In-Hyun Park, PhD

• Anne Eichmann
• Caihong Qiu
• Ferdi Kiral
• Flora Vaccarino
• Francesc Lopez-Giraldez
• Hai Feng Zhang
• Jenny Huanjiao Zhou
• Joel Gelernter
• Jordan Pober
• Jun Lu
• Kun-Yong Kim
• Mei Zhong
• Micha Sam Brickman Raredon
• Qiao Wu
• Richard Flavell
• Shangqin Guo
• Stephanie Halene
• Yibing Qyang

Cells; Central Nervous System Diseases; Nervous System; Stem Cells; Pluripotent Stem Cells; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Neural Stem Cells; Psychiatry and Psychology

• Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturationSun J, Osenberg S, Irwin A, Ma L, Lee N, Xiang Y, Li F, Wan Y, Park I, Maletic-Savatic M, Ballas N. Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation Cell Reports 2023, 42: 111942. PMID: 36640327, DOI: 10.1016/j.celrep.2022.111942.
• Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinasZhang H, Li B, Huang Q, López-Giráldez F, Tanaka Y, Lin Q, Mehta S, Wang G, Graham M, Liu X, Park I, Eichmann A, Min W, Zhou J. Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas Nature Communications 2022, 13: 7637. PMID: 36496409, PMCID: PMC9741628, DOI: 10.1038/s41467-022-35262-w.
• Advanced in vitro models: Microglia in actionCakir B, Kiral F, Park I. Advanced in vitro models: Microglia in action Neuron 2022, 110: 3444-3457. PMID: 36327894, DOI: 10.1016/j.neuron.2022.10.004.
• A nomenclature consensus for nervous system organoids and assembloidsPașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Muotri AR, Park IH, Reiner O, Song H, Studer L, Temple S, Testa G, Treutlein B, Vaccarino FM. A nomenclature consensus for nervous system organoids and assembloids Nature 2022, 609: 907-910. PMID: 36171373, DOI: 10.1038/s41586-022-05219-6.
• Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell developmentPaniagua S, Cakir B, Hu Y, Kiral FR, Tanaka Y, Xiang Y, Patterson B, Gruen JR, Park IH. Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development Frontiers In Cell And Developmental Biology 2022, 10: 967147. PMID: 36016658, PMCID: PMC9395643, DOI: 10.3389/fcell.2022.967147.
• Human Down syndrome microglia are up for a synaptic feastKiral FR, Park IH. Human Down syndrome microglia are up for a synaptic feast Cell Stem Cell 2022, 29: 1007-1008. PMID: 35803219, DOI: 10.1016/j.stem.2022.06.008.
• Getting the right cellsCakir B, Park IH. Getting the right cells ELife 2022, 11: e80373. PMID: 35770899, PMCID: PMC9246363, DOI: 10.7554/elife.80373.
• Live isolation of naïve ESCs via distinct glucose metabolism and stored glycogenKim KT, Oh JY, Park S, Kim SM, Benjamin P, Park IH, Chun KH, Chang YT, Cha HJ. Live isolation of naïve ESCs via distinct glucose metabolism and stored glycogen Metabolic Engineering 2022, 72: 97-106. PMID: 35283260, DOI: 10.1016/j.ymben.2022.03.003.
• Region Specific Brain Organoids to Study Neurodevelopmental DisordersSusaimanickam PJ, Kiral FR, Park IH. Region Specific Brain Organoids to Study Neurodevelopmental Disorders International Journal Of Stem Cells 2022, 15: 26-40. PMID: 35220290, PMCID: PMC8889336, DOI: 10.15283/ijsc22006.
• Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoidsCakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids Nature Communications 2022, 13: 430. PMID: 35058453, PMCID: PMC8776770, DOI: 10.1038/s41467-022-28043-y.
• Exploration of alcohol use disorder-associated brain miRNA–mRNA regulatory networksLim Y, Beane-Ebel JE, Tanaka Y, Ning B, Husted CR, Henderson DC, Xiang Y, Park IH, Farrer LA, Zhang H. Exploration of alcohol use disorder-associated brain miRNA–mRNA regulatory networks Translational Psychiatry 2021, 11: 504. PMID: 34601489, PMCID: PMC8487426, DOI: 10.1038/s41398-021-01635-w.
• Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblastsCho J, Kim S, Lee H, Rah W, Cho HC, Kim NK, Bae S, Shin DH, Lee MG, Park IH, Tanaka Y, Shin E, Yi H, Han JW, Hwang PTJ, Jun HW, Park HJ, Cho K, Lee SW, Jung JK, Levit RD, Sussman MA, Harvey RP, Yoon YS. Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts Nature Biomedical Engineering 2021, 5: 880-896. PMID: 34426676, PMCID: PMC8809198, DOI: 10.1038/s41551-021-00783-0.
• Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsyKang YJ, Clement EM, Park IH, Greenfield LJ, Smith BN, Lee SH. Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy Experimental Neurology 2021, 342: 113724. PMID: 33915166, PMCID: PMC8192495, DOI: 10.1016/j.expneurol.2021.113724.
• Regional specification and complementation with non-neuroectodermal cells in human brain organoidsTanaka Y, Park IH. Regional specification and complementation with non-neuroectodermal cells in human brain organoids Journal Of Molecular Medicine 2021, 99: 489-500. PMID: 33651139, PMCID: PMC8026433, DOI: 10.1007/s00109-021-02051-9.
• How well do brain organoids capture your brain?Kim J, Sullivan GJ, Park IH. How well do brain organoids capture your brain? IScience 2021, 24: 102063. PMID: 33554067, PMCID: PMC7856464, DOI: 10.1016/j.isci.2021.102063.
• Reprogramming progressive cells display low CAG promoter activityHu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, Eastman AE, Park I, Guo S. Reprogramming progressive cells display low CAG promoter activity Stem Cells 2020, 39: 43-54. PMID: 33075202, PMCID: PMC7821215, DOI: 10.1002/stem.3295.
• Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositionsMcKnight I, Hart C, Park IH, Shim JW. Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions Experimental Neurology 2020, 335: 113523. PMID: 33157092, PMCID: PMC7750280, DOI: 10.1016/j.expneurol.2020.113523.
• Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent ModelNoh JE, Oh SH, Park IH, Song J. Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model Frontiers In Cellular Neuroscience 2020, 14: 546659. PMID: 33100972, PMCID: PMC7546889, DOI: 10.3389/fncel.2020.546659.
• AS132 Scalable small molecule derived mini-liver organoids from human pluripotent stem cellsHarrison S, Siller R, Tanaka Y, Bogen I, Dugarte M, Anderson E, Park I, Sullivan G. AS132 Scalable small molecule derived mini-liver organoids from human pluripotent stem cells Journal Of Hepatology 2020, 73: s91. DOI: 10.1016/s0168-8278(20)30712-1.
• Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous MalformationsWang K, Zhang H, He Y, Jiang Q, Tanaka Y, Park IH, Pober JS, Min W, Zhou HJ. Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: 2171-2186. PMID: 32640906, DOI: 10.1161/atvbaha.120.314586.
• Deconstructing and reconstructing the human brain with regionally specified brain organoidsXiang Y, Cakir B, Park IH. Deconstructing and reconstructing the human brain with regionally specified brain organoids Seminars In Cell And Developmental Biology 2020, 111: 40-51. PMID: 32553582, DOI: 10.1016/j.semcdb.2020.05.023.
• Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant NeuronsXiang Y, Tanaka Y, Patterson B, Hwang SM, Hysolli E, Cakir B, Kim KY, Wang W, Kang YJ, Clement EM, Zhong M, Lee SH, Cho YS, Patra P, Sullivan GJ, Weissman SM, Park IH. Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons Molecular Cell 2020, 79: 84-98.e9. PMID: 32526163, PMCID: PMC7375197, DOI: 10.1016/j.molcel.2020.05.016.
• Generation of Regionally Specified Human Brain Organoids Resembling Thalamus DevelopmentXiang Y, Cakir B, Park IH. Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development STAR Protocols 2020, 1: 100001. PMID: 33103124, PMCID: PMC7580078, DOI: 10.1016/j.xpro.2019.100001.
• Implantation of the clinical‐grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid‐lesioned rodent model of Huntington's diseaseYoon Y, Kim HS, Jeon I, Noh J, Park HJ, Lee S, Park I, Stevanato L, Hicks C, Corteling R, Barker RA, Sinden JD, Song J. Implantation of the clinical‐grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid‐lesioned rodent model of Huntington's disease Stem Cells 2020, 38: 936-947. PMID: 32374064, PMCID: PMC7496241, DOI: 10.1002/stem.3191.
• Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal BrainTanaka Y, Cakir B, Xiang Y, Sullivan GJ, Park IH. Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain Cell Reports 2020, 30: 1682-1689.e3. PMID: 32049002, PMCID: PMC7043376, DOI: 10.1016/j.celrep.2020.01.038.
• Engineering of human brain organoids with a functional vascular-like systemCakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH. Engineering of human brain organoids with a functional vascular-like system Nature Methods 2019, 16: 1169-1175. PMID: 31591580, PMCID: PMC6918722, DOI: 10.1038/s41592-019-0586-5.
• The critical role of persistent sodium current in hippocampal gamma oscillationsKang YJ, Clement EM, Sumsky SL, Xiang Y, Park IH, Santaniello S, Greenfield LJ, Garcia-Rill E, Smith BN, Lee SH. The critical role of persistent sodium current in hippocampal gamma oscillations Neuropharmacology 2019, 162: 107787. PMID: 31550457, PMCID: PMC6952064, DOI: 10.1016/j.neuropharm.2019.107787.
• The RNA exosome nuclease complex regulates human embryonic stem cell differentiationBelair C, Sim S, Kim KY, Tanaka Y, Park IH, , Wolin SL. The RNA exosome nuclease complex regulates human embryonic stem cell differentiation Journal Of Cell Biology 2019, 218: 2564-2582. PMID: 31308215, PMCID: PMC6683745, DOI: 10.1083/jcb.201811148.
• hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical OrganoidsXiang Y, Tanaka Y, Cakir B, Patterson B, Kim KY, Sun P, Kang YJ, Zhong M, Liu X, Patra P, Lee SH, Weissman SM, Park IH. hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids Cell Stem Cell 2019, 24: 487-497.e7. PMID: 30799279, PMCID: PMC6853597, DOI: 10.1016/j.stem.2018.12.015.
• Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain OrganoidsXiang Y, Yoshiaki T, Patterson B, Cakir B, Kim K, Cho YS, Park I. Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids Current Protocols In Stem Cell Biology 2018, 47: e61. PMID: 30854156, PMCID: PMC6402040, DOI: 10.1002/cpsc.61.
• Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1aKim KY, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, Ding J, Jung YW, Kim JH, Hysolli E, Lee H, Dajani R, Kim J, Zhong M, Lee JH, Skalnik D, Lim JM, Sullivan GJ, Wang J, Park IH. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a Nature Communications 2018, 9: 2583. PMID: 29968706, PMCID: PMC6030064, DOI: 10.1038/s41467-018-04818-0.
• Correction to: New Advances in Human X Chromosome Status from a Developmental and Stem Cell BiologyPatterson B, Tanaka Y, Park IH. Correction to: New Advances in Human X Chromosome Status from a Developmental and Stem Cell Biology Tissue Engineering And Regenerative Medicine 2018, 15: 125-125. PMID: 30603540, PMCID: PMC6171639, DOI: 10.1007/s13770-017-0111-9.
• New Advances in Human X Chromosome Status from a Developmental and Stem Cell BiologyPatterson B, Tanaka Y, Park IH. New Advances in Human X Chromosome Status from a Developmental and Stem Cell Biology Tissue Engineering And Regenerative Medicine 2017, 14: 643-652. PMID: 29276809, PMCID: PMC5738034, DOI: 10.1007/s13770-017-0096-4.
