Research Departments & Organizations
I am interested in 1) molecular, biochemical and functional aspects of cell surface costimulatory and coinhibitory molecules and 2) translation of laboratory findings to treat human diseases.
Specialized Terms: Lymphocyte activation and tolerance; costimulation and coinhibition; tumor microenvironment; cancer mmunotherapy.
Extensive Research Description
Currently, our laboratory is interested in:
- Identification and characterization of cell surface proteins that control T cell priming, growth, migration, differentiation, tolerance, memory, and survival during immune responses
- Cellular and molecular mechanisms by which tumors escape immunity
- Developing novel approaches for treatment of human diseases based on our laboratory discoveries
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews. Immunology 2013, 13:227-42. 2013
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.
Chen L, Han X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. The Journal Of Clinical Investigation 2015, 125:3384-91. 2015
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.
Sanmamed MF, Chen L. A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. Cell 2018, 175:313-326. 2018