Carolyn Fredericks, MD

• Andrés S Martin
• Angus Nairn
• Christopher van Dyck
• Hilary Blumberg
• James Duncan
• Joel Gelernter
• Lara Chepenik
• Lawrence Staib
• Todd Constable
• Xilin Shen

Alzheimer Disease; Magnetic Resonance Imaging; Neuroimaging; Functional Neuroimaging; Positron Emission Tomography Computed Tomography

• Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performanceJu S, Horien C, Shen X, Abuwarda H, Trainer A, Constable R, Fredericks C. Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance Frontiers In Dementia 2023, 2: 1126016. DOI: 10.3389/frdem.2023.1126016.
• Sex differences in default mode network connectivity in healthy aging adults.Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.
• A Professional Musician with Sight‐Reading Difficulties: A Case StudyTun S, Ficek‐Tani B, Frolov A, Sharp E, Fredericks C. A Professional Musician with Sight‐Reading Difficulties: A Case Study Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.059696.
• Robust prediction of memory and neuroticism in men and women using connectome‐based predictive modelingJu S, Horien C, Constable T, Fredericks C. Robust prediction of memory and neuroticism in men and women using connectome‐based predictive modeling Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.063015.
• Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s diseaseWilson E, Young C, Ramos Benitez J, Swarovski M, Feinstein I, Vandijck M, Le Guen Y, Kasireddy N, Shahid M, Corso N, Wang Q, Kennedy G, Trelle A, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis M, Le Bastard N, Quinn J, van Dyck C, Nairn A, Fredericks C, Tian L, Kerchner G, Montine T, Sha S, Davidzon G, Henderson V, Longo F, Greicius M, Wagner A, Wyss-Coray T, Poston K, Mormino E, Andreasson K. Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease Alzheimer's Research & Therapy 2022, 14: 172. PMID: 36371232, PMCID: PMC9652927, DOI: 10.1186/s13195-022-01116-2.
• Short-term exposure to PM2.5 and daily all-cause dementia and Alzheimer´s disease mortality in Connecticut: a time-stratified case-crossover studyLin C, Goddard E, Chan K, Ma Y, Di Q, Fredericks C, Chen K. Short-term exposure to PM2.5 and daily all-cause dementia and Alzheimer´s disease mortality in Connecticut: a time-stratified case-crossover study ISEE Conference Abstracts 2022, 2022 DOI: 10.1289/isee.2022.p-0045.
• Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum DisordersNapolioni V, Fredericks CA, Kim Y, Channappa D, Khan RR, Kim LH, Zafar F, Couthouis J, Davidzon GA, Mormino EC, Gitler AD, Montine TJ, Schüle B, Greicius MD. Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders Biomedicines 2022, 10: 160. PMID: 35052839, PMCID: PMC8774039, DOI: 10.3390/biomedicines10010160.
• Sex differences in connectivity in the default mode network in healthy aging adultsFicek B, Horien C, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in connectivity in the default mode network in healthy aging adults Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056050.
• Methylphenidate for Apathy in Alzheimer Disease—Why Should We Care?Fredericks C. Methylphenidate for Apathy in Alzheimer Disease—Why Should We Care? JAMA Neurology 2021, 78: 1311-1313. PMID: 34570178, DOI: 10.1001/jamaneurol.2021.2942.
• Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease.Trelle AN, Carr VA, Wilson EN, Swarovski MS, Hunt MP, Toueg TN, Tran TT, Channappa D, Corso NK, Thieu MK, Jayakumar M, Nadiadwala A, Guo W, Tanner NJ, Bernstein JD, Litovsky CP, Guerin SA, Khazenzon AM, Harrison MB, Rutt BK, Deutsch GK, Chin FT, Davidzon GA, Hall JN, Sha SJ, Fredericks CA, Andreasson KI, Kerchner GA, Wagner AD, Mormino EC. Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease. Neurology 2021, 96: e1470-e1481. PMID: 33408146, PMCID: PMC8055319, DOI: 10.1212/wnl.0000000000011477.
• Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseasesMormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, Fredericks CA, Koran ME, Zeineh M, Poston K, Greicius MD, Khalighi M, Davidzon GA, Shen B, Zaharchuk G, Wagner AD, Chin FT. Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 2233-2244. PMID: 32572562, PMCID: PMC7755737, DOI: 10.1007/s00259-020-04923-7.
• Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adultsTrelle AN, Carr VA, Guerin SA, Thieu MK, Jayakumar M, Guo W, Nadiadwala A, Corso NK, Hunt MP, Litovsky CP, Tanner NJ, Deutsch GK, Bernstein JD, Harrison MB, Khazenzon AM, Jiang J, Sha SJ, Fredericks CA, Rutt BK, Mormino EC, Kerchner GA, Wagner AD. Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults ELife 2020, 9: e55335. PMID: 32469308, PMCID: PMC7259949, DOI: 10.7554/elife.55335.
• P4‐576: CONCORDANCE BETWEEN 18F‐PI‐2620 TAU PET/MRI IMAGING AND CLINICAL OUTCOMES IN ALZHEIMER DISEASE AND OTHER TAUOPATHIESKoran M, Davidzon G, Azevedo C, Toueg T, Nadiadwala A, Castillo J, Hall J, Sha S, Fredericks C, Greicius M, Wagner A, Zaharchuk G, Chin F, Mormino E. P4‐576: CONCORDANCE BETWEEN 18F‐PI‐2620 TAU PET/MRI IMAGING AND CLINICAL OUTCOMES IN ALZHEIMER DISEASE AND OTHER TAUOPATHIES Alzheimer's & Dementia 2019, 15: p1541-p1541. DOI: 10.1016/j.jalz.2019.08.124.
