Marc Hammarlund, PhD
he/him/his
Professor of Genetics and of Neuroscience
Research & Publications
Biography
News
Research Summary
Our current research focuses on the following fundamental questions:
(For more information please visit our web site: hammarlab.org.)
- How do neurons respond to injury, disease, and age?
- How do neurons and neuronal circuits develop and maintain normal function over time?
- How can we control neuronal homeostasis, plasticity, and repair at the molecular level?
Answering these questions will provide fundamental insights into the cellular and circuit mechanisms that attempt to maintain neuronal function over time. We hypothesize that these molecular mechanisms also control susceptibility to cognitive decline and neurological disease. We study these questions in the model organism C. elegans. Because C. elegans is transparent and has a relatively simple nervous system, we can manipulate and observe individual neurons in intact, living animals.
Specialized Terms: Axon regeneration and degeneration; Neuronal plasticity; Aging; C. elegans
Extensive Research Description
Please visit our web site: hammarlab.org.
Coauthors
Research Interests
Axons; Cell Biology; Nerve Regeneration; Gene Expression; Caenorhabditis elegans
Research Image
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A single regenerating neuron in vivo, 6 hours after laser axotomy.
Selected Publications
- Molecular topography of an entire nervous systemTaylor SR, Santpere G, Weinreb A, Barrett A, Reilly MB, Xu C, Varol E, Oikonomou P, Glenwinkel L, McWhirter R, Poff A, Basavaraju M, Rafi I, Yemini E, Cook SJ, Abrams A, Vidal B, Cros C, Tavazoie S, Sestan N, Hammarlund M, Hobert O, Miller DM. Molecular topography of an entire nervous system. Cell 2021, 184: 4329-4347.e23. PMID: 34237253, PMCID: PMC8710130, DOI: 10.1016/j.cell.2021.06.023.
- Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondriaDing C, Wu Y, Dabas H, Hammarlund M. Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria. ELife 2022, 11: e73557. PMID: 35285800, PMCID: PMC8920508, DOI: 10.7554/elife.73557.
- A Functional Non-coding RNA Is Produced from xbp-1 mRNALiu X, Beaudoin JD, Davison CA, Kosmaczewski SG, Meyer BI, Giraldez AJ, Hammarlund M. A Functional Non-coding RNA Is Produced from xbp-1 mRNA. Neuron 2020, 107: 854-863.e6. PMID: 32640191, PMCID: PMC7486263, DOI: 10.1016/j.neuron.2020.06.015.
- The neuropeptidergic connectome of C. elegansRipoll-Sánchez L, Watteyne J, Sun H, Fernandez R, Taylor S, Weinreb A, Bentley B, Hammarlund M, Miller D, Hobert O, Beets I, Vértes P, Schafer W. The neuropeptidergic connectome of C. elegans. Neuron 2023, 111: 3570-3589.e5. PMID: 37935195, PMCID: PMC7615469, DOI: 10.1016/j.neuron.2023.09.043.
- A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegansGlomb O, Swaim G, Munoz LLancao P, Lovejoy C, Sutradhar S, Park J, Wu Y, Cason S, Holzbaur E, Hammarlund M, Howard J, Ferguson S, Gramlich M, Yogev S. A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans. Developmental Cell 2023, 58: 1847-1863.e12. PMID: 37751746, PMCID: PMC10574138, DOI: 10.1016/j.devcel.2023.08.031.
- Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegansKhazma T, Grossman A, Guez-Haddad J, Feng C, Dabas H, Sain R, Weitman M, Zalk R, Isupov M, Hammarlund M, Hons M, Opatowsky Y. Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Reports 2023, 42: 113026. PMID: 37635352, PMCID: PMC10675840, DOI: 10.1016/j.celrep.2023.113026.
- Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal RegenerationSekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. Cell Reports 2018, 24: 269. PMID: 29972787, DOI: 10.1016/j.celrep.2018.06.079.
- Inhibiting poly(ADP-ribosylation) improves axon regenerationByrne AB, McWhirter RD, Sekine Y, Strittmatter SM, Miller DM, Hammarlund M. Inhibiting poly(ADP-ribosylation) improves axon regeneration. ELife 2016, 5: e12734. PMID: 27697151, PMCID: PMC5050021, DOI: 10.7554/elife.12734.
- Axon regeneration in C. elegans: Worming our way to mechanisms of axon regenerationByrne AB, Hammarlund M. Axon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration. Experimental Neurology 2016, 287: 300-309. PMID: 27569538, PMCID: PMC5136328, DOI: 10.1016/j.expneurol.2016.08.015.
- RNA ligation in neurons by RtcB inhibits axon regenerationKosmaczewski SG, Han SM, Han B, Meyer B, Baig HS, Athar W, Lin-Moore AT, Koelle MR, Hammarlund M. RNA ligation in neurons by RtcB inhibits axon regeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 8451-8456. PMID: 26100902, PMCID: PMC4500288, DOI: 10.1073/pnas.1502948112.
