Research Departments & Organizations
Psychiatry: Center for Nicotine and Tobacco Use Research at Yale (CENTURY) | Cosgrove Lab Collaborators | Division of Women's Behavioral Health Research | Neuroscience Research Training Program (NRTP) | Psychology Section | Translational Brain Imaging Program | VA National Center for PTSD | Yale Tobacco Center of Regulatory Science
There is a high comorbidity between psychiatric illness and tobacco smoking, with common denominator of cognitive difficulties. The goal of our research is to examine the neurochemical changes, tested by PET brain imaging or Magnetic Resonance techniques, associated with mood disorders and comorbid tobacco addiction and the underlying cognitive decrements. We aim to determine specific systems, such as the nicotinic and glutamatergic, that may be a target for new pharmacotherapies to aid in alleviating mood and cognitive difficulties, and thus aiding with smoking cessation.
Specialized Terms: Neuroreceptor imaging; Mood disorders; Tobacco addiction
Extensive Research Description
Examination of the beta2-nAChR system in bipolar depression and relevance to the persistent tobacco smoking.
Imaging glutamatergic system in depression via PET and MRS to determine role of glutamate and mGluR5 in depression and associated cognitive difficulties.
Imaging ACh changes in the brain in living humans.
In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5.
DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biological Psychiatry 2015, 77:266-275. 2015
In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia.
Esterlis I, Ranganathan M, Bois F, Pittman B, Picciotto MR, Shearer L, Anticevic A, Carlson J, Niciu MJ, Cosgrove KP, D'Souza DC. In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia. Biological Psychiatry 2014, 76:495-502. 2014