• Enhanced Therapeutic and Long-Term Dynamic Vascularization Effects of Human Pluripotent Stem Cell–Derived Endothelial Cells Encapsulated in a Nanomatrix GelLee SJ, Sohn YD, Andukuri A, Kim S, Byun J, Han JW, Park IH, Jun HW, Yoon YS. Enhanced Therapeutic and Long-Term Dynamic Vascularization Effects of Human Pluripotent Stem Cell–Derived Endothelial Cells Encapsulated in a Nanomatrix Gel Circulation 2017, 136: 1939-1954. PMID: 28972000, PMCID: PMC5685906, DOI: 10.1161/circulationaha.116.026329.
• Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron MigrationXiang Y, Tanaka Y, Patterson B, Kang YJ, Govindaiah G, Roselaar N, Cakir B, Kim KY, Lombroso AP, Hwang SM, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee SH, Weissman SM, Park IH. Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration Cell Stem Cell 2017, 21: 383-398.e7. PMID: 28757360, PMCID: PMC5720381, DOI: 10.1016/j.stem.2017.07.007.
• Development of an inducible platform for intercellular protein deliverySiller R, Dufour E, Lycke M, Wilmut I, Jung YW, Park IH, Sullivan GJ. Development of an inducible platform for intercellular protein delivery International Journal Of Pharmaceutics 2017, 522: 1-10. PMID: 28254654, DOI: 10.1016/j.ijpharm.2017.02.067.
• Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cellsHan L, Wu HJ, Zhu H, Kim KY, Marjani SL, Riester M, Euskirchen G, Zi X, Yang J, Han J, Snyder M, Park IH, Irizarry R, Weissman SM, Michor F, Fan R, Pan X. Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells Nucleic Acids Research 2017, 45: gkx026-. PMID: 28126923, PMCID: PMC5605247, DOI: 10.1093/nar/gkx026.
• Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2Lee S, Park C, Han JW, Kim JY, Cho K, Kim EJ, Kim S, Lee SJ, Oh SY, Tanaka Y, Park IH, An HJ, Shin CM, Sharma S, Yoon YS. Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2 Circulation Research 2016, 120: 848-861. PMID: 28003219, PMCID: PMC5336520, DOI: 10.1161/circresaha.116.309833.
• Single cell transcriptomics reveals unanticipated features of early hematopoietic precursorsYang J, Tanaka Y, Seay M, Li Z, Jin J, Garmire LX, Zhu X, Taylor A, Li W, Euskirchen G, Halene S, Kluger Y, Snyder MP, Park IH, Pan X, Weissman SM. Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors Nucleic Acids Research 2016, 45: 1281-1296. PMID: 28003475, PMCID: PMC5388401, DOI: 10.1093/nar/gkw1214.
• Dnmt1 regulates the myogenic lineage specification of muscle stem cellsLiu R, Kim KY, Jung YW, Park IH. Dnmt1 regulates the myogenic lineage specification of muscle stem cells Scientific Reports 2016, 6: 35355. PMID: 27752090, PMCID: PMC5082760, DOI: 10.1038/srep35355.
• Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9Park CY, Sung JJ, Choi SH, Lee DR, Park IH, Kim DW. Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9 Nature Protocols 2016, 11: 2154-2169. PMID: 27711053, DOI: 10.1038/nprot.2016.129.
• Neural Stem Cells Restore Hair Growth through Activation of the Hair Follicle NicheHwang I, Choi KA, Park HS, Jeong H, Kim JO, Seol KC, Kwon HJ, Park IH, Hong S. Neural Stem Cells Restore Hair Growth through Activation of the Hair Follicle Niche Cell Transplantation 2016, 25: 1439-1451. PMID: 27110030, DOI: 10.3727/096368916x691466.
• Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 FamilyHysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH. Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family Stem Cell Reports 2016, 7: 43-54. PMID: 27373925, PMCID: PMC4945581, DOI: 10.1016/j.stemcr.2016.05.014.
• Developing a Model of Human Pluripotent to Hematopoietic Stem Cell Development in Mistrg MiceAstle J, Xiang Y, Rongvaux A, Weibel C, Elizabeth H, Halene S, Park I, Flavell R. Developing a Model of Human Pluripotent to Hematopoietic Stem Cell Development in Mistrg Mice Blood 2015, 126: 4755-4755. DOI: 10.1182/blood.v126.23.4755.4755.
• Histone Deacetylases Positively Regulate Transcription through the Elongation MachineryGreer CB, Tanaka Y, Kim YJ, Xie P, Zhang MQ, Park IH, Kim TH. Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery Cell Reports 2015, 13: 1444-1455. PMID: 26549458, PMCID: PMC4934896, DOI: 10.1016/j.celrep.2015.10.013.
• Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem CellsLee BK, Shen W, Lee J, Rhee C, Chung H, Kim KY, Park IH, Kim J. Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells Cell Reports 2015, 13: 52-60. PMID: 26411691, DOI: 10.1016/j.celrep.2015.08.067.
• Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical NeuronsXiang Y, Kim KY, Gelernter J, Park IH, Zhang H. Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons PLOS ONE 2015, 10: e0134907. PMID: 26266540, PMCID: PMC4534442, DOI: 10.1371/journal.pone.0134907.
• Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient miceAbed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, Tosca L, De Dreuzy E, Paulard A, Granger-Locatelli M, Relouzat F, Prost S, Tachdjian G, Fucharoen S, Daley GQ, Payen E, Chrétien S, Leboulch P, Maouche-Chrétien L. Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice Haematologica 2015, 100: e428-e431. PMID: 26088930, PMCID: PMC4591782, DOI: 10.3324/haematol.2015.127373.
• Transcriptome Signature and Regulation in Human Somatic Cell ReprogrammingTanaka Y, Hysolli E, Su J, Xiang Y, Kim KY, Zhong M, Li Y, Heydari K, Euskirchen G, Snyder MP, Pan X, Weissman SM, Park IH. Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming Stem Cell Reports 2015, 4: 1125-1139. PMID: 26004630, PMCID: PMC4471828, DOI: 10.1016/j.stemcr.2015.04.009.
