John D Murray, PhD
Associate Professor Adjunct of Psychiatry
Research & Publications
Biography
News
Research Summary
Research in the Murray Lab focuses on investigating the dynamics and function of neural circuits, and their dysfunction in psychiatric and neurological disorders. To investigate these issues, we develop modeling, theoretical, and data-analytic approaches to systems neuroscience, in close collaboration with experimentalists.
Coauthors
Research Interests
Cognition; Computer Simulation; Decision Making; Interneurons; Memory, Short-Term; Schizophrenia; Prefrontal Cortex; Computational Biology; Functional Neuroimaging
Selected Publications
- Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topographyBurt JB, DemirtaÅŸ M, Eckner WJ, Navejar NM, Ji JL, Martin WJ, Bernacchia A, Anticevic A, Murray JD. Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography. Nature Neuroscience 2018, 21: 1251-1259. PMID: 30082915, PMCID: PMC6119093, DOI: 10.1038/s41593-018-0195-0.
- Hierarchical Heterogeneity across Human Cortex Shapes Large-Scale Neural DynamicsDemirtaÅŸ M, Burt JB, Helmer M, Ji JL, Adkinson BD, Glasser MF, Van Essen DC, Sotiropoulos SN, Anticevic A, Murray JD. Hierarchical Heterogeneity across Human Cortex Shapes Large-Scale Neural Dynamics. Neuron 2019, 101: 1181-1194.e13. PMID: 30744986, PMCID: PMC6447428, DOI: 10.1016/j.neuron.2019.01.017.
- Generative modeling of brain maps with spatial autocorrelationBurt JB, Helmer M, Shinn M, Anticevic A, Murray JD. Generative modeling of brain maps with spatial autocorrelation. NeuroImage 2020, 220: 117038. PMID: 32585343, DOI: 10.1016/j.neuroimage.2020.117038.
- A flexible framework for simulating and fitting generalized drift-diffusion modelsShinn M, Lam NH, Murray JD. A flexible framework for simulating and fitting generalized drift-diffusion models. ELife 2020, 9: e56938. PMID: 32749218, PMCID: PMC7462609, DOI: 10.7554/elife.56938.
- Confluence of Timing and Reward Biases in Perceptual Decision-Making DynamicsShinn M, Ehrlich D, Lee D, Murray JD, Seo H. Confluence of Timing and Reward Biases in Perceptual Decision-Making Dynamics. Journal Of Neuroscience 2020, 40: 7326-7342. PMID: 32839233, PMCID: PMC7534922, DOI: 10.1523/jneurosci.0544-20.2020.
- A circuit mechanism for decision-making biases and NMDA receptor hypofunctionCavanagh SE, Lam NH, Murray JD, Hunt LT, Kennerley SW. A circuit mechanism for decision-making biases and NMDA receptor hypofunction. ELife 2020, 9: e53664. PMID: 32988455, PMCID: PMC7524553, DOI: 10.7554/elife.53664.
- PsychRNN: An Accessible and Flexible Python Package for Training Recurrent Neural Network Models on Cognitive TasksEhrlich DB, Stone JT, Brandfonbrener D, Atanasov A, Murray JD. PsychRNN: An Accessible and Flexible Python Package for Training Recurrent Neural Network Models on Cognitive Tasks. ENeuro 2020, 8: eneuro.0427-20.2020. PMID: 33328247, PMCID: PMC7814477, DOI: 10.1523/eneuro.0427-20.2020.
- Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSDBurt JB, Preller KH, Demirtas M, Ji JL, Krystal JH, Vollenweider FX, Anticevic A, Murray JD. Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD. ELife 2021, 10: e69320. PMID: 34313217, PMCID: PMC8315798, DOI: 10.7554/elife.69320.
- Trial-to-Trial Variability of Spiking Delay Activity in Prefrontal Cortex Constrains Burst-Coding Models of Working Memory.Li D, Constantinidis C, Murray JD. Trial-to-Trial Variability of Spiking Delay Activity in Prefrontal Cortex Constrains Burst-Coding Models of Working Memory. Journal Of Neuroscience 2021, 41: 8928-8945. PMID: 34551937, PMCID: PMC8549532, DOI: 10.1523/jneurosci.0167-21.2021.
- Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model.Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.
- Transient neuronal suppression for exploitation of new sensory evidenceShinn M, Lee D, Murray JD, Seo H. Transient neuronal suppression for exploitation of new sensory evidence. Nature Communications 2022, 13: 23. PMID: 35013222, PMCID: PMC8748884, DOI: 10.1038/s41467-021-27697-4.
- Geometry of neural computation unifies working memory and planningEhrlich DB, Murray JD. Geometry of neural computation unifies working memory and planning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2115610119. PMID: 36067286, PMCID: PMC9478653, DOI: 10.1073/pnas.2115610119.
- Multitask representations in the human cortex transform along a sensory-to-motor hierarchyIto T, Murray J. Multitask representations in the human cortex transform along a sensory-to-motor hierarchy. Nature Neuroscience 2022, 26: 306-315. PMID: 36536240, DOI: 10.1038/s41593-022-01224-0.
- Functional brain networks reflect spatial and temporal autocorrelationShinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.
- Human generalization of internal representations through prototype learning with goal-directed attentionPettine W, Raman D, Redish A, Murray J. Human generalization of internal representations through prototype learning with goal-directed attention. Nature Human Behaviour 2023, 7: 442-463. PMID: 36894642, DOI: 10.1038/s41562-023-01543-7.