Paula Preston-Hurlburt
Research Associate Immunobiology
Research & Publications
Biography
News
Coauthors
Selected Publications
- HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversalPierce C, Loh L, Steach H, Cheshenko N, Preston-Hurlburt P, Zhang F, Stransky S, Kravets L, Sidoli S, Philbrick W, Nassar M, Krishnaswamy S, Herold K, Herold B. HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal. Journal Of Clinical Investigation 2023, 133: e164317. PMID: 37079384, PMCID: PMC10232005, DOI: 10.1172/jci164317.
- RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice.Joshi AA, Wu Y, Deng S, Preston-Hurlburt P, Forbes JM, Herold KC. RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice. Clinical Immunology 2022, 245: 109165. PMID: 36257528, DOI: 10.1016/j.clim.2022.109165.
- HSV-2 increases replication of HIV in human T cellsPierce C, Preston-Hurlburt P, Loh L, Steach H, Sidoli S, Zhang F, Philbrick W, Nassar M, Krishnaswamy S, Herold K, Herold B. HSV-2 increases replication of HIV in human T cells. The Journal Of Immunology 2022, 208: 182.40-182.40. DOI: 10.4049/jimmunol.208.supp.182.40.
- The receptor for advanced glycation endproducts (RAGE) modulates T cell signalingReed JC, Preston-Hurlburt P, Philbrick W, Betancur G, Korah M, Lucas C, Herold KC. The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling. PLOS ONE 2020, 15: e0236921. PMID: 32986722, PMCID: PMC7521722, DOI: 10.1371/journal.pone.0236921.
- Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patientsPierce CA, Preston-Hurlburt P, Dai Y, Aschner CB, Cheshenko N, Galen B, Garforth SJ, Herrera NG, Jangra RK, Morano NC, Orner E, Sy S, Chandran K, Dziura J, Almo SC, Ring A, Keller MJ, Herold KC, Herold BC. Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients. Science Translational Medicine 2020, 12: eabd5487. PMID: 32958614, PMCID: PMC7658796, DOI: 10.1126/scitranslmed.abd5487.
- HSV-2 infects T follicular helper cells to promote HIV reactivationPierce C, Loh L, Preston-Hurlburt P, Herold K, Herold B. HSV-2 infects T follicular helper cells to promote HIV reactivation. The Journal Of Immunology 2020, 204: 247.24-247.24. DOI: 10.4049/jimmunol.204.supp.247.24.
- Use of CART cells to selectively target autoantigen-specific T cells for the treatment of autoimmune diabetesYu H, Bettini M, Ellis G, Riley J, Collins J, Preston-Hurlburt P, Korah M, Mallone R, Deng S, Wang X, Fremont D, Spiegel D, Cresswell P, Herold K. Use of CART cells to selectively target autoantigen-specific T cells for the treatment of autoimmune diabetes. The Journal Of Immunology 2020, 204: 238.8-238.8. DOI: 10.4049/jimmunol.204.supp.238.8.
- Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosisPerdigoto AL, Preston-Hurlburt P, Clark P, Long SA, Linsley PS, Harris KM, Gitelman SE, Greenbaum CJ, Gottlieb PA, Hagopian W, Woodwyk A, Dziura J, Herold KC. Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis. Diabetologia 2018, 62: 655-664. PMID: 30569273, PMCID: PMC6402971, DOI: 10.1007/s00125-018-4786-9.
- Identification and Analysis of Islet Antigen–Specific CD8+ T Cells with T Cell LibrariesOgura H, Preston-Hurlburt P, Perdigoto AL, Amodio M, Krishnaswamy S, Clark P, Yu H, Egli D, Fouts A, Steck AK, Herold KC. Identification and Analysis of Islet Antigen–Specific CD8+ T Cells with T Cell Libraries. The Journal Of Immunology 2018, 201: 1662-1670. PMID: 30082321, PMCID: PMC6449153, DOI: 10.4049/jimmunol.1800267.
- Microbiota control immune regulation in humanized miceGülden E, Vudattu NK, Deng S, Preston-Hurlburt P, Mamula M, Reed JC, Mohandas S, Herold BC, Torres R, Vieira SM, Lim B, Herazo-Maya JD, Kriegel M, Goodman AL, Cotsapas C, Herold KC. Microbiota control immune regulation in humanized mice. JCI Insight 2017, 2: e91709. PMID: 29093268, PMCID: PMC5752290, DOI: 10.1172/jci.insight.91709.
- Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized miceOgura M, Deng S, Preston-Hurlburt P, Ogura H, Shailubhai K, Kuhn C, Weiner HL, Herold KC. Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice. Clinical Immunology 2017, 183: 240-246. PMID: 28739191, DOI: 10.1016/j.clim.2017.07.005.
- Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus-Herpes Simplex Virus Coinfection.Mesquita PM, Preston-Hurlburt P, Keller MJ, Vudattu N, Espinoza L, Altrich M, Anastos K, Herold KC, Herold BC. Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus-Herpes Simplex Virus Coinfection. The Journal Of Infectious Diseases 2016, 215: 614-622. PMID: 28007920, PMCID: PMC5388286, DOI: 10.1093/infdis/jiw612.
- The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes MellitusDurning SP, Preston-Hurlburt P, Clark PR, Xu D, Herold KC, Group T. The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus. The Journal Of Immunology 2016, 197: 3076-3085. PMID: 27655844, PMCID: PMC5101164, DOI: 10.4049/jimmunol.1600197.
- Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627.Rudensky A, Preston-Hurlburt P, Hong S, Barlow A, Janeway C. Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627. The Journal Of Immunology 2016, 196: 941-6. PMID: 26802059.
- Humanized Mice as a Model for Aberrant Responses in Human T Cell ImmunotherapyVudattu NK, Waldron-Lynch F, Truman LA, Deng S, Preston-Hurlburt P, Torres R, Raycroft MT, Mamula MJ, Herold KC. Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy. The Journal Of Immunology 2014, 193: 587-596. PMID: 24943216, PMCID: PMC4123131, DOI: 10.4049/jimmunol.1302455.
- The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced AsthmaAkirav EM, Henegariu O, Preston-Hurlburt P, Schmidt AM, Clynes R, Herold KC. The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma. PLOS ONE 2014, 9: e95678. PMID: 24759895, PMCID: PMC3997417, DOI: 10.1371/journal.pone.0095678.
- Specific peripheral B cell tolerance defects in patients with multiple sclerosisKinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O’Connor K, Meffre E. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. Journal Of Clinical Investigation 2013, 123: 2737-2741. PMID: 23676463, PMCID: PMC3668812, DOI: 10.1172/jci68775.
- Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple MyelomaWaldron-Lynch F, Inzucchi SE, Menard L, Tai N, Preston-Hurlburt P, Hui P, McClaskey J, Hagopian WA, Meffre E, Marks PW, Wen L, Herold KC. Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple Myeloma. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4317-4323. PMID: 23074233, PMCID: PMC3513536, DOI: 10.1210/jc.2012-2388.
- Analysis of Human Biologics With a Mouse Skin Transplant Model in Humanized MiceWaldron-Lynch F, Deng S, Preston-Hurlburt P, Henegariu O, Herold KC. Analysis of Human Biologics With a Mouse Skin Transplant Model in Humanized Mice. American Journal Of Transplantation 2012, 12: 2652-2662. PMID: 22900715, DOI: 10.1111/j.1600-6143.2012.04178.x.
- Enhanced Anti-Serpin Antibody Activity Inhibits Autoimmune Inflammation in Type 1 DiabetesCzyzyk J, Henegariu O, Preston-Hurlburt P, Baldzizhar R, Fedorchuk C, Esplugues E, Bottomly K, Gorus FK, Herold K, Flavell RA. Enhanced Anti-Serpin Antibody Activity Inhibits Autoimmune Inflammation in Type 1 Diabetes. The Journal Of Immunology 2012, 188: 6319-6327. PMID: 22593614, PMCID: PMC3370061, DOI: 10.4049/jimmunol.1200467.
- RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune ResponsesAkirav EM, Preston-Hurlburt P, Garyu J, Henegariu O, Clynes R, Schmidt AM, Herold KC. RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses. PLOS ONE 2012, 7: e34698. PMID: 22509345, PMCID: PMC3324532, DOI: 10.1371/journal.pone.0034698.
- Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and PatientsWaldron-Lynch F, Henegariu O, Deng S, Preston-Hurlburt P, Tooley J, Flavell R, Herold KC. Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients. Science Translational Medicine 2012, 4: 118ra12. PMID: 22277969, PMCID: PMC4131554, DOI: 10.1126/scitranslmed.3003401.
- Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade Evidence of Improved Immune RegulationAblamunits V, Henegariu O, Hansen JB, Opare-Addo L, Preston-Hurlburt P, Santamaria P, Mandrup-Poulsen T, Herold KC. Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade Evidence of Improved Immune Regulation. Diabetes 2011, 61: 145-154. PMID: 22043003, PMCID: PMC3237664, DOI: 10.2337/db11-1033.
- NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti‐CD3 antibodyAblamunits V, Henegariu O, Preston‐Hurlburt P, Herold KC. NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti‐CD3 antibody. European Journal Of Immunology 2011, 41: 1832-1842. PMID: 21538351, PMCID: PMC3517122, DOI: 10.1002/eji.201041258.
- TH17 cells mediate pulmonary collateral primingAlbrecht M, Chen HC, Preston-Hurlburt P, Ranney P, Hoymann HG, Maxeiner J, Staudt V, Taube C, Bottomly HK, Dittrich AM. TH17 cells mediate pulmonary collateral priming. Journal Of Allergy And Clinical Immunology 2011, 128: 168-177.e8. PMID: 21459426, PMCID: PMC3129446, DOI: 10.1016/j.jaci.2011.01.067.
- Th17 Cells In The Lung Facilitate Priming Towards New AntigensAlbrecht M, Preston-Hurlburt P, Bottomly K, Dittrich A. Th17 Cells In The Lung Facilitate Priming Towards New Antigens. Journal Of Allergy And Clinical Immunology 2010, 125: ab193. DOI: 10.1016/j.jaci.2009.12.757.
- 21. Mainzer Allergie-WorkshopRennert S, Krause S, Becker W, Petersen A, Schocker F, Papenfuß K, Jappe U, Brehler R, Lange L, Riffelmann F, Nemat K, Hompes S, Holzhauser T, Lidholm J, Reese G, Vieths S, Seismann H, Blank S, Braren I, Greunke K, Cifuentes L, Grunwald T, Bredehorst R, Ollert M, Spillner E, von der Gathen Y, Sander I, Flagge A, Brüning T, Raulf-Heimsoth M, Zahradnik E, Fleischer C, Schierl R, Sültz J, Nowak D, Buters J, Weichenmeier I, Ochs S, Kreyling W, Boere A, Schober W, Behrendt H, Jaeger T, Kerzl R, Huss-Marp J, Ring J, Darsow U, Roeschmann K, Vroling A, van Drunen C, Ulmer A, Gilles S, Mariani V, Zhang X, Jakob T, Müller M, Pastore S, Traidl-Hoffmann C, Oeder S, Dietrich S, Fromme H, Schäfer V, Renne J, Werfel T, Wittmann M, Grusser M, Maurer M, Dudeck A, Suender C, Heydrich S, Bros M, Wiechmann N, Besche V, Hövelmeyer N, Reissig S, Massoumi R, Grabbe S, Waisman A, Reske-Kunz A, Gschwandtner M, Roßbach K, Bäumer W, Kietzmann M, Dijkstra D, Stark H, Gutzmer R, Höhn Y, Thamsen M, Trojandt S, Bovensiepen C, Bellinghausen I, Hilmenyuk T, Saloga J, Luxemburger U, Türeci Ö, Wiesner H, Kohlrautz V, Wahn U, Stock P, Mommert S, Köther G, Sudowe S, Barwig C, Montermann E, Milovanovic M, Koch C, Hilt K, Hartmann B, Heine G, Worm M, Ambach A, Hoefeld-Fegeler M, Besser C, Weren A, Schraven B, Bonekoh B, Gollnick H, Raap M, Bruder M, Kapp A, Raap U, Grosber M, Hausteiner C, Bubel E, Groben S, Bornschein S, Lahmann C, Zilker T, Eberlein B, Henningsen P, Huber D, Biedermann T, Kunz J, Fischer J, Kempf W, Wölbing F, Alexopoulou A, Albert A, Pfaar O, Distler A, Hörmann K, Klimek L, Wieczorek D, Büsing M, Wedi B, Rerinck H, Przybilla B, Ruëff F, Weigert C, Ghoreschi K, Röcken M, Muhr P, Zeitvogel J, Ott H, Wiederholt T, Andresen-Bergström M, Skazik C, Merk H, Karlberg A, Zwadlo-Klarwasser G, Baron J, Frankenberg U, Lorenz N, Steinbrink K, Pföhler C, Dietrich K, Thomas P, Baran W, Hänsel A, Meurer M, Schäkel K, Mamerow D, Niebuhr M, Bonnekoh B, Bunselmeyer B, Laubach H, Schiller M, Stanke M, Luger T, Böcking C, Köllisch G, Pfefferle P, Renz H, Conrad M, Teich R, Ferstl R, Brand S, Yildirim A, Kirschning C, Garn H, Eilbacher I, Stein K, Hanuszkiewicz A, Holst O, Heine H, Guenova E, Hoetzenecker W, Mailhammer R, Weindl G, Sauer K, Schaller M, Hiller J, Förster S, Eyerich K, Hofmann H, Ilchmann A, Burgdorf S, Waibler Z, Kurts C, Scheurer S, Kalinke U, Toda M, Adler H, Hofmann C, Becker C, Hemmer W, Focke M, Marzban G, Mayer D, Laimer M, Jarisch R, McIntyre M, Thiebes V, Mempel M, Jeßberger B, Vrtala S, Mauss V, Eben R, Walker A, Herzinger T, Berking C, Reese I, Sonar S, Ehmke M, Dietze J, Nockher W, Reuter S, Dehzad N, Martin H, Jung M, Heinz A, Stassen M, Buhl R, Taube C, Lingner S, Hennig C, Remke J, Hansen G, Dittrich A, Peters M, Bufe A, Polte T, Schütze N, Simon J, Lehmann I, Albrecht M, Preston-Hurlburt P, Bottomoly H, Pilzner C, Bühling F, Reinheckel T, Lauenstein H, Braun A, Welte T, Groneberg D, Greiner T, Zimmer A, Abram M, Fokuhl V, Luger E, Radbruch A, Zemlin M, Kilic A, Yildirim A, Alrifai M, Hagner S, Renzing A, Closs E, Bopp T, Schmitt E, Dicke T, Seyfarth F, Hipler U, Elsner P, Schliemann S, Konakovsky V, Moser P, Wantke F, Sesztak-Greinecker G, Götz M, Schmid R, Hoffmann-Sommergruber K. 21. Mainzer Allergie-Workshop. Allergo Journal 2009, 18: 30-59. DOI: 10.1007/bf03361982.
- Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodelingLai D, Wan M, Wu J, Preston-Hurlburt P, Kushwaha R, Grundström T, Imbalzano AN, Chi T. Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 1169-1174. PMID: 19164553, PMCID: PMC2633529, DOI: 10.1073/pnas.0811274106.