• Relative preservation of facial expression recognition in posterior cortical atrophy.Pressman PS, Gola K, Shdo SM, Miller BL, Fredericks C, Mielke C, Pelak V, Rankin KP. Relative preservation of facial expression recognition in posterior cortical atrophy. Neurology 2019, 92: e1064-e1071. PMID: 30760634, PMCID: PMC6442010, DOI: 10.1212/wnl.0000000000007075.
• Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?Fredericks CA, Brown JA, Deng J, Kramer A, Ossenkoppele R, Rankin K, Kramer JH, Miller BL, Rabinovici GD, Seeley WW. Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar? NeuroImage Clinical 2018, 21: 101628. PMID: 30528957, PMCID: PMC6411779, DOI: 10.1016/j.nicl.2018.101628.
• P4‐322: THE CONTRIBUTION OF EARLY ALZHEIMER'S DISEASE MARKERS TO INDIVIDUAL DIFFERENCES IN EPISODIC MEMORY IN COGNITIVELY NORMAL OLDER ADULTSTrelle A, Bernstein J, Carr V, Deutsch G, Fredericks C, Guerin S, Guo W, Harrison M, Jayakumar M, Jiang J, Kerchner G, Khazhenzon A, Litovsky C, Mormino B, Nadiadwala A, Sha S, Tanner N, Thieu M, Wagner A. P4‐322: THE CONTRIBUTION OF EARLY ALZHEIMER'S DISEASE MARKERS TO INDIVIDUAL DIFFERENCES IN EPISODIC MEMORY IN COGNITIVELY NORMAL OLDER ADULTS Alzheimer's & Dementia 2018, 14: p1585-p1585. DOI: 10.1016/j.jalz.2018.07.145.
• P4‐315: TAU PET IMAGING WITH 18F‐PI2620 IN AGING AND ALZHEIMER'S DISEASEMormino E, Nadiadwala A, Azevedo C, Guo W, Castillo J, Hall J, Trelle A, Sha S, Jayakumar M, Tanner N, Harrison M, Deutsch G, Fredericks C, Greicius M, Srinivas S, James M, Zaharchuk G, Wagner A, Chin F. P4‐315: TAU PET IMAGING WITH 18F‐PI2620 IN AGING AND ALZHEIMER'S DISEASE Alzheimer's & Dementia 2018, 14: p1577-p1578. DOI: 10.1016/j.jalz.2018.07.138.
• Early affective changes and increased connectivity in preclinical Alzheimer's diseaseFredericks CA, Sturm VE, Brown JA, Hua AY, Bilgel M, Wong DF, Resnick SM, Seeley WW. Early affective changes and increased connectivity in preclinical Alzheimer's disease Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2018, 10: 471-479. PMID: 30302368, PMCID: PMC6174255, DOI: 10.1016/j.dadm.2018.06.002.
• [P2–388]: INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR?Fredericks C, Brown J, Deng J, Ossenkoppele R, Rankin K, Kramer J, Miller B, Rabinovici G, Seeley W. [P2–388]: INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR? Alzheimer's & Dementia 2017, 13: p778-p778. DOI: 10.1016/j.jalz.2017.06.1043.
• [IC‐P‐031]: INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR?Fredericks C, Brown J, Deng J, Ossenkoppele R, Rankin K, Kramer J, Miller B, Rabinovici G, Seeley W. [IC‐P‐031]: INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR? Alzheimer's & Dementia 2017, 13: p28-p29. DOI: 10.1016/j.jalz.2017.06.2303.
• Primary chronic traumatic encephalopathy in an older patient with late-onset AD phenotypeFredericks CA, Koestler M, Seeley W, Miller B, Boxer A, Grinberg LT. Primary chronic traumatic encephalopathy in an older patient with late-onset AD phenotype Neurology Clinical Practice 2015, 5: 475-479. PMID: 26716062, PMCID: PMC4684670, DOI: 10.1212/cpj.0000000000000161.
• Predicting success: What medical student measures predict resident performance in neurology?Burish MJ, Fredericks CA, Engstrom JW, Tateo VL, Josephson SA. Predicting success: What medical student measures predict resident performance in neurology? Clinical Neurology And Neurosurgery 2015, 135: 69-72. PMID: 26038279, DOI: 10.1016/j.clineuro.2015.05.007.
• A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumabFredericks C, Kvam K, Bear J, Crabtree G, Josephson. A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab Lupus 2014, 23: 711-713. PMID: 24531080, DOI: 10.1177/0961203314524292.
• Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala–anterior paralimbic neural systemBlond BN, Fredericks CA, Blumberg HP. Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala–anterior paralimbic neural system Bipolar Disorders 2012, 14: 340-355. PMID: 22631619, PMCID: PMC3880745, DOI: 10.1111/j.1399-5618.2012.01015.x.
• Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditionsFredericks CA, Drabant EM, Edge MD, Tillie JM, Hallmayer J, Ramel W, Kuo JR, Mackey S, Gross JJ, Dhabhar FS. Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions Brain Behavior And Immunity 2009, 24: 350-357. PMID: 19883751, PMCID: PMC2826575, DOI: 10.1016/j.bbi.2009.10.014.
• Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar DisorderChepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.
• The role of the ventral prefrontal cortex in mood disordersFredericks C, Kalmar J, Blumberg H. The role of the ventral prefrontal cortex in mood disorders 2006, 545-578. DOI: 10.1093/acprof:oso/9780198565741.003.0021.
• Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorderBlumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder Bipolar Disorders 2005, 7: 570-576. PMID: 16403182, PMCID: PMC2291299, DOI: 10.1111/j.1399-5618.2005.00264.x.
• A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal CorticesBlumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.