• Role of Zscan4 in secondary murine iPSC derivation mediated by protein extracts of ESC or iPSCKwon YW, Paek JS, Cho HJ, Lee CS, Lee HJ, Park IH, Roh TY, Kang CM, Yang HM, Park YB, Kim HS. Role of Zscan4 in secondary murine iPSC derivation mediated by protein extracts of ESC or iPSC Biomaterials 2015, 59: 102-115. PMID: 25956855, DOI: 10.1016/j.biomaterials.2015.03.031.
• Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative MiceTucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice PLOS ONE 2015, 10: e0125947. PMID: 25950705, PMCID: PMC4423907, DOI: 10.1371/journal.pone.0125947.
• In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington’s DiseaseJeon I, Choi C, Lee N, Im W, Kim M, Oh SH, Park IH, Kim HS, Song J. In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington’s Disease International Journal Of Stem Cells 2014, 7: 43-47. PMID: 24921027, PMCID: PMC4049731, DOI: 10.15283/ijsc.2014.7.1.43.
• X Chromosome of Female Cells Shows Dynamic Changes in Status during Human Somatic Cell ReprogrammingKim KY, Hysolli E, Tanaka Y, Wang B, Jung YW, Pan X, Weissman SM, Park IH. X Chromosome of Female Cells Shows Dynamic Changes in Status during Human Somatic Cell Reprogramming Stem Cell Reports 2014, 2: 896-909. PMID: 24936474, PMCID: PMC4050354, DOI: 10.1016/j.stemcr.2014.04.003.
• Trivalent Chromatin Marks the Way iNHysolli E, Park IH. Trivalent Chromatin Marks the Way iN Cell Stem Cell 2013, 13: 510-512. PMID: 24209756, PMCID: PMC4665996, DOI: 10.1016/j.stem.2013.10.007.
• Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2)Tanaka Y, Kim KY, Zhong M, Pan X, Weissman SM, Park IH. Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2) Human Molecular Genetics 2013, 23: 1045-1055. PMID: 24129406, PMCID: PMC3900111, DOI: 10.1093/hmg/ddt500.
• An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant HematopoiesisCheng J, Guo S, Chen S, Mastriano SJ, Liu C, D’Alessio A, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J. An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis Cell Reports 2013, 5: 471-481. PMID: 24120864, PMCID: PMC3834864, DOI: 10.1016/j.celrep.2013.08.050.
• Investigation of Rett syndrome using pluripotent stem cellsDajani R, Koo S, Sullivan GJ, Park I. Investigation of Rett syndrome using pluripotent stem cells Journal Of Cellular Biochemistry 2013, 114: 2446-2453. PMID: 23744605, PMCID: PMC3773984, DOI: 10.1002/jcb.24597.
• Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental StrokeChang DJ, Lee N, Park IH, Choi C, Jeon I, Kwon J, Oh SH, Shin DA, Tae J, Lee DR, Lee H, Hong K, Daley G, Song J, Moon H. Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke Cell Transplantation 2013, 22: 1427-1440. PMID: 23044029, DOI: 10.3727/096368912x657314.
• Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells” Science Translational Medicine 2013, 5: 188le2. PMID: 23740897, PMCID: PMC3936961, DOI: 10.1126/scitranslmed.3005065.
• MeCP2 Regulates the Synaptic Expression of a Dysbindin-BLOC-1 Network Component in Mouse Brain and Human Induced Pluripotent Stem Cell-Derived NeuronsLarimore J, Ryder PV, Kim KY, Ambrose LA, Chapleau C, Calfa G, Gross C, Bassell GJ, Pozzo-Miller L, Smith Y, Talbot K, Park IH, Faundez V. MeCP2 Regulates the Synaptic Expression of a Dysbindin-BLOC-1 Network Component in Mouse Brain and Human Induced Pluripotent Stem Cell-Derived Neurons PLOS ONE 2013, 8: e65069. PMID: 23750231, PMCID: PMC3672180, DOI: 10.1371/journal.pone.0065069.
• Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cellsLee JB, Werbowetski-Ogilvie TE, Lee JH, McIntyre BA, Schnerch A, Hong SH, Park IH, Daley GQ, Bernstein ID, Bhatia M. Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells Blood 2013, 122: 1162-1173. PMID: 23733337, DOI: 10.1182/blood-2012-12-471649.
• Pluripotent Stem Cell Models of Shwachman-Diamond Syndrome Reveal a Common Mechanism for Pancreatic and Hematopoietic DysfunctionTulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, Nakamura T, Schlaeger TM, Shimamura A, Daley GQ. Pluripotent Stem Cell Models of Shwachman-Diamond Syndrome Reveal a Common Mechanism for Pancreatic and Hematopoietic Dysfunction Cell Stem Cell 2013, 12: 727-736. PMID: 23602541, PMCID: PMC3755012, DOI: 10.1016/j.stem.2013.04.002.
• Transformation of somatic cells into stem cell‐like cells under a stromal nicheLee ST, Gong SP, Yum KE, Lee EJ, Lee CH, Choi JH, Kim DY, Han H, Kim K, Hysolli E, Ahn JY, Park I, Han JY, Jeong J, Lim JM. Transformation of somatic cells into stem cell‐like cells under a stromal niche The FASEB Journal 2013, 27: 2644-2656. PMID: 23580613, PMCID: PMC4050423, DOI: 10.1096/fj.12-223065.
• Modelling human disease with pluripotent stem cells.Siller R, Greenhough S, Park IH, Sullivan GJ. Modelling human disease with pluripotent stem cells. Current Gene Therapy 2013, 13: 99-110. PMID: 23444871, PMCID: PMC3785403, DOI: 10.2174/1566523211313020004.
• Two methods for full-length RNA sequencing for low quantities of cells and single cellsPan X, Durrett RE, Zhu H, Tanaka Y, Li Y, Zi X, Marjani SL, Euskirchen G, Ma C, LaMotte RH, Park IH, Snyder MP, Mason CE, Weissman SM. Two methods for full-length RNA sequencing for low quantities of cells and single cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 110: 594-599. PMID: 23267071, PMCID: PMC3545756, DOI: 10.1073/pnas.1217322109.