- A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte developmentJani A, Wan M, Zhang J, Cui K, Wu J, Preston-Hurlburt P, Khatri R, Zhao K, Chi T. A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte development. Journal Of Cell Biology 2008, 183: i7-i7. DOI: 10.1083/jcb1833oia7.
- A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte developmentJani A, Wan M, Zhang J, Cui K, Wu J, Preston-Hurlburt P, Khatri R, Zhao K, Chi T. A novel genetic strategy reveals unexpected roles of the Swi–Snf–like chromatin-remodeling BAF complex in thymocyte development. Journal Of Experimental Medicine 2008, 205: 2813-2825. PMID: 18955569, PMCID: PMC2585832, DOI: 10.1084/jem.20080938.
- Dual receptor T cells extend the immune repertoire for foreign antigensHe X, Janeway CA, Levine M, Robinson E, Preston-Hurlburt P, Viret C, Bottomly K. Dual receptor T cells extend the immune repertoire for foreign antigens. Nature Immunology 2002, 3: 127-134. PMID: 11812989, DOI: 10.1038/ni751.
- MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling PathwaysMedzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.
- A human homologue of the Drosophila Toll protein signals activation of adaptive immunityMedzhitov R, Preston-Hurlburt P, Janeway C. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388: 394-397. PMID: 9237759, DOI: 10.1038/41131.
- The Specificity and Orientation of a TCR to its Peptide–MHC Class II LigandsSant'Angelo D, Waterbury G, Preston-Hurlburt P, Yoon S, Medzhitov R, Hong S, Janeway C. The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands. Immunity 1996, 4: 367-376. PMID: 8612131, DOI: 10.1016/s1074-7613(00)80250-2.
- Rules for the Presentation of Peptides by Class II Molecules of the Major Histocompatibility ComplexJaneway C, Preston-Hurlburt P, Al-Ramadi B, Rothbard J, Murphy D, Reich E, Rudensky A. Rules for the Presentation of Peptides by Class II Molecules of the Major Histocompatibility Complex. 1993, 181-188. DOI: 10.1007/978-3-642-51479-1_24.
- Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifsRudensky A, Preston-Hurlburt, P, Al-Ramadi B, Rothbard J, Janeway C. Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature 1992, 359: 429-431. PMID: 1328884, DOI: 10.1038/359429a0.
- Peptides bound to MHCJaneway C, Rudensky A, Preston-Hurlburt P. Peptides bound to MHC. Nature 1992, 357: 120-120. DOI: 10.1038/357120b0.
- On the complexity of selfRudensky A, Rath S, Preston-Hurlburt P, Murphy D, Janeway C. On the complexity of self. Nature 1991, 353: 660-662. PMID: 1656278, DOI: 10.1038/353660a0.
- Sequence analysis of peptides bound to MHC class II moleculesRudensky A, Preston-Hurlburt P, Hong S, Barlow A, Janeway C. Sequence analysis of peptides bound to MHC class II molecules. Nature 1991, 353: 622-627. PMID: 1656276, DOI: 10.1038/353622a0.
- The role of tyrosine at the ligand-binding site of the nicotinic acetylcholine receptorPearce S, Preston-Hurlburt P, Hawrot E. The role of tyrosine at the ligand-binding site of the nicotinic acetylcholine receptor. Proceedings Of The Royal Society B 1990, 241: 207-213. PMID: 1979446, DOI: 10.1098/rspb.1990.0087.
- Monoclonal antibodies directed against a synthetic peptide corresponding to the α-bungarotoxin binding region of the acetylcholine receptorPreston-Hurlburt P, Wilson P, Dowding A, Hawrot E. Monoclonal antibodies directed against a synthetic peptide corresponding to the α-bungarotoxin binding region of the acetylcholine receptor. Biochimica Et Biophysica Acta 1990, 1033: 324-328. PMID: 2317509, DOI: 10.1016/0304-4165(90)90141-i.