 27681177, PMCID: PMC5206297, DOI: 10.1152/ajpcell.00171.2016.
- Oxalate, inflammasome, and progression of kidney diseaseErmer T, Eckardt KU, Aronson PS, Knauf F. Oxalate, inflammasome, and progression of kidney disease Current Opinion In Nephrology & Hypertension 2016, 25: 363-371. PMID: 27191349, PMCID: PMC4891250, DOI: 10.1097/mnh.0000000000000229.
- Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate SecretionKnauf F, Thomson RB, Heneghan JF, Jiang Z, Adebamiro A, Thomson CL, Barone C, Asplin JR, Egan ME, Alper SL, Aronson PS. Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion Journal Of The American Society Of Nephrology 2016, 28: 242-249. PMID: 27313231, PMCID: PMC5198290, DOI: 10.1681/asn.2016030279.
- Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 miceMulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C, Romoli S, Desai J, Grigorescu M, Kumar SV, Rathkolb B, Wolf E, Hrabě de Angelis M, Bäuerle T, Dietel B, Wagner CA, Amann K, Eckardt KU, Aronson PS, Anders HJ, Knauf F. Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice American Journal Of Physiology. Renal Physiology 2016, 310: f785-f795. PMID: 26764204, PMCID: PMC5504458, DOI: 10.1152/ajprenal.00488.2015.
- Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites IDENTIFICATION OF A MULTIFUNCTIONAL PHOSPHORYLATION SITE*Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M. Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites IDENTIFICATION OF A MULTIFUNCTIONAL PHOSPHORYLATION SITE* Journal Of Biological Chemistry 2014, 290: 1952-1965. PMID: 25480791, PMCID: PMC4303652, DOI: 10.1074/jbc.m114.590174.
- Overexpression of Pendrin in Intercalated Cells Produces Chloride-Sensitive HypertensionJacques T, Picard N, Miller RL, Riemondy KA, Houillier P, Sohet F, Ramakrishnan SK, Büsst CJ, Jayat M, Cornière N, Hassan H, Aronson PS, Hennings JC, Hübner CA, Nelson RD, Chambrey R, Eladari D. Overexpression of Pendrin in Intercalated Cells Produces Chloride-Sensitive Hypertension Journal Of The American Society Of Nephrology 2013, 24: 1104-1113. PMID: 23766534, PMCID: PMC3699825, DOI: 10.1681/asn.2012080787.
- NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathyKnauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.
- Ezrin Is Required for the Functional Regulation of the Epithelial Sodium Proton Exchanger, NHE3Hayashi H, Tamura A, Krishnan D, Tsukita S, Suzuki Y, Kocinsky HS, Aronson PS, Orlowski J, Grinstein S, Alexander RT. Ezrin Is Required for the Functional Regulation of the Epithelial Sodium Proton Exchanger, NHE3 PLOS ONE 2013, 8: e55623. PMID: 23405179, PMCID: PMC3566197, DOI: 10.1371/journal.pone.0055623.
- Urinary Metabolic Phenotyping the slc26a6 (Chloride–Oxalate Exchanger) Null Mouse ModelGarcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E. Urinary Metabolic Phenotyping the slc26a6 (Chloride–Oxalate Exchanger) Null Mouse Model Journal Of Proteome Research 2012, 11: 4425-4435. PMID: 22594923, PMCID: PMC4028149, DOI: 10.1021/pr2012544.
- Sat1 is dispensable for active oxalate secretion in mouse duodenumKo N, Knauf F, Jiang Z, Markovich D, Aronson PS. Sat1 is dispensable for active oxalate secretion in mouse duodenum American Journal Of Physiology - Cell Physiology 2012, 303: c52-c57. PMID: 22517357, PMCID: PMC3404526, DOI: 10.1152/ajpcell.00385.2011.
- Net Intestinal Transport of Oxalate Reflects Passive Absorption and SLC26A6-mediated SecretionKnauf F, Ko N, Jiang Z, Robertson WG, Van Itallie CM, Anderson JM, Aronson PS. Net Intestinal Transport of Oxalate Reflects Passive Absorption and SLC26A6-mediated Secretion Journal Of The American Society Of Nephrology 2011, 22: 2247-2255. PMID: 22021714, PMCID: PMC3250206, DOI: 10.1681/asn.2011040433.
- Effects of pH on Potassium: New Explanations for Old ObservationsAronson PS, Giebisch G. Effects of pH on Potassium: New Explanations for Old Observations Journal Of The American Society Of Nephrology 2011, 22: 1981-1989. PMID: 21980112, PMCID: PMC3231780, DOI: 10.1681/asn.2011040414.
- Cholinergic signaling inhibits oxalate transport by human intestinal T84 cellsHassan HA, Cheng M, Aronson PS. Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells American Journal Of Physiology - Cell Physiology 2011, 302: c46-c58. PMID: 21956166, PMCID: PMC3328906, DOI: 10.1152/ajpcell.00075.2011.
- The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of miceLeviel F, Hübner CA, Houillier P, Morla L, Moghrabi S, Brideau G, Hatim H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D. The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice Journal Of Clinical Investigation 2010, 120: 1627-1635. PMID: 20389022, PMCID: PMC2860930, DOI: 10.1172/jci40145.
- Role of SLC26A6-mediated Cl⁻-oxalate exchange in renal physiology and pathophysiology.Aronson PS. Role of SLC26A6-mediated Cl⁻-oxalate exchange in renal physiology and pathophysiology. Journal Of Nephrology 2010, 23 Suppl 16: s158-64. PMID: 21170874.
- ESRD as a Window into America's Cost Crisis in Health CareKnauf F, Aronson PS. ESRD as a Window into America's Cost Crisis in Health Care Journal Of The American Society Of Nephrology 2009, 20: 2093-2097. PMID: 19729435, DOI: 10.1681/asn.2009070715.
- Prestin's Anion Transport and Voltage-Sensing Capabilities Are IndependentBai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D. Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent Biophysical Journal 2009, 96: 3179-3186. PMID: 19383462, PMCID: PMC2718310, DOI: 10.1016/j.bpj.2008.12.3948.
- CHAPTER 5 TRANSPORT OF SOLUTES AND WATERAronson P, Boron W, Boulpaep E. CHAPTER 5 TRANSPORT OF SOLUTES AND WATER 2009, 106-146. DOI: 10.1016/b978-1-4160-3115-4.50008-1.
- Chapter 11 Proximal Renal Tubular AcidosisAronson P, Giebisch G. Chapter 11 Proximal Renal Tubular Acidosis 2009, 199-212. DOI: 10.1016/b978-0-12-449851-8.00011-5.
- Phenotypic and Functional Analysis of Human SLC26A6 Variants in Patients With Familial Hyperoxaluria and Calcium Oxalate NephrolithiasisMonico CG, Weinstein A, Jiang Z, Rohlinger AL, Cogal AG, Bjornson BB, Olson JB, Bergstralh EJ, Milliner DS, Aronson PS. Phenotypic and Functional Analysis of Human SLC26A6 Variants in Patients With Familial Hyperoxaluria and Calcium Oxalate Nephrolithiasis American Journal Of Kidney Diseases 2008, 52: 1096-1103. PMID: 18951670, PMCID: PMC2710965, DOI: 10.1053/j.ajkd.2008.07.041.