- A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegansLee H, Kim SA, Coakley S, Mugno P, Hammarlund M, Hilliard MA, Lu H. A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegans. Lab On A Chip 2014, 14: 4513-4522. PMID: 25257026, PMCID: PMC4213302, DOI: 10.1039/c4lc00789a.
- The RtcB RNA ligase is an essential component of the metazoan unfolded protein responseKosmaczewski SG, Edwards TJ, Han SM, Eckwahl MJ, Meyer BI, Peach S, Hesselberth JR, Wolin SL, Hammarlund M. The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. EMBO Reports 2014, 15: 1278-1285. PMID: 25366321, PMCID: PMC4264930, DOI: 10.15252/embr.201439531.
- Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone MigrationEdwards TJ, Hammarlund M. Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration. Cell Reports 2014, 8: 272-283. PMID: 25001284, PMCID: PMC4127196, DOI: 10.1016/j.celrep.2014.06.008.
- Axon regeneration in C. elegansHammarlund M, Jin Y. Axon regeneration in C. elegans. Current Opinion In Neurobiology 2014, 27: 199-207. PMID: 24794753, PMCID: PMC4122601, DOI: 10.1016/j.conb.2014.04.001.
- Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neuronsLuo L, Cook N, Venkatachalam V, Martinez-Velazquez LA, Zhang X, Calvo AC, Hawk J, MacInnis BL, Frank M, Ng JH, Klein M, Gershow M, Hammarlund M, Goodman MB, Colón-Ramos DA, Zhang Y, Samuel AD. Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 2776-2781. PMID: 24550307, PMCID: PMC3932917, DOI: 10.1073/pnas.1315205111.
- Insulin/IGF1 Signaling Inhibits Age-Dependent Axon RegenerationByrne AB, Walradt T, Gardner KE, Hubbert A, Reinke V, Hammarlund M. Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration. Neuron 2014, 81: 561-573. PMID: 24440228, PMCID: PMC3924874, DOI: 10.1016/j.neuron.2013.11.019.
- Axon Regeneration Genes Identified by RNAi Screening in C. elegansNix P, Hammarlund M, Hauth L, Lachnit M, Jorgensen EM, Bastiani M. Axon Regeneration Genes Identified by RNAi Screening in C. elegans. Journal Of Neuroscience 2014, 34: 629-645. PMID: 24403161, PMCID: PMC3870940, DOI: 10.1523/jneurosci.3859-13.2014.
- Neuron-Specific Feeding RNAi in C. elegans and Its Use in a Screen for Essential Genes Required for GABA Neuron FunctionFirnhaber C, Hammarlund M. Neuron-Specific Feeding RNAi in C. elegans and Its Use in a Screen for Essential Genes Required for GABA Neuron Function. PLOS Genetics 2013, 9: e1003921. PMID: 24244189, PMCID: PMC3820814, DOI: 10.1371/journal.pgen.1003921.
- Rapid and Permanent Neuronal Inactivation In Vivo via Subcellular Generation of Reactive Oxygen with the Use of KillerRedWilliams DC, Bejjani RE, Ramirez PM, Coakley S, Kim SA, Lee H, Wen Q, Samuel A, Lu H, Hilliard MA, Hammarlund M. Rapid and Permanent Neuronal Inactivation In Vivo via Subcellular Generation of Reactive Oxygen with the Use of KillerRed. Cell Reports 2013, 5: 553-563. PMID: 24209746, PMCID: PMC3877846, DOI: 10.1016/j.celrep.2013.09.023.
- Neural Regeneration in Caenorhabditis elegansBejjani R, Hammarlund M. Neural Regeneration in Caenorhabditis elegans. Annual Review Of Genetics 2012, 46: 499-513. PMID: 22974301, PMCID: PMC3700416, DOI: 10.1146/annurev-genet-110711-155550.
- Notch Signaling Inhibits Axon RegenerationBejjani R, Hammarlund M. Notch Signaling Inhibits Axon Regeneration. Neuron 2012, 73: 268-278. PMID: 22284182, PMCID: PMC3690129, DOI: 10.1016/j.neuron.2011.11.017.
- In vivo Laser Axotomy in C. elegansByrne AB, Edwards TJ, Hammarlund M. In vivo Laser Axotomy in C. elegans. Journal Of Visualized Experiments 2011, 2707. PMID: 21633331, PMCID: PMC3168200, DOI: 10.3791/2707.
- Axon Regeneration Requires a Conserved MAP Kinase PathwayHammarlund M, Nix P, Hauth L, Jorgensen EM, Bastiani M. Axon Regeneration Requires a Conserved MAP Kinase Pathway. Science 2009, 323: 802-806. PMID: 19164707, PMCID: PMC2729122, DOI: 10.1126/science.1165527.
- Mutations in β-Spectrin Disrupt Axon Outgrowth and Sarcomere StructureHammarlund M, Davis W, Jorgensen E. Mutations in β-Spectrin Disrupt Axon Outgrowth and Sarcomere Structure. Journal Of Cell Biology 2000, 149: 931-942. PMID: 10811832, PMCID: PMC2174563, DOI: 10.1083/jcb.149.4.931.