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Bluma Lesch, MD, PhD

Associate Professor of Genetics and of Obstetrics, Gynecology, and Reproductive Sciences
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About

Titles

Associate Professor of Genetics and of Obstetrics, Gynecology, and Reproductive Sciences

Biography

Bluma Lesch works on mechanisms of transcriptional regulation in the context of development, evolution, and disease, with a special interest in the genetics and epigenetics of the mammalian germ line. Her research integrates information across a wide range of biological scales, from molecular mechanism to organismal development to species evolution, using both experimental and computational approaches. Current projects focus on (1) uncovering the rules and mechanisms of gene regulatory evolution, (2) defining transgenerational epigenetic contributions to offspring phenotype, and (3) using the unique regulatory biology of the germ line to discover fundamental gene regulatory mechanisms that go awry in disease.

Dr. Lesch earned her B.S. from Yale University in 2003. She obtained her Ph.D. in 2010 from Rockefeller University and her M.D. in 2011 from Weill Cornell Medical College in New York City. She was a postdoctoral fellow at the Whitehead Institute in Cambridge, MA, from 2011-2017, where she was awarded an NIH Kirschstein postdoctoral fellowship and also named a Hope Funds for Cancer Research postdoctoral fellow. She received a Burroughs Wellcome Career Award for Medical Scientists in 2015, and returned to New Haven to join the Yale faculty in 2017. She was names a Searle Scholar in 2019 and a Pew Biomedical Scholar in 2021.

Appointments

Research

Overview

Medical Subject Headings (MeSH)

Chromatin Assembly and Disassembly; Computational Biology; Embryonic and Fetal Development; Epigenetic Memory; Evolution, Molecular; Gene Expression Regulation; Germ Cells; Heredity; Reproduction; Stem Cells

Research at a Glance

Yale Co-Authors

Frequent collaborators of Bluma Lesch's published research.

Publications

2024

2023

2022

2021

Academic Achievements & Community Involvement

  • honor

    Pew Scholar

  • honor

    Searle Scholar Award

  • honor

    Kingsley Fellow

  • honor

    Burroughs-Wellcome Career Award

  • honor

    Whitehead Institute Postdoctoral Association Education Award

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