• A Dual Role of Evi-1 During Developmental HematopoiesisKonantz M, Grauer M, Grzywna S, Park I, Daley G, Kanz L, Lengerke C. A Dual Role of Evi-1 During Developmental Hematopoiesis Blood 2012, 120: 765-765. DOI: 10.1182/blood.v120.21.765.765.
• Impact of retrotransposons in pluripotent stem cellsTanaka Y, Chung L, Park IH. Impact of retrotransposons in pluripotent stem cells Molecules And Cells 2012, 34: 509-516. PMID: 23135636, PMCID: PMC3784326, DOI: 10.1007/s10059-012-0242-8.
• Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cellsMacLean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 17567-17572. PMID: 23045682, PMCID: PMC3491455, DOI: 10.1073/pnas.1215468109.
• Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cellsMoon SH, Ban K, Kim C, Kim SS, Byun J, Song MK, Park IH, Yu SP, Yoon YS. Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells International Journal Of Cardiology 2012, 168: 41-52. PMID: 23044428, PMCID: PMC3556195, DOI: 10.1016/j.ijcard.2012.09.077.
• Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patientChae JI, Kim DW, Lee N, Jeon YJ, Jeon I, Kwon J, Kim J, Soh Y, Lee DS, Seo KS, Choi NJ, Park BC, Kang SH, Ryu J, Oh SH, Shin DA, Lee DR, Tae J, Park IH, Daley GQ, Song J. Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient Biochemical Journal 2012, 446: 359-371. PMID: 22694310, DOI: 10.1042/bj20111495.
• Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem CellsGe X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y. Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem Cells Circulation 2012, 126: 1695-1704. PMID: 22914687, PMCID: PMC3586776, DOI: 10.1161/circulationaha.112.116996.
• Neuronal Properties, In Vivo Effects, and Pathology of a Huntington's Disease Patient‐Derived Induced Pluripotent Stem CellsJeon I, Lee N, Li J, Park I, Park KS, Moon J, Shim SH, Choi C, Chang D, Kwon J, Oh S, Shin DA, Kim HS, Tae J, Lee DR, Kim M, Kang K, Daley GQ, Brundin P, Song J. Neuronal Properties, In Vivo Effects, and Pathology of a Huntington's Disease Patient‐Derived Induced Pluripotent Stem Cells Stem Cells 2012, 30: 2054-2062. PMID: 22628015, DOI: 10.1002/stem.1135.
• Cellular reprogramming: a novel tool for investigating autism spectrum disordersKim KY, Jung YW, Sullivan GJ, Chung L, Park IH. Cellular reprogramming: a novel tool for investigating autism spectrum disorders Trends In Molecular Medicine 2012, 18: 463-471. PMID: 22771169, PMCID: PMC3785941, DOI: 10.1016/j.molmed.2012.06.002.
• Excision of a Viral Reprogramming Cassette by Delivery of Synthetic Cre mRNALoh Y, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park I, Daley GQ. Excision of a Viral Reprogramming Cassette by Delivery of Synthetic Cre mRNA Current Protocols In Stem Cell Biology 2012, 21: 4a.5.1-4a.5.16. PMID: 22605648, PMCID: PMC3397830, DOI: 10.1002/9780470151808.sc04a05s21.
• Role of Pluripotent Stem Cells in Regenerative MedicineHay D, Hysolli E, Zhou X, Liu R, Kim J, Adams B, Sullivan G, Park I. Role of Pluripotent Stem Cells in Regenerative Medicine 2012, 21-37. DOI: 10.1201/b11937-4.
• Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) using retroviral vector with GFP.Kim KY, Hysolli E, Park IH. Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) using retroviral vector with GFP. Journal Of Visualized Experiments 2012 PMID: 22491226, PMCID: PMC3466658, DOI: 10.3791/3804.
• Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells (iPSCs) Using Retroviral Vector with GFPKim K, Hysolli E, Park I. Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells (iPSCs) Using Retroviral Vector with GFP Journal Of Visualized Experiments 2012 DOI: 10.3791/3804-v.
• Human induced pluripotent stem cells and neurodegenerative diseaseJung YW, Hysolli E, Kim KY, Tanaka Y, Park IH. Human induced pluripotent stem cells and neurodegenerative disease Current Opinion In Neurology 2012, 25: 125-130. PMID: 22357218, PMCID: PMC3786112, DOI: 10.1097/wco.0b013e3283518226.
• Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerabilityBilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 5803-5808. PMID: 22451909, PMCID: PMC3326463, DOI: 10.1073/pnas.1202922109.
• Humanized murine model for HBV and HCV using human induced pluripotent stem cellsZhou XL, Sullivan GJ, Sun P, Park IH. Humanized murine model for HBV and HCV using human induced pluripotent stem cells Archives Of Pharmacal Research 2012, 35: 261-269. PMID: 22370780, PMCID: PMC3731984, DOI: 10.1007/s12272-012-0206-8.
• Overcoming reprogramming resistance of Fanconi anemia cellsMüller LU, Milsom MD, Harris CE, Vyas R, Brumme KM, Parmar K, Moreau LA, Schambach A, Park IH, London WB, Strait K, Schlaeger T, DeVine AL, Grassman E, D'Andrea A, Daley GQ, Williams DA. Overcoming reprogramming resistance of Fanconi anemia cells Blood 2012, 119: 5449-5457. PMID: 22371882, PMCID: PMC3369681, DOI: 10.1182/blood-2012-02-408674.
• The lesser known story of X chromosome reactivationHysolli E, Tanaka Y, Kim K, Jung Y, Park IH. The lesser known story of X chromosome reactivation Cell Cycle 2012, 11: 229-235. PMID: 22234239, PMCID: PMC3293375, DOI: 10.4161/cc.11.2.18998.
• Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nature Biotechnology 2011, 29: 1132-44. PMID: 22119741, PMCID: PMC3454460, DOI: 10.1038/nbt.2051.
