Alan Anticevic, PhD
Glenn H. Greenberg Associate Professor of Psychiatry and Associate Professor of Psychology; Director, Division of Neurocognition, Neurocomputation, and Neurogenetics (N3), Psychiatry
Research & Publications
Biography
News
Extensive Research Description
Our group's research focus is centered on computational and cognitive neuroscience of mental illness. Specifically, we study at the neural system level mechanisms involved in higher order cognitive operations, such as working memory, as well as their interaction with neural systems involved in affective processes, with the aim of understanding how these computations may go awry in the context of severe mental illness. Methodologically, we use use a combination of tools, such as task-based, resting-state, pharmacological multi-modal neuroimaging, as well as computational modeling approaches to map neural alterations that lead to poor mental health outcomes. The combination of these tools informs a quantitative and personalized 'Computational Psychiatry' framework for development of neuro-behavioral markers that can explicitly inform treatment. The overarching goal of the group is to develop neurobiologically principled and computationally grounded mapping between neural and behavioral levels of analyses in people to inform personalized and rational treatment design for mental health symptoms.
Specific Research Areas
- Pharmacological Neuroimaging & Computational Modeling
- Cognition-Affective Computations in Mental Illness
- Mapping Neuro-behavioral Variation to Inform Mental Health Treatments
- Computational Informatics Architectures for Multi-modal Imaging
Coauthors
Research Interests
Affect; Mental Disorders; Cognition; Diagnosis, Computer-Assisted; Emotions; Memory, Short-Term; Schizophrenia; Computational Biology; Substance-Related Disorders; Neuroimaging
Public Health Interests
Bioinformatics; Biomarkers; Clinical Trials; Mental Health; Modeling; Substance Use, Addiction
Selected Publications
- Bridging Levels of Understanding in Schizophrenia Through Computational ModelingAnticevic A, Murray JD, Barch DM. Bridging Levels of Understanding in Schizophrenia Through Computational Modeling. Clinical Psychological Science 2015, 3: 433-459. PMID: 25960938, PMCID: PMC4421907, DOI: 10.1177/2167702614562041.
- Altered global brain signal in schizophreniaYang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7438-7443. PMID: 24799682, PMCID: PMC4034208, DOI: 10.1073/pnas.1405289111.
- Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and SchizophreniaAnticevic A, Savic A, Repovs G, Yang G, McKay DR, Sprooten E, Knowles EE, Krystal JH, Pearlson GD, Glahn DC. Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia. Schizophrenia Bulletin 2014, 41: 133-143. PMID: 24782562, PMCID: PMC4266289, DOI: 10.1093/schbul/sbu051.
- The Frontoparietal Control SystemCole MW, Repovš G, Anticevic A. The Frontoparietal Control System. The Neuroscientist 2014, 20: 652-664. PMID: 24622818, PMCID: PMC4162869, DOI: 10.1177/1073858414525995.
- Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing SchizophreniaAnticevic A, Tang Y, Cho YT, Repovs G, Cole MW, Savic A, Wang F, Krystal JH, Xu K. Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing Schizophrenia. Schizophrenia Bulletin 2013, 40: 1105-1116. PMID: 24366718, PMCID: PMC4133672, DOI: 10.1093/schbul/sbt165.
- Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive DisorderAnticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.
- Multi-task connectivity reveals flexible hubs for adaptive task controlCole MW, Reynolds JR, Power JD, Repovs G, Anticevic A, Braver TS. Multi-task connectivity reveals flexible hubs for adaptive task control. Nature Neuroscience 2013, 16: 1348-1355. PMID: 23892552, PMCID: PMC3758404, DOI: 10.1038/nn.3470.
- Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar IllnessAnticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, Savic A, Krystal JH, Pearlson GD, Glahn DC. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness. Cerebral Cortex 2013, 24: 3116-3130. PMID: 23825317, PMCID: PMC4224238, DOI: 10.1093/cercor/bht165.
- Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humansDriesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry 2013, 18: 1199-1204. PMID: 23337947, PMCID: PMC3646075, DOI: 10.1038/mp.2012.194.
- Connectivity, Pharmacology, and Computation: Toward a Mechanistic Understanding of Neural System Dysfunction in SchizophreniaAnticevic A, Cole MW, Repovs G, Savic A, Driesen NR, Yang G, Cho YT, Murray JD, Glahn DC, Wang XJ, Krystal JH. Connectivity, Pharmacology, and Computation: Toward a Mechanistic Understanding of Neural System Dysfunction in Schizophrenia. Frontiers In Psychiatry 2013, 4: 169. PMID: 24399974, PMCID: PMC3871997, DOI: 10.3389/fpsyt.2013.00169.