- World Kidney Day 2008: think globally, speak locally.Davis CL, Harmon WE, Himmelfarb J, Hostetter T, Powe N, Smedberg P, Szczech LA, Aronson PS. World Kidney Day 2008: think globally, speak locally. Journal Of The American Society Of Nephrology : JASN 2008, 19: 413-6. PMID: 18272837, DOI: 10.1681/ASN.2008010070.
- Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cellsZhang J, Bobulescu IA, Goyal S, Aronson PS, Baum MG, Moe OW. Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells American Journal Of Physiology. Renal Physiology 2007, 293: f761-f766. PMID: 17581925, PMCID: PMC2861566, DOI: 10.1152/ajprenal.00117.2007.
- Ontogeny of NHE8 in the rat proximal tubuleBecker AM, Zhang J, Goyal S, Dwarakanath V, Aronson PS, Moe OW, Baum M. Ontogeny of NHE8 in the rat proximal tubule American Journal Of Physiology. Renal Physiology 2007, 293: f255-f261. PMID: 17429030, PMCID: PMC4119019, DOI: 10.1152/ajprenal.00400.2006.
- Role of Anion Transporter SLC26A6 (CFEX) in Prevention of Hyperoxaluria and UrolithiasisAronson P. Role of Anion Transporter SLC26A6 (CFEX) in Prevention of Hyperoxaluria and Urolithiasis AIP Conference Proceedings 2007, 900: 141-148. DOI: 10.1063/1.2723570.
- NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activityKocinsky HS, Dynia DW, Wang T, Aronson PS. NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity American Journal Of Physiology. Renal Physiology 2007, 293: f212-f218. PMID: 17409282, DOI: 10.1152/ajprenal.00042.2007.
- Specificity and Regulation of Renal Sulfate TransportersMarkovich D, Aronson PS. Specificity and Regulation of Renal Sulfate Transporters Annual Review Of Physiology 2007, 69: 361-375. PMID: 17002596, DOI: 10.1146/annurev.physiol.69.040705.141319.
- Membrane Curvature Alters the Activation Kinetics of the Epithelial Na+/H+ Exchanger, NHE3*Alexander RT, Malevanets A, Durkan AM, Kocinsky HS, Aronson PS, Orlowski J, Grinstein S. Membrane Curvature Alters the Activation Kinetics of the Epithelial Na+/H+ Exchanger, NHE3* Journal Of Biological Chemistry 2007, 282: 7376-7384. PMID: 17218318, DOI: 10.1074/jbc.m608557200.
- Regulation of anion exchanger Slc26a6 by protein kinase CHassan HA, Mentone S, Karniski LP, Rajendran VM, Aronson PS. Regulation of anion exchanger Slc26a6 by protein kinase C American Journal Of Physiology - Cell Physiology 2006, 292: c1485-c1492. PMID: 17151144, DOI: 10.1152/ajpcell.00447.2006.
- Essential roles of CFEX-mediated Cl−–oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasisAronson PS. Essential roles of CFEX-mediated Cl−–oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis Kidney International 2006, 70: 1207-1213. PMID: 16883319, DOI: 10.1038/sj.ki.5001741.
- Pendrin Regulation in Mouse Kidney Primarily Is Chloride-DependentVallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Deschênes G, Breton S, Meneton P, Loffing J, Aronson PS, Chambrey R, Eladari D. Pendrin Regulation in Mouse Kidney Primarily Is Chloride-Dependent Journal Of The American Society Of Nephrology 2006, 17: 2153-2163. PMID: 16825334, DOI: 10.1681/asn.2005101054.
- The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediatesKnauf F, Mohebbi N, Teichert C, Herold D, Rogina B, Helfand S, Gollasch M, Luft FC, Aronson PS. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates Biochemical Journal 2006, 397: 25-29. PMID: 16608441, PMCID: PMC1479758, DOI: 10.1042/bj20060409.
- Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6Jiang Z, Asplin JR, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, Aronson PS. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6 Nature Genetics 2006, 38: 474-478. PMID: 16532010, DOI: 10.1038/ng1762.
- Role of SLC26‐Mediated Cl−/Base Exchange in Proximal Tubule NaCl TransportAronson PS. Role of SLC26‐Mediated Cl−/Base Exchange in Proximal Tubule NaCl Transport 2006, 273: 148-163. PMID: 17120766, DOI: 10.1002/0470029579.ch10.
- Ion exchangers mediating Na+, HCO3 - and Cl- transport in the renal proximal tubule.Aronson PS. Ion exchangers mediating Na+, HCO3 - and Cl- transport in the renal proximal tubule. Journal Of Nephrology 2006, 19 Suppl 9: s3-s10. PMID: 16736438.
- Immunolocalization of anion transporter Slc26a7 in mouse kidneyDudas PL, Mentone S, Greineder CF, Biemesderfer D, Aronson PS. Immunolocalization of anion transporter Slc26a7 in mouse kidney American Journal Of Physiology. Renal Physiology 2005, 290: f937-f945. PMID: 16263805, DOI: 10.1152/ajprenal.00197.2004.
- Role of PDZK1 in membrane expression of renal brush border ion exchangersThomson RB, Wang T, Thomson BR, Tarrats L, Girardi A, Mentone S, Soleimani M, Kocher O, Aronson PS. Role of PDZK1 in membrane expression of renal brush border ion exchangers Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13331-13336. PMID: 16141316, PMCID: PMC1201624, DOI: 10.1073/pnas.0506578102.
- Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sitesKocinsky HS, Girardi AC, Biemesderfer D, Nguyen T, Mentone S, Orlowski J, Aronson PS. Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites American Journal Of Physiology. Renal Physiology 2005, 289: f249-f258. PMID: 15687252, DOI: 10.1152/ajprenal.00082.2004.
- Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytomaMazal PR, Exner M, Haitel A, Krieger S, Thomson RB, Aronson PS, Susani M. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma Human Pathology 2005, 36: 22-28. PMID: 15712178, DOI: 10.1016/j.humpath.2004.09.011.
- NHE2‐mediated bicarbonate reabsorption in the distal tubule of NHE3 null miceBailey MA, Giebisch G, Abbiati T, Aronson PS, Gawenis LR, Shull GE, Wang T. NHE2‐mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice The Journal Of Physiology 2004, 561: 765-775. PMID: 15604231, PMCID: PMC1665379, DOI: 10.1113/jphysiol.2004.074716.
- Renal and intestinal transport defects in Slc26a6-null miceWang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, Lorenz JN, Seidler U, Aronson PS, Soleimani M. Renal and intestinal transport defects in Slc26a6-null mice American Journal Of Physiology - Cell Physiology 2004, 288: c957-c965. PMID: 15574486, DOI: 10.1152/ajpcell.00505.2004.