• Evi-1 Regulates Myelopoiesis and Hematopoietic Stem Cell Development in Zebrafish and Human Pluripotent Stem CellsKonantz M, Grauer M, Grzywna S, Brugman M, Kanz L, Park I, Daley G, Baum C, Lengerke C. Evi-1 Regulates Myelopoiesis and Hematopoietic Stem Cell Development in Zebrafish and Human Pluripotent Stem Cells Blood 2011, 118: 1281-1281. DOI: 10.1182/blood.v118.21.1281.1281.
• Gene-Correction Rescues Reprogramming of Fanconi Anemia Fibroblasts and Enables Hematopoietic Differentiation of FA Induced Pluripotent Stem Cells in Vitro and In VivoMueller L, Milsom M, Harris C, Vyas R, Brumme K, Parmar K, Schambach A, Grassman E, Park I, Wendy L, Strait K, Schlaeger T, Devine A, D'Andrea A, Daley G, Williams D. Gene-Correction Rescues Reprogramming of Fanconi Anemia Fibroblasts and Enables Hematopoietic Differentiation of FA Induced Pluripotent Stem Cells in Vitro and In Vivo Blood 2011, 118: 672-672. DOI: 10.1182/blood.v118.21.672.672.
• Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent CellsMacLean G, Menne T, Park I, Daley G, Orkin S. Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells Blood 2011, 118: 921-921. DOI: 10.1182/blood.v118.21.921.921.
• Cell cycle adaptations of embryonic stem cellsBallabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW. Cell cycle adaptations of embryonic stem cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 19252-19257. PMID: 22084091, PMCID: PMC3228440, DOI: 10.1073/pnas.1116794108.
• Research highlights.Jung YW, Park IH. Research highlights. Regenerative Medicine 2011, 6: 685-7. PMID: 22050520, DOI: 10.2217/rme.11.96.
• Research HighlightsJung Y, Park I. Research Highlights Regenerative Medicine 2011, 6: 685-687. DOI: 10.2217/rme.11.96.
• Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndromeKim KY, Hysolli E, Park IH. Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14169-14174. PMID: 21807996, PMCID: PMC3161557, DOI: 10.1073/pnas.1018979108.
• Induced pluripotent stem cell models from X‐linked adrenoleukodystrophy patientsJang J, Kang H, Kim H, Kim JY, Huh YJ, Kim D, Yoo J, Lee J, Lim B, Lee J, Yoon T, Park I, Hwang D, Daley GQ, Kim D. Induced pluripotent stem cell models from X‐linked adrenoleukodystrophy patients Annals Of Neurology 2011, 70: 402-409. PMID: 21721033, DOI: 10.1002/ana.22486.
• Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative MiceTucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice PLOS ONE 2011, 6: e18992. PMID: 21559507, PMCID: PMC3084746, DOI: 10.1371/journal.pone.0018992.
• Induced pluripotent stem cells for neural tissue engineeringWang A, Tang Z, Park IH, Zhu Y, Patel S, Daley GQ, Li S. Induced pluripotent stem cells for neural tissue engineering Biomaterials 2011, 32: 5023-5032. PMID: 21514663, PMCID: PMC3100451, DOI: 10.1016/j.biomaterials.2011.03.070.
• Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cellsNostro M, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef S, Park I, Basford C, Wheeler M, Daley G, Elefanty A, Stanley E, Keller G. Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells Development 2011, 138: 1445-1445. PMCID: PMC3264773, DOI: 10.1242/dev.065904.
• Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cellsNostro M, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef S, Park I, Basford C, Wheeler M, Daley G, Elefanty A, Stanley E, Keller G. Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells Journal Of Cell Science 2011, 124: e1-e1. DOI: 10.1242/jcs.087957.
• Analysis of Differential Proteomes of Induced Pluripotent Stem Cells by Protein-Based Reprogramming of FibroblastsJin J, Kwon YW, Paek JS, Cho HJ, Yu J, Lee JY, Chu IS, Park IH, Park YB, Kim HS, Kim Y. Analysis of Differential Proteomes of Induced Pluripotent Stem Cells by Protein-Based Reprogramming of Fibroblasts Journal Of Proteome Research 2011, 10: 977-989. PMID: 21175196, DOI: 10.1021/pr100624f.
• Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cellsNostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G. Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells Development 2011, 138: 861-871. PMID: 21270052, PMCID: PMC3035090, DOI: 10.1242/dev.055236.
• Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficienciesPessach IM, Ordovas-Montanes J, Zhang SY, Casanova JL, Giliani S, Gennery AR, Al-Herz W, Manos PD, Schlaeger TM, Park IH, Rucci F, Agarwal S, Mostoslavsky G, Daley GQ, Notarangelo LD. Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies Journal Of Allergy And Clinical Immunology 2010, 127: 1400-1407.e4. PMID: 21185069, PMCID: PMC3081993, DOI: 10.1016/j.jaci.2010.11.008.
• MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell StatesNeveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS. MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States Cell Stem Cell 2010, 7: 671-681. PMID: 21112562, DOI: 10.1016/j.stem.2010.11.012.
• Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cellsLoewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL. Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells Nature Genetics 2010, 42: 1113-1117. PMID: 21057500, PMCID: PMC3040650, DOI: 10.1038/ng.710.
• Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)Tolar J, Park IH, Xia L, Lees CJ, Peacock B, Webber B, McElmurry RT, Eide CR, Orchard PJ, Kyba M, Osborn MJ, Lund TC, Wagner JE, Daley GQ, Blazar BR. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome) Blood 2010, 117: 839-847. PMID: 21037085, PMCID: PMC3035077, DOI: 10.1182/blood-2010-05-287607.
• Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular MechanismsNi Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS. Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms Journal Of Virology 2010, 85: 43-50. PMID: 20962093, PMCID: PMC3014194, DOI: 10.1128/jvi.01774-10.
• Five classic articles in somatic cell reprogramming.Park IH. Five classic articles in somatic cell reprogramming. The Yale Journal Of Biology And Medicine 2010, 83: 135-7. PMID: 20885901, PMCID: PMC2946127.
• Research highlights.Gaines P, Liu R, Park IH. Research highlights. Regenerative Medicine 2010, 5: 501-3. PMID: 20632853, DOI: 10.2217/rme.10.47.
