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Lisa Fucito, PhD

Associate Professor of Psychiatry; Director, Tobacco Treatment Service, Psychiatry

Research Summary

Cigarette smoking and heavy alcohol consumption are the first and third preventable causes of death and disease in the U.S., respectively. Both also frequently co-occur with other modifiable health risk behaviors such as insufficient sleep and physical inactivity/poor nutrition. Despite these health risks, a substantial number of individuals are unable to successfully quit smoking or reduce their drinking. Current efficacious treatments have limitations: (1) not integrated with primary and/or specialty healthcare where most individuals who smoke and/or drink are treated; (2) do not address the multimorbidities that frequently accompany these behaviors; and (3) pose accessibility barriers. There is a need to identify effective integrated models that attenuate healthcare barriers as well as interventions that generalize across multiple negative health behaviors. Multiple health behavior change interventions have the potential to maximize health benefits and reduce health costs.

My research focuses on:

  1. Developing novel prevention and intervention strategies that promote multiple health behavior change.
  2. Using health feedback (e.g., biosensor data & biomarkers) to motivate health behavior change.
  3. Testing primary healthcare topics (e.g., sleep) as a "gateway" to addressing alcohol and tobacco use.
  4. Utilizing technology to assess and deliver interventions to reduce treatment access barriers.
  5. Identifying factors that optimize treatment response and mediate behavior change.
  6. Examining harm reduction strategies and interventions.
  7. Characterizing risk behavior profiles.

Specialized Terms: Treatments for tobacco and alcohol use; Moderators of treatment response; Risk behavior mechanisms; Sleep disturbance and substance use; Multiple health behavior change; M-health; Health feedback

Extensive Research Description

Current Research Projects:

A photoplethysmography sensor-based personalized feedback intervention for heavy-drinking young adults targeting heart rate variability, resting heart rate, and sleep. PI: Fucito. Funding: NIAAA R21AA028886. The current proposal will conduct the first controlled test of a feedback/brief advice intervention targeting HRV, RHR, and sleep via PPG sensors and electronic daily diaries for heavy-drinking young adults.This study will yield important preliminary data to support a larger investigation of this novel approach with heavy-drinking young adults.

Enhancing Tobacco Treatment for Yale Cancer Center Patients: A Pilot Test of an Embedded Pharmacist Model. PI: Fuchs, Fucito. Funding: NCI – C3i Initiative, P30CA016359-S. This service implementation project involves the implementation and evaluation of a novel, pharmacist-delivered intervention and a proactive, electronic outreach model to increase the number of cancer patients who are offered tobacco treatment and participate in treatment. The goal is to increase the number who are screened and treated for tobacco use across the Yale Cancer Center Network statewide.

Gain-framed Messages and NRT Sampling to Promote Smoking Cessation in Lung Cancer Screening Programs PI: Toll; Yale Site PI: Fucito. Funding: NCI R01CA207229. The purpose of this study is to test a mobile tobacco intervention for promoting smoking cessation among smokers receiving lung cancer screening.

Contingency Management to Promote Smoking Abstinence in Cancer Patients. PI: Toll; Yale Site PI: Fucito. Funding: NCI R01CA251158. This project will conduct a randomized, controlled test of the effect of adding contingency management to standard smoking cessation treatment to enhance rates of smoking cessation for cancer patients before their cancer surgery.

Switching to a non-tobacco-based oral nicotine product among adult cigarette smokers: Exploring the roles of product characteristics and user history. Pilot PI: Fucito. Funding: FDA U54DA036151. The purpose of this study is to investigate the potential reduction in harm of switching from combustible smoking to new oral nicotine pouches in adult smokers. The study will examine changes in tobacco harm exposure from switching as well as factors that may influence the likelihood of switching such as nicotine concentration, flavor, and user characteristics.


Research Interests

Alcohol Drinking; Alcoholism; Nicotine; Sleep; Technology; Exercise; Tobacco Use Cessation; Vulnerable Populations; Harm Reduction; Secondary Prevention; Tertiary Prevention; Sedentary Behavior; Mobile Applications; Tobacco Use; Sleep Hygiene; Health Risk Behaviors

Public Health Interests

Behavioral Health; Mental Health; Substance Use, Addiction

Selected Publications

Clinical Trials

ConditionsStudy Title
Addictive Behaviors; Tobacco AddictionVarenicline for treatment of e-cigarette dependence
Alcohol Addiction; Men's Health; Women's HealthA PPG Sensor-Based Feedback Intervention for Heavy Drinking Young Adults
Addictive Behaviors; Tobacco Addiction; COVID-19 Inpatient; COVID-19 OutpatientReal-Time Surveillance of E-Cigarette, or Vaping, Product-Use Associated Lung Injury (EVALI)
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco AddictionSwitching to Potential Reduced Exposure Products in Adult Smokers (JUUL)