Dibyadeep Datta
Assistant Professor of Psychiatry
Research & Publications
Biography
News
Coauthors
Selected Publications
- Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry PerspectivesDatta D. Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry Perspectives. The Journals Of Gerontology Series A 2023, 78: 1523-1534. PMID: 37279946, PMCID: PMC10460555, DOI: 10.1093/gerona/glad134.
- 557. Nanoscale Imaging of pT217-Tau in Aged Rhesus Macaque: Trans-Synaptic Propagation and Seeding of Tau Pathology in Entorhinal CortexDatta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. 557. Nanoscale Imaging of pT217-Tau in Aged Rhesus Macaque: Trans-Synaptic Propagation and Seeding of Tau Pathology in Entorhinal Cortex. Biological Psychiatry 2023, 93: s319. DOI: 10.1016/j.biopsych.2023.02.797.
- Nanoscale imaging of pT217‐tau in aged rhesus macaque: Trans‐synaptic propagation and seeding of tau pathology in entorhinal cortexDatta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. Nanoscale imaging of pT217‐tau in aged rhesus macaque: Trans‐synaptic propagation and seeding of tau pathology in entorhinal cortex. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.064956.
- P477. Anatomical Evaluation of Calcium-Related Schizophrenia Risk Genes in Rhesus Macaque Dorsolateral Prefrontal CortexDatta D, Mentone S, Morozov Y, Arnsten A. P477. Anatomical Evaluation of Calcium-Related Schizophrenia Risk Genes in Rhesus Macaque Dorsolateral Prefrontal Cortex. Biological Psychiatry 2022, 91: s281-s282. DOI: 10.1016/j.biopsych.2022.02.713.
- Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer’s diseaseDatta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer’s disease. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054671.
- Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human PrimatesLeslie SN, Kanyo J, Datta D, Wilson RS, Zeiss C, Duque A, Lam TT, Arnsten AFT, Nairn AC. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers In Aging Neuroscience 2021, 13: 767322. PMID: 34867294, PMCID: PMC8637411, DOI: 10.3389/fnagi.2021.767322.
- Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory PerformanceDatta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance. Frontiers In Aging Neuroscience 2021, 13: 760270. PMID: 34867287, PMCID: PMC8634091, DOI: 10.3389/fnagi.2021.760270.
- M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performanceGalvin VC, Yang S, Lowet AS, Datta D, Duque A, Arnsten AF, Wang M. M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance. Current Research In Neurobiology 2021, 2: 100016. PMID: 35098156, PMCID: PMC8794314, DOI: 10.1016/j.crneur.2021.100016.
- Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspectiveArnsten AFT, Datta D, Preuss TM. Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspective. American Journal Of Primatology 2021, 83: e23254. PMID: 33960505, PMCID: PMC8550995, DOI: 10.1002/ajp.23254.
- Subcellular Localization of Schizophrenia Risk Genes Encoding Cav1.2 (CACNA1C) and VIPR2 in Rhesus Macaque Dorsolateral Prefrontal CortexDatta D, Mentone S, Morozov Y, Arnsten A. Subcellular Localization of Schizophrenia Risk Genes Encoding Cav1.2 (CACNA1C) and VIPR2 in Rhesus Macaque Dorsolateral Prefrontal Cortex. Biological Psychiatry 2021, 89: s308. DOI: 10.1016/j.biopsych.2021.02.768.
- Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular ChangesWoo E, Sansing LH, Arnsten AFT, Datta D. Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. Chronic Stress 2021, 5: 24705470211029254. PMID: 34485797, PMCID: PMC8408896, DOI: 10.1177/24705470211029254.
- The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortexArnsten AFT, Datta D, Wang M. The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex. Molecular Psychiatry 2020, 26: 3684-3700. PMID: 33319854, PMCID: PMC8203737, DOI: 10.1038/s41380-020-00973-3.
- The calcium‐containing smooth endoplasmic reticulum is a focus of risk factors for early‐ and late‐onset Alzheimer’s diseaseDatta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. The calcium‐containing smooth endoplasmic reticulum is a focus of risk factors for early‐ and late‐onset Alzheimer’s disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.047651.
- Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortexLeslie S, Datta D, Wang M, van Dyck C, Arnsten A, Nairn A. Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortex. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.042017.
- Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell CircuitsDatta D, Enwright JF, Arion D, Paspalas CD, Morozov YM, Lewis DA, Arnsten AFT. Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits. Frontiers In Neuroanatomy 2020, 14: 578483. PMID: 33328902, PMCID: PMC7714912, DOI: 10.3389/fnana.2020.578483.
- Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal CortexGlausier J, Datta D, Fish K, Chung D, Melchitzky D, Lewis D. Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex. Neuroscience 2020, 452: 181-191. PMID: 33212224, PMCID: PMC7770119, DOI: 10.1016/j.neuroscience.2020.10.022.
- Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of TauLeslie SN, Datta D, Christensen KR, van Dyck CH, Arnsten AFT, Nairn AC. Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. Frontiers In Aging Neuroscience 2020, 12: 576723. PMID: 33192469, PMCID: PMC7655962, DOI: 10.3389/fnagi.2020.576723.
- Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's diseaseArnsten AFT, Datta D, Del Tredici K, Braak H. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & Dementia 2020, 17: 115-124. PMID: 33075193, PMCID: PMC7983919, DOI: 10.1002/alz.12192.
- The importance of diversity and outreach in geroscience research: Insights from the Annual Biomedical Research Conference for Minority StudentsLee M, Datta D, Hill C, Bitto A. The importance of diversity and outreach in geroscience research: Insights from the Annual Biomedical Research Conference for Minority Students. GeroScience 2020, 42: 1005-1012. PMID: 32363429, PMCID: PMC7287005, DOI: 10.1007/s11357-020-00191-3.
- Neuron-Glia Inflammatory Interactions in Aging Rhesus Macaque Dorsolateral Prefrontal Cortex Layer IIIDatta D, Morozov Y, Arnsten A. Neuron-Glia Inflammatory Interactions in Aging Rhesus Macaque Dorsolateral Prefrontal Cortex Layer III. Biological Psychiatry 2020, 87: s425. DOI: 10.1016/j.biopsych.2020.02.1084.
- P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOADDatta D, Morozov Y, Arellano J, van Dyck C, Arnsten A. P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD. Alzheimer's & Dementia 2019, 15: p1329-p1329. DOI: 10.1016/j.jalz.2019.06.3804.
- F164. Ultrastructural Localization of Classical Complement Cascade Signaling Protein C1q in Rhesus Macaque Dorsolateral Prefrontal CortexDatta D, Morozov Y, van Dyck C, Arnsten A. F164. Ultrastructural Localization of Classical Complement Cascade Signaling Protein C1q in Rhesus Macaque Dorsolateral Prefrontal Cortex. Biological Psychiatry 2019, 85: s276-s277. DOI: 10.1016/j.biopsych.2019.03.701.
- P3‐182: SUBCELLULAR DISTRIBUTION OF PHOSPHODIESTERASE 4D (PDE4D) IN RHESUS MACAQUE DORSOLATERAL PREFRONTAL CORTEX: IMPLICATIONS FOR TAUOPATHY IN ALZHEIMER'S DISEASEDatta D, Arnsten A. P3‐182: SUBCELLULAR DISTRIBUTION OF PHOSPHODIESTERASE 4D (PDE4D) IN RHESUS MACAQUE DORSOLATERAL PREFRONTAL CORTEX: IMPLICATIONS FOR TAUOPATHY IN ALZHEIMER'S DISEASE. Alzheimer's & Dementia 2018, 14: p1137-p1137. DOI: 10.1016/j.jalz.2018.06.1540.
- P3‐088: THE AGING RHESUS MONKEY IS AN APPROPRIATE NEW ANIMAL MODEL FOR STUDYING THE ETIOLOGY AND TREATMENT OF TAU PATHOLOGY IN ASSOCIATION CORTEXArnsten A, Carlyle B, Leslie S, Preuss T, Crimins J, Datta D, Anita H, van Dyck C, Rosene D, Nairn A, Paspalas C. P3‐088: THE AGING RHESUS MONKEY IS AN APPROPRIATE NEW ANIMAL MODEL FOR STUDYING THE ETIOLOGY AND TREATMENT OF TAU PATHOLOGY IN ASSOCIATION CORTEX. Alzheimer's & Dementia 2018, 14: p1099-p1099. DOI: 10.1016/j.jalz.2018.06.1444.
- [O2–02–03]: ULTRASTRUCTURAL EVIDENCE FOR IMPAIRED MITOCHONDRIAL FISSION IN THE AGED RHESUS MONKEY DORSOLATERAL PREFRONTAL CORTEX: RELEVANCE TO THE PATHOGENESIS OF ALZHEIMER's DISEASEDatta D, Morozov Y, Paspalas A. [O2–02–03]: ULTRASTRUCTURAL EVIDENCE FOR IMPAIRED MITOCHONDRIAL FISSION IN THE AGED RHESUS MONKEY DORSOLATERAL PREFRONTAL CORTEX: RELEVANCE TO THE PATHOGENESIS OF ALZHEIMER's DISEASE. Alzheimer's & Dementia 2017, 13: p553-p553. DOI: 10.1016/j.jalz.2017.07.151.
