W. Mark Saltzman, PhD
Goizueta Foundation Professor of Biomedical Engineering and Professor of Cellular and Molecular Physiology and of Chemical EngineeringCards
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Department Chair, Biomedical Engineering
Contact Info
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Department Chair, Biomedical Engineering
Contact Info
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Department Chair, Biomedical Engineering
Contact Info
About
Titles
Goizueta Foundation Professor of Biomedical Engineering and Professor of Cellular and Molecular Physiology and of Chemical Engineering
Affiliated Faculty, Yale Institute for Global Health; Department Chair, Biomedical Engineering
Biography
W. Mark Saltzman is an engineer and educator. His research has impacted the fields of drug delivery, biomaterials, nanobiotechnology, and tissue engineering. This work is described in more than 350 research papers and patents. He is also the sole author of three textbooks: Biomedical Engineering, Tissue Engineering, and Drug Delivery. During more than 35 years leading independent research programs at Johns Hopkins, Cornell, and Yale, he has introduced mathematical models for guiding the design of drug delivery systems, developed new methods for drug delivery to brain tumors, produced the first controlled delivery systems for nerve growth factors, the first delivery systems for long-term protection against STDs using antibodies, and new materials for delivery of DNA and RNA. In the course of this work, he has been the primary mentor for 43 doctoral students and 27 postdoctoral associates; many of these scholars are now leading their own independent research programs at top-rate universities.
Prof. Saltzman graduated from Iowa State University with a BS in chemical engineering and received MS and PhD degrees in chemical engineering and medical engineering from MIT. He was appointed the Goizueta Foundation Professor of Chemical and Biomedical Engineering at Yale in 2002. He was the founding chair of Yale’s Department of Biomedical Engineering and served in that role for 12 years. From 2016-2022, he was the Head of Jonathan Edwards College, one of Yale’s fourteen residential colleges.
Prof. Saltzman is an elected member of the US National Academy of Medicine and the US National Academy of Engineering.
Appointments
Cellular & Molecular Physiology
ProfessorSecondaryChemical and Environmental Engineering
ProfessorSecondaryDermatology
ProfessorSecondary
Other Departments & Organizations
- Cellular & Molecular Physiology
- Center for Biomedical and Interventional Technology (CBIT)
- Center for RNA Science and Medicine
- Chemical and Environmental Engineering
- Dean's Workshops
- Dermatology
- Developmental Therapeutics
- Diabetes Research Center
- Global Health Studies
- Graduate Program in Cellular and Molecular Physiology
- Interdepartmental Neuroscience Program
- Liver Center
- Molecular Medicine, Pharmacology, and Physiology
- Neuroscience Track
- NIH T32 Program
- Rheumatic Diseases Research Core
- Vascular Biology and Therapeutics Program
- WHRY Pilot Project Program Investigators
- Women's Health Research at Yale
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale CTAP
- Yale Institute for Global Health
- Yale Ventures
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
Education & Training
- PhD
- Massachusetts Institute of Technology (1987)
- BS
- Iowa State University (1981)
Research
Overview
W. Mark Saltzman is an engineer and educator. His research has impacted the fields of drug delivery, biomaterials, nanobiotechnology, and tissue engineering. This work is described in more than 350 research papers and patents. He is also the sole author of three textbooks: Biomedical Engineering, Tissue Engineering, and Drug Delivery. During more than 35 years leading independent research programs at Johns Hopkins, Cornell, and Yale, he has introduced mathematical models for guiding the design of drug delivery systems, developed new methods for drug delivery to brain tumors, produced the first controlled delivery systems for nerve growth factors, the first delivery systems for long-term protection against STDs using antibodies, and new materials for delivery of DNA and RNA. In the course of this work, he has been the primary mentor for 43 doctoral students and 27 postdoctoral associates; many of these scholars are now leading their own independent research programs at top-rate universities.
Prof. Saltzman graduated from Iowa State University with a BS in chemical engineering and received MS and PhD degrees in chemical engineering and medical engineering from MIT. He was appointed the Goizueta Foundation Professor of Chemical and Biomedical Engineering at Yale in 2002. He was the founding chair of Yale’s Department of Biomedical Engineering and served in that role for 12 years. From 2016-2022, he was the Head of Jonathan Edwards College, one of Yale’s fourteen residential colleges.
Prof. Saltzman is an elected member of the US National Academy of Medicine and the US National Academy of Engineering.
Medical Subject Headings (MeSH)
- View Lab Website
Saltzman Research Group
Research at a Glance
Yale Co-Authors
Marie Egan, MD
Peter M. Glazer, MD, PhD
Ranjit S. Bindra, MD, PhD
Akiko Iwasaki, PhD
Anne Eichmann, PhD
Bernadette Marquez-Nostra, PhD
Publications
2024
Enhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticles
Chang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticles. Journal Of Investigative Dermatology 2024 PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.Peer-Reviewed Original ResearchAltmetricConceptsMonophosphoryl lipid ATumor microenvironmentImmunomodulatory agentsStimulation of anti-tumor immune responseEfficacy of monophosphoryl lipid AT-helper (Th)1 responsesAnti-tumor immune responseTumor-draining lymph nodesToxicity associated with systemic administrationImmune responseModel of malignant melanomaAgonist monophosphoryl lipid ABiodegradable nanoparticlesImmunogenic tumor microenvironmentAntitumor immune responseDraining lymph nodesSystemic side effectsNatural killer cellsGradual drug releaseKiller cellsAntitumor efficacyMalignant melanomaImproved survivalLymph nodesChemotherapeutic agentsNext generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutation
Gupta A, Barone C, Quijano E, Piotrowski-Daspit A, Perera J, Riccardi A, Jamali H, Turchick A, Zao W, Saltzman W, Glazer P, Egan M. Next generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutation. Journal Of Cystic Fibrosis 2024 PMID: 39107154, DOI: 10.1016/j.jcf.2024.07.009.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorCystic fibrosis transmembrane conductance regulator geneF508del-CFTR mutationPeptide nucleic acidCFBE cellsBronchial epithelial cellsCystic fibrosisTriplex-forming peptide nucleic acidsDonor DNACFTR mutationsEpithelial cellsCFTR functionMutations associated with genetic diseasesPrimary nasal epithelial cellsAnalysis of genomic DNAGenetic diseasesIncreased CFTR functionDevelopment of peptide nucleic acidsImprove CFTR functionTransmembrane conductance regulatorAutosomal recessive genetic diseaseNasal epithelial cellsAir-liquid interfaceCystic fibrosis bronchial epithelial cellsHuman bronchial epithelial cellsBranching in poly(amine-co-ester) polyplexes impacts mRNA transfection
Shin K, Suh H, Suberi A, Whang C, Ene M, Grundler J, Grun M, Saltzman W. Branching in poly(amine-co-ester) polyplexes impacts mRNA transfection. Biomaterials 2024, 311: 122692. PMID: 38986360, PMCID: PMC11298310, DOI: 10.1016/j.biomaterials.2024.122692.Peer-Reviewed Original ResearchConceptsPolymer branchingTransfection in vivoPhysicochemical propertiesPoly(amine-co-esterMRNA deliveryTerminal groupsPolymer featuresIn vitroPolymerNucleic acid deliveryMonomer compositionAnalysis of physicochemical propertiesStructural parametersCationic polymersStability of polyplexesMRNA transfectionTransfection efficiencyAcid deliveryDelivery vehiclesTransfectionMRNAEnhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-lifeModifying the Backbone Chemistry of PEG‐based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles
Grundler J, Whang C, Shin K, Savan N, Zhong M, Saltzman W. Modifying the Backbone Chemistry of PEG‐based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles. Advanced Healthcare Materials 2024, e2304040. PMID: 38734871, DOI: 10.1002/adhm.202304040.Peer-Reviewed Original ResearchConceptsBottlebrush block copolymersPerformance of nanoparticlesBottlebrush polymersBlock copolymersBiomedical applicationsLinear hydrophilic polymersBackbone chemistryLocation of functional groupsPoly(lactic acidBottlebrush backboneNanoparticle shellHydrophilic polymersPolymer backboneSurface functionalizationHeterobifunctional poly(ethylene glycolPoly(ethylene glycolHierarchical controlBlood circulation half-livesEnhanced tumor accumulationNanoparticlesPolymerReduced cellular uptakeNanoparticle physicochemical propertiesBottlebrushConventional nanoparticlesPilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation
Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024 DOI: 10.1002/btm2.10661.Peer-Reviewed Original ResearchAltmetricConceptsVaginal dosage formsBioadhesive nanoparticlesCynomolgus monkeysAnalysis of inflammatory biomarkersVaginal microbicidesVaginal canalMultiple dosesInflammatory biomarkersTherapeutic efficacyVaginal fluidSystemic circulationLong-term deliveryNoninvasive imagingClinical translationDosage formsNon-human primatesDelivery vehiclesMonkeysDeliveryVaginitisUterusMicrobicidesSafety evaluationBiodistributionDoseExploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors
Murray M, Noronha K, Wang Y, Friedman A, Paradkar S, Suh H, Sundaram R, Brenner C, Saltzman W, Bindra R. Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors. Molecular Cancer Therapeutics 2024, 23: 1176-1187. PMID: 38691846, PMCID: PMC11292319, DOI: 10.1158/1535-7163.mct-24-0012.Peer-Reviewed Original ResearchCitationsAltmetricConceptsConvection-enhanced deliveryCentral nervous systemTreatment of primary central nervous systemPrimary central nervous systemSustained drug release in vitroTumor growth delayAssociated with lower survival ratesBone marrow suppressionComplex mutational profilesNAMPT inhibitorsRelease in vitroIntracranial GBM xenograftsBlood-brain barrierDrug release in vitroRetinal toxicityMarrow suppressionNAMPTiGrowth delayTherapeutic vulnerabilitiesExtended survivalLow survival rateGBM xenograftsMutation profilesPromoter methylationAnticancer activity in vitroThe Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.Peer-Reviewed Original ResearchConceptsFetal drug deliverySuccess of nanomedicineDrug deliveryPharmacological drug treatmentsMinimally invasive strategyFetal therapyFetal applicationsClinical studiesCongenital diseaseInvasive strategyDrug treatmentClinical translationClinical practiceTherapyMedical interventionsDeliveryFetalNanomedicineBirthDiseaseFindingsACliniciansCompartmentalized ocular lymphatic system mediates eye–brain immunity
Yin X, Zhang S, Lee J, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo L, Poulet M, Fischer S, Zhou T, Mohammed F, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas J, Saltzman W, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. Compartmentalized ocular lymphatic system mediates eye–brain immunity. Nature 2024, 628: 204-211. PMID: 38418880, PMCID: PMC10990932, DOI: 10.1038/s41586-024-07130-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsResponse to herpes simplex virusCentral nervous systemImmune response to herpes simplex virusPosterior eyeImmune responseTherapeutic immune responsesOptic nerve sheathCervical lymph nodesAdeno-associated virusCNS diseaseDeep cervical lymph nodesHerpes simplex virusImmune protected miceCentral nervous system tissueLymphatic drainage systemImmunological featuresAnatomical extensionNerve sheathOptic nerveGene therapyLymph nodesMultiple dosesSimplex virusLymphatic circuitLymphatic signalNanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake
Grundler J, Shin K, Suh H, Whang C, Fulgoni G, Pierce R, Saltzman W. Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake. ACS Nano 2024, 18: 2815-2827. PMID: 38227820, DOI: 10.1021/acsnano.3c05921.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBottlebrush block copolymersSurface topographyBlock copolymersPoly(ethylene glycolClinical translation of nanomedicinePEGylated nanoparticlesEnhanced tumor uptakeNanoscale surface topographyTranslation of nanomedicinesRough surface topographyLinear block copolymersProlonged systemic circulationPerformance of nanocarriersPolymer coatingNanoparticle coatingSmooth surfaced nanoparticlesTumor uptakeTumor accumulationBiomedical applicationsNanoparticle formulationSystemic circulationClinical translationTumor extravasationNanoparticlesCoating
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