- The role of default network deactivation in cognition and diseaseAnticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends In Cognitive Sciences 2012, 16: 584-592. PMID: 23142417, PMCID: PMC3501603, DOI: 10.1016/j.tics.2012.10.008.
- NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophreniaAnticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.
- Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis HistoryAnticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History. Biological Psychiatry 2012, 73: 565-573. PMID: 22980587, PMCID: PMC3549314, DOI: 10.1016/j.biopsych.2012.07.031.
- A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interferenceAnticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research 2012, 141: 8-14. PMID: 22863548, PMCID: PMC3879404, DOI: 10.1016/j.schres.2012.07.007.
- Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and IntelligenceCole MW, Yarkoni T, Repovš G, Anticevic A, Braver TS. Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence. Journal Of Neuroscience 2012, 32: 8988-8999. PMID: 22745498, PMCID: PMC3392686, DOI: 10.1523/jneurosci.0536-12.2012.
- Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation AbnormalitiesAnticevic A, Repovs G, Barch DM. Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation Abnormalities. Schizophrenia Bulletin 2011, 39: 168-178. PMID: 21914644, PMCID: PMC3523909, DOI: 10.1093/schbul/sbr107.
- Automated landmark identification for human cortical surface-based registrationAnticevic A, Repovs G, Dierker DL, Harwell JW, Coalson TS, Barch DM, Van Essen DC. Automated landmark identification for human cortical surface-based registration. NeuroImage 2011, 59: 2539-2547. PMID: 21925612, PMCID: PMC3476835, DOI: 10.1016/j.neuroimage.2011.08.093.
- Negative and Nonemotional Interference with Visual Working Memory in SchizophreniaAnticevic A, Repovs G, Corlett PR, Barch DM. Negative and Nonemotional Interference with Visual Working Memory in Schizophrenia. Biological Psychiatry 2011, 70: 1159-1168. PMID: 21861986, DOI: 10.1016/j.biopsych.2011.07.010.
- Variable Global Dysconnectivity and Individual Differences in SchizophreniaCole MW, Anticevic A, Repovs G, Barch D. Variable Global Dysconnectivity and Individual Differences in Schizophrenia. Biological Psychiatry 2011, 70: 43-50. PMID: 21496789, PMCID: PMC3204885, DOI: 10.1016/j.biopsych.2011.02.010.
- Emotion Effects on Attention, Amygdala Activation, and Functional Connectivity in SchizophreniaAnticevic A, Repovs G, Barch DM. Emotion Effects on Attention, Amygdala Activation, and Functional Connectivity in Schizophrenia. Schizophrenia Bulletin 2011, 38: 967-980. PMID: 21415225, PMCID: PMC3446234, DOI: 10.1093/schbul/sbq168.
- Amygdala Recruitment in Schizophrenia in Response to Aversive Emotional Material: A Meta-analysis of Neuroimaging StudiesAnticevic A, Van Snellenberg JX, Cohen RE, Repovs G, Dowd EC, Barch DM. Amygdala Recruitment in Schizophrenia in Response to Aversive Emotional Material: A Meta-analysis of Neuroimaging Studies. Schizophrenia Bulletin 2010, 38: 608-621. PMID: 21123853, PMCID: PMC3329999, DOI: 10.1093/schbul/sbq131.
- Resisting emotional interference: Brain regions facilitating working memory performance during negative distractionAnticevic A, Barch D, Repovs G. Resisting emotional interference: Brain regions facilitating working memory performance during negative distraction. Cognitive, Affective, & Behavioral Neuroscience 2010, 10: 159-173. PMID: 20498341, PMCID: PMC3856369, DOI: 10.3758/cabn.10.2.159.
- When less is more: TPJ and default network deactivation during encoding predicts working memory performanceAnticevic A, Repovs G, Shulman GL, Barch DM. When less is more: TPJ and default network deactivation during encoding predicts working memory performance. NeuroImage 2009, 49: 2638-2648. PMID: 19913622, PMCID: PMC3226712, DOI: 10.1016/j.neuroimage.2009.11.008.
- Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophreniaAnticevic A, Dierker DL, Gillespie SK, Repovs G, Csernansky JG, Van Essen DC, Barch DM. Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia. NeuroImage 2008, 41: 835-848. PMID: 18434199, PMCID: PMC2527864, DOI: 10.1016/j.neuroimage.2008.02.052.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Mental Health & Behavioral Research | Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD |
| Mental Health & Behavioral Research | A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia |
| Diseases of the Nervous System; Mental Health & Behavioral Research | Teen Brain and Behavior Study |
| Diseases of the Nervous System; Mental Health & Behavioral Research | Examination of Glutamate and mGluR5 in Psychiatric Disorders |
| Diseases of the Nervous System; Mental Health & Behavioral Research | Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder |