Evangelos K. Oikonomou, MD, DPhil
Clinical Fellow; Cardiovascular Medicine, Yale School of Medicine
Research & Publications
Biography
News
Coauthors
Selected Publications
- An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized clinical trialsOikonomou E, Thangaraj P, Bhatt D, Ross J, Young L, Krumholz H, Suchard M, Khera R. An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized clinical trials. Npj Digital Medicine 2023, 6: 217. PMID: 38001154, PMCID: PMC10673945, DOI: 10.1038/s41746-023-00963-z.
- Severe aortic stenosis detection by deep learning applied to echocardiographyHolste G, Oikonomou E, Mortazavi B, Coppi A, Faridi K, Miller E, Forrest J, McNamara R, Ohno-Machado L, Yuan N, Gupta A, Ouyang D, Krumholz H, Wang Z, Khera R. Severe aortic stenosis detection by deep learning applied to echocardiography. European Heart Journal 2023, 44: 4592-4604. PMID: 37611002, PMCID: PMC11004929, DOI: 10.1093/eurheartj/ehad456.
- Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trialsOikonomou EK, Spatz ES, Suchard MA, Khera R. Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trials. The Lancet Digital Health 2022, 4: e796-e805. PMID: 36307193, PMCID: PMC9768739, DOI: 10.1016/s2589-7500(22)00170-4.
- A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)Oikonomou EK, Van Dijk D, Parise H, Suchard MA, de Lemos J, Antoniades C, Velazquez EJ, Miller EJ, Khera R. A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST). European Heart Journal 2021, 42: 2536-2548. PMID: 33881513, PMCID: PMC8488385, DOI: 10.1093/eurheartj/ehab223.
- Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical deviceOikonomou EK, Antonopoulos AS, Schottlander D, Marwan M, Mathers C, Tomlins P, Siddique M, Klüner LV, Shirodaria C, Mavrogiannis MC, Thomas S, Fava A, Deanfield J, Channon KM, Neubauer S, Desai MY, Achenbach S, Antoniades C. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovascular Research 2021, 117: 2677-2690. PMID: 34450625, DOI: 10.1093/cvr/cvab286.
- Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT StudyOikonomou EK, Desai MY, Marwan M, Kotanidis CP, Antonopoulos AS, Schottlander D, Channon KM, Neubauer S, Achenbach S, Antoniades C. Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study. Journal Of The American College Of Cardiology 2020, 76: 755-757. PMID: 32762910, DOI: 10.1016/j.jacc.2020.05.078.
- A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiographyOikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal 2019, 40: 3529-3543. PMID: 31504423, PMCID: PMC6855141, DOI: 10.1093/eurheartj/ehz592.
- Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome dataOikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Centeno E, Thomas S, Herdman L, Kotanidis CP, Thomas KE, Griffin BP, Flamm SD, Antonopoulos AS, Shirodaria C, Sabharwal N, Deanfield J, Neubauer S, Hopewell JC, Channon KM, Achenbach S, Antoniades C. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. The Lancet 2018, 392: 929-939. PMID: 30170852, PMCID: PMC6137540, DOI: 10.1016/s0140-6736(18)31114-0.
- Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced CardiotoxicityOikonomou EK, Kokkinidis DG, Kampaktsis PN, Amir EA, Marwick TH, Gupta D, Thavendiranathan P. Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity. JAMA Cardiology 2019, 4: 1007-1018. PMID: 31433450, PMCID: PMC6705141, DOI: 10.1001/jamacardio.2019.2952.
- Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation IndexElnabawi YA, Oikonomou EK, Dey AK, Mancio J, Rodante JA, Aksentijevich M, Choi H, Keel A, Erb-Alvarez J, Teague HL, Joshi AA, Playford MP, Lockshin B, Choi AD, Gelfand JM, Chen MY, Bluemke DA, Shirodaria C, Antoniades C, Mehta NN. Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index. JAMA Cardiology 2019, 4: 885-891. PMID: 31365032, PMCID: PMC6669789, DOI: 10.1001/jamacardio.2019.2589.
- The role of adipose tissue in cardiovascular health and diseaseOikonomou EK, Antoniades C. The role of adipose tissue in cardiovascular health and disease. Nature Reviews Cardiology 2018, 16: 83-99. PMID: 30287946, DOI: 10.1038/s41569-018-0097-6.
- A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and ProgressionOikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.
- Video-Based Kinematic Analysis of Movement Quality in a Phase 3 Clinical Trial of Troriluzole in Adults with Spinocerebellar Ataxia: A Post Hoc AnalysisL’Italien G, Oikonomou E, Khera R, Potashman M, Beiner M, Maclaine G, Schmahmann J, Perlman S, Coric V. Video-Based Kinematic Analysis of Movement Quality in a Phase 3 Clinical Trial of Troriluzole in Adults with Spinocerebellar Ataxia: A Post Hoc Analysis. Neurology And Therapy 2024, 1-15. PMID: 38814532, DOI: 10.1007/s40120-024-00625-6.
- Coronary Plaque Erosion: Epidemiology, Diagnosis, and TreatmentTheofilis P, Vlachakis P, Papanikolaou A, Karakasis P, Oikonomou E, Tsioufis K, Tousoulis D. Coronary Plaque Erosion: Epidemiology, Diagnosis, and Treatment. International Journal Of Molecular Sciences 2024, 25: 5786. PMCID: PMC11171599, DOI: 10.3390/ijms25115786.
- Young and Older Patients with Acute Myocardial Infarction: Differences in Risk Factors and Angiographic CharacteristicsSagris M, Theofilis P, Mistakidou V, Oikonomou E, Tsioufis K, Tousoulis D. Young and Older Patients with Acute Myocardial Infarction: Differences in Risk Factors and Angiographic Characteristics. Hellenic Journal Of Cardiology 2024 PMID: 38734305, DOI: 10.1016/j.hjc.2024.05.008.
- Automated Video-based Characterization of Movement Quality in a Phase III Clinical Trial of Troriluzole in Subjects with Spinocerebellar Ataxia (P6-3.014)Beiner M, Oikonomou E, L’Italien G, Khera R, Potashman M, Schmahmann J, Perlman S, Coric V. Automated Video-based Characterization of Movement Quality in a Phase III Clinical Trial of Troriluzole in Subjects with Spinocerebellar Ataxia (P6-3.014). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205170.
- Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort studyOikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.
- MicroRNAs in Atrial Fibrillation: Mechanisms, Vascular Implications, and Therapeutic PotentialVardas E, Theofilis P, Oikonomou E, Vardas P, Tousoulis D. MicroRNAs in Atrial Fibrillation: Mechanisms, Vascular Implications, and Therapeutic Potential. Biomedicines 2024, 12: 811. PMID: 38672166, PMCID: PMC11048414, DOI: 10.3390/biomedicines12040811.
- CROSS-MODAL VALIDATION OF AN ARTIFICIAL INTELLIGENCE VIDEO-BASED APPROACH FOR THE AUTOMATED RISK STRATIFICATION OF AORTIC STENOSISOikonomou E, Holste G, Nadkarni G, Wang Z, Khera R. CROSS-MODAL VALIDATION OF AN ARTIFICIAL INTELLIGENCE VIDEO-BASED APPROACH FOR THE AUTOMATED RISK STRATIFICATION OF AORTIC STENOSIS. Journal Of The American College Of Cardiology 2024, 83: 1418. DOI: 10.1016/s0735-1097(24)03408-9.
