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Ranjit S. Bindra, MD, PhD

Harvey and Kate Cushing Professor of Therapeutic Radiology and Professor of Pathology; Vice Chair for Translational Research, Therapeutic Radiology; Scientific Director, Chênevert Family Brain Tumor Center at Smilow Cancer Hospital and Yale Cancer Center; Chief, Pediatrics Central Nervous System Radiotherapy Program, Therapeutic Radiology; Chief, Central Nervous System Radiotherapy Program, Therapeutic Radiology

Contact Information

Ranjit S. Bindra, MD, PhD

Patient Care Location

Office Location

Mailing Address

  • Therapeutic Radiology

    P. O. Box 208040

    New Haven, CT 06520-8040

    United States



Dr. Ranjit Bindra is a physician-scientist at Yale School of Medicine and Co-Director of the Yale Brain Tumor Center at Smilow Cancer Hospital. In the laboratory, his group recently led a team of four major laboratories at Yale, which reported the stunning discovery that IDH1/2-mutant tumors harbor a profound DNA repair defect that renders them exquisitely sensitive to PARP inhibitors. This work was published in Science Translational Medicine, and Nature, and it has received international attention with major clinical implications Dr. Bindra is now translating this work directly into patients, in four phase I/II clinical trials, including an innovative, biomarker-driven trial specifically targeting the Adolescent/Young Adult (AYA) cancer patient population. In addition, he is lead co-PI of a 35-site, NCI-sponsored Phase II trial testing the PARP inhibitor, olaparib, in adult IDH1/2-mutant solid tumors (NCT03212274). As a biotech entrepreneur he recently co-founded Cybrexa Therapeutics, a Series B round-funded company focused on developing an entirely new class of small molecule DNA repair inhibitors, which directly target the tumor microenvironment. Dr. Bindra received his undergraduate degree in Molecular Biophysics and Biochemistry from Yale University in 1998, and both his MD and PhD from the Yale School of Medicine in 2007. He completed his medical internship, radiation oncology residency, and post-doctoral research studies at the Memorial Sloan-Kettering Cancer Center (MSKCC) in 2012.

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Education & Training

  • Resident
    Memorial Sloan-Kettering Cancer Center (2012)
  • Intern
    Memorial Sloan-Kettering Cancer Center (2008)
  • MD
    Yale University School of Medicine (2007)
  • PhD
    Yale University Graduate School (2005)
  • BS
    Yale University (1998)

Departments & Organizations