Antonio Giraldez, PhD

Fergus F. Wallace Professor of Genetics; Chair, Genetics

Research Departments & Organizations

Center for RNA Science and Medicine

Gene Regulation and Functional Genomics

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Yale Stem Cell Center

Research Interests

Autism Spectrum Disorder; Computational Biology; Developmental Biology; Gene Expression Regulation, Developmental; Genomics; RNA Recognition Motif; Systems Biology

Research Summary

In our laboratory we investigate the gene regulatory code that  shapes vertebrate embryonic development using zebrafish as a model system. We combine genomics, genetics, embryology, machine learning and computational biology to address a central question in biology: how does a fertilized egg develop into a complex multicellular embryo. This process requires a precise spatial and temporal regulation of gene expression. We are primarily focus on understanding i) the mechanisms that activate the genome after fertilization, ii) the post-transcriptional regulatory code that shapes mRNA stability and translation across vertebrates using the maternal to zygotic transition as a model, and iii) the gene regulatory code that specifies different cell types during embryogenesis. Our research is focusing in four main areas: Mechanisms of Genome activation, mechanisms of post-transcriptional regulation, computational modeling of gene expression and animal models to understand autism.

Selected Publications

See list of PubMed publications

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