- M97. Impairments in Mitochondrial Fission in Rhesus Monkey Dorsolateral Prefrontal Cortex: Ultrastructural Evidence for a Novel Cellular Mechanism of AgingDatta D, Morozov Y. M97. Impairments in Mitochondrial Fission in Rhesus Monkey Dorsolateral Prefrontal Cortex: Ultrastructural Evidence for a Novel Cellular Mechanism of Aging. Schizophrenia Bulletin 2017, 43: s246-s246. PMCID: PMC5475857, DOI: 10.1093/schbul/sbx022.092.
- Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?Yan Z, Kim E, Datta D, Lewis D, Soderling S. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? Journal Of Neuroscience 2016, 36: 11411-11417. PMID: 27911743, PMCID: PMC5125208, DOI: 10.1523/jneurosci.2360-16.2016.
- Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in SchizophreniaDatta D, Arion D, Roman K, Volk D, Lewis D. Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia. American Journal Of Psychiatry 2016, 174: 163-171. PMID: 27523502, PMCID: PMC5288270, DOI: 10.1176/appi.ajp.2016.16020204.
- Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in SchizophreniaHoftman G, Datta D, Lewis D. Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia. Biological Psychiatry 2016, 81: 862-873. PMID: 27455897, PMCID: PMC5136518, DOI: 10.1016/j.biopsych.2016.05.022.
- Reciprocal Alterations in Regulator of G Protein Signaling 4 and microRNA16 in SchizophreniaKimoto S, Glausier J, Fish K, Volk D, Bazmi H, Arion D, Datta D, Lewis D. Reciprocal Alterations in Regulator of G Protein Signaling 4 and microRNA16 in Schizophrenia. Schizophrenia Bulletin 2015, 42: 396-405. PMID: 26424323, PMCID: PMC4753606, DOI: 10.1093/schbul/sbv139.
- Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in SchizophreniaDatta D, Arion D, Corradi J, Lewis D. Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia. Biological Psychiatry 2015, 78: 775-785. PMID: 25981171, PMCID: PMC4600637, DOI: 10.1016/j.biopsych.2015.03.030.
- Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorderArion D, Corradi J, Tang S, Datta D, Boothe F, He A, Cacace A, Zaczek R, Albright C, Tseng G, Lewis D. Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder. Molecular Psychiatry 2015, 20: 1397-1405. PMID: 25560755, PMCID: PMC4492919, DOI: 10.1038/mp.2014.171.
- Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal CortexGonzalez-Burgos G, Miyamae T, Pafundo D, Yoshino H, Rotaru D, Hoftman G, Datta D, Zhang Y, Hammond M, Sampson A, Fish K, Ermentrout G, Lewis D. Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex. Cerebral Cortex 2014, 25: 4076-4093. PMID: 24904071, PMCID: PMC4626828, DOI: 10.1093/cercor/bhu122.
- Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal CortexDatta D, Arion D, Lewis D. Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex. Cerebral Cortex 2014, 25: 2295-2305. PMID: 24610118, PMCID: PMC4494034, DOI: 10.1093/cercor/bhu040.
- Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis PatientsHarberts E, Datta D, Chen S, Wohler J, Oh U, Jacobson S. Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients. Journal Of Neuroimmune Pharmacology 2012, 8: 51-57. PMID: 22956240, PMCID: PMC4765953, DOI: 10.1007/s11481-012-9397-5.
- NFkB activation promotes immune activation in HTLV-I-associated myelopathy / tropical spastic paraparesisMcCormick M, Oh U, Datta D, Turner R, Bobb K, Monie D, Sliskovic D, Zhang J, Meshulam J, Jacobson S. NFkB activation promotes immune activation in HTLV-I-associated myelopathy / tropical spastic paraparesis. Retrovirology 2011, 8: a117. PMCID: PMC3112584, DOI: 10.1186/1742-4690-8-s1-a117.
- Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic diseaseOh U, McCormick M, Datta D, Turner R, Bobb K, Monie D, Sliskovic D, Tanaka Y, Zhang J, Meshulam J, Jacobson S. Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease. Blood 2011, 117: 3363-3369. PMID: 21212284, PMCID: PMC3069676, DOI: 10.1182/blood-2010-10-306571.
- Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorderCampbell D, Datta D, Jones S, Batey Lee E, Sutcliffe J, Hammock E, Levitt P. Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2011, 3: 101-112. PMID: 21484202, PMCID: PMC3113442, DOI: 10.1007/s11689-010-9071-2.
- Flexible, Bowl-Shaped N-Heterocyclic Carbene Ligands: Substrate Specificity in Iridium-Catalyzed Ketone HydrosilylationChianese A, Mo A, Datta D. Flexible, Bowl-Shaped N-Heterocyclic Carbene Ligands: Substrate Specificity in Iridium-Catalyzed Ketone Hydrosilylation. Organometallics 2008, 28: 465-472. DOI: 10.1021/om800878m.