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James Dziura, MPH, PhD

Professor of Emergency Medicine and of Biostatistics and of Medicine (Endocrinology); Co-Director, Yale Center for Analytical Sciences (YCAS); Director, Yale Data Coordinating Center; Professor, Biostatistics

Contact Information

James Dziura, MPH, PhD

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Research Summary

A major focus of my research career has centered on the design, analysis and coordination of clinical trials. Over the past ten years I have overseen data coordinating and biostatistical efforts for numerous studies including trials evaluating a computer-assisted screening and brief intervention to reduce alcohol use in Latino drinkers, determining the efficacy of a novel integrated tobacco order set embedded within the EMR to promote sustained smoking abstinence in hospitalized smokers, and examining pharmaceutical and behavioral interventions in children and adults with autism spectrum and Tourette disorders through the Research Unit on Pediatric Psychopharmacology (RUPP) Autism network and the Behavioral Sciences Consortium for Tourette Syndrome. I served as the PI of the data coordinating center for the RUPP Autism Network study of Guanfacine for the treatment of hyperactivity. I am currently the Director of the Data Coordinating Center for the multicenter Autism Biomarkers for Clinical Trials (ABC-CT) study. I'm also a senior statistician for the PCORI funded Strategies to Reduce Injuries and Develop confidence in Elders (STRIDE) trial, a cluster randomized trial of 6000 participants from 80 primary care practices.

Extensive Research Description

Much of my recent contributions have been in the area of Emergency Medicine. Collaborations include evaluating and testing a disability scale in older visitors to the ED, examining the efficacy of a bilingual computer-assisted screen and brief intervention for Latino unhealthy drinkers, determining prognostic factors for patients in ED chest pain observation, describing the diagnostic accuracy of point-of-care ultrasound and the evaluation of a network analytic model for adherence and abstinence. Additionally, I've studied the behavioral factors involved with motor vehicle crashes. Through the NIDA funded Yale-Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS) I am actively engaged in the mentorship and training of junior clinician scientists with an emphasis on designing research studies that improve health outcomes of patients with and at risk for drug abuse, addiction, and HIV.

Another area of research concentration is the epidemiology and treatment of metabolic disorders such as obesity and diabetes. My dissertation focused on the effects of physical activity on body weight maintenance and diabetes in older individuals. More recent contributions have examined metabolic consequences of obesity in children and behavioral approaches to weight reduction. I've also studied mechanisms of insulin resistance in children and adults.


Research Interests

Clinical Trials as Topic; Data Collection; Diabetes Mellitus; Emergency Medicine; Epidemiology; Nutritional and Metabolic Diseases; Obesity; Statistics as Topic

Selected Publications

Clinical Trials

ConditionsStudy Title
Mental Health & Behavioral ResearchKetamine for Adolescent Suicidality
Children's Health; Diseases of the Digestive System - LiverThe Role of Hepatic De Novo Lipogenesis (DNL) in the Pathogenesis of Hepatic Steatosis