Our group's research focus is centered on computational and cognitive neuroscience of mental illness. Specifically, we study at the neural system level mechanisms involved in higher order cognitive operations, such as working memory, as well as their interaction with neural systems involved in affective processes, with the aim of understanding how these computations may go awry in the context of severe mental illness. Methodologically, we use use a combination of tools, such as task-based, resting-state, pharmacological multi-modal neuroimaging, as well as computational modeling approaches to map neural alterations that lead to poor mental health outcomes. The combination of these tools informs a quantitative and personalized 'Computational Psychiatry' framework for development of neuro-behavioral markers that can explicitly inform treatment. The overarching goal of the group is to develop neurobiologically principled and computationally grounded mapping between neural and behavioral levels of analyses in people to inform personalized and rational treatment design for mental health symptoms.
Specific Research Areas
Affect; Mental Disorders; Cognition; Diagnosis, Computer-Assisted; Emotions; Memory, Short-Term; Schizophrenia; Computational Biology; Substance-Related Disorders; Neuroimaging
Bioinformatics; Biomarkers; Clinical Trials; Mental Health; Modeling; Substance Use, Addiction
Conditions | Study Title |
---|---|
Mental Health & Behavioral Research | Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD |
Mental Health & Behavioral Research | A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia |
Diseases of the Nervous System; Mental Health & Behavioral Research | Teen Brain and Behavior Study |
Diseases of the Nervous System; Mental Health & Behavioral Research | Examination of Glutamate and mGluR5 in Psychiatric Disorders |
Diseases of the Nervous System; Mental Health & Behavioral Research | Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder |