Welcome to the Chen Lab


The Chen Lab works to understand the molecular, biochemical, and functional aspects of cell surface molecular pathways, including costimulatory and coinhibitory molecules, in the control and modulation of immune responses. We are interested in translating laboratory findings into the development of new treatment options for cancer, autoimmune diseases, viral infections, transplantation rejection, and inflammation.  


Research Interests






Infectious Disease


Coinhibition & Costimulation

Immune Functions 

Co-Signaling Molecules 

Modulation of Immune Responses 

Lymphocyte Activation & Deactivation 

Principle Investigator

Lieping Chen, MD, PhD

United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)

Lieping Chen, MD, PhD,

In 1982, Dr. Lieping Chen obtained his MD from Fujian Medical School in Fuzhou City, China. After completing his clinical training in hematology and oncology at Fujian Union Hospital and Beijing Union Medical College Cancer Center, Dr. Chen earned a Ph.D. in experimental pathology from ...

Innovation to Impact: Dr. Lieping Chen and NextCure

Dr. Lieping Chen is a pioneer in the field of immuno-oncology and his discoveries have led to life-saving drugs for cancer patients. Now, with the support of the Yale Office of Cooperative Research, Dr. Chen has launched a startup—NextCure—that is poised to lead to even more breakthrough treatments.