Skip to Main Content

Todd Constable, PhD

Elizabeth Mears and House Jameson Professor of Radiology and Biomedical Imaging and Professor of Neurosurgery; Director MRI Research

Contact Information

Todd Constable, PhD

Research Summary

My research is focused on developing and validating novel approaches to functional Magnetic Resonance Imaging (fMRI) and using these methods to improve our understanding of brain function. This work includes approaches for quantitative neuroimaging and methods for assessing brain function via connectivity mapping. These developments are applied in the neurosurgical environment to localizing epileptogenic tissue and mapping function prior to surgical intervention. These studies provide a framework for validating the fMRI techniques through comparisons with cortical stimulation, behavioral analyses, Wada testing, and patient outcomes. They also improve our understanding of the link between fMRI signal changes and neuronal activity, through comparisons of fMRI in vivo with EEG/ERP recordings obtained in patients with depth electrodes and/or subdural grids. We are also interested in better understanding basic language and memory processing in humans and factors that influence the networks revealed by neuroimaging.

Specialized Terms: Development of MRI techniques to allow faster scanning and/or to provide functional information; Quantitative information and high quality pictures of anatomy; Application of new methods to answer fundamental questions in basic science and medicine with emphasis on applications in neuroscience.

Extensive Research Description

Dr. Todd Constable's research primarily focuses on functional magnetic resonance (MR) and understanding cognitive processes that are related to language and memory and how these processes may be altered in different disease states or with different medications. An important aspect of some of the imaging techniques he is developing is the ability to separate indirect physiologic changes associated with particular diseases or medications from those that directly impact neuronal processes.


Research Interests

Anatomy; Diagnostic Imaging; Magnetic Resonance Imaging; Neurosurgery; Radiology; Neuroimaging

Selected Publications

Clinical Trials

ConditionsStudy Title
COVID-19 OutpatientAre you are currently experiencing brain fog from Long COVID?
Mental Health & Behavioral ResearchKetamine for Adolescent Suicidality
Alzheimer's Disease; Mental Health & Behavioral ResearchKetamine for the Treatment of Depression in Parkinson's Disease
Mental Health & Behavioral ResearchStudy of Brain Function Across the Lifespan
Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral ResearchBrain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Children's Health; Diseases of the Endocrine System; Immune SystemStudy to investigate adipocyte cell and lipid turnover in obese adolescents