- EVIDENCE FROM RANDOMIZED CONTROLLED TRIAL TO REAL-WORLD PATIENTS USING ELECTRONIC HEALTH RECORD-ADAPTED DIGITAL TWINS: A NOVEL APPLICATION OF GENERATIVE ARTIFICIAL INTELLIGENCEThangaraj P, Shankar S, Oikonomou E, Khera R. EVIDENCE FROM RANDOMIZED CONTROLLED TRIAL TO REAL-WORLD PATIENTS USING ELECTRONIC HEALTH RECORD-ADAPTED DIGITAL TWINS: A NOVEL APPLICATION OF GENERATIVE ARTIFICIAL INTELLIGENCE. Journal Of The American College Of Cardiology 2024, 83: 2340. DOI: 10.1016/s0735-1097(24)04330-4.
- MULTINATIONAL REAL-WORLD EVALUATION OF A MACHINE LEARNING-DERIVED TOOL FOR ANATOMICAL VERSUS FUNCTIONAL TESTING IN SUSPECTED CORONARY ARTERY DISEASEOikonomou E, Aminorroaya A, Dhingra L, Khera R. MULTINATIONAL REAL-WORLD EVALUATION OF A MACHINE LEARNING-DERIVED TOOL FOR ANATOMICAL VERSUS FUNCTIONAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2024, 83: 1357. DOI: 10.1016/s0735-1097(24)03347-3.
- HEART FAILURE RISK PREDICTION USING ARTIFICIAL INTELLIGENCE ON ECG PHOTOS IN LARGE CONTEMPORARY COHORTDhingra L, Sangha V, Aminorroaya A, Camargos A, Oikonomou E, Khera R. HEART FAILURE RISK PREDICTION USING ARTIFICIAL INTELLIGENCE ON ECG PHOTOS IN LARGE CONTEMPORARY COHORT. Journal Of The American College Of Cardiology 2024, 83: 277. DOI: 10.1016/s0735-1097(24)02267-8.
- TRENDS IN KNOWLEDGE OF RISK FACTOR TARGETS AMONG PATIENTS WITH DIABETES MELLITUS IN THE UNITED STATES: A NATIONALLY REPRESENTATIVE STUDYBansal B, Aminorroaya A, Dhingra L, Oikonomou E, Khera R. TRENDS IN KNOWLEDGE OF RISK FACTOR TARGETS AMONG PATIENTS WITH DIABETES MELLITUS IN THE UNITED STATES: A NATIONALLY REPRESENTATIVE STUDY. Journal Of The American College Of Cardiology 2024, 83: 1882. DOI: 10.1016/s0735-1097(24)03872-5.
- Leveraging the Full Potential of Wearable Devices in CardiomyopathiesOikonomou E, Khera R. Leveraging the Full Potential of Wearable Devices in Cardiomyopathies. Journal Of Cardiac Failure 2024 PMID: 38452997, DOI: 10.1016/j.cardfail.2024.02.011.
- The Efficacy of Coronary Sinus Reducer in Patients with Refractory Angina: A Systematic Review and Meta-AnalysisTheofilis P, Vlachakis P, Sagris M, Mantzouranis E, Sakalidis A, Soulaidopoulos S, Chasikidis C, Oikonomou E, Tsioufis K, Tousoulis D. The Efficacy of Coronary Sinus Reducer in Patients with Refractory Angina: A Systematic Review and Meta-Analysis. Reviews In Cardiovascular Medicine 2024, 25: 82. DOI: 10.31083/j.rcm2503082.
- Renal Congestion in Heart Failure: Insights in Novel Diagnostic Modalities.Dimitriadis K, Damianaki A, Bletsa E, Pyrpyris N, Tsioufis P, Theofilis P, Beneki E, Tatakis F, Kasiakogias A, Oikonomou E, Petras D, Siasos G, Aggeli K, Tsioufis K. Renal Congestion in Heart Failure: Insights in Novel Diagnostic Modalities. Cardiology In Review 2024 PMID: 38427026, DOI: 10.1097/crd.0000000000000673.
- Unveiling the Role of Endothelial Dysfunction: A Possible Key to Enhancing Catheter Ablation Success in Atrial FibrillationZakynthinos G, Tsolaki V, Oikonomou E, Pantelidis P, Gialamas I, Kalogeras K, Zakynthinos E, Vavuranakis M, Siasos G. Unveiling the Role of Endothelial Dysfunction: A Possible Key to Enhancing Catheter Ablation Success in Atrial Fibrillation. International Journal Of Molecular Sciences 2024, 25: 2317. PMID: 38396990, PMCID: PMC10889579, DOI: 10.3390/ijms25042317.
- Expression of Circulating miR-21 and -29 and their Association with Myocardial Fibrosis in Hypertrophic Cardiomyopathy.Angelopoulos A, Oikonomou E, Antonopoulos A, Theofilis P, Zisimos K, Katsarou O, Gazouli M, Lazaros G, Papanikolaou P, Siasos G, Tousoulis D, Tsioufis K, Vlachopoulos C. Expression of Circulating miR-21 and -29 and their Association with Myocardial Fibrosis in Hypertrophic Cardiomyopathy. Current Medicinal Chemistry 2024, 31: 3987-3996. PMID: 38299392, DOI: 10.2174/0109298673286017240103073130.
- Biometric contrastive learning for data-efficient deep learning from electrocardiographic imagesSangha V, Khunte A, Holste G, Mortazavi B, Wang Z, Oikonomou E, Khera R. Biometric contrastive learning for data-efficient deep learning from electrocardiographic images. Journal Of The American Medical Informatics Association 2024, 31: 855-865. PMID: 38269618, PMCID: PMC10990541, DOI: 10.1093/jamia/ocae002.
- Silent Myocardial Ischemia: From Pathophysiology to Diagnosis and TreatmentTheofilis P, Antonopoulos A, Sagris M, Papanikolaou A, Oikonomou E, Tsioufis K, Tousoulis D. Silent Myocardial Ischemia: From Pathophysiology to Diagnosis and Treatment. Biomedicines 2024, 12: 259. PMID: 38397860, PMCID: PMC10886642, DOI: 10.3390/biomedicines12020259.
- Targeting the Gut Microbiome to Treat Cardiometabolic DiseaseTheofilis P, Vlachakis P, Oikonomou E, Tsioufis K, Tousoulis D. Targeting the Gut Microbiome to Treat Cardiometabolic Disease. Current Atherosclerosis Reports 2024, 26: 25-34. PMID: 38180642, DOI: 10.1007/s11883-023-01183-2.
- Acute Coronary Syndromes in Women: A Narrative Review of Sex-Specific Characteristics.Theofilis P, Vlachakis P, Mantzouranis E, Sakalidis A, Chrysohoou C, Leontsinis I, Lazaros G, Dimitriadis K, Drakopoulou M, Vordoni A, Oikonomou E, Tsioufis K, Tousoulis D. Acute Coronary Syndromes in Women: A Narrative Review of Sex-Specific Characteristics. Angiology 2023, 33197231218331. PMID: 37995282, DOI: 10.1177/00033197231218331.
- Diabetes Mellitus in Acute Coronary SyndromeStampouloglou P, Anastasiou A, Bletsa E, Lygkoni S, Chouzouri F, Xenou M, Katsarou O, Theofilis P, Zisimos K, Tousoulis D, Vavuranakis M, Siasos G, Oikonomou E. Diabetes Mellitus in Acute Coronary Syndrome. Life 2023, 13: 2226. PMID: 38004366, PMCID: PMC10671950, DOI: 10.3390/life13112226.
- Ultrasonographic assessment and clinical outcomes after deployment of a suture-mediated femoral vascular closure device.Papoutsis D, Mourouzis K, Bozini N, Aznaouridis K, Oikonomou E, Chatzimichael K, Brountzos E, Vavuranakis M, Tsioufis C, Lekakis J, Siasos G, Tousoulis D. Ultrasonographic assessment and clinical outcomes after deployment of a suture-mediated femoral vascular closure device. CardioVascular Journal Of Africa 2023, 34: 1-6. PMID: 38032689, DOI: 10.5830/cvja-2023-054.
- Mid-term outcomes in aortic stenosis patients treated with contemporary balloon expandable and self-expanding valves; does valve size have an impact on outcome?Kalogeras K, Jabbour R, Pracon R, Kabir T, Shannon J, Duncan A, Oikonomou E, Katsianos E, Patel N, Cadiz S, Siasos G, Vavouranakis M, Davies S, Dalby M, Panoulas V. Mid-term outcomes in aortic stenosis patients treated with contemporary balloon expandable and self-expanding valves; does valve size have an impact on outcome? European Heart Journal 2023, 44: ehad655.2224. DOI: 10.1093/eurheartj/ehad655.2224.
- Association of fatty liver with left ventricular concentric remodeling: Insights from the Corinthia studyTheofilis P, Mystakidi V, Goliopoulou A, Papamikroulis G, Lazaros G, Vogiatzi G, Anastasiou M, Tsalamandris S, Vavuranaki G, Korakas E, Lambadiari V, Siasos G, Oikonomou E, Tousoulis D. Association of fatty liver with left ventricular concentric remodeling: Insights from the Corinthia study. European Heart Journal 2023, 44: ehad655.2415. DOI: 10.1093/eurheartj/ehad655.2415.
- The effect of anthracycline-based chemotherapy on endothelial function and arterial stiffness in breast cancer patientsAnastasiou M, Oikonomou E, Theofilis P, Papamikroulis G, Gazouli M, Pesiridis T, Goliopoulou A, Papatheodoridi D, Psyrri A, Zagouri F, Siasos G, Tousoulis D. The effect of anthracycline-based chemotherapy on endothelial function and arterial stiffness in breast cancer patients. European Heart Journal 2023, 44: ehad655.2675. DOI: 10.1093/eurheartj/ehad655.2675.
- Post-coronavirus disease-19: the impact of cardiopulmonary rehabilitation on arterial stiffness, left ventricular deformation, and ventricular-arterial couplingGounaridi M, Vontetsianos A, Oikonomou E, Theofilis P, Chynkiamis N, Lampsas S, Anastasiou A, Papamikroulis G, Kalogeras K, Pesiridis T, Vavuranakis M, Bakakos P, Koulouris N, Siasos G. Post-coronavirus disease-19: the impact of cardiopulmonary rehabilitation on arterial stiffness, left ventricular deformation, and ventricular-arterial coupling. European Heart Journal 2023, 44: ehad655.2601. DOI: 10.1093/eurheartj/ehad655.2601.
- DOACs or warfarin use in morbidly obese patients (BMI > 40 kg/m2) on anticoagulant therapy? : a systematic review and meta-analysisSagris M, Ktenopoulos N, Pamporis K, Theofilis P, Oikonomou E, Tsioufis K, Tousoulis D. DOACs or warfarin use in morbidly obese patients (BMI > 40 kg/m2) on anticoagulant therapy? : a systematic review and meta-analysis. European Heart Journal 2023, 44: ehad655.2537. DOI: 10.1093/eurheartj/ehad655.2537.
- The efficacy of coronary sinus reduction in refractory angina: A meta-analysisTheofilis P, Oikonomou E, Lampsas S, Sagris M, Tsioufis K, Tousoulis D. The efficacy of coronary sinus reduction in refractory angina: A meta-analysis. European Heart Journal 2023, 44: ehad655.1291. DOI: 10.1093/eurheartj/ehad655.1291.
- Predicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiographyOikonomou E, Holste G, Mcnamara R, Velazquez E, Nadkarni G, Ouyang D, Krumholz H, Wang Z, Khera R. Predicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiography. European Heart Journal 2023, 44: ehad655.040. DOI: 10.1093/eurheartj/ehad655.040.
- New-Onset Atrial Fibrillation in the Critically Ill COVID-19 Patients Hospitalized in the Intensive Care UnitZakynthinos G, Tsolaki V, Oikonomou E, Vavouranakis M, Siasos G, Zakynthinos E. New-Onset Atrial Fibrillation in the Critically Ill COVID-19 Patients Hospitalized in the Intensive Care Unit. Journal Of Clinical Medicine 2023, 12: 6989. PMID: 38002603, PMCID: PMC10672690, DOI: 10.3390/jcm12226989.
- Abstract 19045: Detection of Left Ventricular Systolic Dysfunction From PDF Outputs of ECGs Obtained on Wearable DevicesSangha V, Khunte A, Dhingra L, Oikonomou E, Khera R. Abstract 19045: Detection of Left Ventricular Systolic Dysfunction From PDF Outputs of ECGs Obtained on Wearable Devices. Circulation 2023, 148: a19045-a19045. DOI: 10.1161/circ.148.suppl_1.19045.
- Abstract 17074: Development and Multinational Validation of a Machine Learning-Based Optimization for Efficient Screening for Elevated Lipoprotein(a)Aminorroaya A, Dhingra L, Saadatagah S, Spatz E, Oikonomou E, Khera R. Abstract 17074: Development and Multinational Validation of a Machine Learning-Based Optimization for Efficient Screening for Elevated Lipoprotein(a). Circulation 2023, 148: a17074-a17074. DOI: 10.1161/circ.148.suppl_1.17074.
- Abstract 19135: Deep Learning Model for Detection of Conduction Disorders and Arrhythmias From PDF Outputs of Commercially Available Wearable DevicesSangha V, Khunte A, Dhingra L, Oikonomou E, Khera R. Abstract 19135: Deep Learning Model for Detection of Conduction Disorders and Arrhythmias From PDF Outputs of Commercially Available Wearable Devices. Circulation 2023, 148: a19135-a19135. DOI: 10.1161/circ.148.suppl_1.19135.
- Abstract 17128: Detection of Hypertrophic Cardiomyopathy From Noisy Single-Lead ElectrocardiographyKhunte A, Aminorroaya A, Dhingra L, Sangha V, Oikonomou E, Sen S, Krumholz H, Kramer C, Desai M, Khera R. Abstract 17128: Detection of Hypertrophic Cardiomyopathy From Noisy Single-Lead Electrocardiography. Circulation 2023, 148: a17128-a17128. DOI: 10.1161/circ.148.suppl_1.17128.
- Abstract 17106: Comparing Pre- and Post- Pandemic Personal Health Monitoring Using Wearable Devices in United States Adults With or at Risk for Cardiovascular Disease: A Nationally Representative StudyDhingra L, Aminorroaya A, Oikonomou E, Sangha V, Krumholz H, Khera R. Abstract 17106: Comparing Pre- and Post- Pandemic Personal Health Monitoring Using Wearable Devices in United States Adults With or at Risk for Cardiovascular Disease: A Nationally Representative Study. Circulation 2023, 148: a17106-a17106. DOI: 10.1161/circ.148.suppl_1.17106.
- Abstract 17073: Evaluation of Impact of Septal Reduction Therapy on Deep Learning-Based Electrocardiographic Markers Hypertrophic CardiomyopathyDhingra L, Aminorroaya A, Khunte A, Sangha V, Oikonomou E, Sen S, Krumholz H, Kramer C, Desai M, Khera R. Abstract 17073: Evaluation of Impact of Septal Reduction Therapy on Deep Learning-Based Electrocardiographic Markers Hypertrophic Cardiomyopathy. Circulation 2023, 148: a17073-a17073. DOI: 10.1161/circ.148.suppl_1.17073.
