Ningwen Tai, PhD
Associate Research Scientist in Medicine (Endocrinology)
Research & Publications
Biography
Locations
Coauthors
Selected Publications
- NLRP6 deficiency expands a novel CD103+ B cell population that confers immune tolerance in NOD micePearson J, Peng J, Huang J, Yu X, Tai N, Hu Y, Sha S, Flavell R, Zhao H, Wong F, Wen L. NLRP6 deficiency expands a novel CD103+ B cell population that confers immune tolerance in NOD mice. Frontiers In Immunology 2023, 14: 1147925. PMID: 36911699, PMCID: PMC9995752, DOI: 10.3389/fimmu.2023.1147925.
- Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swineCotero V, Graf J, Miwa H, Hirschstein Z, Qanud K, Huerta TS, Tai N, Ding Y, Jimenez-Cowell K, Tomaio JN, Song W, Devarajan A, Tsaava T, Madhavan R, Wallace K, Loghin E, Morton C, Fan Y, Kao TJ, Akhtar K, Damaraju M, Barenboim L, Maietta T, Ashe J, Tracey KJ, Coleman TR, Di Carlo D, Shin D, Zanos S, Chavan SS, Herzog RI, Puleo C. Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine. Nature Biomedical Engineering 2022, 6: 683-705. PMID: 35361935, PMCID: PMC10127248, DOI: 10.1038/s41551-022-00870-w.
- IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD MiceHuang J, Tan Q, Tai N, Pearson JA, Li Y, Chao C, Zhang L, Peng J, Xing Y, Zhang L, Hu Y, Zhou Z, Wong FS, Wen L. IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice. Frontiers In Immunology 2021, 12: 702955. PMID: 34394099, PMCID: PMC8362616, DOI: 10.3389/fimmu.2021.702955.
- Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and functionHuang J, Peng J, Pearson JA, Efthimiou G, Hu Y, Tai N, Xing Y, Zhang L, Gu J, Jiang J, Zhao H, Zhou Z, Wong FS, Wen L. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular & Molecular Immunology 2021, 18: 328-338. PMID: 33432061, PMCID: PMC8027372, DOI: 10.1038/s41423-020-00590-8.
- Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell FunctionsPearson JA, Tai N, Ekanayake-Alper DK, Peng J, Hu Y, Hager K, Compton S, Wong FS, Smith PC, Wen L. Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions. Frontiers In Immunology 2019, 10: 2654. PMID: 31798584, PMCID: PMC6863139, DOI: 10.3389/fimmu.2019.02654.
- 7-LB: Dichloroacetate Improves Cognitive Function during Hypoglycemia in T1DM PatientsGROSKREUTZ D, TRICO D, TAI N, BELFORT-DEAGUIAR R, LEVENTHAL J, LAM W, KNIGHT M, GANNON J, HERZOG R. 7-LB: Dichloroacetate Improves Cognitive Function during Hypoglycemia in T1DM Patients. Diabetes 2019, 68 DOI: 10.2337/db19-7-lb.
- Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetesLiu M, Peng J, Tai N, Pearson JA, Hu C, Guo J, Hou L, Zhao H, Wong FS, Wen L. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 2018, 61: 2333-2343. PMID: 30094467, PMCID: PMC6182661, DOI: 10.1007/s00125-018-4705-0.
- TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cellsGülden E, Chao C, Tai N, Pearson JA, Peng J, Majewska-Szczepanik M, Zhou Z, Wong FS, Wen L. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells. Journal Of Autoimmunity 2018, 93: 57-65. PMID: 29960834, PMCID: PMC6108920, DOI: 10.1016/j.jaut.2018.06.003.
- Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD miceTan Q, Tai N, Li Y, Pearson J, Pennetti S, Zhou Z, Wong FS, Wen L. Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 2018, 3: e95882. PMID: 29321370, PMCID: PMC5821212, DOI: 10.1172/jci.insight.95882.
- Microbial antigen mimics activate diabetogenic CD8 T cells in NOD miceTai N, Peng J, Liu F, Gulden E, Hu Y, Zhang X, Chen L, Wong FS, Wen L. Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice. Journal Of Experimental Medicine 2016, 213: 2129-2146. PMID: 27621416, PMCID: PMC5030808, DOI: 10.1084/jem.20160526.
- The induction of autoimmune hepatitis in the human leucocyte antigen‐DR4 non‐obese diabetic mice autoimmune hepatitis mouse modelYuksel M, Xiao X, Tai N, Vijay M, Gülden E, Beland K, Lapierre P, Alvarez F, Hu Z, Colle I, Ma Y, Wen L. The induction of autoimmune hepatitis in the human leucocyte antigen‐DR4 non‐obese diabetic mice autoimmune hepatitis mouse model. Clinical & Experimental Immunology 2016, 186: 164-176. PMID: 27414259, PMCID: PMC5054566, DOI: 10.1111/cei.12843.
- The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetesTai N, Wong FS, Wen L. The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes. Journal Of Autoimmunity 2016, 71: 26-34. PMID: 27021275, PMCID: PMC4903935, DOI: 10.1016/j.jaut.2016.03.006.
- Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCsHu Y, Peng J, Tai N, Hu C, Zhang X, Wong FS, Wen L. Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs. The Journal Of Immunology 2015, 195: 4176-4184. PMID: 26401004, PMCID: PMC4765177, DOI: 10.4049/jimmunol.1500884.
- A novel “humanized mouse” model for autoimmune hepatitis and the association of gut microbiota with liver inflammationYuksel M, Wang Y, Tai N, Peng J, Guo J, Beland K, Lapierre P, David C, Alvarez F, Colle I, Yan H, Mieli-Vergani G, Vergani D, Ma Y, Wen L. A novel “humanized mouse” model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology 2015, 62: 1536-1550. PMID: 26185095, PMCID: PMC4763614, DOI: 10.1002/hep.27998.
- The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesityTai N, Wong FS, Wen L. The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity. Reviews In Endocrine And Metabolic Disorders 2015, 16: 55-65. PMID: 25619480, PMCID: PMC4348024, DOI: 10.1007/s11154-015-9309-0.
- TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic MiceTai N, Wong FS, Wen L. TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice. The Journal Of Immunology 2013, 191: 2926-2937. PMID: 23956420, PMCID: PMC3788667, DOI: 10.4049/jimmunol.1300547.
- Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple MyelomaWaldron-Lynch F, Inzucchi SE, Menard L, Tai N, Preston-Hurlburt P, Hui P, McClaskey J, Hagopian WA, Meffre E, Marks PW, Wen L, Herold KC. Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple Myeloma. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4317-4323. PMID: 23074233, PMCID: PMC3513536, DOI: 10.1210/jc.2012-2388.
- TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetesDong B, Qi D, Yang L, Huang Y, Xiao X, Tai N, Wen L, Wong F. TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. AJP Heart And Circulatory Physiology 2012, 303: h732-h742. PMID: 22842069, PMCID: PMC3468457, DOI: 10.1152/ajpheart.00948.2011.
- The Dual Effects of B Cell Depletion on Antigen-Specific T Cells in BDC2.5NOD MiceXiang Y, Peng J, Tai N, Hu C, Zhou Z, Wong FS, Wen L. The Dual Effects of B Cell Depletion on Antigen-Specific T Cells in BDC2.5NOD Mice. The Journal Of Immunology 2012, 188: 4747-4758. PMID: 22490442, PMCID: PMC4361183, DOI: 10.4049/jimmunol.1103055.
- MyD88 Expression on Villin Inhibits Obesity in High Fat Diet Mice (120.5)Chao C, Xiang Y, Wang Y, Peng J, Hu Y, Tai N, Hoshi N, Zhou Z, Medzhitov R, Wen L. MyD88 Expression on Villin Inhibits Obesity in High Fat Diet Mice (120.5). The Journal Of Immunology 2012, 188: 120.5-120.5. DOI: 10.4049/jimmunol.188.supp.120.5.
- B cell depletion - a double-edged sword (123.18)Tai N, Wen L. B cell depletion - a double-edged sword (123.18). The Journal Of Immunology 2012, 188: 123.18-123.18. DOI: 10.4049/jimmunol.188.supp.123.18.
- IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 miceTai N, Yasuda H, Xiang Y, Zhang L, Rodriguez-Pinto D, Yokono K, Sherwin R, Wong FS, Nagata M, Wen L. IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice. Clinical Immunology 2011, 139: 336-349. PMID: 21458378, DOI: 10.1016/j.clim.2011.03.003.
- Cross Talk Between Pathogenic CD4+T Cells and B Cells (143.35)Xiang Y, Peng J, Tai N, Hu C, Zhou Z, Wen L. Cross Talk Between Pathogenic CD4+T Cells and B Cells (143.35). The Journal Of Immunology 2010, 184: 143.35-143.35. DOI: 10.4049/jimmunol.184.supp.143.35.
- Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD miceXiao X, Ma B, Dong B, Zhao P, Tai N, Chen L, Wong FS, Wen L. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal Of Autoimmunity 2009, 32: 85-93. PMID: 19200691, DOI: 10.1016/j.jaut.2008.12.003.
- Identification of a cis-acting element of human dihydrofolate reductase mRNATai N, Schmitz JC, Chen TM, O’Neill M, Chu E. Identification of a cis-acting element of human dihydrofolate reductase mRNA. Biochemical And Biophysical Research Communications 2007, 369: 795-800. PMID: 18045573, DOI: 10.1016/j.bbrc.2007.09.044.
- RNA-binding protein HUR regulates VEGF expression in human colorectal cancer cellsYoo P, Mulkeen A, Silva T, Schmitz J, Tai N, Uchio E, Chu E, Cha C. RNA-binding protein HUR regulates VEGF expression in human colorectal cancer cells. Journal Of Surgical Research 2006, 130: 219-220. DOI: 10.1016/j.jss.2005.11.163.
- Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNANingwen T, SCHMITZ JC, CHEN TM, Edward C. Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA. Biochemical Journal 2004, 378: 999-1006. PMID: 14664697, PMCID: PMC1224025, DOI: 10.1042/bj20031396.
- Thymidylate synthase as a translational regulator of cellular gene expressionLiu J, Schmitz JC, Lin X, Tai N, Yan W, Farrell M, Bailly M, Chen T, Chu E. Thymidylate synthase as a translational regulator of cellular gene expression. Biochimica Et Biophysica Acta 2002, 1587: 174-182. PMID: 12084459, DOI: 10.1016/s0925-4439(02)00080-7.
- Translational Regulation as a Novel Mechanism for the Development of Cellular Drug ResistanceSchmitz J, Liu J, Lin X, Chen T, Yan W, Tai N, Gollerkeri A, Chu E. Translational Regulation as a Novel Mechanism for the Development of Cellular Drug Resistance. Cancer And Metastasis Reviews 2001, 20: 33-41. PMID: 11831645, DOI: 10.1023/a:1013100306315.