• Reprogramming of T Cells from Human Peripheral BloodLoh YH, Hartung O, Li H, Guo C, Sahalie JM, Manos PD, Urbach A, Heffner GC, Grskovic M, Vigneault F, Lensch MW, Park IH, Agarwal S, Church GM, Collins JJ, Irion S, Daley GQ. Reprogramming of T Cells from Human Peripheral Blood Cell Stem Cell 2010, 7: 15-19. PMID: 20621044, PMCID: PMC2913590, DOI: 10.1016/j.stem.2010.06.004.
• Erratum to: Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation PropensityKim D, Lee J, Leem J, Huh Y, Kim J, Kim H, Park I, Daley G, Hwang D, Kim D. Erratum to: Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation Propensity Stem Cell Reviews And Reports 2010, 6: 334-334. DOI: 10.1007/s12015-010-9151-4.
• Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation PropensityKim DS, Lee JS, Leem JW, Huh YJ, Kim JY, Kim HS, Park IH, Daley GQ, Hwang DY, Kim DW. Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation Propensity Stem Cell Reviews And Reports 2010, 6: 270-281. PMID: 20376579, DOI: 10.1007/s12015-010-9138-1.
• Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patientsAgarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients Nature 2010, 464: 292-296. PMID: 20164838, PMCID: PMC3058620, DOI: 10.1038/nature08792.
• DYS-HAC-iPS Cells: The Combination of Gene and Cell Therapy to Treat Duchenne Muscular DystrophyPark IH. DYS-HAC-iPS Cells: The Combination of Gene and Cell Therapy to Treat Duchenne Muscular Dystrophy Molecular Therapy 2010, 18: 238-240. PMID: 20125163, PMCID: PMC2839312, DOI: 10.1038/mt.2009.303.
• Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cellsGrigoriadis AE, Kennedy M, Bozec A, Brunton F, Stenbeck G, Park IH, Wagner EF, Keller GM. Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells Blood 2010, 115: 2769-2776. PMID: 20065292, PMCID: PMC2854424, DOI: 10.1182/blood-2009-07-234690.
• The Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (. Evi-1) gene Regulates Zebrafish Embryonic Blood Development.Konantz M, Brugman M, Park I, Daley G, Nuesslein-Volhard C, Baum C, Lengerke C. The Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (. Evi-1) gene Regulates Zebrafish Embryonic Blood Development. Blood 2009, 114: 1461-1461. DOI: 10.1182/blood.v114.22.1461.1461.
• Hematopoietic Development From Human Induced Pluripotent Stem Cells.Grauer M, Konantz M, Niebuhr N, Kanz L, Park I, Daley G, Lengerke C. Hematopoietic Development From Human Induced Pluripotent Stem Cells. Blood 2009, 114: 2530-2530. DOI: 10.1182/blood.v114.22.2530.2530.
• Natural Killer Cells Derived From Human Pluripotent Stem Cells Provide a Novel Method to Treat HIV-1 Infection.Ni Z, Knorr D, Clouser C, Southern P, Mansky L, Park I, Kaufman D. Natural Killer Cells Derived From Human Pluripotent Stem Cells Provide a Novel Method to Treat HIV-1 Infection. Blood 2009, 114: 280-280. DOI: 10.1182/blood.v114.22.280.280.
• Telomere Elongation in Dyskeratosis Congenita Induced Pluripotent Stem Cells.Agarwal S, Loh Y, McLoughlin E, Huang J, Park I, Miller J, Huo H, Okuka M, Reis R, Loewer S, Keefe D, Goldman F, Klingelhutz A, Liu L, Daley G. Telomere Elongation in Dyskeratosis Congenita Induced Pluripotent Stem Cells. Blood 2009, 114: 497-497. DOI: 10.1182/blood.v114.22.497.497.
• A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem CellsLee JH, Park IH, Gao Y, Li JB, Li Z, Daley GQ, Zhang K, Church GM. A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells PLOS Genetics 2009, 5: e1000718. PMID: 19911041, PMCID: PMC2766639, DOI: 10.1371/journal.pgen.1000718.
• Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblastsDoi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ, Feinberg AP. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts Nature Genetics 2009, 41: 1350-1353. PMID: 19881528, PMCID: PMC2958040, DOI: 10.1038/ng.471.
• Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cellsChan EM, Ratanasirintrawoot S, Park IH, Manos PD, Loh YH, Huo H, Miller JD, Hartung O, Rho J, Ince TA, Daley GQ, Schlaeger TM. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells Nature Biotechnology 2009, 27: 1033-1037. PMID: 19826408, DOI: 10.1038/nbt.1580.
• Generation of functional human hepatic endoderm from human induced pluripotent stem cellsSullivan GJ, Hay DC, Park I, Fletcher J, Hannoun Z, Payne CM, Dalgetty D, Black JR, Ross JA, Samuel K, Wang G, Daley GQ, Lee J, Church GM, Forbes SJ, Iredale JP, Wilmut I. Generation of functional human hepatic endoderm from human induced pluripotent stem cells Hepatology 2009, 51: 329-335. PMID: 19877180, PMCID: PMC2799548, DOI: 10.1002/hep.23335.
• Cardiomyocyte Differentiation of Human Induced Pluripotent Stem CellsZwi L, Caspi O, Arbel G, Huber I, Gepstein A, Park IH, Gepstein L. Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells Circulation 2009, 120: 1513-1523. PMID: 19786631, DOI: 10.1161/circulationaha.109.868885.
• Hematopoietic Development from Human Induced Pluripotent Stem CellsLengerke C, Grauer M, Niebuhr NI, Riedt T, Kanz L, Park I, Daley GQ. Hematopoietic Development from Human Induced Pluripotent Stem Cells Annals Of The New York Academy Of Sciences 2009, 1176: 219-227. PMID: 19796250, PMCID: PMC2849804, DOI: 10.1111/j.1749-6632.2009.04606.x.