- Abstract 15639: An Explainable Machine Learning-Based Phenomapping Strategy for Adaptive Predictive Enrichment in Randomized Controlled Trials of Preventive InterventionsOikonomou E, Thangaraj P, Bhatt D, Ross J, Young L, Krumholz H, Suchard M, Khera R. Abstract 15639: An Explainable Machine Learning-Based Phenomapping Strategy for Adaptive Predictive Enrichment in Randomized Controlled Trials of Preventive Interventions. Circulation 2023, 148: a15639-a15639. DOI: 10.1161/circ.148.suppl_1.15639.
- Machine learning in precision diabetes care and cardiovascular risk predictionOikonomou E, Khera R. Machine learning in precision diabetes care and cardiovascular risk prediction. Cardiovascular Diabetology 2023, 22: 259. PMID: 37749579, PMCID: PMC10521578, DOI: 10.1186/s12933-023-01985-3.
- Use of Smart Devices to Track Cardiovascular Health Goals in the United StatesAminorroaya A, Dhingra L, Nargesi A, Oikonomou E, Krumholz H, Khera R. Use of Smart Devices to Track Cardiovascular Health Goals in the United States. JACC Advances 2023, 2: 100544. PMID: 38094515, PMCID: PMC10718569, DOI: 10.1016/j.jacadv.2023.100544.
- Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devicesKhunte A, Sangha V, Oikonomou E, Dhingra L, Aminorroaya A, Mortazavi B, Coppi A, Brandt C, Krumholz H, Khera R. Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devices. Npj Digital Medicine 2023, 6: 124. PMID: 37433874, PMCID: PMC10336107, DOI: 10.1038/s41746-023-00869-w.
- Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020Dhingra L, Aminorroaya A, Oikonomou E, Nargesi A, Wilson F, Krumholz H, Khera R. Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020. JAMA Network Open 2023, 6: e2316634. PMID: 37285157, PMCID: PMC10248745, DOI: 10.1001/jamanetworkopen.2023.16634.
- Abstract 60: Impact of a Multisite, Protocol-Driven, Nurse Practitioner-Led, Cardiovascular Prevention Program in a Hispanic Medicare Advantage Population at High Risk for ASCVD: Healthy Heart Program at Cano Health.MCCLOSKEY V, Nasir K, Khera R, Oikonomou E, Diaz R, Kenney R, Aguilar R, Gulati M, Cingolani O, Gluckman T, Blankstein R, Hernandez M, Rivera J. Abstract 60: Impact of a Multisite, Protocol-Driven, Nurse Practitioner-Led, Cardiovascular Prevention Program in a Hispanic Medicare Advantage Population at High Risk for ASCVD: Healthy Heart Program at Cano Health. Circulation 2023, 147: a60-a60. DOI: 10.1161/circ.147.suppl_1.60.
- Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes.Oikonomou EK, Suchard MA, McGuire DK, Khera R. Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes. Diabetes Care 2022, 45: 965-974. PMID: 35120199, PMCID: PMC9016734, DOI: 10.2337/dc21-1765.
- Effects of canagliflozin on human myocardial redox signalling: clinical implicationsKondo H, Akoumianakis I, Badi I, Akawi N, Kotanidis CP, Polkinghorne M, Stadiotti I, Sommariva E, Antonopoulos AS, Carena MC, Oikonomou EK, Reus EM, Sayeed R, Krasopoulos G, Srivastava V, Farid S, Chuaiphichai S, Shirodaria C, Channon KM, Casadei B, Antoniades C. Effects of canagliflozin on human myocardial redox signalling: clinical implications. European Heart Journal 2021, 42: 4947-4960. PMID: 34293101, PMCID: PMC8691807, DOI: 10.1093/eurheartj/ehab420.
- Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1574-1582. PMID: 34266986, PMCID: PMC10275580, DOI: 10.3899/jrheum.210040.
- Non-steroidal treatment of cardiac sarcoidosis: A systematic reviewGallegos C, Oikonomou EK, Grimshaw A, Gulati M, Young BD, Miller EJ. Non-steroidal treatment of cardiac sarcoidosis: A systematic review. IJC Heart & Vasculature 2021, 34: 100782. PMID: 33997256, PMCID: PMC8105294, DOI: 10.1016/j.ijcha.2021.100782.
- Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibitionAkoumianakis I, Badi I, Douglas G, Chuaiphichai S, Herdman L, Akawi N, Margaritis M, Antonopoulos AS, Oikonomou EK, Psarros C, Galiatsatos N, Tousoulis D, Kardos A, Sayeed R, Krasopoulos G, Petrou M, Schwahn U, Wohlfart P, Tennagels N, Channon KM, Antoniades C. Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition. Science Translational Medicine 2020, 12 PMID: 32350133, PMCID: PMC7212010, DOI: 10.1126/scitranslmed.aav8824.
- Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular diseaseOikonomou EK, Siddique M, Antoniades C. Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease. Cardiovascular Research 2020, 116: 2040-2054. PMID: 32090243, PMCID: PMC7585409, DOI: 10.1093/cvr/cvaa021.
- Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidasesAkoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science Translational Medicine 2019, 11 PMID: 31534019, PMCID: PMC7212031, DOI: 10.1126/scitranslmed.aav5055.
- Cardiac Computed TomographyOikonomou EK, West HW, Antoniades C. Cardiac Computed Tomography. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 2207-2219. PMID: 31510795, DOI: 10.1161/atvbaha.119.312899.
- Perivascular adipose tissue and coronary atherosclerosisMancio J, Oikonomou EK, Antoniades C. Perivascular adipose tissue and coronary atherosclerosis. Heart 2018, 104: 1654. PMID: 29853488, DOI: 10.1136/heartjnl-2017-312324.
- Stem Cell Therapy for Congenital Heart DiseaseTsilimigras DI, Oikonomou EK, Moris D, Schizas D, Economopoulos KP, Mylonas KS. Stem Cell Therapy for Congenital Heart Disease. Circulation 2017, 136: 2373-2385. PMID: 29229621, DOI: 10.1161/circulationaha.117.029607.
- Detecting human coronary inflammation by imaging perivascular fatAntonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Science Translational Medicine 2017, 9 PMID: 28701474, DOI: 10.1126/scitranslmed.aal2658.
- Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stressMargaritis M, Sanna F, Lazaros G, Akoumianakis I, Patel S, Antonopoulos AS, Duke C, Herdman L, Psarros C, Oikonomou EK, Shirodaria C, Petrou M, Sayeed R, Krasopoulos G, Lee R, Tousoulis D, Channon KM, Antoniades C. Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. European Heart Journal 2017, 38: 3094-3104. PMID: 28444175, PMCID: PMC5837455, DOI: 10.1093/eurheartj/ehx177.
- Abstract 15265: Clopidogrel Response Variability is Associated With Endothelial Dysfunction in Coronary Artery Disease Patients Receiving Dual Antiplatelet TherapyOikonomou E, Siasos G, Zaromitidou M, Maniatis K, Mourouzis K, Kokkou E, Antonopoulos A, Zografos T, Tsalamandris S, Dimitropoulos S, Zisimos K, Kioufis S, Papavasiliou A, Tousoulis D. Abstract 15265: Clopidogrel Response Variability is Associated With Endothelial Dysfunction in Coronary Artery Disease Patients Receiving Dual Antiplatelet Therapy. Circulation 2015, 132 DOI: 10.1161/circ.132.suppl_3.15265.
- Abstract 9993: Friedreich Ataxia is Associated with Endothelial Dysfunction and Increased Arterial StiffnessSiasos G, Gialafos E, Tousoulis D, Oikonomou E, Michalea S, Kollia C, Aggeli C, Maniatis K, Paraskevopoulos T, Zisimos K, Kioufis S, Papavassiliou A, Stefanadis C. Abstract 9993: Friedreich Ataxia is Associated with Endothelial Dysfunction and Increased Arterial Stiffness. Circulation 2011, 124 DOI: 10.1161/circ.124.suppl_21.a9993.