Anna Eisenstein, MD/PhD
Assistant Professor
Research & Publications
Biography
News
Research Summary
I am an Assistant Professor of Dermatology at Yale School of Medicine and Director of the Hidradenitis Suppurativa Clinic. My current research endeavors seek to uncover the underlying pathogenesis of inflammatory conditions. During my postdoctoral fellowship in the laboratory of Andrew Wang, I explored fundamental allergy biology and the role of manmade xenobiotics in the development of allergic disease. Over the course of my postdoctoral training and during my PhD in the laboratory of Katya Ravid, DSc at Boston University Chobanian & Avedisian School of Medicine, I developed an interest in the impact of the external environment – from food preservatives and additives in topical products to the nutrients we ingest – on inflammation in the body, and in particular, at the skin barrier.
Coauthors
Research Interests
Allergens; Allergy and Immunology; Dermatology; Eczema; Molecular Biology; Hidradenitis Suppurativa
Selected Publications
- Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDsEisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, Israni-Winger K, Tian H, Luan HH, Wang A. Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. Immunity 2022, 55: 1082-1095.e5. PMID: 35588739, PMCID: PMC9205175, DOI: 10.1016/j.immuni.2022.04.015.
- Skin-limited Langerhans cell histiocytosis presenting as crusted papules in an acneiform distribution in an adolescent man.Choi R, Ko CJ, Eisenstein A. Skin-limited Langerhans cell histiocytosis presenting as crusted papules in an acneiform distribution in an adolescent man. JAAD Case Reports 2022, 20: 37-39. PMID: 35036502, PMCID: PMC8753055, DOI: 10.1016/j.jdcr.2021.11.024.
- Food Allergy: Searching for the Modern Environmental Culprit.Eisenstein AS, Hilliard B, Silwal S, Wang A. Food Allergy: Searching for the Modern Environmental Culprit. The Yale Journal Of Biology And Medicine 2020, 93: 733-747. PMID: 33380935, PMCID: PMC7757057.
- Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and AdipogenesisEisenstein A, Chitalia S, Ravid K. Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis. International Journal Of Molecular Sciences 2020, 21: 7470. PMID: 33050467, PMCID: PMC7589187, DOI: 10.3390/ijms21207470.
- 051 Non-steroidal anti-inflammatory drugs act as adjuvant in allergic sensitizationEisenstein A, Hilliard B, Wang A. 051 Non-steroidal anti-inflammatory drugs act as adjuvant in allergic sensitization. Journal Of Investigative Dermatology 2020, 140: s5. DOI: 10.1016/j.jid.2020.03.053.
- Emerging Biomarkers in Cutaneous Melanoma.Eisenstein A, Gonzalez EC, Raghunathan R, Xu X, Wu M, McLean EO, McGee J, Ryu B, Alani RM. Emerging Biomarkers in Cutaneous Melanoma. Molecular Diagnosis & Therapy 2018, 22: 203-218. PMID: 29411301, DOI: 10.1007/s40291-018-0318-z.
- Quantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesionsEisenstein A, Panova IP, Chung HJ, Goldberg LJ, Zhang Q, Lazova R, Bhawan J, Busam KJ, Symanowski JT, Alani RM, Ryu B. Quantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesions. Melanoma Research 2018, 28: 71-75. PMID: 29227334, PMCID: PMC5805139, DOI: 10.1097/cmr.0000000000000416.
- The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases.Eisenstein A, Patterson S, Ravid K. The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. Journal Of Cellular Physiology 2015, 230: 2891-7. PMID: 25975415, PMCID: PMC4811601, DOI: 10.1002/jcp.25043.
- An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis.Eisenstein A, Carroll SH, Johnston-Cox H, Farb M, Gokce N, Ravid K. An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis. The Journal Of Biological Chemistry 2014, 289: 21071-81. PMID: 24928509, PMCID: PMC4110311, DOI: 10.1074/jbc.M114.566406.
- G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.Eisenstein A, Ravid K. G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. Journal Of Cellular Physiology 2014, 229: 414-21. PMID: 24114647, PMCID: PMC4362544, DOI: 10.1002/jcp.24473.
- The macrophage A2B adenosine receptor regulates tissue insulin sensitivity.Johnston-Cox H, Eisenstein AS, Koupenova M, Carroll S, Ravid K. The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PloS One 2014, 9: e98775. PMID: 24892847, PMCID: PMC4043770, DOI: 10.1371/journal.pone.0098775.
- Integration of basic science and clinical medicine: the innovative approach of the cadaver biopsy project at the Boston University School of Medicine.Eisenstein A, Vaisman L, Johnston-Cox H, Gallan A, Shaffer K, Vaughan D, O'Hara C, Joseph L. Integration of basic science and clinical medicine: the innovative approach of the cadaver biopsy project at the Boston University School of Medicine. Academic Medicine : Journal Of The Association Of American Medical Colleges 2014, 89: 50-3. PMID: 24280854, DOI: 10.1097/ACM.0000000000000054.
- A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors.Sun Y, Duan Y, Eisenstein AS, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal Of Cell Science 2012, 125: 4507-17. PMID: 22767505, PMCID: PMC3500865, DOI: 10.1242/jcs.105023.
- Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and SurvivalNguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival. Journal Of Clinical Oncology 2010, 28: 3958-3964. PMID: 20679621, PMCID: PMC2940394, DOI: 10.1200/jco.2009.27.0793.
- Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3?Stark JR, Perner S, Stampfer MJ, Sinnott JA, Finn S, Eisenstein AS, Ma J, Fiorentino M, Kurth T, Loda M, Giovannucci EL, Rubin MA, Mucci LA. Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3? Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2009, 27: 3459-64. PMID: 19433685, PMCID: PMC2717753, DOI: 10.1200/JCO.2008.20.4669.
- Testing a multigene signature of prostate cancer death in the Swedish Watchful Waiting Cohort.Mucci LA, Pawitan Y, Demichelis F, Fall K, Stark JR, Adami HO, Andersson SO, Andrén O, Eisenstein A, Holmberg L, Huang W, Kantoff PW, Kim R, Perner S, Stampfer MJ, Johansson JE, Rubin MA. Testing a multigene signature of prostate cancer death in the Swedish Watchful Waiting Cohort. Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology 2008, 17: 1682-8. PMID: 18583469, PMCID: PMC2536630, DOI: 10.1158/1055-9965.EPI-08-0044.
- Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort.Mucci LA, Pawitan Y, Demichelis F, Fall K, Stark JR, Adami HO, Andersson SO, Andrén O, Eisenstein AS, Holmberg L, Huang W, Kantoff PW, Perner S, Stampfer MJ, Johansson JE, Rubin MA. Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort. Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology 2008, 17: 249-51. PMID: 18199732, DOI: 10.1158/1055-9965.EPI-07-0722.