• A role for Lin28 in primordial germ-cell development and germ-cell malignancyWest JA, Viswanathan SR, Yabuuchi A, Cunniff K, Takeuchi A, Park IH, Sero JE, Zhu H, Perez-Atayde A, Frazier AL, Surani MA, Daley GQ. A role for Lin28 in primordial germ-cell development and germ-cell malignancy Nature 2009, 460: 909-913. PMID: 19578360, PMCID: PMC2729657, DOI: 10.1038/nature08210.
• Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem CellsZou J, Maeder ML, Mali P, Pruett-Miller SM, Thibodeau-Beganny S, Chou BK, Chen G, Ye Z, Park IH, Daley GQ, Porteus MH, Joung JK, Cheng L. Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells Cell Stem Cell 2009, 5: 97-110. PMID: 19540188, PMCID: PMC2720132, DOI: 10.1016/j.stem.2009.05.023.
• Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1 Nature 2009, 459: 1126-1130. PMID: 19458618, PMCID: PMC2724004, DOI: 10.1038/nature08062.
• Correction: Corrigendum: Targeted and genome-scale strategies reveal gene-body methylation signatures in human cellsBall M, Billy Li J, Gao Y, Lee J, LeProust E, Park I, Xie B, Daley G, Church G. Correction: Corrigendum: Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells Nature Biotechnology 2009, 27: 485-485. DOI: 10.1038/nbt0509-485b.
• Targeted and genome-scale strategies reveal gene-body methylation signatures in human cellsBall MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells Nature Biotechnology 2009, 27: 361-368. PMID: 19329998, PMCID: PMC3566772, DOI: 10.1038/nbt.1533.
• Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogrammingDeng J, Shoemaker R, Xie B, Gore A, LeProust EM, Antosiewicz-Bourget J, Egli D, Maherali N, Park IH, Yu J, Daley GQ, Eggan K, Hochedlinger K, Thomson J, Wang W, Gao Y, Zhang K. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming Nature Biotechnology 2009, 27: 353-360. PMID: 19330000, PMCID: PMC2715272, DOI: 10.1038/nbt.1530.
• Generation of induced pluripotent stem cells from human bloodLoh YH, Agarwal S, Park IH, Urbach A, Huo H, Heffner GC, Kim K, Miller JD, Ng K, Daley GQ. Generation of induced pluripotent stem cells from human blood Blood 2009, 113: 5476-5479. PMID: 19299331, PMCID: PMC2689048, DOI: 10.1182/blood-2009-02-204800.
• Human iPS Cell Derivation/ReprogrammingPark I, Daley GQ. Human iPS Cell Derivation/Reprogramming Current Protocols In Stem Cell Biology 2009, 8: 4a.1.1-4a.1.8. PMID: 19170021, DOI: 10.1002/9780470151808.sc04a01s8.
• Patient-Specific Induced Pluripotent Stem Cells in Hurler SyndromeTolar J, Park I, Xia L, Osborn M, McElmurry R, Orchard P, Daley G, Blazar B. Patient-Specific Induced Pluripotent Stem Cells in Hurler Syndrome Blood 2008, 112: 386-386. DOI: 10.1182/blood.v112.11.386.386.
• Regulatory networks define phenotypic classes of human stem cell linesMüller FJ, Laurent LC, Kostka D, Ulitsky I, Williams R, Lu C, Park IH, Rao MS, Shamir R, Schwartz PH, Schmidt NO, Loring JF. Regulatory networks define phenotypic classes of human stem cell lines Nature 2008, 455: 401-405. PMID: 18724358, PMCID: PMC2637443, DOI: 10.1038/nature07213.
• Disease-Specific Induced Pluripotent Stem CellsPark IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-Specific Induced Pluripotent Stem Cells Cell 2008, 134: 877-886. PMID: 18691744, PMCID: PMC2633781, DOI: 10.1016/j.cell.2008.07.041.
• Generation of human-induced pluripotent stem cellsPark IH, Lerou PH, Zhao R, Huo H, Daley GQ. Generation of human-induced pluripotent stem cells Nature Protocols 2008, 3: 1180-1186. PMID: 18600223, DOI: 10.1038/nprot.2008.92.
• Reprogramming of human somatic cells to pluripotency with defined factorsPark IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors Nature 2007, 451: 141-146. PMID: 18157115, DOI: 10.1038/nature06534.
• Debugging cellular reprogrammingPark IH, Daley GQ. Debugging cellular reprogramming Nature Cell Biology 2007, 9: 871-873. PMID: 17671453, DOI: 10.1038/ncb0807-871.
• In vitro generation of germ cells from murine embryonic stem cellsWest JA, Park IH, Daley GQ, Geijsen N. In vitro generation of germ cells from murine embryonic stem cells Nature Protocols 2006, 1: 2026-2036. PMID: 17487192, DOI: 10.1038/nprot.2006.303.
• A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.Bachmann RA, Kim JH, Wu AL, Park IH, Chen J. A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1. The Journal Of Biological Chemistry 2006, 281: 7357-63. PMID: 16407298, DOI: 10.1074/jbc.M512218200.
• Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.Park IH, Erbay E, Nuzzi P, Chen J. Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1. Experimental Cell Research 2005, 309: 211-9. PMID: 15963500, DOI: 10.1016/j.yexcr.2005.05.017.
• Mammalian target of rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation.Park IH, Chen J. Mammalian target of rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation. The Journal Of Biological Chemistry 2005, 280: 32009-17. PMID: 16043480, DOI: 10.1074/jbc.M506120200.
• IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients.Erbay E, Park IH, Nuzzi PD, Schoenherr CJ, Chen J. IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. The Journal Of Cell Biology 2003, 163: 931-6. PMID: 14662739, PMCID: PMC2173600, DOI: 10.1083/jcb.200307158.
• PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.Fang Y, Park IH, Wu AL, Du G, Huang P, Frohman MA, Walker SJ, Brown HA, Chen J. PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Current Biology : CB 2003, 13: 2037-44. PMID: 14653992, DOI: 10.1016/j.cub.2003.11.021.
• Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.Park IH, Bachmann R, Shirazi H, Chen J. Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. The Journal Of Biological Chemistry 2002, 277: 31423-9. PMID: 12087098, DOI: 10.1074/jbc.M204080200.