- Immunolocalization of NHE8 in rat kidneyGoyal S, Mentone S, Aronson PS. Immunolocalization of NHE8 in rat kidney American Journal Of Physiology. Renal Physiology 2004, 288: f530-f538. PMID: 15522984, DOI: 10.1152/ajprenal.00229.2004.
- The Cl−/HCO3− exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balanceQuentin F, Chambrey R, Trinh-Trang-Tan MM, Fysekidis M, Cambillau M, Paillard M, Aronson PS, Eladari D. The Cl−/HCO3− exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance American Journal Of Physiology. Renal Physiology 2004, 287: f1179-f1188. PMID: 15292050, DOI: 10.1152/ajprenal.00211.2004.
- Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cellsGirardi AC, Knauf F, Demuth HU, Aronson PS. Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells American Journal Of Physiology - Cell Physiology 2004, 287: c1238-c1245. PMID: 15213057, DOI: 10.1152/ajpcell.00186.2004.
- WNK4 regulates apical and basolateral Cl– flux in extrarenal epitheliaKahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP. WNK4 regulates apical and basolateral Cl– flux in extrarenal epithelia Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 2064-2069. PMID: 14769928, PMCID: PMC357052, DOI: 10.1073/pnas.0308434100.
- Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKDThomson RB, Mentone S, Kim R, Earle K, Delpire E, Somlo S, Aronson PS. Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD American Journal Of Physiology. Renal Physiology 2003, 285: f870-f880. PMID: 12851251, DOI: 10.1152/ajprenal.00153.2003.
- Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base statusWagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP. Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status Kidney International 2002, 62: 2109-2117. PMID: 12427135, DOI: 10.1046/j.1523-1755.2002.00671.x.
- Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin proteinKarniski LP, Wang T, Everett LA, Green ED, Giebisch G, Aronson PS. Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein American Journal Of Physiology. Renal Physiology 2002, 283: f952-f956. PMID: 12372770, DOI: 10.1152/ajprenal.00182.2002.
- Renal expression of novel Na+/H+exchanger isoform NHE8Goyal S, Heuvel G, Aronson PS. Renal expression of novel Na+/H+exchanger isoform NHE8 American Journal Of Physiology. Renal Physiology 2002, 284: f467-f473. PMID: 12409279, DOI: 10.1152/ajprenal.00352.2002.
- Functional characterization and immunolocalization of the transporter encoded by the life-extending gene IndyKnauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 14315-14319. PMID: 12391301, PMCID: PMC137881, DOI: 10.1073/pnas.222531899.
- Specificity of Anion Exchange Mediated by Mouse Slc26a6*Jiang Z, Grichtchenko II, Boron WF, Aronson PS. Specificity of Anion Exchange Mediated by Mouse Slc26a6* Journal Of Biological Chemistry 2002, 277: 33963-33967. PMID: 12119287, DOI: 10.1074/jbc.m202660200.
- Ion exchangers mediating NaCl transport in the renal proximal tubuleAronson PS. Ion exchangers mediating NaCl transport in the renal proximal tubule Cell Biochemistry And Biophysics 2002, 36: 147-153. PMID: 12139400, DOI: 10.1385/cbb:36:2-3:147.
- Use of transgenic animals to study renal acid-base transport.Wang T, Giebisch G, Aronson PS. Use of transgenic animals to study renal acid-base transport. Journal Of Nephrology 2002, 15 Suppl 5: s151-60. PMID: 12027214.
- Role of NHE isoforms in mediating bicarbonate reabsorption along the nephronWang T, Hropot M, Aronson P, Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron American Journal Of Physiology. Renal Physiology 2001, 281: f1117-f1122. PMID: 11704563, DOI: 10.1152/ajprenal.2001.281.6.f1117.
- Association of Na+-H+ Exchanger Isoform NHE3 and Dipeptidyl Peptidase IV in the Renal Proximal Tubule*Girardi A, Degray B, Nagy T, Biemesderfer D, Aronson P. Association of Na+-H+ Exchanger Isoform NHE3 and Dipeptidyl Peptidase IV in the Renal Proximal Tubule* Journal Of Biological Chemistry 2001, 276: 46671-46677. PMID: 11590171, DOI: 10.1074/jbc.m106897200.
- Essential role of NHE3 in facilitating formate-dependent NaCl absorption in the proximal tubuleWang T, Yang C, Abbiati T, Shull G, Giebisch G, Aronson P. Essential role of NHE3 in facilitating formate-dependent NaCl absorption in the proximal tubule American Journal Of Physiology. Renal Physiology 2001, 281: f288-f292. PMID: 11457720, DOI: 10.1152/ajprenal.2001.281.2.f288.
- Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cellsKnauf F, Yang C, Thomson R, Mentone S, Giebisch G, Aronson P. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 9425-9430. PMID: 11459928, PMCID: PMC55437, DOI: 10.1073/pnas.141241098.
- Properties of the Na+-H+ exchanger in renal microvillus membrane vesicles. 1980.Kinsella JL, Aronson PS. Properties of the Na+-H+ exchanger in renal microvillus membrane vesicles. 1980. Journal Of The American Society Of Nephrology : JASN 2001, 12: 1085-95. PMID: 11316869.
- Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytesMennone A, Biemesderfer D, Negoianu D, Yang C, Abbiati T, Schultheis P, Shull G, Aronson P, Boyer J. Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes AJP Gastrointestinal And Liver Physiology 2001, 280: g247-g254. PMID: 11208547, DOI: 10.1152/ajpgi.2001.280.2.g247.
- Active (9.6 S) and Inactive (21 S) Oligomers of NHE3 in Microdomains of the Renal Brush Border*Biemesderfer D, DeGray B, Aronson P. Active (9.6 S) and Inactive (21 S) Oligomers of NHE3 in Microdomains of the Renal Brush Border* Journal Of Biological Chemistry 2000, 276: 10161-10167. PMID: 11120742, DOI: 10.1074/jbc.m008098200.
- Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activityWhyte D, Li C, Thomson R, Nix S, Zanjani R, Karp S, Aronson P, Igarashi P. Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity American Journal Of Physiology 1999, 277: f587-f598. PMID: 10516284, DOI: 10.1152/ajprenal.1999.277.4.f587.
- Ksp-cadherin gene promoter. II. Kidney-specific activity in transgenic miceIgarashi P, Shashikant C, Thomson R, Whyte D, Liu-Chen S, Ruddle F, Aronson P. Ksp-cadherin gene promoter. II. Kidney-specific activity in transgenic mice American Journal Of Physiology 1999, 277: f599-f610. PMID: 10516285, DOI: 10.1152/ajprenal.1999.277.4.f599.
- Mechanism of proximal tubule bicarbonate absorption in NHE3 null miceWang T, Yang C, Abbiati T, Schultheis P, Shull G, Giebisch G, Aronson P. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice American Journal Of Physiology 1999, 277: f298-f302. PMID: 10444585, DOI: 10.1152/ajprenal.1999.277.2.f298.
- Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidneyThomson R, Aronson P. Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney American Journal Of Physiology 1999, 277: f146-f156. PMID: 10409308, DOI: 10.1152/ajprenal.1999.277.1.f146.
- Specific Association of Megalin and the Na+/H+ Exchanger Isoform NHE3 in the Proximal Tubule*Biemesderfer D, Nagy T, DeGray B, Aronson P. Specific Association of Megalin and the Na+/H+ Exchanger Isoform NHE3 in the Proximal Tubule* Journal Of Biological Chemistry 1999, 274: 17518-17524. PMID: 10364184, DOI: 10.1074/jbc.274.25.17518.
- Immunochemical characterization of Na+/H+exchanger isoform NHE4Pizzonia J, Biemesderfer D, Abu-Alfa A, Wu M, Exner M, Isenring P, Igarashi P, Aronson P. Immunochemical characterization of Na+/H+exchanger isoform NHE4 American Journal Of Physiology 1998, 275: f510-f517. PMID: 9755122, DOI: 10.1152/ajprenal.1998.275.4.f510.
- cDNA Cloning and Chromosomal Localization of the Human and Mouse Isoforms of Ksp-CadherinThomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS. cDNA Cloning and Chromosomal Localization of the Human and Mouse Isoforms of Ksp-Cadherin Genomics 1998, 51: 445-451. PMID: 9721215, DOI: 10.1006/geno.1998.5402.
- Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchangerSchultheis P, Clarke L, Meneton P, Miller M, Soleimani M, Gawenis L, Riddle T, Duffy J, Doetschman T, Wang T, Giebisch G, Aronson P, Lorenz J, Shull G. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger Nature Genetics 1998, 19: 282-285. PMID: 9662405, DOI: 10.1038/969.
- Effect of metabolic acidosis on NaCl transport in the proximal tubuleWang T, Egbert A, Aronson P, Giebisch G. Effect of metabolic acidosis on NaCl transport in the proximal tubule American Journal Of Physiology 1998, 274: f1015-f1019. PMID: 9841491, DOI: 10.1152/ajprenal.1998.274.6.f1015.
- Membrane Topology of NHE3 EPITOPES WITHIN THE CARBOXYL-TERMINAL HYDROPHILIC DOMAIN ARE EXOPLASMIC*Biemesderfer D, DeGray B, Aronson P. Membrane Topology of NHE3 EPITOPES WITHIN THE CARBOXYL-TERMINAL HYDROPHILIC DOMAIN ARE EXOPLASMIC* Journal Of Biological Chemistry 1998, 273: 12391-12396. PMID: 9575193, DOI: 10.1074/jbc.273.20.12391.
- Sodium/Hydrogen Exchanger Gene Defect in Slow-Wave Epilepsy Mutant MiceCox G, Lutz C, Yang C, Biemesderfer D, Bronson R, Fu A, Aronson P, Noebels J, Frankel W. Sodium/Hydrogen Exchanger Gene Defect in Slow-Wave Epilepsy Mutant Mice Cell 1997, 91: 139-148. PMID: 9335342, DOI: 10.1016/s0092-8674(01)80016-7.
- Mechanisms of chloride transport in the proximal tubuleAronson PS, Giebisch G. Mechanisms of chloride transport in the proximal tubule American Journal Of Physiology 1997, 273: f179-f192. PMID: 9277578, DOI: 10.1152/ajprenal.1997.273.2.f179.
- Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidneyBiemesderfer D, Rutherford PA, Nagy T, Pizzonia JH, Abu-Alfa AK, Aronson PS. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney American Journal Of Physiology 1997, 273: f289-f299. PMID: 9277590, DOI: 10.1152/ajprenal.1997.273.2.f289.
- Ion exchangers mediating NaCl transport in the proximal tubule.Aronson PS. Ion exchangers mediating NaCl transport in the proximal tubule. Wiener Klinische Wochenschrift 1997, 109: 435-40. PMID: 9261983.
- Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat.Rutherford PA, Pizzonia JH, Biemesderfer D, Abu-Alfa A, Reilly R, Aronson PS. Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. Nephron 1997, 5: 490-7. PMID: 9438178.
- Sodium-hydrogen exchange isoform expression in blood cells: implications for studies in diabetes mellitusRutherford P, Pizzonia J, Abu-Alfa A, Biemesderfer D, Reilly R, Aronson P. Sodium-hydrogen exchange isoform expression in blood cells: implications for studies in diabetes mellitus Experimental And Clinical Endocrinology & Diabetes 1997, 105: 13-16. PMID: 9288535, DOI: 10.1055/s-0029-1211787.
- Role of NHE3 in Mediating Renal Brush Border Na+-H+ Exchange ADAPTATION TO METABOLIC ACIDOSIS*Wu M, Biemesderfer D, Giebisch G, Aronson P. Role of NHE3 in Mediating Renal Brush Border Na+-H+ Exchange ADAPTATION TO METABOLIC ACIDOSIS* Journal Of Biological Chemistry 1996, 271: 32749-32752. PMID: 8955109, DOI: 10.1074/jbc.271.51.32749.
- Mechanism of H(+)-coupled formate transport in rabbit renal microvillus membranesSaleh AM, Rudnick H, Aronson PS. Mechanism of H(+)-coupled formate transport in rabbit renal microvillus membranes American Journal Of Physiology 1996, 271: f401-f407. PMID: 8770172, DOI: 10.1152/ajprenal.1996.271.2.f401.
- Mechanisms of stimulation of proximal tubule chloride transport by formate and oxalateWang T, Egbert AL, Abbiati T, Aronson PS, Giebisch G. Mechanisms of stimulation of proximal tubule chloride transport by formate and oxalate American Journal Of Physiology 1996, 271: f446-f450. PMID: 8770178, DOI: 10.1152/ajprenal.1996.271.2.f446.
- Pathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles*Kuo S, Aronson P. Pathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles* Journal Of Biological Chemistry 1996, 271: 15491-15497. PMID: 8663096, DOI: 10.1074/jbc.271.26.15491.
- Role of ion exchangers in mediating NaCl transport in the proximal tubuleAronson P. Role of ion exchangers in mediating NaCl transport in the proximal tubule Kidney International 1996, 49: 1665-1670. PMID: 8743473, DOI: 10.1038/ki.1996.243.
- Isolation and cDNA Cloning of Ksp-cadherin, a Novel Kidney-specific Member of the Cadherin Multigene Family *Thomson R, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson P. Isolation and cDNA Cloning of Ksp-cadherin, a Novel Kidney-specific Member of the Cadherin Multigene Family * Journal Of Biological Chemistry 1995, 270: 17594-17601. PMID: 7615566, DOI: 10.1074/jbc.270.29.17594.
- 1994 Homer W. Smith Award. From flies to physiology--accidental findings along the trail of renal NaCl transport.Aronson PS. 1994 Homer W. Smith Award. From flies to physiology--accidental findings along the trail of renal NaCl transport. Journal Of The American Society Of Nephrology 1995, 5: 2001-13. PMID: 7579047, DOI: 10.1681/asn.v5122001.
- Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoidsBaum M, Biemesderfer D, Gentry D, Aronson PS. Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids American Journal Of Physiology 1995, 268: f815-f820. PMID: 7771509, DOI: 10.1152/ajprenal.1995.268.5.f815.
- Stimulation of chloride transport by cAMP in rat proximal tubulesWang T, Segal AS, Giebisch G, Aronson PS. Stimulation of chloride transport by cAMP in rat proximal tubules American Journal Of Physiology 1995, 268: f204-f210. PMID: 7864157, DOI: 10.1152/ajprenal.1995.268.2.f204.
- Effects of inhibitors on anion exchangers in rabbit renal brush border membrane vesicles.McConnell KR, Aronson PS. Effects of inhibitors on anion exchangers in rabbit renal brush border membrane vesicles. Journal Of Biological Chemistry 1994, 269: 21489-21494. PMID: 8063783, DOI: 10.1016/s0021-9258(17)31830-6.
- Weak acid permeability of a villous membrane: Formic acid transport across rat proximal tubuleKrahn T, Aronson P, Weinstein A. Weak acid permeability of a villous membrane: Formic acid transport across rat proximal tubule Bulletin Of Mathematical Biology 1994, 56: 459-490. PMID: 8087078, DOI: 10.1007/bf02460467.
- Acute Regulation of Na+:HCO3- Cotransport System In Kidney Proximal TubulesSoleimani M, Bizal G, Hattabaugh Y, Aronson P, Bergman J. Acute Regulation of Na+:HCO3- Cotransport System In Kidney Proximal Tubules 1994, 309-317. DOI: 10.1007/978-3-642-79301-1_36.
- NHE3: a Na+/H+ exchanger isoform of renal brush borderBiemesderfer D, Pizzonia J, Abu-Alfa A, Exner M, Reilly R, Igarashi P, Aronson PS. NHE3: a Na+/H+ exchanger isoform of renal brush border American Journal Of Physiology 1993, 265: f736-f742. PMID: 8238556, DOI: 10.1152/ajprenal.1993.265.5.f736.
- Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ERBiemesderfer D, Dekan G, Aronson PS, Farquhar MG. Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER American Journal Of Physiology 1993, 264: f1011-f1020. PMID: 8322889, DOI: 10.1152/ajprenal.1993.264.6.f1011.
- Effects of formate and oxalate on chloride absorption in rat distal tubuleWang T, Agulian SK, Giebisch G, Aronson PS. Effects of formate and oxalate on chloride absorption in rat distal tubule American Journal Of Physiology 1993, 264: f730-f736. PMID: 8386473, DOI: 10.1152/ajprenal.1993.264.4.f730.
- Immunocytochemical characterization of Na(+)-H+ exchanger isoform NHE-1 in rabbit kidneyBiemesderfer D, Reilly RF, Exner M, Igarashi P, Aronson PS. Immunocytochemical characterization of Na(+)-H+ exchanger isoform NHE-1 in rabbit kidney American Journal Of Physiology 1992, 263: f833-f840. PMID: 1279986, DOI: 10.1152/ajprenal.1992.263.5.f833.
- cDNA cloning and localization of a band 3-related protein from ileumChow A, Dobbins JW, Aronson PS, Igarashi P. cDNA cloning and localization of a band 3-related protein from ileum American Journal Of Physiology 1992, 263: g345-g352. PMID: 1415547, DOI: 10.1152/ajpgi.1992.263.3.g345.
- Effects of formate and oxalate on volume absorption in rat proximal tubuleWang T, Giebisch G, Aronson PS. Effects of formate and oxalate on volume absorption in rat proximal tubule American Journal Of Physiology 1992, 263: f37-f42. PMID: 1636743, DOI: 10.1152/ajprenal.1992.263.1.f37.
- Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogsZweifach A, Desir G, Aronson P, Giebisch G. Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogs The Journal Of Membrane Biology 1992, 128: 115-122. PMID: 1501239, DOI: 10.1007/bf00231884.
- Assembly of distinctive coated pit and microvillar microdomains in the renal brush borderBiemesderfer D, Dekan G, Aronson PS, Farquhar MG. Assembly of distinctive coated pit and microvillar microdomains in the renal brush border American Journal Of Physiology 1992, 262: f55-f67. PMID: 1733297, DOI: 10.1152/ajprenal.1992.262.1.f55.
- cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cellsReilly RF, Hildebrandt F, Biemesderfer D, Sardet C, Pouyssegur J, Aronson PS, Slayman CW, Igarashi P. cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cells American Journal Of Physiology 1991, 261: f1088-f1094. PMID: 1661081, DOI: 10.1152/ajprenal.1991.261.6.f1088.
- Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcriptHildebrandt F, Pizzonia J, Reilly R, Rebouças N, Sardet C, Pouysségur J, Slayman C, Aronson P, Igarashi P. Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcript Biochimica Et Biophysica Acta 1991, 1129: 105-108. PMID: 1661611, DOI: 10.1016/0167-4781(91)90221-7.
- A Ca-activated K channel from rabbit renal brush-border membrane vesicles in planar lipid bilayersZweifach A, Desir GV, Aronson PS, Giebisch GH. A Ca-activated K channel from rabbit renal brush-border membrane vesicles in planar lipid bilayers American Journal Of Physiology 1991, 261: f187-f196. PMID: 1713419, DOI: 10.1152/ajprenal.1991.261.1.f187.
- Molecular biology of renal Na(+)-H+ exchangers.Igarashi P, Reilly RF, Hildebrandt F, Biemesderfer D, Rebouças NA, Slayman CW, Aronson PS. Molecular biology of renal Na(+)-H+ exchangers. Kidney International Supplement 1991, 33: s84-9. PMID: 1653876.
- Na+-H+ Exchanger and Its Role in Essential Hypertension and Diabetes MellitusHuot S, Aronson P. Na+-H+ Exchanger and Its Role in Essential Hypertension and Diabetes Mellitus Diabetes Care 1991, 14: 521-535. PMID: 1650693, DOI: 10.2337/diacare.14.6.521.
- Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesiclesSoleimani M, Lesoine GA, Bergman JA, Aronson PS. Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles Journal Of Biological Chemistry 1991, 266: 8706-8710. PMID: 2026588, DOI: 10.1016/s0021-9258(18)31503-5.
- Increased Na(+)-H+ antiporter activity in apical membrane vesicles from mutant LLC-PK1 cellsReilly RF, Haggerty JG, Aronson PS, Adelberg EA, Slayman CW. Increased Na(+)-H+ antiporter activity in apical membrane vesicles from mutant LLC-PK1 cells American Journal Of Physiology 1991, 260: c738-c744. PMID: 1673319, DOI: 10.1152/ajpcell.1991.260.4.c738.
- High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesiclesDesir GV, Cragoe EJ, Aronson PS. High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles Journal Of Biological Chemistry 1991, 266: 2267-2271. PMID: 1846621, DOI: 10.1016/s0021-9258(18)52238-9.
- Properties of the renal Na(+)-HCO3- cotransporter.Aronson PS, Soleimani M, Grassl SM. Properties of the renal Na(+)-HCO3- cotransporter. Seminars In Nephrology 1991, 11: 28-36. PMID: 1900129.
- Basolateral transport pathways for K+ and Cl- in rabbit proximal tubule: effects on cell volumeSchild L, Aronson PS, Giebisch G. Basolateral transport pathways for K+ and Cl- in rabbit proximal tubule: effects on cell volume American Journal Of Physiology 1991, 260: f101-f109. PMID: 1992774, DOI: 10.1152/ajprenal.1991.260.1.f101.
- Mechanisms of Na+, Cl−, and HCO3− Transport in the Proximal TubuleAronson P. Mechanisms of Na+, Cl−, and HCO3− Transport in the Proximal Tubule 1991, 99-115. DOI: 10.1007/978-3-662-35158-1_7.
- Characterization of Na(+)-H+ exchangers on villus cells in rabbit ileumKnickelbein RG, Aronson PS, Dobbins JW. Characterization of Na(+)-H+ exchangers on villus cells in rabbit ileum American Journal Of Physiology 1990, 259: g802-g806. PMID: 2173416, DOI: 10.1152/ajpgi.1990.259.5.g802.
- Rabbit ileal brush-border membrane Cl-HCO3 exchanger is activated by an internal pH-sensitive modifier siteMugharbil A, Knickelbein RG, Aronson PS, Dobbins JW. Rabbit ileal brush-border membrane Cl-HCO3 exchanger is activated by an internal pH-sensitive modifier site American Journal Of Physiology 1990, 259: g666-g670. PMID: 2171352, DOI: 10.1152/ajpgi.1990.259.4.g666.
- Effects of apical membrane Cl(-)-formate exchange on cell volume in rabbit proximal tubuleSchild L, Aronson PS, Giebisch G. Effects of apical membrane Cl(-)-formate exchange on cell volume in rabbit proximal tubule American Journal Of Physiology 1990, 258: f530-f536. PMID: 2316663, DOI: 10.1152/ajprenal.1990.258.3.f530.
- Heterogeneity of Anion Exchangers Mediating Chloride Transport in the Proximal TubuleaARONSON P, KUO S. Heterogeneity of Anion Exchangers Mediating Chloride Transport in the Proximal Tubulea Annals Of The New York Academy Of Sciences 1989, 574: 96-101. PMID: 2634360, DOI: 10.1111/j.1749-6632.1989.tb25139.x.
- Ionic mechanism of Na+-HCO3 − cotransport in rabbit renal basolateral membrane vesicles*Soleimani M, Aronson PS. Ionic mechanism of Na+-HCO3 − cotransport in rabbit renal basolateral membrane vesicles* Journal Of Biological Chemistry 1989, 264: 18302-18308. PMID: 2509453, DOI: 10.1016/s0021-9258(18)51463-0.
- The Renal Proximal Tubule: A Model for Diversity of Anion Exchangers and Stilbene-sensitive Anion TransportersAronson PS. The Renal Proximal Tubule: A Model for Diversity of Anion Exchangers and Stilbene-sensitive Anion Transporters Annual Review Of Physiology 1989, 51: 419-441. PMID: 2653190, DOI: 10.1146/annurev.ph.51.030189.002223.
- Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.Soleimani M, Aronson PS. Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Clinical Investigation 1989, 83: 945-951. PMID: 2921327, PMCID: PMC303770, DOI: 10.1172/jci113980.
- Identification and Purification of a Renal Amiloride-binding Protein with Properties of the Na+-H+ ExchangerHuot SJ, Cassel D, Igarashi P, Cragoe EJ, Slayman CW, Aronson PS. Identification and Purification of a Renal Amiloride-binding Protein with Properties of the Na+-H+ Exchanger Journal Of Biological Chemistry 1989, 264: 683-686. PMID: 2536021, DOI: 10.1016/s0021-9258(19)84996-7.
- Membrane distribution of sodium-hydrogen and chloride-bicarbonate exchangers in crypt and villus cell membranes from rabbit ileum.Knickelbein RG, Aronson PS, Dobbins JW. Membrane distribution of sodium-hydrogen and chloride-bicarbonate exchangers in crypt and villus cell membranes from rabbit ileum. Journal Of Clinical Investigation 1988, 82: 2158-2163. PMID: 2848868, PMCID: PMC442800, DOI: 10.1172/jci113838.
- Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.Kuo SM, Aronson PS. Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles. Journal Of Biological Chemistry 1988, 263: 9710-9717. PMID: 3384817, DOI: 10.1016/s0021-9258(19)81576-4.
- Formate: A Critical Intermediate for Chloride Transport in the Proximal TubuleKarniski L, Aronson P. Formate: A Critical Intermediate for Chloride Transport in the Proximal Tubule Physiology 1987, 2: 160-164. DOI: 10.1152/physiologyonline.1987.2.5.160.
- Evidence for carrier-mediated Cl-SO4 exchange in rabbit ileal basolateral membrane vesiclesSchron CM, Knickelbein RG, Aronson PS, Dobbins JW. Evidence for carrier-mediated Cl-SO4 exchange in rabbit ileal basolateral membrane vesicles American Journal Of Physiology 1987, 253: g404-g410. PMID: 3631275, DOI: 10.1152/ajpgi.1987.253.3.g404.
- Anion exchange pathways for Cl- transport in rabbit renal microvillus membranesKarniski LP, Aronson PS. Anion exchange pathways for Cl- transport in rabbit renal microvillus membranes American Journal Of Physiology 1987, 253: f513-f521. PMID: 3631282, DOI: 10.1152/ajprenal.1987.253.3.f513.
- Stoichiometry of Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.Soleimani M, Grassi SM, Aronson PS. Stoichiometry of Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Clinical Investigation 1987, 79: 1276-1280. PMID: 3558825, PMCID: PMC424331, DOI: 10.1172/jci112948.
- Covalent modification of the renal Na+/H+ exchanger by N,N'-dicyclohexylcarbodiimide.Igarashi P, Aronson PS. Covalent modification of the renal Na+/H+ exchanger by N,N'-dicyclohexylcarbodiimide. Journal Of Biological Chemistry 1987, 262: 860-868. PMID: 3027072, DOI: 10.1016/s0021-9258(19)75866-9.
- Effect of formate on volume reabsorption in the rabbit proximal tubule.Schild L, Giebisch G, Karniski LP, Aronson PS. Effect of formate on volume reabsorption in the rabbit proximal tubule. Journal Of Clinical Investigation 1987, 79: 32-38. PMID: 3793930, PMCID: PMC423979, DOI: 10.1172/jci112803.
- The Proximal NephronGiebisch G, Aronson P. The Proximal Nephron 1987, 285-316. DOI: 10.1007/978-1-4684-5404-8_14.
- Properties and physiologic roles of the plasma membrane sodium-hydrogen exchanger.Seifter JL, Aronson PS. Properties and physiologic roles of the plasma membrane sodium-hydrogen exchanger. Journal Of Clinical Investigation 1986, 78: 859-864. PMID: 3020091, PMCID: PMC423701, DOI: 10.1172/jci112671.
- Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.Grassl SM, Aronson PS. Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Biological Chemistry 1986, 261: 8778-8783. PMID: 3013862, DOI: 10.1016/s0021-9258(19)84448-4.
- Chloride transport in the mammalian proximal tubuleSchild L, Giebisch G, Karniski L, Aronson PS. Chloride transport in the mammalian proximal tubule Pflügers Archiv - European Journal Of Physiology 1986, 407: s156-s159. PMID: 3822761, DOI: 10.1007/bf00584945.
- Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesiclesMoseley RH, Meier PJ, Aronson PS, Boyer JL. Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles American Journal Of Physiology 1986, 250: g35-g43. PMID: 3002192, DOI: 10.1152/ajpgi.1986.250.1.g35.
- Inactivation of the renal microvillus membrane Na+-H+ exchanger by histidine-specific reagents.Grillo FG, Aronson PS. Inactivation of the renal microvillus membrane Na+-H+ exchanger by histidine-specific reagents. Journal Of Biological Chemistry 1986, 261: 1120-1125. PMID: 3003054, DOI: 10.1016/s0021-9258(17)36063-5.
- Oxalate transport by anion exchange across rabbit ileal brush border.Knickelbein RG, Aronson PS, Dobbins JW. Oxalate transport by anion exchange across rabbit ileal brush border. Journal Of Clinical Investigation 1986, 77: 170-175. PMID: 3003149, PMCID: PMC423323, DOI: 10.1172/jci112272.
- The Proximal NephronGiebisch G, Aronson P. The Proximal Nephron 1986, 669-700. DOI: 10.1007/978-1-4613-2097-5_37.
- Chapter 4 Molecular Properties and Physiological Roles of the Renal Na+-H+ ExchangerAronson P, Igarashi P. Chapter 4 Molecular Properties and Physiological Roles of the Renal Na+-H+ Exchanger 1986, 26: 57-75. DOI: 10.1016/s0070-2161(08)60726-1.
- Properties of the Renal Na+‐H+ ExchangeraARONSON P. Properties of the Renal Na+‐H+ Exchangera Annals Of The New York Academy Of Sciences 1985, 456: 220-228. PMID: 3004289, DOI: 10.1111/j.1749-6632.1985.tb14867.x.
- pH gradient-stimulated sulfate transport by rabbit ileal brush-border membrane vesicles: evidence for SO4-OH exchangeSchron CM, Knickelbein RG, Aronson PS, Della Puca J, Dobbins JW. pH gradient-stimulated sulfate transport by rabbit ileal brush-border membrane vesicles: evidence for SO4-OH exchange American Journal Of Physiology 1985, 249: g607-g613. PMID: 4061648, DOI: 10.1152/ajpgi.1985.249.5.g607.
- Effects of cations on pH gradient-stimulated sulfate transport in rabbit ileal brush-border membrane vesiclesSchron CM, Knickelbein RG, Aronson PS, Della Puca J, Dobbins JW. Effects of cations on pH gradient-stimulated sulfate transport in rabbit ileal brush-border membrane vesicles American Journal Of Physiology 1985, 249: g614-g621. PMID: 4061649, DOI: 10.1152/ajpgi.1985.249.5.g614.
- Kinetic Properties of the Plasma Membrane Na+ -H+ ExchangerAronson PS. Kinetic Properties of the Plasma Membrane Na+ -H+ Exchanger Annual Review Of Physiology 1985, 47: 545-560. PMID: 2581505, DOI: 10.1146/annurev.ph.47.030185.002553.
- Interrelationships among quinidine, amiloride, and lithium as inhibitors of the renal Na+-H+ exchanger.Mahnensmith RL, Aronson PS. Interrelationships among quinidine, amiloride, and lithium as inhibitors of the renal Na+-H+ exchanger. Journal Of Biological Chemistry 1985, 260: 12586-12592. PMID: 2995381, DOI: 10.1016/s0021-9258(17)38911-1.
- Chloride/formate exchange with formic acid recycling: a mechanism of active chloride transport across epithelial membranes.Karniski LP, Aronson PS. Chloride/formate exchange with formic acid recycling: a mechanism of active chloride transport across epithelial membranes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 6362-6365. PMID: 3862136, PMCID: PMC391054, DOI: 10.1073/pnas.82.18.6362.
- Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of couplingKnickelbein R, Aronson PS, Schron CM, Seifter J, Dobbins JW. Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling American Journal Of Physiology 1985, 249: g236-g245. PMID: 3927745, DOI: 10.1152/ajpgi.1985.249.2.g236.
- Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.Guggino SE, Aronson PS. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes. Journal Of Clinical Investigation 1985, 76: 543-547. PMID: 4031062, PMCID: PMC423858, DOI: 10.1172/jci112004.
- The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes.Mahnensmith RL, Aronson PS. The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes. Circulation Research 1985, 56: 773-788. PMID: 2988813, DOI: 10.1161/01.res.56.6.773.
- Substrate and inhibitor specificity of anion exchangers on the brush border membrane of rabbit ileumKnickelbein R, Aronson P, Dobbins J. Substrate and inhibitor specificity of anion exchangers on the brush border membrane of rabbit ileum The Journal Of Membrane Biology 1985, 88: 199-204. PMID: 3005584, DOI: 10.1007/bf01868433.
- Cl- transport via anion exchange in Necturus renal microvillus membranesSeifter JL, Aronson PS. Cl- transport via anion exchange in Necturus renal microvillus membranes American Journal Of Physiology 1984, 247: f888-f895. PMID: 6507628, DOI: 10.1152/ajprenal.1984.247.6.f888.
- Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesiclesSeifter JL, Knickelbein R, Aronson PS. Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles American Journal Of Physiology 1984, 247: f753-f759. PMID: 6093589, DOI: 10.1152/ajprenal.1984.247.5.f753.
- Ion transport processes in apical membranes of epithelia.Warnock DG, Greger R, Dunham PB, Benjamin MA, Frizzell RA, Field M, Spring KR, Ives HE, Aronson PS, Seifter J. Ion transport processes in apical membranes of epithelia. Federation Proceedings 1984, 43: 2473-87. PMID: 6734823.
- Electrochemical driving forces for secondary active transport: energetics and kinetics of Na+-H+ exchange and Na+-glucose cotransport.Aronson PS. Electrochemical driving forces for secondary active transport: energetics and kinetics of Na+-H+ exchange and Na+-glucose cotransport. Society Of General Physiologists Series 1984, 38: 49-70. PMID: 6695212.
- Mechanisms of active H+ secretion in the proximal tubuleAronson PS. Mechanisms of active H+ secretion in the proximal tubule American Journal Of Physiology 1983, 245: f647-f659. PMID: 6318566, DOI: 10.1152/ajprenal.1983.245.6.f647.
- Hydrogen ion cotransport by the renal brush border glutamate transporter.Nelson P, Dean G, Aronson P, Rudnick G. Hydrogen ion cotransport by the renal brush border glutamate transporter. Biochemistry 1983, 22: 5459-63. PMID: 6140027, DOI: 10.1021/bi00292a030.
- Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchangeKnickelbein R, Aronson PS, Atherton W, Dobbins JW. Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange American Journal Of Physiology 1983, 245: g504-g510. PMID: 6624918, DOI: 10.1152/ajpgi.1983.245.4.g504.
- Interaction of external H+ with the Na+-H+ exchanger in renal microvillus membrane vesicles.Aronson PS, Suhm MA, Nee J. Interaction of external H+ with the Na+-H+ exchanger in renal microvillus membrane vesicles. Journal Of Biological Chemistry 1983, 258: 6767-6771. PMID: 6304054, DOI: 10.1016/s0021-9258(18)32287-7.
- Specificity and modes of the anion exchanger in dog renal microvillus membranesGuggino SE, Martin GJ, Aronson PS. Specificity and modes of the anion exchanger in dog renal microvillus membranes American Journal Of Physiology 1983, 244: f612-f621. PMID: 6859253, DOI: 10.1152/ajprenal.1983.244.6.f612.
- Urate transport via anion exchange in dog renal microvillus membrane vesiclesKahn AM, Aronson PS. Urate transport via anion exchange in dog renal microvillus membrane vesicles American Journal Of Physiology 1983, 244: f56-f63. PMID: 6849384, DOI: 10.1152/ajprenal.1983.244.1.f56.
- Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesiclesAronson P, Nee J, Suhm M. Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles Nature 1982, 299: 161-163. PMID: 7110335, DOI: 10.1038/299161a0.
- The effect of diuretics on extrarenal potassium tolerance.Tanoue LT, Aronson PS, Bia MJ. The effect of diuretics on extrarenal potassium tolerance. The Yale Journal Of Biology And Medicine 1982, 55: 421-8. PMID: 7183021, PMCID: PMC2596565.
- Red-cell sodium-lithium countertransport and essential hypertension.Aronson PS. Red-cell sodium-lithium countertransport and essential hypertension. The New England Journal Of Medicine 1982, 307: 317. PMID: 7088092, DOI: 10.1056/NEJM198207293070517.
- Determination of the coupling ratio for Na+-H+ exchange in renal microvillus membrane vesiclesKinsella J, Aronson P. Determination of the coupling ratio for Na+-H+ exchange in renal microvillus membrane vesicles Biochimica Et Biophysica Acta 1982, 689: 161-164. PMID: 7104347, DOI: 10.1016/0005-2736(82)90200-0.
- Glucose and alanine inhibition of phosphate transport in renal microvillus membrane vesiclesBarrett PQ, Aronson PS. Glucose and alanine inhibition of phosphate transport in renal microvillus membrane vesicles American Journal Of Physiology 1982, 242: f126-f131. PMID: 7065130, DOI: 10.1152/ajprenal.1982.242.2.f126.
- Interaction of NH4+ and Li+ with the renal microvillus membrane Na+-H+ exchangerKinsella JL, Aronson PS. Interaction of NH4+ and Li+ with the renal microvillus membrane Na+-H+ exchanger American Journal Of Physiology 1981, 241: c220-c226. PMID: 6272583, DOI: 10.1152/ajpcell.1981.241.5.c220.
- Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesiclesKinsella JL, Aronson PS. Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles American Journal Of Physiology 1981, 241: f374-f379. PMID: 7315961, DOI: 10.1152/ajprenal.1981.241.4.f374.
- Use of ionophores to study Na+ transport pathways in renal microvillus membrane vesicles.Aronson PS, Kinsella JL. Use of ionophores to study Na+ transport pathways in renal microvillus membrane vesicles. The FASEB Journal 1981, 40: 2213-7. PMID: 6263713.
- Identifying secondary active solute transport in epitheliaAronson PS. Identifying secondary active solute transport in epithelia American Journal Of Physiology 1981, 240: f1-f11. PMID: 6257121, DOI: 10.1152/ajprenal.1981.240.1.f1.
- Mechanism of increased potassium secretion in potassium loading and sodium deprivationHayslett J, Myketey N, Binder H, Aronson P. Mechanism of increased potassium secretion in potassium loading and sodium deprivation American Journal Of Physiology 1980, 239: f378-f382. PMID: 6252786, DOI: 10.1152/ajprenal.1980.239.4.f378.
- Properties of the Na+-H+ exchanger in renal microvillus membrane vesicles.Kinsella JL, Aronson PS. Properties of the Na+-H+ exchanger in renal microvillus membrane vesicles. The American Journal Of Physiology 1980, 238: F461-9. PMID: 7386626, DOI: 10.1152/ajprenal.1980.238.6.F461.
- pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles.Blomstedt JW, Aronson PS. pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles. The Journal Of Clinical Investigation 1980, 65: 931-4. PMID: 7358852, PMCID: PMC434483, DOI: 10.1172/JCI109748.
- Harmaline inhibition of Na-dependent transport in renal microvillus membrane vesicles.Aronson PS, Bounds SE. Harmaline inhibition of Na-dependent transport in renal microvillus membrane vesicles. The American Journal Of Physiology 1980, 238: F210-7. PMID: 7369363, DOI: 10.1152/ajprenal.1980.238.3.F210.
- Chapter 20 The Mechanism of Coupling between Glucose Transport and Electrical Potential in the Proximal Tubule: A Study of Potential-Dependent Phlorizin Binding to Isolated Renal Microvillus MembranesAronson P. Chapter 20 The Mechanism of Coupling between Glucose Transport and Electrical Potential in the Proximal Tubule: A Study of Potential-Dependent Phlorizin Binding to Isolated Renal Microvillus Membranes 1980, 13: 283-290. DOI: 10.1016/s0070-2161(08)60288-9.
- Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin BAronson PS, Hayslett JP, Kashgarian M. Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin B American Journal Of Physiology 1979, 236: f392-f397. PMID: 434214, DOI: 10.1152/ajprenal.1979.236.4.f392.
- Energy-dependence of phlorizin binding to isolated renal microvillus membranesAronson P. Energy-dependence of phlorizin binding to isolated renal microvillus membranes The Journal Of Membrane Biology 1978, 42: 81-98. PMID: 671529, DOI: 10.1007/bf01870395.
- The Na+ gradient-dependent transport of D-glucose in renal brush border membranes.Aronson PS, Sacktor B. The Na+ gradient-dependent transport of D-glucose in renal brush border membranes. The Journal Of Biological Chemistry 1975, 250: 6032-9. PMID: 1150669.
- Further studies on the previously proposed saturable high affinity site for D-glucose in renal brush border membrane preparations.Mitchell ME, Aronson PS, Sacktor B. Further studies on the previously proposed saturable high affinity site for D-glucose in renal brush border membrane preparations. The Journal Of Biological Chemistry 1974, 249: 6971-5. PMID: 4420797.
- Transport of D-glucose by brush border membranes isolated from the renal cortex.Aronson PS, Sacktor B. Transport of D-glucose by brush border membranes isolated from the renal cortex. Biochimica Et Biophysica Acta 1974, 356: 231-43. PMID: 4855244, DOI: 10.1016/0005-2736(74)90286-7.